Details for: REG1A

Gene ID: 5967

Symbol: REG1A

Ensembl ID: ENSG00000115386

Description: regenerating family member 1 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 504.9466
    Cell Significance Index: 253.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 142.1876
    Cell Significance Index: -67.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 99.8328
    Cell Significance Index: -66.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 60.6264
    Cell Significance Index: 908.4300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 49.9979
    Cell Significance Index: 379.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 31.2173
    Cell Significance Index: 3563.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.7647
    Cell Significance Index: -69.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 17.9380
    Cell Significance Index: 3063.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.9536
    Cell Significance Index: 80.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.6869
    Cell Significance Index: 135.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.4648
    Cell Significance Index: 143.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.0836
    Cell Significance Index: 185.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.7456
    Cell Significance Index: 164.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5412
    Cell Significance Index: 251.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2569
    Cell Significance Index: 2037.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1235
    Cell Significance Index: 230.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2287
    Cell Significance Index: 84.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5603
    Cell Significance Index: 106.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1658
    Cell Significance Index: 26.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1050
    Cell Significance Index: 12.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0209
    Cell Significance Index: 2.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0155
    Cell Significance Index: 8.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0003
    Cell Significance Index: 0.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0042
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0350
    Cell Significance Index: -7.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0532
    Cell Significance Index: -1.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2489
    Cell Significance Index: -5.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2577
    Cell Significance Index: -5.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2699
    Cell Significance Index: -53.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3359
    Cell Significance Index: -67.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3552
    Cell Significance Index: -64.0300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3649
    Cell Significance Index: -5.1900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.4062
    Cell Significance Index: -5.2000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.4273
    Cell Significance Index: -2.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4371
    Cell Significance Index: -60.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4638
    Cell Significance Index: -47.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4670
    Cell Significance Index: -13.7600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4740
    Cell Significance Index: -4.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4848
    Cell Significance Index: -59.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5009
    Cell Significance Index: -30.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5747
    Cell Significance Index: -8.6600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.9834
    Cell Significance Index: -8.7400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.1670
    Cell Significance Index: -12.3100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.4587
    Cell Significance Index: -9.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.5161
    Cell Significance Index: -53.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6162
    Cell Significance Index: -90.7000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -1.6583
    Cell Significance Index: -11.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.7745
    Cell Significance Index: -92.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.8323
    Cell Significance Index: -59.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.8558
    Cell Significance Index: -50.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.8737
    Cell Significance Index: -59.6800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.9625
    Cell Significance Index: -32.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -2.0459
    Cell Significance Index: -34.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -2.0709
    Cell Significance Index: -32.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1128
    Cell Significance Index: -77.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.1517
    Cell Significance Index: -45.8300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -2.1946
    Cell Significance Index: -15.9500
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -2.2987
    Cell Significance Index: -10.9500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -2.3738
    Cell Significance Index: -23.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.4053
    Cell Significance Index: -60.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.5116
    Cell Significance Index: -67.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -2.5241
    Cell Significance Index: -64.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.6218
    Cell Significance Index: -68.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.6600
    Cell Significance Index: -57.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.6970
    Cell Significance Index: -58.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.7222
    Cell Significance Index: -57.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.7415
    Cell Significance Index: -60.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.7714
    Cell Significance Index: -57.4900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -2.7800
    Cell Significance Index: -17.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -2.8379
    Cell Significance Index: -48.5100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -2.8729
    Cell Significance Index: -36.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.8734
    Cell Significance Index: -59.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.8986
    Cell Significance Index: -48.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -3.0216
    Cell Significance Index: -69.8100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -3.0485
    Cell Significance Index: -60.0000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -3.1281
    Cell Significance Index: -33.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -3.3253
    Cell Significance Index: -66.7600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -3.4009
    Cell Significance Index: -30.7600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -3.4467
    Cell Significance Index: -68.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -3.4623
    Cell Significance Index: -68.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -3.4707
    Cell Significance Index: -60.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -3.4893
    Cell Significance Index: -84.5200
  • Cell Name: PP cell (CL0000696)
    Fold Change: -3.6976
    Cell Significance Index: -37.5900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -3.7695
    Cell Significance Index: -73.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -3.7761
    Cell Significance Index: -39.0900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -3.8847
    Cell Significance Index: -37.2900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -3.9456
    Cell Significance Index: -52.6000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -3.9603
    Cell Significance Index: -40.9700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -4.0888
    Cell Significance Index: -49.7400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -4.1312
    Cell Significance Index: -66.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -4.1328
    Cell Significance Index: -59.4400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -4.1396
    Cell Significance Index: -29.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -4.2890
    Cell Significance Index: -65.1400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -4.3626
    Cell Significance Index: -59.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -4.5369
    Cell Significance Index: -65.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -4.5808
    Cell Significance Index: -65.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -4.6030
    Cell Significance Index: -65.5300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -4.6453
    Cell Significance Index: -65.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antimicrobial Peptide**: REG1A exhibits antimicrobial properties, making it an essential component of the innate immune system. Its ability to bind to peptidoglycan and oligosaccharides suggests a role in modulating the immune response to microbial pathogens. 2. **Regenerative Properties**: As a member of the regenerating family, REG1A is involved in tissue regeneration and repair. Its expression in various epithelial cells underscores its potential role in maintaining epithelial barrier function and promoting wound healing. 3. **Cellular Expression**: REG1A is significantly expressed in epithelial cells of the exocrine pancreas, colon, and intestinal crypts, highlighting its involvement in mucosal immunity and GALT. **Pathways and Functions:** 1. **Antimicrobial Humoral Immune Response**: REG1A mediates the antimicrobial humoral immune response by interacting with antimicrobial peptides, such as cathelicidins, to modulate the immune response to microbial pathogens. 2. **Extracellular Exosome**: REG1A is involved in the regulation of cell population proliferation and differentiation through the extracellular exosome, a complex of proteins and lipids secreted by cells that can influence nearby cells. 3. **Growth Factor Activity**: REG1A exhibits growth factor activity, promoting the proliferation and differentiation of various cell types, including epithelial cells and oligodendrocyte precursor cells. 4. **Inhibitor Activity**: REG1A acts as an inhibitor of molecular function, modulating the activity of various proteins involved in immune regulation and tissue repair. **Clinical Significance:** 1. **Immune-Related Disorders**: Dysregulation of REG1A has been implicated in various immune-related disorders, including autoimmune diseases and inflammatory bowel disease. Understanding the mechanisms of REG1A's function and regulation may provide novel therapeutic strategies for these conditions. 2. **Cancer**: REG1A's role in tissue regeneration and repair suggests its potential as a biomarker for cancer diagnosis and prognosis. Its expression in various epithelial cells highlights its involvement in cancer development and progression. 3. **Infectious Diseases**: REG1A's antimicrobial properties make it an attractive target for the development of novel antimicrobial therapies. Its involvement in the antimicrobial humoral immune response suggests its potential role in the treatment of infectious diseases. In conclusion, REG1A is a multifunctional peptide that plays a crucial role in maintaining immune homeostasis, tissue regeneration, and epithelial barrier function. Its unique characteristics and functions have significant implications for our understanding of immune regulation and the development of novel therapeutic strategies for immune-related disorders. Further research is necessary to fully elucidate the mechanisms of REG1A's function and regulation, with potential applications in the treatment of various diseases, including autoimmune disorders, cancer, and infectious diseases.

