Details for: TBCE

Gene ID: 6905

Symbol: TBCE

Ensembl ID: ENSG00000284770

Description: tubulin folding cofactor E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.7658
    Cell Significance Index: -8.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.5049
    Cell Significance Index: -8.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.2348
    Cell Significance Index: 80.8600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.0672
    Cell Significance Index: 13.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.4951
    Cell Significance Index: 22.5300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.2954
    Cell Significance Index: 18.8800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.1943
    Cell Significance Index: 17.3400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.9836
    Cell Significance Index: 8.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8125
    Cell Significance Index: 154.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6385
    Cell Significance Index: 18.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5834
    Cell Significance Index: 15.8800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.4960
    Cell Significance Index: 3.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4799
    Cell Significance Index: 47.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3758
    Cell Significance Index: 22.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3627
    Cell Significance Index: 327.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3602
    Cell Significance Index: 22.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3595
    Cell Significance Index: 41.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3098
    Cell Significance Index: 33.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3096
    Cell Significance Index: 4.7900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2999
    Cell Significance Index: 3.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2900
    Cell Significance Index: 13.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2753
    Cell Significance Index: 18.5100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2720
    Cell Significance Index: 2.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2681
    Cell Significance Index: 12.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2627
    Cell Significance Index: 42.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2466
    Cell Significance Index: 49.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2291
    Cell Significance Index: 3.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2221
    Cell Significance Index: 6.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2203
    Cell Significance Index: 6.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2194
    Cell Significance Index: 3.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1999
    Cell Significance Index: 10.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1985
    Cell Significance Index: 10.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1604
    Cell Significance Index: 11.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1273
    Cell Significance Index: 45.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0990
    Cell Significance Index: 11.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0826
    Cell Significance Index: 1.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0682
    Cell Significance Index: 13.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0484
    Cell Significance Index: 8.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0264
    Cell Significance Index: 0.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0247
    Cell Significance Index: 38.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0123
    Cell Significance Index: 23.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0117
    Cell Significance Index: 21.5700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0081
    Cell Significance Index: 0.1400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0060
    Cell Significance Index: 0.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0039
    Cell Significance Index: 0.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0137
    Cell Significance Index: -6.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0263
    Cell Significance Index: -3.8200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0349
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0365
    Cell Significance Index: -7.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0623
    Cell Significance Index: -1.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0659
    Cell Significance Index: -6.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0849
    Cell Significance Index: -2.7200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1178
    Cell Significance Index: -1.1400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1427
    Cell Significance Index: -1.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1433
    Cell Significance Index: -5.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1513
    Cell Significance Index: -4.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1524
    Cell Significance Index: -3.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1542
    Cell Significance Index: -5.0500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1594
    Cell Significance Index: -2.0600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1646
    Cell Significance Index: -2.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1647
    Cell Significance Index: -2.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1685
    Cell Significance Index: -3.6400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1728
    Cell Significance Index: -2.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1767
    Cell Significance Index: -3.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1819
    Cell Significance Index: -8.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1854
    Cell Significance Index: -2.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1869
    Cell Significance Index: -11.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1964
    Cell Significance Index: -4.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1989
    Cell Significance Index: -5.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2088
    Cell Significance Index: -2.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2097
    Cell Significance Index: -4.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2295
    Cell Significance Index: -5.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2373
    Cell Significance Index: -3.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2387
    Cell Significance Index: -4.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2479
    Cell Significance Index: -10.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2641
    Cell Significance Index: -4.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2734
    Cell Significance Index: -7.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2754
    Cell Significance Index: -5.4200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2834
    Cell Significance Index: -4.2400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2861
    Cell Significance Index: -4.0000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2963
    Cell Significance Index: -4.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3027
    Cell Significance Index: -4.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3113
    Cell Significance Index: -5.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3485
    Cell Significance Index: -8.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3513
    Cell Significance Index: -8.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3524
    Cell Significance Index: -3.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3539
    Cell Significance Index: -8.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3550
    Cell Significance Index: -10.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3556
    Cell Significance Index: -4.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3654
    Cell Significance Index: -7.5800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3691
    Cell Significance Index: -2.8400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3696
    Cell Significance Index: -7.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBCE is a protein-coding gene that is involved in the folding and assembly of tubulins, which are critical components of microtubules. The gene is highly expressed in various cell types, including epithelial cells, muscle cells, and neurons. TBCE is a chaperone protein that interacts with tubulins and facilitates their proper folding and assembly. The gene is also involved in several cellular processes, including protein folding, microtubule organization, and cytoskeleton dynamics. **Pathways and Functions:** TBCE is involved in several key pathways, including: 1. **Post-chaperonin tubulin folding pathway**: TBCE interacts with tubulins and facilitates their proper folding and assembly. 2. **Microtubule organization**: TBCE is essential for maintaining the stability and organization of microtubules. 3. **Cytoskeleton dynamics**: TBCE regulates the dynamics of the cytoskeleton, including microtubules and actin filaments. 4. **Protein-folding chaperone binding**: TBCE interacts with other chaperone proteins and facilitates their binding to client proteins. 5. **Protein binding**: TBCE interacts with various proteins, including tubulins, actin, and microtubule-associated proteins. **Clinical Significance:** Dysregulation of TBCE has been linked to several diseases, including: 1. **Cancer**: TBCE mutations have been identified in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders**: TBCE mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular diseases**: TBCE mutations have been linked to cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 4. **Muscle atrophy**: TBCE mutations have been associated with muscle atrophy and weakness. In conclusion, TBCE is a critical gene that plays a pivotal role in maintaining cellular homeostasis. Its dysregulation has been linked to several diseases, emphasizing the need for further research into its mechanisms and clinical implications. As an expert immunologist, I believe that understanding the functions and pathways of TBCE will provide valuable insights into the development of novel therapeutic strategies for these diseases.

