Details for: ASH2L

Gene ID: 9070

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ASH2L

Ensembl ID: ENSG00000129691

Description: ASH2 like, histone lysine methyltransferase complex subunit

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • hematopoietic stem cell CL0000037
    CSI 8.44
    rCSI 5.61%
    PRS 80.48
  • erythroblast CL0000765
    CSI 6.31
    rCSI 16.75%
    PRS 83.95
  • regular atrial cardiac myocyte CL0002129
    CSI 4.88
    rCSI 15.71%
    PRS 74.43
  • choroid plexus epithelial cell CL0000706
    CSI 3.45
    rCSI 5.66%
    PRS 66.91
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.43
    rCSI 8.86%
    PRS 72.84
  • pancreatic D cell CL0000173
    CSI 3.32
    rCSI 3.27%
    PRS 80.45
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.2
    rCSI 3.99%
    PRS 57.17
  • pro-B cell CL0000826
    CSI 3.17
    rCSI 2.63%
    PRS 80.06
  • interstitial cell of Cajal CL0002088
    CSI 2.86
    rCSI 3.64%
    PRS 82.6
  • pancreatic A cell CL0000171
    CSI 2.81
    rCSI 2.95%
    PRS 81.05
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 2.74
    rCSI 6.59%
    PRS 90.76
  • retinal rod cell CL0000604
    CSI 2.53
    rCSI 4.46%
    PRS 73.39
  • melanocyte CL0000148
    CSI 2.52
    rCSI 1.87%
    PRS 70.8
  • naive B cell CL0000788
    CSI 2.51
    rCSI 2.15%
    PRS 84.54
  • interneuron CL0000099
    CSI 2.39
    rCSI 4.81%
    PRS 67.33
  • erythroid lineage cell CL0000764
    CSI 2.34
    rCSI 15.03%
    PRS 87.71
  • ionocyte CL0005006
    CSI 2.28
    rCSI 2.44%
    PRS 78.56
  • hematopoietic precursor cell CL0008001
    CSI 2.27
    rCSI 2.33%
    PRS 89.5
  • common myeloid progenitor CL0000049
    CSI 2.26
    rCSI 1.82%
    PRS 79.94
  • cerebellar granule cell CL0001031
    CSI 2.24
    rCSI 3.29%
    PRS 70.29
  • acinar cell CL0000622
    CSI 2.18
    rCSI 3.2%
    PRS 87.06
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.17
    rCSI 1.51%
    PRS 80.81
  • vascular leptomeningeal cell CL4023051
    CSI 2.16
    rCSI 3.78%
    PRS 70.92
  • mesodermal cell CL0000222
    CSI 2.09
    rCSI 2.51%
    PRS 75.25
  • hepatic stellate cell CL0000632
    CSI 2.06
    rCSI 7.7%
    PRS 69.83
  • hepatocyte CL0000182
    CSI 2.05
    rCSI 3.67%
    PRS 76.76
  • cerebral cortex endothelial cell CL1001602
    CSI 2.04
    rCSI 3.54%
    PRS 68.77
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.01
    rCSI 5.94%
    PRS 78.73
  • neural crest cell CL0011012
    CSI 1.99
    rCSI 1.57%
    PRS 65.8
  • endocardial cell CL0002350
    CSI 1.97
    rCSI 9.44%
    PRS 74.31
  • stem cell CL0000034
    CSI 1.95
    rCSI 1.88%
    PRS 70.42
  • retinal bipolar neuron CL0000748
    CSI 1.91
    rCSI 3.58%
    PRS 65.61
  • Mueller cell CL0000636
    CSI 1.89
    rCSI 4.31%
    PRS 68.96
  • erythrocyte CL0000232
    CSI 1.8
    rCSI 4.09%
    PRS 78.48
  • extravillous trophoblast CL0008036
    CSI 1.8
    rCSI 2.23%
    PRS 75.29
  • promyelocyte CL0000836
    CSI 1.77
    rCSI 2.55%
    PRS 83.95
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.77
    rCSI 2.51%
    PRS 74.24
  • ciliated epithelial cell CL0000067
    CSI 1.76
    rCSI 1.55%
    PRS 66.42
  • amacrine cell CL0000561
    CSI 1.74
    rCSI 5.04%
    PRS 66.82
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.72
    rCSI 1.33%
    PRS 80.18
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.72
    rCSI 4.36%
