No CSI details found for gene ID: 6677
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2012818500
Symbol: HYALP_HUMAN
Name: Hyaluronidase PH-20
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8234258
Title: Molecular cloning of the human and monkey sperm surface protein PH-20.
PubMed ID: 8234258
PubMed ID: 8282124
Title: The human sperm protein PH-20 has hyaluronidase activity.
PubMed ID: 8282124
PubMed ID: 8575780
Title: Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1.
PubMed ID: 8575780
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9288901
Title: In vitro mutagenesis of PH-20 hyaluronidase from human sperm.
PubMed ID: 9288901
PubMed ID: 21248752
Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
PubMed ID: 21248752
DOI: 10.1038/nature09639
Sequence Information:
- Length: 509
- Mass: 57848
- Checksum: 5ADB4739747E32E8
- Sequence:
MGVLKFKHIF FRSFVKSSGV SQIVFTFLLI PCCLTLNFRA PPVIPNVPFL WAWNAPSEFC LGKFDEPLDM SLFSFIGSPR INATGQGVTI FYVDRLGYYP YIDSITGVTV NGGIPQKISL QDHLDKAKKD ITFYMPVDNL GMAVIDWEEW RPTWARNWKP KDVYKNRSIE LVQQQNVQLS LTEATEKAKQ EFEKAGKDFL VETIKLGKLL RPNHLWGYYL FPDCYNHHYK KPGYNGSCFN VEIKRNDDLS WLWNESTALY PSIYLNTQQS PVAATLYVRN RVREAIRVSK IPDAKSPLPV FAYTRIVFTD QVLKFLSQDE LVYTFGETVA LGASGIVIWG TLSIMRSMKS CLLLDNYMET ILNPYIINVT LAAKMCSQVL CQEQGVCIRK NWNSSDYLHL NPDNFAIQLE KGGKFTVRGK PTLEDLEQFS EKFYCSCYST LSCKEKADVK DTDAVDVCIA DGVCIDAFLK PPMETEEPQI FYNASPSTLS ATMFIVSILF LIISSVASL
Details Unavailable
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{
"geneID": 6677,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AJ494724.1"
]
},
"symbol": "SPAM1",
"created": {
"$date": {
"$numberLong": "1738333349188"
}
},
"crossReference": {
"enseGeneID": "ENSG00000106304",
"enseRnaID": [
"ENST00000460182.5"
],
"enseProtID": [
"ENSP00000417934.1"
]
},
"genePos": {
"end": 123971414,
"start": 123925241
},
"chrom": {
"pos": "7",
"type": 1,
"loc": "7q31.32"
},
"desc": "sperm adhesion molecule 1",
"geneType": 5,
"mim": [
{
"id": 600930,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-1474165",
"term": "Reproduction",
"cat": 10
},
{
"id": "R-HSA-1187000",
"term": "Fertilization",
"cat": 11
},
{
"id": "R-HSA-2534343",
"term": "Interaction With Cumulus Cells And The Zona Pellucida",
"cat": 12
},
{
"id": "GO:0004415",
"term": "hyalurononglucosaminidase activity",
"cat": 0
},
{
"id": "GO:0005975",
"term": "carbohydrate metabolic process",
"cat": 1
},
{
"id": "GO:0007155",
"term": "cell adhesion",
"cat": 1
},
{
"id": "GO:0007339",
"term": "binding of sperm to zona pellucida",
"pubMed": [
8195297
],
"cat": 1
},
{
"id": "GO:0007342",
"term": "fusion of sperm to egg plasma membrane involved in single fertilization",
"cat": 1
},
{
"id": "GO:0030214",
"term": "hyaluronan catabolic process",
"cat": 1
},
{
"id": "GO:0001669",
"term": "acrosomal vesicle",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0098552",
"term": "side of membrane",
"cat": 2
}
],
"geneRelations": [
{
"type": 1,
"similarGenes": [
"105375483"
]
}
],
"protein": [
{
"symbol": "HYALP_HUMAN",
"name": "Hyaluronidase PH-20",
"accession": [
"P38567",
"Q8TC30"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EC": [
"3.2.1.35",
"3.2.1.35"
],
"EMBL": [
"L13781",
"S67798",
"X84347",
"AC004690",
"CH236947",
"CH471070",
"BC026163"
],
"CCDS": [
"CCDS5790.1",
"CCDS5791.1"
],
"PIR": [
"S40465"
],
"RefSeq": [
"NP_001167515.1",
"NP_001167516.1",
"NP_001167517.1",
"NP_003108.2",
"NP_694859.1"
],
"AlphaFoldDB": [
"P38567"
],
"SMR": [
"P38567"
],
