Details for: TAB2 AS1

Gene ID: 105378049

Symbol: TAB2 AS1

Ensembl ID: ENSG00000225924

Description: TAB2 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7012
    Cell Significance Index: 10.2200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.1278
    Cell Significance Index: 0.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1087
    Cell Significance Index: 1.8800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0817
    Cell Significance Index: 0.9700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0654
    Cell Significance Index: 0.9500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0521
    Cell Significance Index: 0.7200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0461
    Cell Significance Index: 0.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0155
    Cell Significance Index: 0.2000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0102
    Cell Significance Index: 0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0098
    Cell Significance Index: 1.4300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0031
    Cell Significance Index: 0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0012
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0010
    Cell Significance Index: 1.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0004
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0012
    Cell Significance Index: -0.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0021
    Cell Significance Index: -0.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0029
    Cell Significance Index: -0.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0034
    Cell Significance Index: -0.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0050
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0052
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0056
    Cell Significance Index: -0.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0062
    Cell Significance Index: -0.3800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0065
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0080
    Cell Significance Index: -0.5400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0092
    Cell Significance Index: -0.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0095
    Cell Significance Index: -0.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0097
    Cell Significance Index: -0.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0098
    Cell Significance Index: -0.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0107
    Cell Significance Index: -0.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0114
    Cell Significance Index: -0.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0116
    Cell Significance Index: -0.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0123
    Cell Significance Index: -0.5800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0124
    Cell Significance Index: -0.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0130
    Cell Significance Index: -0.3300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0131
    Cell Significance Index: -0.1800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0133
    Cell Significance Index: -0.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0141
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0156
    Cell Significance Index: -0.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0161
    Cell Significance Index: -0.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0162
    Cell Significance Index: -0.2300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0164
    Cell Significance Index: -0.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0189
    Cell Significance Index: -0.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0193
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0197
    Cell Significance Index: -0.5800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0201
    Cell Significance Index: -0.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0210
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0211
    Cell Significance Index: -0.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0212
    Cell Significance Index: -0.4200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0213
    Cell Significance Index: -0.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0223
    Cell Significance Index: -0.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0224
    Cell Significance Index: -0.4900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0229
    Cell Significance Index: -0.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0229
    Cell Significance Index: -0.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0229
    Cell Significance Index: -0.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0231
    Cell Significance Index: -0.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0253
    Cell Significance Index: -0.4300
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0256
    Cell Significance Index: -0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0262
    Cell Significance Index: -0.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0276
    Cell Significance Index: -0.5100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0287
    Cell Significance Index: -0.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0287
    Cell Significance Index: -0.7000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0294
    Cell Significance Index: -0.4300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0300
    Cell Significance Index: -0.6100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0301
    Cell Significance Index: -0.6000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0303
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0315
    Cell Significance Index: -0.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0315
    Cell Significance Index: -0.6200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0323
    Cell Significance Index: -0.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0332
    Cell Significance Index: -0.4600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0333
    Cell Significance Index: -0.3400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0334
    Cell Significance Index: -0.4400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0345
    Cell Significance Index: -0.3900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0347
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0355
    Cell Significance Index: -0.5100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0356
    Cell Significance Index: -0.4100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0359
    Cell Significance Index: -0.4700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0359
    Cell Significance Index: -0.4600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0363
    Cell Significance Index: -0.4900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0363
    Cell Significance Index: -0.3100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0366
    Cell Significance Index: -0.4800
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0377
    Cell Significance Index: -0.4400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0378
    Cell Significance Index: -0.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0384
    Cell Significance Index: -0.4800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0384
    Cell Significance Index: -0.4100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0384
    Cell Significance Index: -0.3600
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0397
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAB2 AS1 is a long non-coding RNA (lncRNA) transcript that is antisense to the TAB2 gene. It is significantly expressed in various cell types, including progenitor cells, endothelial cells, granulocyte-monocyte progenitor cells, goblet cells, intestinal crypt stem cells, early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and transit amplifying cells. The expression of TAB2 AS1 is tightly regulated and is often associated with specific cellular contexts. **Pathways and Functions:** TAB2 AS1 modulates cellular processes through its interactions with target genes and regulatory networks. Its expression is linked to the regulation of cell proliferation, differentiation, and survival. In immune cells, TAB2 AS1 is involved in the regulation of immune cell development and function. Specifically, it is required for the proper development and differentiation of T lymphocytes, natural killer cells, and dendritic cells. Additionally, TAB2 AS1 is involved in the regulation of endothelial cell function and angiogenesis. The mechanisms by which TAB2 AS1 regulates cellular processes are complex and multifaceted. It interacts with various transcription factors and regulatory proteins to modulate gene expression. For example, TAB2 AS1 has been shown to interact with the transcription factor SOX2 to regulate the expression of genes involved in stem cell maintenance and differentiation. **Clinical Significance:** The dysregulation of TAB2 AS1 has been implicated in various diseases, including immune-related disorders and cancer. For example, alterations in TAB2 AS1 expression have been observed in patients with multiple sclerosis, rheumatoid arthritis, and other autoimmune diseases. Additionally, TAB2 AS1 has been shown to be overexpressed in certain types of cancer, including breast cancer and colon cancer. The clinical significance of TAB2 AS1 is also evident in its role as a potential biomarker for disease diagnosis and prognosis. For example, studies have shown that TAB2 AS1 expression levels can be used to predict the risk of disease progression in patients with multiple sclerosis. In conclusion, TAB2 AS1 is a critical regulator of immune cell development, tissue homeostasis, and cellular differentiation. Its dysregulation has been implicated in various diseases, including immune-related disorders and cancer. Further research is needed to fully understand the mechanisms by which TAB2 AS1 regulates cellular processes and to explore its potential as a therapeutic target for disease treatment. **Future Directions:** Future studies should focus on elucidating the mechanisms by which TAB2 AS1 regulates cellular processes and its role in disease development. Additionally, the development of novel therapeutic strategies targeting TAB2 AS1 may provide new avenues for treating immune-related disorders and cancer. Further research is also needed to fully understand the clinical significance of TAB2 AS1 and to explore its potential as a biomarker for disease diagnosis and prognosis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.