Gene TRGV4 - ENSG00000211698 | NCBI Gene ID: 6977

Details for: TRGV4

Gene ID: 6977

Symbol: TRGV4

Ensembl ID: ENSG00000211698

Description: T cell receptor gamma variable 4

Associated with

Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Innate immune response
(GO:0045087)
T cell receptor complex
(GO:0042101)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: goblet cell (CL0000160)
Fold Change: 1.63
Marker Score: 10804.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.25
Marker Score: 7568
Cell Name: abnormal cell (CL0001061)
Fold Change: 1.22
Marker Score: 3647
Cell Name: absorptive cell (CL0000212)
Fold Change: 1.06
Marker Score: 32721
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 798
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2396
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5302.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.8
Marker Score: 733
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1255
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.76
Marker Score: 665
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179.5
Cell Name: fibroblast (CL0000057)
Fold Change: 0.7
Marker Score: 672
Cell Name: mast cell (CL0000097)
Fold Change: 0.68
Marker Score: 393
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.64
Marker Score: 948
Cell Name: neutrophil (CL0000775)
Fold Change: 0.64
Marker Score: 389
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 233
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.55
Marker Score: 1341
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 435.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.43
Marker Score: 378
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.38
Marker Score: 1210
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.37
Marker Score: 99
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.34
Marker Score: 300
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.32
Marker Score: 313
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.31
Marker Score: 241.5
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.3
Marker Score: 68
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.3
Marker Score: 200.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.3
Marker Score: 265
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.29
Marker Score: 399
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.27
Marker Score: 753
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.26
Marker Score: 174
Cell Name: platelet (CL0000233)
Fold Change: 0.26
Marker Score: 118
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.23
Marker Score: 154
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.23
Marker Score: 146
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.22
Marker Score: 123
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.2
Marker Score: 167
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.19
Marker Score: 94
Cell Name: B cell (CL0000236)
Fold Change: 0.18
Marker Score: 174
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.18
Marker Score: 257
Cell Name: plasma cell (CL0000786)
Fold Change: 0.18
Marker Score: 200
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.18
Marker Score: 109
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.14
Marker Score: 106
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.13
Marker Score: 292
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.12
Marker Score: 125
Cell Name: Unknown (CL0000548)
Fold Change: 0.12
Marker Score: 85
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.12
Marker Score: 226
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.1
Marker Score: 133
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.1
Marker Score: 45
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.1
Marker Score: 172
Cell Name: macrophage (CL0000235)
Fold Change: 0.09
Marker Score: 101
Cell Name: mature T cell (CL0002419)
Fold Change: 0.09
Marker Score: 891
Cell Name: T cell (CL0000084)
Fold Change: 0.09
Marker Score: 154
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.09
Marker Score: 74
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.09
Marker Score: 139
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.09
Marker Score: 37
Cell Name: type II NK T cell (CL0000922)
Fold Change: 0.08
Marker Score: 26
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.07
Marker Score: 119
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.07
Marker Score: 18
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.07
Marker Score: 21
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 136
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.07
Marker Score: 114
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.07
Marker Score: 63
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.06
Marker Score: 49
Cell Name: blood cell (CL0000081)
Fold Change: 0.06
Marker Score: 735
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.06
Marker Score: 3332
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.06
Marker Score: 22
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.06
Marker Score: 154
Cell Name: group 2 innate lymphoid cell (CL0001069)
Fold Change: 0.06
Marker Score: 21
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.06
Marker Score: 18
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.06
Marker Score: 21
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.06
Marker Score: 44
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.06
Marker Score: 20
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.06
Marker Score: 33
Cell Name: Unknown (CL0000003)
Fold Change: 0.05
Marker Score: 169
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.05
Marker Score: 58.5
Cell Name: thymocyte (CL0000893)
Fold Change: 0.05
Marker Score: 54
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.05
Marker Score: 35
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.05
Marker Score: 27
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.05
Marker Score: 19
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.05
Marker Score: 22
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.05
Marker Score: 26
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.05
Marker Score: 33
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.05
Marker Score: 39
Cell Name: memory T cell (CL0000813)
Fold Change: 0.05
Marker Score: 20
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.05
Marker Score: 15
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.05
Marker Score: 50
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.05
Marker Score: 33
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.04
Marker Score: 23
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.04
Marker Score: 22
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.04
Marker Score: 19
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.04
Marker Score: 21
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.04
Marker Score: 31
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.04
Marker Score: 36
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.04
Marker Score: 21
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.04
Marker Score: 22
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.04
Marker Score: 14
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.04
Marker Score: 22
Cell Name: monocyte (CL0000576)
Fold Change: 0.03
Marker Score: 45
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.03
Marker Score: 26
Cell Name: leukocyte (CL0000738)
Fold Change: 0.03
Marker Score: 18
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.03
Marker Score: 20

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Other Information

Description

**Key characteristics:** - TRGV4 is a type I transmembrane protein with a molecular weight of approximately 115 kDa. - It is expressed on the surface of various cell types, including goblet cells, neoplastic cells, abnormal cells, absorptive cells, early T lineage precursor cells, intestinal crypt stem cells, transit amplifying cells, brush cells, and intestinal epithelial cells. - It is a member of the T cell receptor gamma (TCR) superfamily of immune receptors, which are expressed on T cells. **Pathways and functions:** - TRGV4 is involved in the adaptive immune response and is expressed on cells that are exposed to foreign antigens. - It is a key receptor for the activation of T cells. - TRGV4 is expressed on cells in the gut, where it is involved in the immune response to pathogens such as bacteria and viruses. - It is also expressed on cells in the skin, where it is involved in the immune response to allergens and parasites. - In the context of cancer, TRGV4 is often overexpressed on tumor cells, where it contributes to the tumor's ability to evade immune surveillance. **Clinical significance:** - Mutations in TRGV4 have been linked to several human diseases, including inflammatory bowel disease, colorectal cancer, and cancer of the lung, breast, and ovary. - Targeting TRGV4 with antibodies or small molecules is a promising strategy for cancer immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.