    PRS 67.77
  • lung secretory cell CL1000272
    CSI 1.68
    rCSI 4.16%
    PRS 77.02
  • retina horizontal cell CL0000745
    CSI 1.65
    rCSI 2.51%
    PRS 74.37
  • radial glial cell CL0000681
    CSI 1.63
    rCSI 2.26%
    PRS 76.26
  • pancreatic acinar cell CL0002064
    CSI 1.6
    rCSI 2.13%
    PRS 83.25
  • ependymal cell CL0000065
    CSI 1.56
    rCSI 3.16%
    PRS 55.86
  • peripheral nervous system neuron CL2000032
    CSI 1.56
    rCSI 2.12%
    PRS 68.96
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.54
    rCSI 1.78%
    PRS 69.81
  • dendritic cell, human CL0001056
    CSI 1.52
    rCSI 2.34%
    PRS 86
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 1.5
    rCSI 5.85%
    PRS 92.64
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.45
    rCSI 2.56%
    PRS 58.49
  • glioblast CL0000030
    CSI 1.45
    rCSI 2.31%
    PRS 69.26
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.42
    rCSI 1.69%
    PRS 59.25
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.41
    rCSI 2.28%
    PRS 60.99
  • chondrocyte CL0000138
    CSI 1.41
    rCSI 2.24%
    PRS 70.33
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.4
    rCSI 1.27%
    PRS 75.69
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.39
    rCSI 2.33%
    PRS 59.29
  • parietal epithelial cell CL1000452
    CSI 1.37
    rCSI 3.66%
    PRS 68.95
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.36
    rCSI 3.05%
    PRS 60.05
  • erythroid progenitor cell CL0000038
    CSI 1.34
    rCSI 7.69%
    PRS 83.49
  • type B pancreatic cell CL0000169
    CSI 1.33
    rCSI 2.95%
    PRS 76.83
  • retinal cone cell CL0000573
    CSI 1.32
    rCSI 2.13%
    PRS 67.37
  • renal interstitial pericyte CL1001318
    CSI 1.32
    rCSI 3.64%
    PRS 72.61
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.3
    rCSI 1.68%
    PRS 60.44
  • epicardial adipocyte CL1000309
    CSI 1.29
    rCSI 4.19%
    PRS 75.22
  • mesenchymal cell CL0008019
    CSI 1.21
    rCSI 3.08%
    PRS 70.88
  • promonocyte CL0000559
    CSI 1.17
    rCSI 2.01%
    PRS 84.11
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.09
    rCSI 2.66%
    PRS 57.32
  • cardiac muscle cell CL0000746
    CSI 1.03
    rCSI 1.48%
    PRS 67.27
  • placental villous trophoblast CL2000060
    CSI 1.02
    rCSI 1.57%
    PRS 76.57
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.99
    rCSI 6.19%
    PRS 69.15
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.97
    rCSI 5.68%
    PRS 60.09
  • primitive red blood cell CL0002355
    CSI 0.89
    rCSI 4.78%
    PRS 84.57
  • cardiac neuron CL0010022
    CSI 0.86
    rCSI 2.77%
    PRS 74.62
  • glial cell CL0000125
    CSI 0.86
    rCSI 3.26%
    PRS 68.38
  • neural progenitor cell CL0011020
    CSI 0.78
    rCSI 3.41%
    PRS 66.05
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.74
    rCSI 2.67%
    PRS 57.23
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.73
    rCSI 2.27%
    PRS 60.96
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.67
    rCSI 2.53%
    PRS 59.77
  • podocyte CL0000653
    CSI 0.62
    rCSI 2.74%
    PRS 77.99
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.6
    rCSI 1.86%
    PRS 63.39
  • direct pathway medium spiny neuron CL4023026
    CSI 0.25
    rCSI 5.9%
    PRS 57.69
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.24
    rCSI 5.81%
    PRS 58.25

