Details for: RRM2P2

Gene ID: 6244

Symbol: RRM2P2

Ensembl ID: ENSG00000236484

Description: ribonucleotide reductase M2 polypeptide pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.2310
    Cell Significance Index: 2.2100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0961
    Cell Significance Index: 0.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0738
    Cell Significance Index: 1.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0138
    Cell Significance Index: 0.1800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0122
    Cell Significance Index: 0.1100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.0119
    Cell Significance Index: 0.1200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0034
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0003
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0023
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0026
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0058
    Cell Significance Index: -0.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0124
    Cell Significance Index: -0.4000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0136
    Cell Significance Index: -0.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0146
    Cell Significance Index: -0.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0150
    Cell Significance Index: -0.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0167
    Cell Significance Index: -0.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0182
    Cell Significance Index: -0.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0187
    Cell Significance Index: -0.5000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0189
    Cell Significance Index: -0.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0189
    Cell Significance Index: -0.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0192
    Cell Significance Index: -0.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0198
    Cell Significance Index: -0.3900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0235
    Cell Significance Index: -0.2400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0239
    Cell Significance Index: -0.2500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0263
    Cell Significance Index: -0.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0293
    Cell Significance Index: -0.3600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0302
    Cell Significance Index: -0.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0320
    Cell Significance Index: -0.7000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0328
    Cell Significance Index: -0.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0356
    Cell Significance Index: -0.9700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0369
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0422
    Cell Significance Index: -0.4000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0437
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0460
    Cell Significance Index: -0.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0506
    Cell Significance Index: -0.6900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0514
    Cell Significance Index: -0.5600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0639
    Cell Significance Index: -0.6700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0681
    Cell Significance Index: -0.8100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0770
    Cell Significance Index: -0.7000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0816
    Cell Significance Index: -0.9100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0840
    Cell Significance Index: -0.7400
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0862
    Cell Significance Index: -0.9100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0864
    Cell Significance Index: -0.7900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0889
    Cell Significance Index: -1.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0899
    Cell Significance Index: -1.2800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0905
    Cell Significance Index: -1.0600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0908
    Cell Significance Index: -1.0800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0914
    Cell Significance Index: -0.8000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0925
    Cell Significance Index: -1.1700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0959
    Cell Significance Index: -0.9500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0960
    Cell Significance Index: -0.9100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0967
    Cell Significance Index: -1.1400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0982
    Cell Significance Index: -0.9100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0996
    Cell Significance Index: -1.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0998
    Cell Significance Index: -1.1900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1014
    Cell Significance Index: -0.6600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1022
    Cell Significance Index: -1.2800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1028
    Cell Significance Index: -1.2900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1035
    Cell Significance Index: -1.1100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1048
    Cell Significance Index: -1.2700
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1050
    Cell Significance Index: -1.2500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1057
    Cell Significance Index: -1.2700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1071
    Cell Significance Index: -1.2100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1101
    Cell Significance Index: -1.3200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1115
    Cell Significance Index: -0.7000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1146
    Cell Significance Index: -0.6800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1323
    Cell Significance Index: -1.2400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1362
    Cell Significance Index: -1.2000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1526
    Cell Significance Index: -1.2600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1677
    Cell Significance Index: -1.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RRM2P2 is a pseudogene, which implies that it lacks the ability to produce a functional protein. However, this pseudogene has been found to be significantly expressed in numerous cell types, including astrocytes, fibroblasts, mesenchymal stem cells, plasma cells, oligodendrocytes, neutrophils, neurons, glutamatergic neurons, stromal cells, and retinal rod cells. This widespread expression suggests that RRM2P2 may have evolved to regulate specific cellular processes or interact with other genes to maintain cellular homeostasis. **Pathways and Functions:** The exact mechanisms by which RRM2P2 regulates cellular processes are not fully understood. However, its expression in various cell types suggests that it may be involved in the regulation of cell growth, differentiation, and survival. RRM2P2 has been found to interact with other genes involved in DNA synthesis and repair, suggesting that it may play a role in maintaining genomic stability. Additionally, its expression in immune cells suggests that RRM2P2 may be involved in the regulation of immune responses, potentially modulating the activity of immune cells such as T cells and B cells. **Clinical Significance:** The clinical significance of RRM2P2 is an area of active research. Given its widespread expression and potential involvement in regulating cellular homeostasis and immune responses, alterations in RRM2P2 expression could contribute to various diseases. For example, dysregulation of RRM2P2 has been implicated in several types of cancer, including breast cancer, lung cancer, and leukemia. Additionally, RRM2P2 may play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where cellular homeostasis is disrupted. In conclusion, the RRM2P2 gene is a complex and enigmatic gene that has shed light on the intricate mechanisms of cellular homeostasis and immune regulation. Further research is necessary to fully elucidate the functions and clinical significance of RRM2P2, but its discovery highlights the importance of considering pseudogenes as potential regulatory elements in the human genome. **Future Directions:** Future studies should aim to elucidate the mechanisms by which RRM2P2 regulates cellular processes and interacts with other genes. Additionally, the clinical significance of RRM2P2 should be further explored, including its potential role in various diseases and its use as a biomarker for disease diagnosis and prognosis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.