Details for: SPRR2E

Gene ID: 6704

Symbol: SPRR2E

Ensembl ID: ENSG00000203785

Description: small proline rich protein 2E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 27.4075
    Cell Significance Index: 1006.1100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.3606
    Cell Significance Index: 20.2900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.3290
    Cell Significance Index: 3.0000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.0043
    Cell Significance Index: 10.3600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.5408
    Cell Significance Index: 3.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1700
    Cell Significance Index: 4.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1500
    Cell Significance Index: 2.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0926
    Cell Significance Index: 1.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0647
    Cell Significance Index: 0.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0640
    Cell Significance Index: 1.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0020
    Cell Significance Index: 0.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0012
    Cell Significance Index: -0.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0034
    Cell Significance Index: -0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0114
    Cell Significance Index: -8.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0176
    Cell Significance Index: -3.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0193
    Cell Significance Index: -2.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0252
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0284
    Cell Significance Index: -3.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0286
    Cell Significance Index: -12.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0561
    Cell Significance Index: -11.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0571
    Cell Significance Index: -7.8400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0925
    Cell Significance Index: -0.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1855
    Cell Significance Index: -3.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2020
    Cell Significance Index: -5.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2024
    Cell Significance Index: -12.4400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2109
    Cell Significance Index: -1.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2128
    Cell Significance Index: -4.1600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2322
    Cell Significance Index: -3.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2510
    Cell Significance Index: -13.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2532
    Cell Significance Index: -11.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2685
    Cell Significance Index: -12.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2800
    Cell Significance Index: -13.1600
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.3100
    Cell Significance Index: -2.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3171
    Cell Significance Index: -11.1100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3195
    Cell Significance Index: -4.5400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.3197
    Cell Significance Index: -2.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3202
    Cell Significance Index: -8.5500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.3205
    Cell Significance Index: -3.1300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.3328
    Cell Significance Index: -4.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3363
    Cell Significance Index: -11.0100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3383
    Cell Significance Index: -4.2600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3427
    Cell Significance Index: -2.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3448
    Cell Significance Index: -9.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3510
    Cell Significance Index: -11.1800
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.3558
    Cell Significance Index: -2.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3686
    Cell Significance Index: -9.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3818
    Cell Significance Index: -8.3600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3986
    Cell Significance Index: -9.9400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.4065
    Cell Significance Index: -4.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4263
    Cell Significance Index: -10.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4338
    Cell Significance Index: -12.5000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.4503
    Cell Significance Index: -3.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4522
    Cell Significance Index: -11.2800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4531
    Cell Significance Index: -5.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4601
    Cell Significance Index: -13.1900
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.4815
    Cell Significance Index: -3.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4846
    Cell Significance Index: -13.1900
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.4955
    Cell Significance Index: -3.0900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.5045
    Cell Significance Index: -6.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5149
    Cell Significance Index: -5.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5204
    Cell Significance Index: -7.1000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5305
    Cell Significance Index: -11.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5310
    Cell Significance Index: -6.8000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5314
    Cell Significance Index: -11.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5371
    Cell Significance Index: -12.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5383
    Cell Significance Index: -13.0400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.5410
    Cell Significance Index: -6.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5434
    Cell Significance Index: -10.9100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5551
    Cell Significance Index: -11.0700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5619
    Cell Significance Index: -11.0600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5682
    Cell Significance Index: -7.1700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5692
    Cell Significance Index: -9.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5739
    Cell Significance Index: -12.4000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5758
    Cell Significance Index: -9.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5796
    Cell Significance Index: -9.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5869
    Cell Significance Index: -12.5000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.5980
    Cell Significance Index: -5.6800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5985
    Cell Significance Index: -6.1100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.5992
    Cell Significance Index: -6.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6027
    Cell Significance Index: -11.1400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6072
    Cell Significance Index: -8.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6098
    Cell Significance Index: -8.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6185
    Cell Significance Index: -12.2300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6231
    Cell Significance Index: -7.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6272
    Cell Significance Index: -9.2600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6278
    Cell Significance Index: -6.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6359
    Cell Significance Index: -11.0000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6581
    Cell Significance Index: -7.8700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6637
    Cell Significance Index: -10.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6726
    Cell Significance Index: -10.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.6730
    Cell Significance Index: -6.9800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.6758
    Cell Significance Index: -8.5500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6795
    Cell Significance Index: -10.3200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.6866
    Cell Significance Index: -8.1700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.6935
    Cell Significance Index: -5.2800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.6974
    Cell Significance Index: -7.9200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.7143
    Cell Significance Index: -7.7600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.7188
    Cell Significance Index: -7.8900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.7225
    Cell Significance Index: -8.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proline-rich protein**: SPRR2E belongs to the small proline-rich protein family, which is characterized by the presence of proline-rich sequences in their amino acid sequences. 2. **Epidermal development**: SPRR2E is significantly expressed in epithelial cells of the epidermis, suggesting its role in the development and maintenance of this tissue. 3. **Cornified envelope formation**: SPRR2E is involved in the formation of the cornified envelope, a critical structure that provides mechanical strength and barrier function to the skin. 4. **Immune function**: SPRR2E is implicated in the regulation of T cell responses and the formation of the cornified envelope in leukocytes, indicating its role in immune homeostasis. **Pathways and Functions:** 1. **Cornified envelope formation**: SPRR2E interacts with other proteins to form the cornified envelope, a process that involves the cross-linking of keratin filaments and the deposition of lipids and other molecules. 2. **Protein binding**: SPRR2E binds to other proteins, such as keratins and lipids, to facilitate the formation of the cornified envelope. 3. **Peptide cross-linking**: SPRR2E is involved in the cross-linking of peptides, which is essential for the formation of the cornified envelope. 4. **Cytoskeleton organization**: SPRR2E may play a role in the organization of the cytoskeleton, which is critical for maintaining the structure and function of epithelial cells. **Clinical Significance:** Dysregulation of SPRR2E has been implicated in various skin disorders, including psoriasis, ichthyosis, and epidermolysis bullosa. Understanding the molecular mechanisms underlying these disorders may lead to the development of novel therapeutic strategies. Additionally, SPRR2E's role in immune function makes it an attractive target for the treatment of autoimmune diseases, such as atopic dermatitis. In conclusion, SPRR2E is a small proline-rich protein that plays a critical role in epidermal development and immune function. Its dysregulation has been implicated in various skin disorders, highlighting the importance of understanding its molecular mechanisms and potential therapeutic applications.

Genular Protein ID: 3295471325

Symbol: SPR2E_HUMAN

Name: Small proline-rich protein 2E

UniProtKB Accession Codes:

P22531 Q5T9T4 Q96RM2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 8 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3133554

Title: Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.

PubMed ID: 3133554

DOI: 10.1128/mcb.8.5.2195-2203.1988

PubMed ID: 11279051

Title: Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.

PubMed ID: 11279051

DOI: 10.1074/jbc.m100336200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 72
  • Mass: 7855
  • Checksum: 87B4420A98A3D448
  • Sequence:
    • MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKCPPVTPS 
PPCQPKCPPK SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.