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ASH2L](/details-gene/9070) (ASH2 like, histone lysine methyltransferase complex subunit) is a protein-coding gene located on chromosome 8p11.23. It functions as a critical core component of several histone methyltransferase complexes, including the Set1/COMPASS, MLL1/2, and MLL3/4 complexes, which are responsible for the methylation of histone H3 at lysine 4 (H3K4). This epigenetic modification is a key hallmark of active gene transcription. Consequently, [ASH2L](/details-gene/9070) plays a fundamental role in the epigenetic regulation of gene expression, chromatin organization, and developmental processes. Expression data indicates its highest significance in the hematopoietic system, particularly in primitive cell types such as the [hematopoietic stem cell](/details-cell/CL0000037) and [erythroblast](/details-cell/CL0000765), highlighting its essential role in hematopoiesis and cell lineage specification. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [ASH2L](/details-gene/9070) underscores its fundamental importance in cellular proliferation and differentiation, with a pronounced role in the hematopoietic system. The gene exhibits its highest significance scores in [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 8.44), [erythroblast](/details-cell/CL0000765) (CSI: 6.31), [pro-B cell](/details-cell/CL0000826) (CSI: 3.17), and [hematopoietic multipotent progenitor cell](/details-cell/CL0000837) (CSI: 2.74). This pattern suggests that [ASH2L](/details-gene/9070) is integral to maintaining the transcriptional programs that govern self-renewal and lineage commitment within the blood cell hierarchy. This is consistent with research indicating its downregulation during induced megakaryocytic differentiation of leukemia cell lines [Link](https://doi.org/10.1007/s001090100222). Beyond the hematopoietic system, [ASH2L](/details-gene/9070) shows significant expression in a diverse array of specialized, terminally differentiated cells. These include [regular atrial cardiac myocyte](/details-cell/CL0002129) (CSI: 4.88), [choroid plexus epithelial cell](/details-cell/CL0000706) (CSI: 3.45), [kidney loop of Henle thin ascending limb epithelial cell](/details-cell/CL1001107) (CSI: 3.43), and various neuronal subtypes like [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 3.20). This broad, yet cell-type-specific, high expression suggests a ubiquitous but critical role in maintaining the active chromatin states required for the specialized functions of diverse tissues. ## Pathways and Molecular Function The functional annotations for [ASH2L](/details-gene/9070) confirm its role as a central epigenetic regulator. It is a core component of multiple [histone methyltransferase complex](/details-cell/GO:0035097)es, including the [Mll1 complex](/details-cell/GO:0071339), [Mll1/2 complex](/details-cell/GO:0044665), and [Mll3/4 complex](/details-cell/GO:0044666), as established by numerous studies [Link](https://doi.org/10.1016/s1097-2765(04)00081-4), [Link](https://doi.org/10.1128/mcb.24.13.5639-5649.2004), [Link](https://doi.org/10.1074/jbc.m701574200). These complexes are essential for '[PKMTs methylate histone lysines](/details-cell/R-HSA-3214841),' a process fundamental to '[Epigenetic regulation of gene expression](/details-cell/R-HSA-212165)' and '[Positive regulation of transcription by rna polymerase ii](/details-cell/GO:0045944).' The gene's high significance in hematopoietic precursors is strongly supported by its involvement in biological processes like '[Hemopoiesis](/details-cell/GO:0030097)' and its role in pathways such as '[Transcriptional regulation by runx1](/details-cell/R-HSA-8878171).' Furthermore, its participation in broad developmental programs, such as '[Activation of hox genes during differentiation](/details-cell/R-HSA-5619507)' and '[Developmental biology](/details-cell/R-HSA-1266738),' aligns with its critical function in cell fate decisions. [ASH2L](/details-gene/9070) also integrates with key signaling pathways, notably '[Signaling by wnt](/details-cell/R-HSA-195721),' through its ability to bind beta-catenin ([beta-catenin binding](/details-cell/GO:0008013)) and participate in the '[Formation of the beta-catenin:tcf transactivating complex](/details-cell/R-HSA-201722).' ## Research Directions The data highlights [ASH2L](/details-gene/9070) as a master regulator in hematopoiesis and a key maintenance factor in diverse specialized cells. This central role suggests several avenues for future investigation. **Proposed Hypotheses:** 1. Given its top significance score in [hematopoietic stem cell](/details-cell/CL0000037) and its known function in MLL complexes often rearranged in leukemia, [ASH2L](/details-gene/9070) is likely indispensable for maintaining HSC self-renewal and multipotency. Its dose-dependent downregulation may be a prerequisite for proper myeloid and lymphoid lineage commitment. 2. The high expression of [ASH2L](/details-gene/9070) in metabolically active, terminally differentiated cells like [regular atrial cardiac myocyte](/details-cell/CL0002129) and neurons suggests it is required to sustain the high transcriptional output and stable epigenetic landscape necessary for their long-term function and viability. Loss of [ASH2L](/details-gene/9070) function in these cells could lead to progressive functional decline and cellular stress. **Experimental Approach:** To test the first hypothesis regarding the role of [ASH2L](/details-gene/9070) in HSC function, a conditional knockout mouse model using a hematopoietic-specific Cre recombinase (e.g., *Vav1-Cre;Ash2l-flox/flox*) would be ideal. Deletion of [ASH2L](/details-gene/9070) in the adult hematopoietic system would allow for the assessment of its role in homeostasis. The experimental readout would involve quantifying the number and function of HSCs through flow cytometry and competitive bone marrow transplantation assays. Furthermore, single-cell RNA-seq and ATAC-seq on sorted HSCs from knockout and control mice would reveal the immediate transcriptional and chromatin accessibility changes resulting from [ASH2L](/details-gene/9070) loss, clarifying its direct molecular targets. **Therapeutic Potential:** As a non-catalytic core component of several oncogenic MLL/KMT2 complexes, [ASH2L](/details-gene/9070) represents an attractive therapeutic target, particularly in hematological malignancies. The MLL complexes are frequently dysregulated in acute leukemias, making their components prime targets for drug development. Therefore, developing small molecule inhibitors that disrupt the interaction of [ASH2L](/details-gene/9070) with other core components of the complex (e.g., WDR5 or RbBP5) could be a viable strategy for **inhibition**. This approach could selectively dismantle the histone methyltransferase complex, leading to the downregulation of oncogenic gene programs. However, the gene's broad expression and essential role in healthy tissues, especially in the hematopoietic system, suggest that systemic inhibition could lead to significant on-target toxicity. Thus, targeted delivery systems or therapies aimed at context-specific dependencies might be required for clinical application.

