Details for: ZP2

Gene ID: 7783

Symbol: ZP2

Ensembl ID: ENSG00000103310

Description: zona pellucida glycoprotein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4048
    Cell Significance Index: 6.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3937
    Cell Significance Index: 8.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2128
    Cell Significance Index: 40.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1809
    Cell Significance Index: 2.5900
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.1765
    Cell Significance Index: 1.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1741
    Cell Significance Index: 2.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1576
    Cell Significance Index: 2.7000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1311
    Cell Significance Index: 0.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0978
    Cell Significance Index: 5.8700
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.0950
    Cell Significance Index: 0.7500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0917
    Cell Significance Index: 1.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0895
    Cell Significance Index: 4.0600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0703
    Cell Significance Index: 0.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0653
    Cell Significance Index: 1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0585
    Cell Significance Index: 1.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0498
    Cell Significance Index: 5.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0458
    Cell Significance Index: 4.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0425
    Cell Significance Index: 38.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0421
    Cell Significance Index: 1.3500
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.0395
    Cell Significance Index: 0.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0377
    Cell Significance Index: 1.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0354
    Cell Significance Index: 0.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0347
    Cell Significance Index: 0.7600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0313
    Cell Significance Index: 0.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0276
    Cell Significance Index: 1.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0235
    Cell Significance Index: 3.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0126
    Cell Significance Index: 0.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0124
    Cell Significance Index: 0.3700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0082
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0038
    Cell Significance Index: 0.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0038
    Cell Significance Index: 0.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0036
    Cell Significance Index: 0.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0032
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0023
    Cell Significance Index: 0.4600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0008
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0027
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0034
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0037
    Cell Significance Index: -0.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0039
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0039
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0042
    Cell Significance Index: -0.6100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0048
    Cell Significance Index: -0.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0056
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0065
    Cell Significance Index: -0.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0065
    Cell Significance Index: -0.6800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0104
    Cell Significance Index: -0.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0117
    Cell Significance Index: -0.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0129
    Cell Significance Index: -0.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0130
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0131
    Cell Significance Index: -1.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0131
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0136
    Cell Significance Index: -0.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0138
    Cell Significance Index: -0.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0152
    Cell Significance Index: -0.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0153
    Cell Significance Index: -0.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0153
    Cell Significance Index: -0.5800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0159
    Cell Significance Index: -0.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0160
    Cell Significance Index: -0.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0166
    Cell Significance Index: -0.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0184
    Cell Significance Index: -0.4500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0194
    Cell Significance Index: -0.1600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0210
    Cell Significance Index: -0.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0212
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0213
    Cell Significance Index: -0.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0214
    Cell Significance Index: -0.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0215
    Cell Significance Index: -0.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0218
    Cell Significance Index: -0.3100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0219
    Cell Significance Index: -0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0221
    Cell Significance Index: -0.5900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0228
    Cell Significance Index: -0.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0236
    Cell Significance Index: -0.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0236
    Cell Significance Index: -0.6600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0246
    Cell Significance Index: -0.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0259
    Cell Significance Index: -0.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0261
    Cell Significance Index: -0.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0273
    Cell Significance Index: -0.3300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0274
    Cell Significance Index: -0.1700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0275
    Cell Significance Index: -0.3200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0278
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0282
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZP2 is a type II transmembrane glycoprotein, comprising 12 exons and 11 introns, with a molecular weight of approximately 45 kDa. Its unique structure, featuring a large extracellular domain and a small intracellular domain, enables it to interact with various ligands, including sperm, cumulus cells, and other extracellular matrix components. ZP2 is highly glycosylated, with multiple N-linked and O-linked glycosylation sites, which contribute to its stability and function. **Pathways and Functions:** ZP2 is intricately involved in several key pathways, including: 1. **Acrosin binding**: ZP2 interacts with acrosin, a protease essential for sperm penetration of the zona pellucida, facilitating fertilization. 2. **Sperm binding**: ZP2 serves as a receptor for sperm, binding to specific integrins on the sperm surface, enabling sperm-egg recognition and fusion. 3. **Polyspermy prevention**: ZP2 helps prevent polyspermy by interacting with sperm surface proteins, inhibiting multiple fertilization attempts. 4. **Regulation of acrosome reaction**: ZP2 modulates the acrosome reaction, a critical event in fertilization, by interacting with acrosin and other components of the acrosomal complex. 5. **Cell-cell interactions**: ZP2 interacts with cumulus cells and other extracellular matrix components, influencing cell adhesion, migration, and differentiation. **Clinical Significance:** ZP2's involvement in fertilization and reproductive biology highlights its potential as a therapeutic target for conditions related to infertility, such as polyspermy and recurrent miscarriage. Moreover, ZP2's expression in various tissues, including the hematopoietic system, suggests potential roles in immune regulation and disease, such as autoimmune disorders and cancer. Furthermore, ZP2's involvement in cell-cell interactions and tissue development underscores its potential as a biomarker for various diseases, including gastrointestinal disorders and neurological conditions. In conclusion, ZP2 is a complex and multifaceted protein that plays a critical role in fertilization, immune regulation, and tissue development. Further research into the biology and clinical significance of ZP2 will provide valuable insights into its potential therapeutic applications and shed light on its intricate mechanisms of action.

