Details for: KRT38

Gene ID: 8687

Symbol: KRT38

Ensembl ID: ENSG00000171360

Description: keratin 38

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 8.6169
    Cell Significance Index: 219.5400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.1109
    Cell Significance Index: 50.3900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.1727
    Cell Significance Index: 37.1400
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.5980
    Cell Significance Index: 21.0300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.4266
    Cell Significance Index: 18.4600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2149
    Cell Significance Index: 2.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2140
    Cell Significance Index: 2.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0743
    Cell Significance Index: 1.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0517
    Cell Significance Index: 0.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0142
    Cell Significance Index: 0.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0125
    Cell Significance Index: 0.6500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0096
    Cell Significance Index: 0.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0095
    Cell Significance Index: 0.1100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0068
    Cell Significance Index: -1.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0077
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0078
    Cell Significance Index: -1.5600
  • Cell Name: airway submucosal gland duct basal cell (CL4033024)
    Fold Change: -0.0083
    Cell Significance Index: -0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0100
    Cell Significance Index: -1.8100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0197
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0270
    Cell Significance Index: -0.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0313
    Cell Significance Index: -1.0000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0320
    Cell Significance Index: -0.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0328
    Cell Significance Index: -1.5400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0351
    Cell Significance Index: -0.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0411
    Cell Significance Index: -1.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0436
    Cell Significance Index: -1.5300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0497
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0537
    Cell Significance Index: -1.5400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0619
    Cell Significance Index: -0.7400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0632
    Cell Significance Index: -0.8300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0640
    Cell Significance Index: -0.4300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0652
    Cell Significance Index: -0.7100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0659
    Cell Significance Index: -0.6500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0766
    Cell Significance Index: -0.9700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0781
    Cell Significance Index: -1.0800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0784
    Cell Significance Index: -1.0100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0790
    Cell Significance Index: -0.6700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0827
    Cell Significance Index: -0.9400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0830
    Cell Significance Index: -1.0000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0858
    Cell Significance Index: -1.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0861
    Cell Significance Index: -2.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0865
    Cell Significance Index: -0.8200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0912
    Cell Significance Index: -1.2300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0922
    Cell Significance Index: -0.9800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0924
    Cell Significance Index: -1.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0949
    Cell Significance Index: -1.1200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0967
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1008
    Cell Significance Index: -1.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1017
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1064
    Cell Significance Index: -2.0800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1097
    Cell Significance Index: -1.1200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1115
    Cell Significance Index: -1.3700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1117
    Cell Significance Index: -1.2300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1137
    Cell Significance Index: -1.3500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1166
    Cell Significance Index: -1.4200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1172
    Cell Significance Index: -1.4000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1176
    Cell Significance Index: -1.1500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1188
    Cell Significance Index: -1.0800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1201
    Cell Significance Index: -1.3000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1203
    Cell Significance Index: -1.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1264
    Cell Significance Index: -0.7500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1289
    Cell Significance Index: -1.3900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1305
    Cell Significance Index: -0.8700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.1315
    Cell Significance Index: -1.2400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1352
    Cell Significance Index: -0.9000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1366
    Cell Significance Index: -1.2000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1391
    Cell Significance Index: -1.6100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1395
