Details for: OR13C3

Gene ID: 138803

Symbol: OR13C3

Ensembl ID: ENSG00000204246

Description: olfactory receptor family 13 subfamily C member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.1580
    Cell Significance Index: 1.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1317
    Cell Significance Index: 3.5300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1231
    Cell Significance Index: 1.5000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1194
    Cell Significance Index: 1.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0927
    Cell Significance Index: 0.9600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0768
    Cell Significance Index: 0.7800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0677
    Cell Significance Index: 0.8700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0568
    Cell Significance Index: 0.6600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0310
    Cell Significance Index: 0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0269
    Cell Significance Index: 7.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0244
    Cell Significance Index: 0.3500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0238
    Cell Significance Index: 0.2800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0102
    Cell Significance Index: 0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0015
    Cell Significance Index: 0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0007
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0026
    Cell Significance Index: -0.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0027
    Cell Significance Index: -0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0034
    Cell Significance Index: -0.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0038
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0054
    Cell Significance Index: -0.6200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0059
    Cell Significance Index: -0.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0077
    Cell Significance Index: -0.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0079
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0089
    Cell Significance Index: -0.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0092
    Cell Significance Index: -0.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0098
    Cell Significance Index: -0.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0098
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0100
    Cell Significance Index: -0.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0108
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0116
    Cell Significance Index: -0.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0116
    Cell Significance Index: -0.3300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0116
    Cell Significance Index: -0.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0142
    Cell Significance Index: -0.1400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0146
    Cell Significance Index: -0.7600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0151
    Cell Significance Index: -0.2100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0156
    Cell Significance Index: -0.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0160
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0162
    Cell Significance Index: -0.3500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0166
    Cell Significance Index: -0.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0174
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0184
    Cell Significance Index: -0.3900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0189
    Cell Significance Index: -0.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0193
    Cell Significance Index: -0.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0196
    Cell Significance Index: -0.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0196
    Cell Significance Index: -0.5000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0204
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0213
    Cell Significance Index: -0.6100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0218
    Cell Significance Index: -0.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0230
    Cell Significance Index: -0.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0235
    Cell Significance Index: -0.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0235
    Cell Significance Index: -0.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0241
    Cell Significance Index: -0.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0241
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0243
    Cell Significance Index: -0.4200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0253
    Cell Significance Index: -0.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0254
    Cell Significance Index: -0.4700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0255
    Cell Significance Index: -0.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0261
    Cell Significance Index: -0.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0263
    Cell Significance Index: -0.3500
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0286
    Cell Significance Index: -0.3400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0303
    Cell Significance Index: -0.3200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0310
    Cell Significance Index: -0.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0328
    Cell Significance Index: -0.4300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0329
    Cell Significance Index: -0.4100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0333
    Cell Significance Index: -0.4500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0334
    Cell Significance Index: -0.4100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0334
    Cell Significance Index: -0.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0346
    Cell Significance Index: -0.8300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0349
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0350
    Cell Significance Index: -0.4900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0351
    Cell Significance Index: -0.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0352
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0355
    Cell Significance Index: -0.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0356
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0357
    Cell Significance Index: -0.4900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0358
    Cell Significance Index: -0.4000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0360
    Cell Significance Index: -0.4300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0360
    Cell Significance Index: -0.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0364
    Cell Significance Index: -0.4600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0369
    Cell Significance Index: -0.4900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0377
    Cell Significance Index: -0.4000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0382
    Cell Significance Index: -0.4900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0386
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR13C3 is a G protein-coupled receptor that binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Expression Patterns:** The OR13C3 gene is expressed in various cell types, including progenitor cells, endothelial cells, and neurons, suggesting a broad range of functions beyond olfactory perception. 3. **Cellular Localization:** The receptor is localized to the plasma membrane, allowing it to interact with odorant molecules and transmit signals. 4. **Evolutionary Conservation:** The OR13C3 gene is conserved across species, indicating its importance in maintaining olfactory function. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR13C3 detects odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor Signaling:** The receptor activates G proteins, which in turn activate downstream signaling pathways involved in olfactory perception. 3. **Olfactory Signaling Pathway:** OR13C3 is part of the olfactory signaling pathway, which involves the coordinated action of multiple olfactory receptors to generate a comprehensive olfactory perception. 4. **Sensory Perception:** OR13C3 plays a role in sensory perception beyond olfaction, potentially influencing other sensory modalities such as taste and touch. **Clinical Significance:** 1. **Olfactory Disorders:** Mutations in the OR13C3 gene have been associated with olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological Disorders:** OR13C3 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common symptom. 3. **Cancer Research:** The OR13C3 gene has been identified as a potential biomarker for cancer, as altered expression patterns have been observed in various cancer types. 4. **Therapeutic Applications:** OR13C3-based therapies have been explored for the treatment of olfactory disorders and other conditions, such as Parkinson's disease. In conclusion, OR13C3 is a crucial gene involved in olfactory perception and sensory processing. Its widespread expression in various cell types and its role in detecting chemical stimuli highlight its significance in maintaining olfactory function. Further research is needed to fully understand the functions and clinical implications of OR13C3, but its potential as a therapeutic target and biomarker for various diseases makes it an exciting area of investigation.

Genular Protein ID: 3823786857

Symbol: O13C3_HUMAN

Name: Olfactory receptor 13C3

UniProtKB Accession Codes:

Q8NGS6 Q5VVG1 Q6IF52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 5 GO 4 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 347
  • Mass: 38729
  • Checksum: 6318EA2A850871D7
  • Sequence:
    • MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY PKIEIVYFAL 
ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD ICYTSSSVPS TLVSLISKKR 
NISFSGCAVQ MFFGFAMGST ECLLLGMMAF DRYVAICNPL RYPIILSKVA YVLMASVSWL 
SGGINSAVQT LLAMRLPFCG NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP 
LMVIFFSYMF ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE 
EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.