Details for: ASH2L

Gene ID: 9070

Symbol: ASH2L

Ensembl ID: ENSG00000129691

Description: ASH2 like, histone lysine methyltransferase complex subunit

Associated with

Other Information

Genular Protein ID: 2358140809

Symbol: ASH2L_HUMAN

Name: Set1/Ash2 histone methyltransferase complex subunit ASH2

UniProtKB Accession Codes:

Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 12 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 27 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11466562

Title: ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines.

PubMed ID: 11466562

DOI: 10.1007/s001090100222

PubMed ID: 10393421

Title: Cloning and characterization of ASH2L and ash2l, human and mouse homologs of the Drosophila ash2 gene.

PubMed ID: 10393421

DOI: 10.1159/000015248

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 14992727

Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

PubMed ID: 14992727

DOI: 10.1016/s1097-2765(04)00081-4

PubMed ID: 15199122

Title: Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

PubMed ID: 15199122

DOI: 10.1128/mcb.24.13.5639-5649.2004

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 16253997

Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.

PubMed ID: 16253997

DOI: 10.1074/jbc.m508312200

PubMed ID: 17355966

Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.

PubMed ID: 17355966

DOI: 10.1074/jbc.m609809200

PubMed ID: 17500065

Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

PubMed ID: 17500065

DOI: 10.1074/jbc.m701574200

PubMed ID: 17998332

Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

PubMed ID: 17998332

DOI: 10.1128/mcb.01356-07

PubMed ID: 18838538

Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.

PubMed ID: 18838538

DOI: 10.1128/mcb.00976-08

PubMed ID: 19131338

Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

PubMed ID: 19131338

DOI: 10.1074/jbc.m805872200

PubMed ID: 19556245

Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.

PubMed ID: 19556245

DOI: 10.1074/jbc.m109.014498

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21285357

Title: Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.

PubMed ID: 21285357

DOI: 10.1074/jbc.m110.202416

PubMed ID: 21220120

Title: Structural and biochemical insights into MLL1 core complex assembly.

PubMed ID: 21220120

DOI: 10.1016/j.str.2010.09.022

PubMed ID: 22266653

Title: The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

PubMed ID: 22266653

DOI: 10.1093/nar/gkr1235

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21660059

Title: Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.

PubMed ID: 21660059

DOI: 10.1038/embor.2011.101

Sequence Information:

  • Length: 628
  • Mass: 68723
  • Checksum: 8F5F007430D4B863
  • Sequence:
    • MAAAGAGPGQ EAGAGPGPGA VANATGAEEG EMKPVAAGAA APPGEGISAA PTVEPSSGEA 
EGGEANLVDV SGGLETESSN GKDTLEGAGD TSEVMDTQAG SVDEENGRQL GEVELQCGIC 
TKWFTADTFG IDTSSCLPFM TNYSFHCNVC HHSGNTYFLR KQANLKEMCL SALANLTWQS 
RTQDEHPKTM FSKDKDIIPF IDKYWECMTT RQRPGKMTWP NNIVKTMSKE RDVFLVKEHP 
DPGSKDPEED YPKFGLLDQD LSNIGPAYDN QKQSSAVSTS GNLNGGIAAG SSGKGRGAKR 
KQQDGGTTGT TKKARSDPLF SAQRLPPHGY PLEHPFNKDG YRYILAEPDP HAPDPEKLEL 
DCWAGKPIPG DLYRACLYER VLLALHDRAP QLKISDDRLT VVGEKGYSMV RASHGVRKGA 
WYFEITVDEM PPDTAARLGW SQPLGNLQAP LGYDKFSYSW RSKKGTKFHQ SIGKHYSSGY 
GQGDVLGFYI NLPEDTETAK SLPDTYKDKA LIKFKSYLYF EEKDFVDKAE KSLKQTPHSE 
IIFYKNGVNQ GVAYKDIFEG VYFPAISLYK SCTVSINFGP CFKYPPKDLT YRPMSDMGWG 
AVVEHTLADV LYHVETEVDG RRSPPWEP

Genular Protein ID: 2357182319

Symbol: F5H8F7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H8F7

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 489
  • Mass: 55324
  • Checksum: E8D0D1018E9FFE9E
  • Sequence:
    • MTNYSFHCNV CHHSGNTYFL RKQANLKEMC LSALANLTWQ SRTQDEHPKT MFSKDKDIIP 
FIDKYWECMT TRQRPGKMTW PNNIVKTMSK ERDVFLVKEH PDPGSKDPEE DYPKFGLLDQ 
DLSNIGPAYD NQKQSSAVST SGNLNGGIAA GSSGKGRGAK RKQQDGGTTG TTKKARSDPL 
FSAQRLPPHG YPLEHPFNKD GYRYILAEPD PHAPDPEKLE LDCWAGKPIP GDLYRACLYE 
RVLLALHDRA PQLKISDDRL TVVGEKGYSM VRASHGVRKG AWYFEITVDE MPPDTAARLG 
WSQPLGNLQA PLGYDKFSYS WRSKKGTKFH QSIGKHYSSG YGQGDVLGFY INLPEDTETA 
KSLPDTYKDK ALIKFKSYLY FEEKDFVDKA EKSLKQTPHS EIIFYKNGVN QGVAYKDIFE 
GVYFPAISLY KSCTVSINFG PCFKYPPKDL TYRPMSDMGW GAVVEHTLAD VLYHVETEVD 
GRRSPPWEP

Genular Protein ID: 3614076450

Symbol: B4DPT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DPT1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 489
  • Mass: 55266
  • Checksum: EA2DFED18E9FFE9E
  • Sequence:
    • MTNYSFHCNV CHHSGNTYFL RKQANLKEMC LSALANLTWQ SRTQDEHPKT MFSKDKDIIP 
FIDKYWECMT TRQRPGKMTW PNNIVKTMSK ERDVFLVKEH PDPGSKDPEE DYPKFGLLDQ 
DLSNIGPAYD NQKQSSAVST SGNLNGGIAA GSSGKGRGAK RKQQDGGTTG TTKKARSDPL 
FSAQRLPPHG YPLEHPFNKD GYRYILAEPD PHAPDPEKLE LDCWAGKPIP GDLYRACLYE 
RVLLALHDRA PQLKISDDRL TVVGEKGYSM VRASHGVRKG AWYFEITVDE MPPDTAARLG 
WSQPLGNLQA PLGYDKFSYS WRSKKGTKFH QSIGKHYSSG YGQGDVLGFY INLPEDTETA 
KSLPDTYKDK ALIKFKSYLY FEEKDFVDKA EKSLKQTPHS EIIFYKNGVN QGVAYKDIFE 
GVYFPAISLY KSCTVSINFG PCFKYPPKDL TYRPMSGMGW GAVVEHTLAD VLYHVETEVD 
GRRSPPWEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.