PTK7 | ENSG00000112655 | NCBI 5754

Details for: PTK7

Gene ID: 5754

Symbol: PTK7

Ensembl ID: ENSG00000112655

Description: protein tyrosine kinase 7 (inactive)

Associated with

Actin cytoskeleton organization
(GO:0030036)
Atp binding
(GO:0005524)
Axis elongation
(GO:0003401)
Axon
(GO:0030424)
Axon guidance
(GO:0007411)
Axon guidance receptor activity
(GO:0008046)
Cell-cell junction
(GO:0005911)
Cell migration
(GO:0016477)
Cellular response to retinoic acid
(GO:0071300)
Cochlea morphogenesis
(GO:0090103)
Convergent extension
(GO:0060026)
Coreceptor activity
(GO:0015026)
Coronary vasculature development
(GO:0060976)
Establishment of epithelial cell apical/basal polarity
(GO:0045198)
Establishment of planar polarity
(GO:0001736)
Focal adhesion
(GO:0005925)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Kidney development
(GO:0001822)
Lung-associated mesenchyme development
(GO:0060484)
Neuronal cell body
(GO:0043025)
Planar cell polarity pathway involved in neural tube closure
(GO:0090179)
Plasma membrane
(GO:0005886)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of neuron projection development
(GO:0010976)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Signal transduction
(GO:0007165)
Synapse organization
(GO:0050808)
Ventricular septum development
(GO:0003281)
Wound healing
(GO:0042060)

Other Information

Proteins

Inactive tyrosine-protein kinase 7

Genular Protein ID: 821378831

Symbol: PTK7_HUMAN

Name: Inactive tyrosine-protein kinase 7

UniProtKB Accession Codes:

Q13308 A8K974 B7Z477 E9PFZ5 Q13417 Q5T650 Q6IQ54 Q8NFA5 Q8NFA6 Q8NFA7 Q8NFA8

Database IDs:

Citations:

PubMed ID: 7478540

Title: Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.

PubMed ID: 7478540

PubMed ID: 8882711

Title: Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.

PubMed ID: 8882711

DOI: 10.1093/oxfordjournals.jbchem.a021228

PubMed ID: 12427550

Title: Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA.

PubMed ID: 12427550

DOI: 10.1016/s0167-4781(02)00536-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 18471990

Title: Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis.

PubMed ID: 18471990

DOI: 10.1016/j.bbrc.2008.04.168

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20558616

Title: The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome.

PubMed ID: 20558616

DOI: 10.1182/blood-2010-01-262352

PubMed ID: 20837484

Title: The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.

PubMed ID: 20837484

DOI: 10.1074/jbc.m110.165159

PubMed ID: 21103379

Title: Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway.

PubMed ID: 21103379

DOI: 10.1371/journal.pone.0014018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21132015

Title: Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling.

PubMed ID: 21132015

DOI: 10.1038/embor.2010.185

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1070
Mass: 118392
Checksum: 304926A1774EB5F4
Sequence:

MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 
VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 
IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 
KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 
EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 
CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 
VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 
SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 
CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 
GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 
TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG 
RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL 
GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN 
KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ 
LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ 
PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY 
YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ 
AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSTVDSKP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PTK7

Associated with

Other Information

Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. PubMed ID: 7478540

Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. PubMed ID: 8882711

Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA. PubMed ID: 12427550

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. PubMed ID: 18471990

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome. PubMed ID: 20558616

The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. PubMed ID: 20837484

Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway. PubMed ID: 21103379

Initial characterization of the human central proteome. PubMed ID: 21269460

Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling. PubMed ID: 21132015

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846