Genular Protein ID: 2544823070

Symbol: REG1A_HUMAN

Name: Lithostathine-1-alpha

UniProtKB Accession Codes:

P05451 P11379 Q4ZG28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2963000

Title: A novel gene activated in regenerating islets.

PubMed ID: 2963000

DOI: 10.1016/s0021-9258(18)69176-8

PubMed ID: 2332435

Title: Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene.

PubMed ID: 2332435

DOI: 10.1016/s0021-9258(19)39132-x

PubMed ID: 2525567

Title: Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.

PubMed ID: 2525567

DOI: 10.1172/jci114128

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3665916

Title: Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice.

PubMed ID: 3665916

DOI: 10.1111/j.1432-1033.1987.tb13405.x

PubMed ID: 3541906

Title: Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein.

PubMed ID: 3541906

DOI: 10.1042/bj2380227

PubMed ID: 3908481

Title: Isolation, characterization, and distribution of an unusual pancreatic human secretory protein.

PubMed ID: 3908481

DOI: 10.1172/jci112216

PubMed ID: 2493268

Title: N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.

PubMed ID: 2493268

DOI: 10.1016/0167-4838(89)90305-1

PubMed ID: 3108036

Title: Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein.

PubMed ID: 3108036

DOI: 10.1016/0014-5793(87)80688-9

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2764894

Title: The human reg gene encodes pancreatic stone protein.

PubMed ID: 2764894

DOI: 10.1042/bj2600622

PubMed ID: 2226837

Title: Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae.

PubMed ID: 2226837

DOI: 10.1016/0014-5793(90)80454-q

PubMed ID: 2394826

Title: Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain.

PubMed ID: 2394826

DOI: 10.1172/jci114762

PubMed ID: 8654365

Title: Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.

PubMed ID: 8654365

DOI: 10.1002/j.1460-2075.1996.tb00628.x

PubMed ID: 10625646

Title: Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine.

PubMed ID: 10625646

DOI: 10.1074/jbc.275.2.1057

PubMed ID: 8961348

Title: What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy.

PubMed ID: 8961348

DOI: 10.1093/protein/9.11.949

Sequence Information:

  • Length: 166
  • Mass: 18731
  • Checksum: EF93C760DC2DBCC3
  • Sequence:
    • MAQTSSYFML ISCLMFLSQS QGQEAQTELP QARISCPEGT NAYRSYCYYF NEDRETWVDA 
DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SGTDDFNVWI GLHDPKKNRR WHWSSGSLVS 
YKSWGIGAPS SVNPGYCVSL TSSTGFQKWK DVPCEDKFSF VCKFKN

Genular Protein ID: 2004599297

Symbol: A8K7G6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K7G6

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 166
  • Mass: 18732
  • Checksum: E173C760DC2DBCC3
  • Sequence:
    • MAQTSSYFML ISCLMFLSQS QGQEAQTELP QARISCPEGT NAYRSYCYYF NEDRETWVDA 
DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SGTDDFNVWI GLHDPKKNRR WHWSSGSLVS 
YKSWGIGAPS SVNPGYCVSL TSSTGFQKWK DVPCEDKFSF VCKFKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.