"BioGRID": [
"112559"
],
"STRING": [
"9606.ENSP00000345849"
],
"DrugBank": [
"DB08818"
],
"CAZy": [
"GH56"
],
"GlyCosmos": [
"P38567"
],
"GlyGen": [
"P38567"
],
"iPTMnet": [
"P38567"
],
"PhosphoSitePlus": [
"P38567"
],
"BioMuta": [
"SPAM1"
],
"DMDM": [
"585673"
],
"MassIVE": [
"P38567"
],
"PaxDb": [
"9606-ENSP00000345849"
],
"PeptideAtlas": [
"P38567"
],
"ProteomicsDB": [
"55298",
"55299"
],
"Antibodypedia": [
"2991"
],
"DNASU": [
"6677"
],
"Ensembl": [
"ENST00000223028.11",
"ENST00000340011.9",
"ENST00000402183.3",
"ENST00000439500.5",
"ENST00000460182.5",
"ENST00000682466.1"
],
"KEGG": [
"hsa:6677"
],
"MANE-Select": [
"ENST00000682466.1"
],
"UCSC": [
"uc003vle.4"
],
"AGR": [
"HGNC:11217"
],
"CTD": [
"6677"
],
"DisGeNET": [
"6677"
],
"GeneCards": [
"SPAM1"
],
"HGNC": [
"HGNC:11217"
],
"HPA": [
"ENSG00000106304"
],
"MIM": [
"600930"
],
"neXtProt": [
"NX_P38567"
],
"OpenTargets": [
"ENSG00000106304"
],
"PharmGKB": [
"PA36053"
],
"VEuPathDB": [
"HostDB:ENSG00000106304"
],
"eggNOG": [
"ENOG502R6HD"
],
"GeneTree": [
"ENSGT01020000230364"
],
"HOGENOM": [
"CLU_036366_0_1_1"
],
"InParanoid": [
"P38567"
],
"OMA": [
"RAKIVFE"
],
"OrthoDB": [
"5344684at2759"
],
"PhylomeDB": [
"P38567"
],
"TreeFam": [
"TF321598"
],
"BioCyc": [
"MetaCyc:HS02884-MONOMER"
],
"BRENDA": [
"3.2.1.35"
],
"PathwayCommons": [
"P38567"
],
"Reactome": [
"R-HSA-2534343"
],
"BioGRID-ORCS": [
"6677"
],
"GeneWiki": [
"SPAM1"
],
"GenomeRNAi": [
"6677"
],
"Pharos": [
"P38567"
],
"PRO": [
"PR:P38567"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P38567"
],
"Bgee": [
"ENSG00000106304"
],
"ExpressionAtlas": [
"P38567"
],
"GO": [
"GO:0001669",
"GO:0005886",
"GO:0098552",
"GO:0004415",
"GO:0007339",
"GO:0005975",
"GO:0007155",
"GO:0007342",
"GO:0030214"
],
"Gene3D": [
"3.20.20.70"
],
"InterPro": [
"IPR013785",
"IPR017853",
"IPR018155",
"IPR001439"
],
"PANTHER": [
"PTHR11769",
"PTHR11769:SF20"
],
"Pfam": [
"PF01630"
],
"PIRSF": [
"PIRSF038193",
"PIRSF500773"
],
"PRINTS": [
"PR00846",
"PR00848"
],
"SUPFAM": [
"SSF51445"
]
},
"citations": [
{
"title": "Molecular cloning of the human and monkey sperm surface protein PH-20.",
"pubmedID": "8234258",
"doi": "10.1073\/pnas.90.21.10071"
},
{
"title": "The human sperm protein PH-20 has hyaluronidase activity.",
"pubmedID": "8282124",
"doi": "10.1016\/0014-5793(93)80873-s"
},
{
"title": "Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1.",
"pubmedID": "8575780",
"doi": "10.1006\/geno.1995.9931"
},
{
"title": "The DNA sequence of human chromosome 7.",
"pubmedID": "12853948",
"doi": "10.1038\/nature01782"
},
{
"title": "Human chromosome 7: DNA sequence and biology.",
"pubmedID": "12690205",
"doi": "10.1126\/science.1083423"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
},
{
"title": "In vitro mutagenesis of PH-20 hyaluronidase from human sperm.",
"pubmedID": "9288901",
"doi": "10.1111\/j.1432-1033.1997.t01-1-00810.x"
},
{
"title": "Exome sequencing identifies frequent mutation of the SWI\/SNF complex gene PBRM1 in renal carcinoma.",
"pubmedID": "21248752",
"doi": "10.1038\/nature09639"
}
],
"sequence": {
"length": 509,
"mass": 57848,
"checksum": "5ADB4739747E32E8",
"modified": {
"$date": {
"$numberLong": "780969600000"
}
},
"version": 1,
"sequence": "MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFNVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQIFYNASPSTLSATMFIVSILFLIISSVASL"
},
"existence": 0,
"relevance": 1,
"proteinID": 2012818500
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}