Details for: SPAM1

Gene ID: 6677

Symbol: SPAM1

Ensembl ID: ENSG00000106304

Description: sperm adhesion molecule 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6617
    Cell Significance Index: 40.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4974
    Cell Significance Index: 7.2500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.4374
    Cell Significance Index: 8.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4130
    Cell Significance Index: 10.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3574
    Cell Significance Index: 12.5600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3574
    Cell Significance Index: 4.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2900
    Cell Significance Index: 4.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2368
    Cell Significance Index: 5.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2322
    Cell Significance Index: 14.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1213
    Cell Significance Index: 3.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1123
    Cell Significance Index: 5.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1005
    Cell Significance Index: 1.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0960
    Cell Significance Index: 18.2700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0767
    Cell Significance Index: 0.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0648
    Cell Significance Index: 1.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0618
    Cell Significance Index: 3.7100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0454
    Cell Significance Index: 0.4600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0428
    Cell Significance Index: 0.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0425
    Cell Significance Index: 0.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0281
    Cell Significance Index: 0.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0280
    Cell Significance Index: 0.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0277
    Cell Significance Index: 0.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0266
    Cell Significance Index: 2.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0240
    Cell Significance Index: 21.6900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0202
    Cell Significance Index: 0.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0146
    Cell Significance Index: 0.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0144
    Cell Significance Index: 1.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0128
    Cell Significance Index: 1.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0072
    Cell Significance Index: 1.1800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0066
    Cell Significance Index: 0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0046
    Cell Significance Index: 0.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0046
    Cell Significance Index: 0.1100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0040
    Cell Significance Index: 0.0500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0012
    Cell Significance Index: -0.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0015
    Cell Significance Index: -0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0027
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0039
    Cell Significance Index: -0.4500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0059
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0089
    Cell Significance Index: -1.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0089
    Cell Significance Index: -0.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0116
    Cell Significance Index: -0.7800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0123
    Cell Significance Index: -0.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0138
    Cell Significance Index: -1.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0151
    Cell Significance Index: -0.6700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0159
    Cell Significance Index: -0.3100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0172
    Cell Significance Index: -0.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0174
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0177
    Cell Significance Index: -0.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0177
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0181
    Cell Significance Index: -0.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0182
    Cell Significance Index: -1.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0185
    Cell Significance Index: -0.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0186
    Cell Significance Index: -0.6500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0191
    Cell Significance Index: -0.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0191
    Cell Significance Index: -0.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0202
    Cell Significance Index: -0.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0214
    Cell Significance Index: -1.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0232
    Cell Significance Index: -1.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0257
    Cell Significance Index: -0.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0265
    Cell Significance Index: -0.7400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0268
    Cell Significance Index: -0.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0277
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0280
    Cell Significance Index: -0.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0282
    Cell Significance Index: -1.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0284
    Cell Significance Index: -0.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0288
    Cell Significance Index: -0.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0294
    Cell Significance Index: -1.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0297
    Cell Significance Index: -0.6300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0301
    Cell Significance Index: -0.3300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0311
    Cell Significance Index: -0.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0316
    Cell Significance Index: -0.4500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0339
    Cell Significance Index: -0.4100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0341
    Cell Significance Index: -0.6800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0353
    Cell Significance Index: -0.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0354
    Cell Significance Index: -0.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0354
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0378
    Cell Significance Index: -0.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0379
    Cell Significance Index: -0.7900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0391
    Cell Significance Index: -0.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0392
    Cell Significance Index: -1.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0394
    Cell Significance Index: -0.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0399
    Cell Significance Index: -0.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPAM1 is a member of the hyaluronidase family, which is involved in the degradation of hyaluronic acid, a key component of the extracellular matrix. SPAM1 is specifically expressed in various cell types, including blood vessel endothelial cells, plasma cells, and enterocytes. Its expression is also observed in the zona pellucida and cumulus cells, which are essential for sperm binding and fertilization. SPAM1 interacts with other proteins, such as HYALP_HUMAN (hyaluronidase PH-20), to facilitate its function. **Pathways and Functions:** The primary function of SPAM1 is to facilitate the binding of sperm to the zona pellucida through its interaction with the acrosome. This process involves the degradation of hyaluronic acid by SPAM1, which creates a binding site for the sperm. Additionally, SPAM1 is involved in the fusion of sperm to the egg plasma membrane, a critical step in the fertilization process. SPAM1 also plays a role in cell adhesion, carbohydrate metabolic processes, and the catabolism of hyaluronan. Its expression is also observed in the interaction between cumulus cells and the zona pellucida, which is essential for sperm binding. **Clinical Significance:** Dysregulation of SPAM1 has been implicated in various reproductive disorders, including infertility and recurrent miscarriage. Mutations in the SPAM1 gene have been associated with abnormal sperm morphology and reduced fertility. Furthermore, SPAM1 has been shown to play a role in the development of certain cancers, including ovarian and breast cancer. Its expression has also been observed in various types of leukemia, suggesting a potential link between SPAM1 and cancer development. Understanding the role of SPAM1 in fertilization and cancer development will be crucial for the development of novel therapeutic strategies for these diseases. In conclusion, SPAM1 plays a critical role in the process of fertilization, and its dysregulation has been implicated in various reproductive disorders. Further research is needed to fully elucidate the mechanisms by which SPAM1 functions and its potential therapeutic applications. As an immunologist, it is essential to understand the complex interactions between SPAM1 and other proteins involved in fertilization and cancer development to develop novel therapeutic strategies for these diseases.