    Cell Significance Index: -1.1100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1399
    Cell Significance Index: -1.2200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1403
    Cell Significance Index: -1.4000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1438
    Cell Significance Index: -1.3500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1533
    Cell Significance Index: -1.4500
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.1559
    Cell Significance Index: -1.4100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1561
    Cell Significance Index: -1.5400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1570
    Cell Significance Index: -2.0500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1584
    Cell Significance Index: -1.0100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1590
    Cell Significance Index: -1.4600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1599
    Cell Significance Index: -1.8900
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1647
    Cell Significance Index: -1.4600
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1649
    Cell Significance Index: -1.5300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1657
    Cell Significance Index: -2.0700
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.1685
    Cell Significance Index: -1.4500
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1711
    Cell Significance Index: -2.1500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1720
    Cell Significance Index: -1.0800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1730
    Cell Significance Index: -1.4300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1795
    Cell Significance Index: -1.8900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1851
    Cell Significance Index: -2.0500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1962
    Cell Significance Index: -2.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2050
    Cell Significance Index: -2.0800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2051
    Cell Significance Index: -2.1500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2075
    Cell Significance Index: -1.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2112
    Cell Significance Index: -2.0300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2235
    Cell Significance Index: -2.0300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2243
    Cell Significance Index: -1.4600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2353
    Cell Significance Index: -1.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** KRT38 is expressed in a diverse range of cell types, including erythrocytes, megakaryocytes, goblet cells, and hematopoietic stem cells, underscoring its critical role in development and tissue maintenance. 2. **Structural Function:** As an intermediate filament protein, KRT38 provides mechanical stability and resilience to epithelial cells, allowing them to withstand various environmental stresses and mechanical forces. 3. **Cellular Localization:** KRT38 is localized to the cytoskeleton, where it interacts with other keratin proteins and cytoskeletal components to maintain cellular structure and function. 4. **Evolutionary Conservation:** KRT38 is conserved across species, suggesting its essential role in maintaining epithelial cell integrity and function. **Pathways and Functions:** 1. **Cytoskeleton Organization:** KRT38 interacts with other keratin proteins and cytoskeletal components to maintain the structural integrity of epithelial cells. 2. **Epithelial Cell Differentiation:** KRT38 plays a crucial role in keratinization, a process that transforms epithelial cells into stratified squamous epithelial cells. 3. **Formation of the Cornified Envelope:** KRT38 is essential for the assembly of the cornified envelope, a specialized structure that provides mechanical protection to the skin and mucosal epithelium. 4. **Protein Binding:** KRT38 interacts with other proteins, including keratins, cytoskeletal components, and extracellular matrix proteins, to regulate cellular signaling and function. **Clinical Significance:** 1. **Skin Disorders:** Mutations in the KRT38 gene have been associated with skin disorders, such as epidermolysis bullosa simplex (EBS) and epidermolysis bullosa junctional (EBJ). 2. **Cancer:** Aberrant expression of KRT38 has been observed in various types of cancer, including squamous cell carcinoma and basal cell carcinoma, highlighting its potential as a prognostic marker. 3. **Immune Function:** KRT38 is expressed in immune cells, including mononuclear cells and megakaryocytes, suggesting its involvement in immune regulation and function. 4. **Regenerative Medicine:** KRT38's role in epithelial cell differentiation and maintenance makes it a promising target for regenerative medicine applications, particularly in the context of wound healing and tissue repair. In conclusion, Keratin 38 is a critical component of epithelial cell structure and function, playing a pivotal role in keratinization, the formation of the cornified envelope, and immune regulation. Further research is needed to fully elucidate the mechanisms by which KRT38 regulates cellular processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 739613663

Symbol: KRT38_HUMAN

Name: Keratin, type I cuticular Ha8

UniProtKB Accession Codes:

O76015 A2RRM5 Q6A164

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15617563

Title: The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.

PubMed ID: 15617563

DOI: 10.1111/j.1432-0436.2004.07209006.x

Sequence Information:

  • Length: 456
  • Mass: 50480
  • Checksum: 8AE2E9BE95FC8E72
  • Sequence:
    • MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA HANRVRVGST 
PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL NGHEKETMQF LNDRLANYLE 
KVRQLEQENA ELEATLLERS KCHESTVCPD YQSYFHTIEE LQQKILCSKA ENARLIVQID 
NAKLAADDFR IKLESERSLR QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS 
NHEQEVKILR SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE 
GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRFGTELA 
QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE IATYRNLLES EDCKLPCNPC 
STSPSCVTAP CAPRPSCGPC TTCGPTCGAS TTGSRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.