Details for: MT4

Gene ID: 84560

Symbol: MT4

Ensembl ID: ENSG00000102891

Description: metallothionein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 6.4195
    Cell Significance Index: 7.3900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.7112
    Cell Significance Index: 3.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.5649
    Cell Significance Index: 3.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1600
    Cell Significance Index: 70.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1497
    Cell Significance Index: 1.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1055
    Cell Significance Index: 2.0600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0599
    Cell Significance Index: 0.6700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0368
    Cell Significance Index: 0.4700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0282
    Cell Significance Index: 0.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0229
    Cell Significance Index: 0.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0092
    Cell Significance Index: 0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0030
    Cell Significance Index: 0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0031
    Cell Significance Index: -1.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0048
    Cell Significance Index: -1.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0055
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0090
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0106
    Cell Significance Index: -2.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0108
    Cell Significance Index: -1.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0135
    Cell Significance Index: -1.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0165
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0168
    Cell Significance Index: -1.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0172
    Cell Significance Index: -2.1200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0209
    Cell Significance Index: -0.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0233
    Cell Significance Index: -2.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0274
    Cell Significance Index: -0.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0301
    Cell Significance Index: -2.0300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0334
    Cell Significance Index: -2.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0340
    Cell Significance Index: -0.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0356
    Cell Significance Index: -2.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0421
    Cell Significance Index: -1.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0438
    Cell Significance Index: -1.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0442
    Cell Significance Index: -1.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0460
    Cell Significance Index: -1.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0492
    Cell Significance Index: -1.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0526
    Cell Significance Index: -2.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0533
    Cell Significance Index: -1.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0545
    Cell Significance Index: -2.4100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0553
    Cell Significance Index: -0.5300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0554
    Cell Significance Index: -0.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0565
    Cell Significance Index: -2.8600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0613
    Cell Significance Index: -0.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0613
    Cell Significance Index: -1.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0636
    Cell Significance Index: -1.0800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0638
    Cell Significance Index: -0.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0647
    Cell Significance Index: -2.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0652
    Cell Significance Index: -1.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0688
    Cell Significance Index: -2.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0699
    Cell Significance Index: -1.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0718
    Cell Significance Index: -1.0600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0730
    Cell Significance Index: -0.8000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0734
    Cell Significance Index: -0.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0736
    Cell Significance Index: -1.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0747
    Cell Significance Index: -2.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0760
    Cell Significance Index: -1.2800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0763
    Cell Significance Index: -0.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0774
    Cell Significance Index: -2.0700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0780
    Cell Significance Index: -1.3400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0786
    Cell Significance Index: -1.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0838
    Cell Significance Index: -1.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0839
    Cell Significance Index: -1.7800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0849
    Cell Significance Index: -0.8800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0863
    Cell Significance Index: -1.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0882
    Cell Significance Index: -2.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0887
    Cell Significance Index: -1.7800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0926
    Cell Significance Index: -1.8100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0935
    Cell Significance Index: -1.4200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0943
    Cell Significance Index: -1.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0955
    Cell Significance Index: -1.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0958
    Cell Significance Index: -2.0000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0965
    Cell Significance Index: -1.1100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0969
    Cell Significance Index: -1.0200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0973
    Cell Significance Index: -1.1200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0995
    Cell Significance Index: -1.3800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0995
    Cell Significance Index: -1.6000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1019
    Cell Significance Index: -1.2300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1021
    Cell Significance Index: -1.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1022
    Cell Significance Index: -2.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1022
    Cell Significance Index: -2.4500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1028
    Cell Significance Index: -1.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1042
    Cell Significance Index: -2.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1058
    Cell Significance Index: -2.1100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1079
    Cell Significance Index: -1.2800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1080
    Cell Significance Index: -1.5800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1092
    Cell Significance Index: -1.1000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1093
    Cell Significance Index: -1.7700
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1094
    Cell Significance Index: -1.4000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1098
    Cell Significance Index: -0.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1099
    Cell Significance Index: -1.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1107
    Cell Significance Index: -3.5000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1109
    Cell Significance Index: -0.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MT4 is a small, cysteine-rich protein that belongs to the metallothionein family. It is characterized by its ability to bind metals, including zinc, copper, and cadmium, through its cysteine residues. MT4 is highly expressed in cells that require precise metal ion homeostasis, such as immune cells and neurons. The protein is also involved in the regulation of gene expression and cellular signaling pathways. **Pathways and Functions:** MT4 is involved in several cellular pathways that regulate metal ion homeostasis and response to metal ions. These include: 1. **Intracellular zinc ion homeostasis:** MT4 plays a crucial role in regulating zinc ion levels within cells by binding and sequestering excess zinc ions. 2. **Detoxification of copper ion:** MT4 has been shown to bind and remove excess copper ions from cells, helping to prevent oxidative stress and damage. 3. **Cellular response to metal ions:** MT4 mediates the cellular response to metal ions, including cadmium and copper ions, by regulating gene expression and signaling pathways. 4. **Cytoplasmic regulation:** MT4 regulates cytoplasmic metal ion levels by binding and sequestering metal ions, such as zinc and copper. **Clinical Significance:** MT4 has been implicated in various diseases and disorders, including: 1. **Neurodegenerative diseases:** MT4 has been shown to play a role in the regulation of zinc ion homeostasis in neurons, which is critical for maintaining neuronal function and preventing neurodegenerative diseases, such as Alzheimer's disease. 2. **Cancer:** MT4 has been implicated in cancer development and progression, particularly in the regulation of zinc ion homeostasis and the response to metal ions. 3. **Immune system disorders:** MT4 is involved in the regulation of immune cell function and has been implicated in autoimmune disorders, such as rheumatoid arthritis. 4. **Neurodevelopmental disorders:** MT4 has been shown to play a role in the regulation of zinc ion homeostasis in the developing brain, which is critical for proper brain development and function. In conclusion, MT4 is a critical regulator of metal ion homeostasis and response to metal ions in various cell types. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the functions and clinical significance of MT4.

Genular Protein ID: 1772169455

Symbol: MT4_HUMAN

Name: Metallothionein-4

UniProtKB Accession Codes:

P47944 Q14DA1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 27 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8003488

Title: Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia.

PubMed ID: 8003488

DOI: 10.1021/bi00189a029

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 62
  • Mass: 6509
  • Checksum: 55DA475A17BF28C9
  • Sequence:
    • MDPRECVCMS GGICMCGDNC KCTTCNCKTY WKSCCPCCPP GCAKCARGCI CKGGSDKCSC 
CP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.