Genular Protein ID: 2358140809

Symbol: ASH2L_HUMAN

Name: Set1/Ash2 histone methyltransferase complex subunit ASH2

UniProtKB Accession Codes:

Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 27 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11466562

Title: ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines.

PubMed ID: 11466562

DOI: 10.1007/s001090100222

PubMed ID: 10393421

Title: Cloning and characterization of ASH2L and ash2l, human and mouse homologs of the Drosophila ash2 gene.

PubMed ID: 10393421

DOI: 10.1159/000015248

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 14992727

Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

PubMed ID: 14992727

DOI: 10.1016/s1097-2765(04)00081-4

PubMed ID: 15199122

Title: Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

PubMed ID: 15199122

DOI: 10.1128/mcb.24.13.5639-5649.2004

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 16253997

Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.

PubMed ID: 16253997

DOI: 10.1074/jbc.m508312200

PubMed ID: 17355966

Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.

PubMed ID: 17355966

DOI: 10.1074/jbc.m609809200

PubMed ID: 17500065

Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

PubMed ID: 17500065

DOI: 10.1074/jbc.m701574200

PubMed ID: 17998332

Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

PubMed ID: 17998332

DOI: 10.1128/mcb.01356-07

PubMed ID: 18838538

Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.

PubMed ID: 18838538

DOI: 10.1128/mcb.00976-08

PubMed ID: 19131338

Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

PubMed ID: 19131338

DOI: 10.1074/jbc.m805872200

PubMed ID: 19556245

Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.

PubMed ID: 19556245

DOI: 10.1074/jbc.m109.014498

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21285357

Title: Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.

PubMed ID: 21285357

DOI: 10.1074/jbc.m110.202416

PubMed ID: 21220120

Title: Structural and biochemical insights into MLL1 core complex assembly.

PubMed ID: 21220120

DOI: 10.1016/j.str.2010.09.022

PubMed ID: 22266653

Title: The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

PubMed ID: 22266653

DOI: 10.1093/nar/gkr1235

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21660059

Title: Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.

