Details for: REG1B

Gene ID: 5968

Symbol: REG1B

Ensembl ID: ENSG00000172023

Description: regenerating family member 1 beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 552.7352
    Cell Significance Index: 277.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 12.9833
    Cell Significance Index: 1482.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 11.7518
    Cell Significance Index: 176.0900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 9.7138
    Cell Significance Index: 122.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.9846
    Cell Significance Index: 680.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.8775
    Cell Significance Index: 175.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 1.3442
    Cell Significance Index: 19.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 1.2096
    Cell Significance Index: 755.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1719
    Cell Significance Index: 17.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9045
    Cell Significance Index: 816.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7719
    Cell Significance Index: 46.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7611
    Cell Significance Index: 82.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7052
    Cell Significance Index: 48.7700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.5741
    Cell Significance Index: 6.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5516
    Cell Significance Index: 104.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4500
    Cell Significance Index: 73.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3167
    Cell Significance Index: 11.1300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2487
    Cell Significance Index: 1.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1458
    Cell Significance Index: 14.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1194
    Cell Significance Index: 88.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0567
    Cell Significance Index: 6.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0309
    Cell Significance Index: 6.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0103
    Cell Significance Index: 5.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0010
    Cell Significance Index: -0.0500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0437
    Cell Significance Index: -0.5700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0451
    Cell Significance Index: -0.9000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0503
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0547
    Cell Significance Index: -24.8200
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.0635
    Cell Significance Index: -0.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0679
    Cell Significance Index: -2.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0753
    Cell Significance Index: -1.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0803
    Cell Significance Index: -1.1500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0843
    Cell Significance Index: -0.9100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0843
    Cell Significance Index: -1.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0914
    Cell Significance Index: -18.3400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1041
    Cell Significance Index: -0.8700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1131
    Cell Significance Index: -1.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1250
    Cell Significance Index: -24.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1273
    Cell Significance Index: -1.8800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1319
    Cell Significance Index: -0.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1388
    Cell Significance Index: -3.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1452
    Cell Significance Index: -1.1200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1472
    Cell Significance Index: -1.7600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1485
    Cell Significance Index: -1.9800
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1566
    Cell Significance Index: -1.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1595
    Cell Significance Index: -9.7800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1605
    Cell Significance Index: -1.4600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1864
    Cell Significance Index: -1.9800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.2036
    Cell Significance Index: -0.9700
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2136
    Cell Significance Index: -1.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2221
    Cell Significance Index: -6.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2875
    Cell Significance Index: -6.1200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3008
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3788
    Cell Significance Index: -4.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3864
    Cell Significance Index: -39.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3960
    Cell Significance Index: -8.5800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4546
    Cell Significance Index: -4.9900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4628
    Cell Significance Index: -4.8000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.6717
    Cell Significance Index: -5.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7267
    Cell Significance Index: -19.4400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7269
    Cell Significance Index: -11.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7341
    Cell Significance Index: -12.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.7506
    Cell Significance Index: -10.9400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7775
    Cell Significance Index: -19.8100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.7874
    Cell Significance Index: -7.9600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.7908
    Cell Significance Index: -9.4100
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.8046
    Cell Significance Index: -8.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.8202
    Cell Significance Index: -14.0200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8409
    Cell Significance Index: -8.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8476
    Cell Significance Index: -27.7500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8511
    Cell Significance Index: -11.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8745
    Cell Significance Index: -18.1400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.8757
    Cell Significance Index: -14.0800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.9197
    Cell Significance Index: -12.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9518
    Cell Significance Index: -10.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9613
    Cell Significance Index: -19.3000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.9707
    Cell Significance Index: -9.8500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.9801
    Cell Significance Index: -16.1500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -1.0252
    Cell Significance Index: -13.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0659
    Cell Significance Index: -23.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.1195
    Cell Significance Index: -18.8300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -1.1696
    Cell Significance Index: -13.4800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -1.1798
    Cell Significance Index: -13.2100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -1.1877
    Cell Significance Index: -15.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -1.2272
    Cell Significance Index: -13.7200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -1.2316
    Cell Significance Index: -16.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.2326
    Cell Significance Index: -24.1000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.2371
    Cell Significance Index: -7.6800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -1.2601
    Cell Significance Index: -15.3300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.3151
    Cell Significance Index: -16.9000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -1.3285
    Cell Significance Index: -15.4100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.3418
    Cell Significance Index: -17.8300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -1.3483
    Cell Significance Index: -19.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** REG1B is a member of the regenerating family of proteins, which are known for their involvement in immune response and tissue repair. The protein product of REG1B, lithostathine-1-beta, is a small, cysteine-rich peptide that is secreted by various cell types. This peptide has been shown to have antimicrobial properties, making it an essential component of the innate immune response. **Pathways and Functions:** REG1B is involved in several key pathways, including: 1. **Antimicrobial humoral immune response mediated by antimicrobial peptide:** REG1B produces lithostathine-1-beta, which is a potent antimicrobial peptide that can inhibit the growth of various microorganisms. 2. **Extracellular exosome:** REG1B is secreted by cells, and its protein product is transported to other cells via exosomes, where it can interact with other signaling molecules. 3. **Oligosaccharide binding:** REG1B has been shown to bind to oligosaccharides, which are important components of the glycosaminoglycan (GAG) network in the extracellular matrix. 4. **Peptidoglycan binding:** REG1B has been shown to bind to peptidoglycan, a key component of bacterial cell walls. 5. **Positive regulation of cell population proliferation:** REG1B has been shown to promote the proliferation of various cell types, including T cells and pancreatic stellate cells. **Clinical Significance:** REG1B has significant implications for various diseases, including: 1. **Pancreatitis:** REG1B is significantly expressed in pancreatic epithelial cells and has been implicated in the pathogenesis of pancreatitis. 2. **Diabetes:** REG1B is also expressed in pancreatic A cells, and its dysregulation has been linked to the development of diabetes. 3. **Inflammatory diseases:** REG1B has been shown to play a role in mediating inflammatory responses, making it a potential target for the treatment of inflammatory diseases. 4. **Cancer:** REG1B has been shown to promote the proliferation of various cancer cells, including pancreatic cancer cells. In conclusion, REG1B is a multifaceted gene that plays a crucial role in regulating the immune response, pancreatic function, and cell proliferation. Its dysregulation has been implicated in various diseases, making it an important target for future research and therapeutic interventions.

Genular Protein ID: 758676142

Symbol: REG1B_HUMAN

Name: Lithostathine-1-beta

UniProtKB Accession Codes:

P48304

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8348956

Title: A gene homologous to the reg gene is expressed in the human pancreas.

PubMed ID: 8348956

DOI: 10.1016/0014-5793(93)81006-l

PubMed ID: 8110835

Title: Isolation, structural determination and expression of a novel reg gene, human regI beta.

PubMed ID: 8110835

DOI: 10.1016/0167-4781(94)90035-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7607222

Title: The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications.

PubMed ID: 7607222

DOI: 10.1111/j.1432-1033.1995.tb20589.x

Sequence Information:

  • Length: 166
  • Mass: 18665
  • Checksum: D1DC20E11AE5DDE8
  • Sequence:
    • MAQTNSFFML ISSLMFLSLS QGQESQTELP NPRISCPEGT NAYRSYCYYF NEDPETWVDA 
DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI GLHDPKKNRR WHWSSGSLVS 
YKSWDTGSPS SANAGYCASL TSCSGFKKWK DESCEKKFSF VCKFKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.