Details for: LINC00161

Gene ID: 118421

Symbol: LINC00161

Ensembl ID: ENSG00000226935

Description: long intergenic non-protein coding RNA 161

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: club cell (CL0000158)
    Fold Change: 1.2767
    Cell Significance Index: 13.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0872
    Cell Significance Index: 1.1900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0872
    Cell Significance Index: 1.2100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0604
    Cell Significance Index: 0.6300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0405
    Cell Significance Index: 0.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0308
    Cell Significance Index: 1.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0044
    Cell Significance Index: 0.1200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0016
    Cell Significance Index: 0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0010
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0007
    Cell Significance Index: 0.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0010
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0032
    Cell Significance Index: -0.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0038
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0039
    Cell Significance Index: -0.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0050
    Cell Significance Index: -0.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0056
    Cell Significance Index: -0.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0059
    Cell Significance Index: -0.4000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0067
    Cell Significance Index: -0.1000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0071
    Cell Significance Index: -0.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0076
    Cell Significance Index: -0.1300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0080
    Cell Significance Index: -0.0900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0082
    Cell Significance Index: -0.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0087
    Cell Significance Index: -0.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0097
    Cell Significance Index: -0.3100
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0098
    Cell Significance Index: -0.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0102
    Cell Significance Index: -0.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0103
    Cell Significance Index: -0.3600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0104
    Cell Significance Index: -0.1000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0116
    Cell Significance Index: -0.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0118
    Cell Significance Index: -0.2000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0124
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0128
    Cell Significance Index: -0.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0130
    Cell Significance Index: -0.2400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0141
    Cell Significance Index: -0.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0151
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0154
    Cell Significance Index: -0.1700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0160
    Cell Significance Index: -0.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0171
    Cell Significance Index: -0.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0181
    Cell Significance Index: -0.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0190
    Cell Significance Index: -0.4100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0193
    Cell Significance Index: -0.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0197
    Cell Significance Index: -0.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0205
    Cell Significance Index: -0.4000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0206
    Cell Significance Index: -0.4100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0211
    Cell Significance Index: -0.2700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0213
    Cell Significance Index: -0.2200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0214
    Cell Significance Index: -0.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0215
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0220
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0246
    Cell Significance Index: -0.2400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0247
    Cell Significance Index: -0.3300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0260
    Cell Significance Index: -0.2900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0263
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0273
    Cell Significance Index: -0.3000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0274
    Cell Significance Index: -0.2800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0275
    Cell Significance Index: -0.1500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0276
    Cell Significance Index: -0.2700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0277
    Cell Significance Index: -0.2800
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0282
    Cell Significance Index: -0.2900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0284
    Cell Significance Index: -0.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0284
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0298
    Cell Significance Index: -0.2800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0308
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0312
    Cell Significance Index: -0.3800
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0314
    Cell Significance Index: -0.3800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0315
    Cell Significance Index: -0.3800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0316
    Cell Significance Index: -0.4300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0320
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0320
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0321
    Cell Significance Index: -0.3000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0325
    Cell Significance Index: -0.3300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0325
    Cell Significance Index: -0.3900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0328
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0328
    Cell Significance Index: -0.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0334
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0334
    Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00161 is a 2,408-nucleotide-long lincRNA, which is distinct from other lincRNAs due to its unique structure and expression profile. Its expression is widespread, with significant levels observed in various cell types, including progenitor cells, microglial cells, endothelial cells, and neoplastic cells. Interestingly, LINC00161 is also expressed in normal cells, suggesting a potential role in maintaining cellular homeostasis. **Pathways and Functions:** The mechanisms by which LINC00161 exerts its effects are not fully understood. However, several studies suggest that LINC00161 may modulate various cellular processes, including: 1. **Cell migration and invasion**: LINC00161 has been shown to regulate the migration and invasion of cancer cells, suggesting a potential role in tumor progression. 2. **Apoptosis and autophagy**: LINC00161 may influence the regulation of apoptosis and autophagy, two critical cellular processes involved in cell death and survival. 3. **Epigenetic regulation**: LINC00161 has been implicated in the regulation of epigenetic marks, such as DNA methylation and histone modification, which play a crucial role in gene expression. 4. **Stem cell maintenance**: LINC00161 may contribute to the maintenance of stem cell pluripotency and self-renewal, highlighting its potential role in regulating cellular fate. **Clinical Significance:** The clinical significance of LINC00161 is an area of active research. Studies have implicated LINC00161 in various human diseases, including: 1. **Cancer**: LINC00161 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, suggesting a potential role in tumor progression. 2. **Neurological disorders**: LINC00161 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cardiovascular disease**: LINC00161 may contribute to the development of cardiovascular disease by regulating endothelial function and blood vessel formation. In conclusion, LINC00161 is a complex and enigmatic lincRNA that plays a multifaceted role in regulating various cellular processes. Further research is needed to elucidate the mechanisms by which LINC00161 exerts its effects and to explore its potential as a therapeutic target in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.