Details for: TRGV4

Gene ID: 6977

Symbol: TRGV4

Ensembl ID: ENSG00000211698

Description: T cell receptor gamma variable 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1944
    Cell Significance Index: 1.0600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1611
    Cell Significance Index: 1.6700
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.1581
    Cell Significance Index: 1.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1432
    Cell Significance Index: 1.8100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0968
    Cell Significance Index: 1.0300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.0450
    Cell Significance Index: 0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0019
    Cell Significance Index: 0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0041
    Cell Significance Index: -1.8500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0077
    Cell Significance Index: -1.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0144
    Cell Significance Index: -2.0900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0187
    Cell Significance Index: -0.0500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0278
    Cell Significance Index: -0.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0315
    Cell Significance Index: -2.0300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0316
    Cell Significance Index: -0.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0363
    Cell Significance Index: -0.9700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0418
    Cell Significance Index: -0.7100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0424
    Cell Significance Index: -0.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0428
    Cell Significance Index: -0.6000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0443
    Cell Significance Index: -0.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0468
    Cell Significance Index: -1.4900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0541
    Cell Significance Index: -0.5400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0552
    Cell Significance Index: -0.4700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0576
    Cell Significance Index: -0.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0603
    Cell Significance Index: -1.5400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0609
    Cell Significance Index: -0.7200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0617
    Cell Significance Index: -0.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0622
    Cell Significance Index: -0.9100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0641
    Cell Significance Index: -0.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0642
    Cell Significance Index: -0.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0687
    Cell Significance Index: -1.7500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0692
    Cell Significance Index: -0.5600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0699
    Cell Significance Index: -0.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0701
    Cell Significance Index: -1.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0735
    Cell Significance Index: -1.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0748
    Cell Significance Index: -1.4800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0750
    Cell Significance Index: -0.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0790
    Cell Significance Index: -0.9300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0798
    Cell Significance Index: -0.9700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0809
    Cell Significance Index: -1.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0814
    Cell Significance Index: -1.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0849
    Cell Significance Index: -1.5700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0859
    Cell Significance Index: -2.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0861
    Cell Significance Index: -1.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0869
    Cell Significance Index: -1.7000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0909
    Cell Significance Index: -0.8900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0948
    Cell Significance Index: -1.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0989
    Cell Significance Index: -1.2800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0990
    Cell Significance Index: -0.9700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1000
    Cell Significance Index: -1.6200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1008
    Cell Significance Index: -0.7500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1036
    Cell Significance Index: -1.5100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1038
    Cell Significance Index: -1.1600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1059
    Cell Significance Index: -1.2700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1076
    Cell Significance Index: -1.8400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1077
    Cell Significance Index: -1.5900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1086
    Cell Significance Index: -1.2500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1118
    Cell Significance Index: -1.5500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1121
    Cell Significance Index: -0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1123
    Cell Significance Index: -1.8800
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1125
    Cell Significance Index: -1.0000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1136
    Cell Significance Index: -1.2800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1138
    Cell Significance Index: -1.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1151
    Cell Significance Index: -1.7000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1160
    Cell Significance Index: -1.4000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1185
    Cell Significance Index: -1.5600
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1194
    Cell Significance Index: -1.1800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1200
    Cell Significance Index: -1.2900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1207
    Cell Significance Index: -1.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1209
    Cell Significance Index: -1.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1225
    Cell Significance Index: -2.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1238
    Cell Significance Index: -1.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1243
    Cell Significance Index: -3.3800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1244
    Cell Significance Index: -1.0700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1248
    Cell Significance Index: -1.6000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1257
    Cell Significance Index: -1.2700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1257
    Cell Significance Index: -1.0400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1281
    Cell Significance Index: -1.6000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1290
    Cell Significance Index: -1.5700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1290
    Cell Significance Index: -1.7400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1298
    Cell Significance Index: -1.8200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1301
    Cell Significance Index: -1.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1316
    Cell Significance Index: -1.8700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1318
    Cell Significance Index: -1.4000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1328
    Cell Significance Index: -1.1100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1336
    Cell Significance Index: -1.5400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1340
    Cell Significance Index: -1.6300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1344
    Cell Significance Index: -1.5800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1354
    Cell Significance Index: -1.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1357
    Cell Significance Index: -2.3400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1364
    Cell Significance Index: -1.7800
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1382
    Cell Significance Index: -1.4900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1387
    Cell Significance Index: -1.5700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1400
    Cell Significance Index: -1.4300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1408
    Cell Significance Index: -1.8500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1412
    Cell Significance Index: -1.5000
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.1412
    Cell Significance Index: -1.4900
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1419
    Cell Significance Index: -1.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGV4 is a variable region gene within the TCR gamma chain, which is essential for the recognition of antigens by T cells. Its expression is restricted to specific cell types, including those involved in the adaptive immune response. The expression of TRGV4 is significantly upregulated in goblet cells, which are involved in the innate immune response and play a crucial role in the mucosal barrier. The gene's expression is also notable in neoplastic cells and abnormal cells, highlighting its potential role in cancer development and progression. **Pathways and Functions:** TRGV4 is integral to the adaptive immune response, where it plays a critical role in the recognition and elimination of pathogens. The gene's expression is tightly regulated by various signaling pathways, including the Notch and Wnt/β-catenin pathways, which are essential for the development and maintenance of the intestinal epithelial barrier. TRGV4 also interacts with other immune-related genes, including those involved in the T cell receptor complex, thereby modulating the adaptive immune response. In addition to its role in the adaptive immune response, TRGV4 is also involved in the innate immune response, where it interacts with goblet cells and other innate immune cells to modulate the inflammatory response. The gene's expression is also linked to the development and progression of cancer, where it may play a role in the evasion of immune surveillance. **Clinical Significance:** The clinical significance of TRGV4 is multifaceted, with implications for the development and treatment of various diseases. The gene's expression in neoplastic cells and abnormal cells highlights its potential role in cancer development and progression. The gene's involvement in the adaptive and innate immune responses also underscores its potential as a therapeutic target for autoimmune and inflammatory diseases. Furthermore, the expression of TRGV4 in goblet cells and other innate immune cells highlights its potential role in the prevention and treatment of infectious diseases. The gene's interaction with other immune-related genes also underscores its potential as a biomarker for immune-related disorders. In conclusion, TRGV4 is a complex gene that plays a critical role in the adaptive and innate immune responses. Its expression in various cell types and its interaction with other immune-related genes highlight its importance in maintaining immune homeostasis. Further research is needed to fully elucidate the clinical significance of TRGV4 and its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.