Genular Protein ID: 2012818500

Symbol: HYALP_HUMAN

Name: Hyaluronidase PH-20

UniProtKB Accession Codes:

P38567 Q8TC30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 7 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8234258

Title: Molecular cloning of the human and monkey sperm surface protein PH-20.

PubMed ID: 8234258

DOI: 10.1073/pnas.90.21.10071

PubMed ID: 8282124

Title: The human sperm protein PH-20 has hyaluronidase activity.

PubMed ID: 8282124

DOI: 10.1016/0014-5793(93)80873-s

PubMed ID: 8575780

Title: Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1.

PubMed ID: 8575780

DOI: 10.1006/geno.1995.9931

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9288901

Title: In vitro mutagenesis of PH-20 hyaluronidase from human sperm.

PubMed ID: 9288901

DOI: 10.1111/j.1432-1033.1997.t01-1-00810.x

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 509
  • Mass: 57848
  • Checksum: 5ADB4739747E32E8
  • Sequence:
    • MGVLKFKHIF FRSFVKSSGV SQIVFTFLLI PCCLTLNFRA PPVIPNVPFL WAWNAPSEFC 
LGKFDEPLDM SLFSFIGSPR INATGQGVTI FYVDRLGYYP YIDSITGVTV NGGIPQKISL 
QDHLDKAKKD ITFYMPVDNL GMAVIDWEEW RPTWARNWKP KDVYKNRSIE LVQQQNVQLS 
LTEATEKAKQ EFEKAGKDFL VETIKLGKLL RPNHLWGYYL FPDCYNHHYK KPGYNGSCFN 
VEIKRNDDLS WLWNESTALY PSIYLNTQQS PVAATLYVRN RVREAIRVSK IPDAKSPLPV 
FAYTRIVFTD QVLKFLSQDE LVYTFGETVA LGASGIVIWG TLSIMRSMKS CLLLDNYMET 
ILNPYIINVT LAAKMCSQVL CQEQGVCIRK NWNSSDYLHL NPDNFAIQLE KGGKFTVRGK 
PTLEDLEQFS EKFYCSCYST LSCKEKADVK DTDAVDVCIA DGVCIDAFLK PPMETEEPQI 
FYNASPSTLS ATMFIVSILF LIISSVASL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.