Genular Protein ID: 412169850

Symbol: TBCE_HUMAN

Name: Tubulin-specific chaperone E

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8706133

Title: Pathway leading to correctly folded beta-tubulin.

PubMed ID: 8706133

DOI: 10.1016/s0092-8674(00)80100-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27666374

Title: Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy.

PubMed ID: 27666374

DOI: 10.1016/j.ajhg.2016.08.005

PubMed ID: 27666369

Title: TBCE mutations cause early-onset progressive encephalopathy with distal spinal muscular atrophy.

PubMed ID: 27666369

DOI: 10.1016/j.ajhg.2016.08.006

PubMed ID: 12389028

Title: Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome.

PubMed ID: 12389028

DOI: 10.1038/ng1012

Sequence Information:

  • Length: 527
  • Mass: 59346
  • Checksum: C919052D2D463BA1
  • Sequence:
  • MSDTLTADVI GRRVEVNGEH ATVRFAGVVP PVAGPWLGVE WDNPERGKHD GSHEGTVYFK 
    CRHPTGGSFI RPNKVNFGTD FLTAIKNRYV LEDGPEEDRK EQIVTIGNKP VETIGFDSIM 
    KQQSQLSKLQ EVSLRNCAVS CAGEKGGVAE ACPNIRKVDL SKNLLSSWDE VIHIADQLRH 
    LEVLNVSENK LKFPSGSVLT GTLSVLKVLV LNQTGITWAE VLRCVAGCPG LEELYLESNN 
    IFISERPTDV LQTVKLLDLS SNQLIDENQL YLIAHLPRLE QLILSDTGIS SLHFPDAGIG 
    CKTSMFPSLK YLVVNDNQIS QWSFFNELEK LPSLRALSCL RNPLTKEDKE AETARLLIIA 
    SIGQLKTLNK CEILPEERRR AELDYRKAFG NEWKQAGGHK DPEKNRLSEE FLTAHPRYQF 
    LCLKYGAPED WELKTQQPLM LKNQLLTLKI KYPHQLDQKV LEKQLPGSMT IQKVKGLLSR 
    LLKVPVSDLL LSYESPKKPG REIELENDLK SLQFYSVENG DCLLVRW

Genular Protein ID: 3600004349

Symbol: A0A2R8Y6Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 414
  • Mass: 46877
  • Checksum: 2F27838C79E1CC73
  • Sequence:
  • MYPCELCFSC SQLSKLQEVS LRNCAVSCAG EKGGVAEACP NIRKVDLSKN LLSSWDEVIH 
    IADQLRHLEV LNVSENKLKF PSGSVLTGTL SVLKVLVLNQ TGITWAEVLR CVAGCPGLEE 
    LYLESNNIFI SERPTDVLQT VKLLDLSSNQ LIDENQLYLI AHLPRLEQLI LSDTGISSLH 
    FPDAGIGCKT SMFPSLKYLV VNDNQISQWS FFNELEKLPS LRALSCLRNP LTKEDKEAET 
    ARLLIIASIG QLKTLNKCEI LPEERRRAEL DYRKAFGNEW KQAGGHKDPE KNRLSEEFLT 
    AHPRYQFLCL KYGAPEDWEL KTQQPLMLKN QLLTLKIKYP HQLDQKVLEK QLPGSMTIQK 
    VKGLLSRLLK VPVSDLLLSY ESPKKPGREI ELENDLKSLQ FYSVENGDCL LVRW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.