Details for: CCL11

Gene ID: 6356

Symbol: CCL11

Ensembl ID: ENSG00000172156

Description: C-C motif chemokine ligand 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.1765
    Cell Significance Index: 13.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.7613
    Cell Significance Index: 27.2500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.9865
    Cell Significance Index: 9.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0621
    Cell Significance Index: 38.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0064
    Cell Significance Index: 0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0113
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0170
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0187
    Cell Significance Index: -3.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0266
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0309
    Cell Significance Index: -3.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0359
    Cell Significance Index: -0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0365
    Cell Significance Index: -7.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0392
    Cell Significance Index: -7.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0534
    Cell Significance Index: -6.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0610
    Cell Significance Index: -7.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0679
    Cell Significance Index: -9.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0718
    Cell Significance Index: -5.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0723
    Cell Significance Index: -1.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0836
    Cell Significance Index: -1.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0851
    Cell Significance Index: -10.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0943
    Cell Significance Index: -1.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0966
    Cell Significance Index: -5.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1144
    Cell Significance Index: -3.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1210
    Cell Significance Index: -3.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1503
    Cell Significance Index: -11.2000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1606
    Cell Significance Index: -1.8900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1607
    Cell Significance Index: -1.5900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1679
    Cell Significance Index: -1.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1789
    Cell Significance Index: -2.2600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1820
    Cell Significance Index: -1.9500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1837
    Cell Significance Index: -1.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1850
    Cell Significance Index: -6.4300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1883
    Cell Significance Index: -2.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1932
    Cell Significance Index: -5.4000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1938
    Cell Significance Index: -1.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2003
    Cell Significance Index: -2.2800
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2023
    Cell Significance Index: -1.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2078
    Cell Significance Index: -6.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2096
    Cell Significance Index: -6.6800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2171
    Cell Significance Index: -1.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2299
    Cell Significance Index: -8.4400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2457
    Cell Significance Index: -2.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2479
    Cell Significance Index: -11.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2548
    Cell Significance Index: -11.9800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2668
    Cell Significance Index: -3.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2668
    Cell Significance Index: -7.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2695
    Cell Significance Index: -2.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2732
    Cell Significance Index: -6.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2776
    Cell Significance Index: -7.3000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2853
    Cell Significance Index: -3.6100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2877
    Cell Significance Index: -3.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2895
    Cell Significance Index: -6.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2918
    Cell Significance Index: -7.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2970
    Cell Significance Index: -6.1600
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.3046
    Cell Significance Index: -1.9000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3049
    Cell Significance Index: -1.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3468
    Cell Significance Index: -4.9800
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.3640
    Cell Significance Index: -1.9100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4159
    Cell Significance Index: -7.1100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4171
    Cell Significance Index: -6.1000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4262
    Cell Significance Index: -7.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4280
    Cell Significance Index: -7.2700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.4292
    Cell Significance Index: -3.7100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4396
    Cell Significance Index: -5.9800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4480
    Cell Significance Index: -6.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4483
    Cell Significance Index: -7.2600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4506
    Cell Significance Index: -5.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4527
    Cell Significance Index: -10.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4676
    Cell Significance Index: -5.9000
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.4821
    Cell Significance Index: -4.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4991
    Cell Significance Index: -10.0200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5039
    Cell Significance Index: -5.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5052
    Cell Significance Index: -5.2300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5139
    Cell Significance Index: -5.6300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.5167
    Cell Significance Index: -6.0000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5197
    Cell Significance Index: -7.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5199
    Cell Significance Index: -7.2100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.5244
    Cell Significance Index: -3.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5319
    Cell Significance Index: -7.6500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.5343
    Cell Significance Index: -5.6000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.5450
    Cell Significance Index: -6.4700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5517
    Cell Significance Index: -7.2600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5532
    Cell Significance Index: -7.2600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5583
    Cell Significance Index: -6.3400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5586
    Cell Significance Index: -6.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5614
    Cell Significance Index: -7.1900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5657
    Cell Significance Index: -6.6900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.5669
    Cell Significance Index: -7.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5729
    Cell Significance Index: -7.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5798
    Cell Significance Index: -8.5600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.5803
    Cell Significance Index: -6.9200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5822
    Cell Significance Index: -7.6000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5857
    Cell Significance Index: -7.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5858
    Cell Significance Index: -7.2000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5869
    Cell Significance Index: -6.4200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.5923
    Cell Significance Index: -5.7300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5935
    Cell Significance Index: -7.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL11 is a member of the CC chemokine family, characterized by its four conserved cysteine residues in the extracellular domain. It is a small, 8-amino acid peptide that binds to the CCR3 receptor, which is expressed on the surface of eosinophils, basophils, and T-cells. CCL11 is produced by various cell types, including epithelial cells, fibroblasts, and immune cells, in response to inflammatory stimuli. Its expression is often upregulated in conditions of allergic inflammation, such as asthma and atopic dermatitis. **Pathways and Functions** CCL11 functions as a chemoattractant, guiding the migration of immune cells towards sites of inflammation. Its binding to CCR3 triggers a signaling cascade that activates various cellular responses, including: 1. Chemotaxis: CCL11 promotes the migration of eosinophils, basophils, and T-cells towards the site of inflammation. 2. Cell adhesion: CCL11 interacts with CCR3 to mediate the adhesion of immune cells to the endothelial wall, facilitating their transmigration into the inflamed tissue. 3. Angiogenesis: CCL11 has been shown to promote angiogenesis, the formation of new blood vessels, which is essential for the growth and maintenance of tumors. 4. Cell migration: CCL11 regulates the migration of epithelial cells, influencing tissue repair and remodeling. **Clinical Significance** CCL11 has been implicated in various diseases, including: 1. Allergic inflammation: CCL11 plays a key role in the development of allergic responses, such as asthma and atopic dermatitis. 2. Cancer: CCL11 has been shown to promote tumor growth and metastasis in various types of cancer, including breast and lung cancer. 3. Gastrointestinal disorders: CCL11 has been implicated in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD) and gastroesophageal reflux disease (GERD). 4. Neurological disorders: CCL11 has been shown to play a role in the development of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, CCL11 is a multifunctional chemokine that plays a crucial role in the regulation of immune responses, tissue repair, and cancer development. Further research is needed to fully elucidate the mechanisms of CCL11 and its implications in human disease.