Genular Protein ID: 3484415469

Symbol: ZP2_HUMAN

Name: Zona pellucida sperm-binding protein 2

UniProtKB Accession Codes:

Q05996 B2R7J2 Q4VAN9 Q4VAP0 Q4VAP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8385033

Title: Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes.

PubMed ID: 8385033

DOI: 10.1006/dbio.1993.1087

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28886344

Title: A recurrent missense mutation in ZP3 causes empty follicle syndrome and female infertility.

PubMed ID: 28886344

DOI: 10.1016/j.ajhg.2017.08.001

PubMed ID: 29895852

Title: ZP2 pathogenic variants cause in vitro fertilization failure and female infertility.

PubMed ID: 29895852

DOI: 10.1038/s41436-018-0064-y

Sequence Information:

  • Length: 745
  • Mass: 82357
  • Checksum: 2614DA79738F2CDD
  • Sequence:
    • MACRQRGGSW SPSGWFNAGW STYRSISLFF ALVTSGNSID VSQLVNPAFP GTVTCDEREI 
TVEFPSSPGT KKWHASVVDP LGLDMPNCTY ILDPEKLTLR ATYDNCTRRV HGGHQMTIRV 
MNNSAALRHG AVMYQFFCPA MQVEETQGLS ASTICQKDFM SFSLPRVFSG LADDSKGTKV 
QMGWSIEVGD GARAKTLTLP EAMKEGFSLL IDNHRMTFHV PFNATGVTHY VQGNSHLYMV 
SLKLTFISPG QKVIFSSQAI CAPDPVTCNA THMTLTIPEF PGKLKSVSFE NQNIDVSQLH 
DNGIDLEATN GMKLHFSKTL LKTKLSEKCL LHQFYLASLK LTFLLRPETV SMVIYPECLC 
ESPVSIVTGE LCTQDGFMDV EVYSYQTQPA LDLGTLRVGN SSCQPVFEAQ SQGLVRFHIP 
LNGCGTRYKF EDDKVVYENE IHALWTDFPP SKISRDSEFR MTVKCSYSRN DMLLNINVES 
LTPPVASVKL GPFTLILQSY PDNSYQQPYG ENEYPLVRFL RQPIYMEVRV LNRDDPNIKL 
VLDDCWATST MDPDSFPQWN VVVDGCAYDL DNYQTTFHPV GSSVTHPDHY QRFDMKAFAF 
VSEAHVLSSL VYFHCSALIC NRLSPDSPLC SVTCPVSSRH RRATGATEAE KMTVSLPGPI 
LLLSDDSSFR GVGSSDLKAS GSSGEKSRSE TGEEVGSRGA MDTKGHKTAG DVGSKAVAAV 
AAFAGVVATL GFIYYLYEKR TVSNH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.