PubMed ID: 21660059

DOI: 10.1038/embor.2011.101

Sequence Information:

  • Length: 628
  • Mass: 68723
  • Checksum: 8F5F007430D4B863
  • Sequence:
    • MAAAGAGPGQ EAGAGPGPGA VANATGAEEG EMKPVAAGAA APPGEGISAA PTVEPSSGEA 
EGGEANLVDV SGGLETESSN GKDTLEGAGD TSEVMDTQAG SVDEENGRQL GEVELQCGIC 
TKWFTADTFG IDTSSCLPFM TNYSFHCNVC HHSGNTYFLR KQANLKEMCL SALANLTWQS 
RTQDEHPKTM FSKDKDIIPF IDKYWECMTT RQRPGKMTWP NNIVKTMSKE RDVFLVKEHP 
DPGSKDPEED YPKFGLLDQD LSNIGPAYDN QKQSSAVSTS GNLNGGIAAG SSGKGRGAKR 
KQQDGGTTGT TKKARSDPLF SAQRLPPHGY PLEHPFNKDG YRYILAEPDP HAPDPEKLEL 
DCWAGKPIPG DLYRACLYER VLLALHDRAP QLKISDDRLT VVGEKGYSMV RASHGVRKGA 
WYFEITVDEM PPDTAARLGW SQPLGNLQAP LGYDKFSYSW RSKKGTKFHQ SIGKHYSSGY 
GQGDVLGFYI NLPEDTETAK SLPDTYKDKA LIKFKSYLYF EEKDFVDKAE KSLKQTPHSE 
IIFYKNGVNQ GVAYKDIFEG VYFPAISLYK SCTVSINFGP CFKYPPKDLT YRPMSDMGWG 
AVVEHTLADV LYHVETEVDG RRSPPWEP

Genular Protein ID: 2357182319

Symbol: F5H8F7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H8F7

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 489
  • Mass: 55324
  • Checksum: E8D0D1018E9FFE9E
  • Sequence:
    • MTNYSFHCNV CHHSGNTYFL RKQANLKEMC LSALANLTWQ SRTQDEHPKT MFSKDKDIIP 
FIDKYWECMT TRQRPGKMTW PNNIVKTMSK ERDVFLVKEH PDPGSKDPEE DYPKFGLLDQ 
DLSNIGPAYD NQKQSSAVST SGNLNGGIAA GSSGKGRGAK RKQQDGGTTG TTKKARSDPL 
FSAQRLPPHG YPLEHPFNKD GYRYILAEPD PHAPDPEKLE LDCWAGKPIP GDLYRACLYE 
RVLLALHDRA PQLKISDDRL TVVGEKGYSM VRASHGVRKG AWYFEITVDE MPPDTAARLG 
WSQPLGNLQA PLGYDKFSYS WRSKKGTKFH QSIGKHYSSG YGQGDVLGFY INLPEDTETA 
KSLPDTYKDK ALIKFKSYLY FEEKDFVDKA EKSLKQTPHS EIIFYKNGVN QGVAYKDIFE 
GVYFPAISLY KSCTVSINFG PCFKYPPKDL TYRPMSDMGW GAVVEHTLAD VLYHVETEVD 
GRRSPPWEP

Genular Protein ID: 3614076450

Symbol: B4DPT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DPT1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 489
  • Mass: 55266
  • Checksum: EA2DFED18E9FFE9E
  • Sequence:
    • MTNYSFHCNV CHHSGNTYFL RKQANLKEMC LSALANLTWQ SRTQDEHPKT MFSKDKDIIP 
FIDKYWECMT TRQRPGKMTW PNNIVKTMSK ERDVFLVKEH PDPGSKDPEE DYPKFGLLDQ 
DLSNIGPAYD NQKQSSAVST SGNLNGGIAA GSSGKGRGAK RKQQDGGTTG TTKKARSDPL 
FSAQRLPPHG YPLEHPFNKD GYRYILAEPD PHAPDPEKLE LDCWAGKPIP GDLYRACLYE 
RVLLALHDRA PQLKISDDRL TVVGEKGYSM VRASHGVRKG AWYFEITVDE MPPDTAARLG 
WSQPLGNLQA PLGYDKFSYS WRSKKGTKFH QSIGKHYSSG YGQGDVLGFY INLPEDTETA 
KSLPDTYKDK ALIKFKSYLY FEEKDFVDKA EKSLKQTPHS EIIFYKNGVN QGVAYKDIFE 
GVYFPAISLY KSCTVSINFG PCFKYPPKDL TYRPMSGMGW GAVVEHTLAD VLYHVETEVD 
GRRSPPWEP