Genular Protein ID: 2482046344

Symbol: CCL11_HUMAN

Name: Eotaxin

UniProtKB Accession Codes:

P51671 P50877 Q92490 Q92491

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8597956

Title: Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.

PubMed ID: 8597956

DOI: 10.1038/nm0496-449

PubMed ID: 8609214

Title: Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.

PubMed ID: 8609214

DOI: 10.1172/jci118456

PubMed ID: 8631813

Title: Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.

PubMed ID: 8631813

DOI: 10.1074/jbc.271.13.7725

PubMed ID: 8780731

Title: Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.

PubMed ID: 8780731

DOI: 10.1006/bbrc.1996.1292

PubMed ID: 9169149

Title: Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.

PubMed ID: 9169149

DOI: 10.1006/geno.1997.4656

PubMed ID: 9299399

Title: Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.

PubMed ID: 9299399

DOI: 10.1006/bbrc.1997.7169

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9578468

Title: Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.

PubMed ID: 9578468

DOI: 10.1046/j.1432-1327.1998.2530114.x

PubMed ID: 9712872

Title: Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.

PubMed ID: 9712872

DOI: 10.1074/jbc.273.35.22471

Sequence Information:

  • Length: 97
  • Mass: 10732
  • Checksum: B433C30FDA4C71A7
  • Sequence:
    • MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR RITSGKCPQK 
AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.