Details for: CDRT15

Gene ID: 146822

Symbol: CDRT15

Ensembl ID: ENSG00000223510

Description: CMT1A duplicated region transcript 15

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0546
    Cell Significance Index: 0.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0192
    Cell Significance Index: 0.2800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0144
    Cell Significance Index: 0.1700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0084
    Cell Significance Index: 0.1100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0081
    Cell Significance Index: 0.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0075
    Cell Significance Index: 0.1100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0066
    Cell Significance Index: 0.0800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.0059
    Cell Significance Index: 0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0049
    Cell Significance Index: 0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0027
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0060
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0067
    Cell Significance Index: -0.4500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0068
    Cell Significance Index: -0.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0072
    Cell Significance Index: -0.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0072
    Cell Significance Index: -0.4400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0087
    Cell Significance Index: -0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0091
    Cell Significance Index: -0.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0096
    Cell Significance Index: -0.3100
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0097
    Cell Significance Index: -0.0700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0100
    Cell Significance Index: -0.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0105
    Cell Significance Index: -0.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0106
    Cell Significance Index: -0.4700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0107
    Cell Significance Index: -0.1600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0121
    Cell Significance Index: -0.4600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0121
    Cell Significance Index: -0.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0124
    Cell Significance Index: -0.1200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0127
    Cell Significance Index: -0.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0128
    Cell Significance Index: -0.4700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0137
    Cell Significance Index: -0.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0147
    Cell Significance Index: -0.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0151
    Cell Significance Index: -0.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0153
    Cell Significance Index: -0.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0153
    Cell Significance Index: -0.2600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0155
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0161
    Cell Significance Index: -0.1700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0161
    Cell Significance Index: -0.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0164
    Cell Significance Index: -0.3300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0169
    Cell Significance Index: -0.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0186
    Cell Significance Index: -0.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0188
    Cell Significance Index: -0.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0188
    Cell Significance Index: -0.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0193
    Cell Significance Index: -0.2700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0194
    Cell Significance Index: -0.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0196
    Cell Significance Index: -0.1600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0200
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0202
    Cell Significance Index: -0.5800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0206
    Cell Significance Index: -0.2700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0207
    Cell Significance Index: -0.2400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0208
    Cell Significance Index: -0.2500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0226
    Cell Significance Index: -0.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0227
    Cell Significance Index: -0.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0228
    Cell Significance Index: -0.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0238
    Cell Significance Index: -0.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0239
    Cell Significance Index: -0.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0240
    Cell Significance Index: -0.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0246
    Cell Significance Index: -0.5900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0248
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0251
    Cell Significance Index: -0.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0261
    Cell Significance Index: -0.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0264
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0270
    Cell Significance Index: -0.2800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0270
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0271
    Cell Significance Index: -0.5000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0277
    Cell Significance Index: -0.1800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0278
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0279
    Cell Significance Index: -0.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0280
    Cell Significance Index: -0.3100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0283
    Cell Significance Index: -0.3700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0284
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0286
    Cell Significance Index: -0.4100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0289
    Cell Significance Index: -0.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0293
    Cell Significance Index: -0.3600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0296
    Cell Significance Index: -0.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0298
    Cell Significance Index: -0.1800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0301
    Cell Significance Index: -0.4100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0307
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0308
    Cell Significance Index: -0.2900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0309
    Cell Significance Index: -0.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0319
    Cell Significance Index: -0.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0320
    Cell Significance Index: -0.4100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0321
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Expression:** CDRT15 is significantly expressed in various cell types, including glutamatergic neurons, progenitor cells, microglial cells, endothelial cells, and others. This widespread expression suggests that CDRT15 plays a crucial role in maintaining tissue homeostasis and regulating cellular processes. 2. **Protein Structure:** The protein encoded by CDRT15, CDRTF_HUMAN, lacks a clear structural motif, making it challenging to predict its function. However, its expression in various cell types suggests that CDRTF_HUMAN may be involved in regulating cellular processes, such as cell proliferation, differentiation, and survival. 3. **Cellular Distribution:** CDRT15 is expressed in the cerebral cortex, forebrain, and other regions of the central nervous system, as well as in the heart and other organs. This widespread distribution suggests that CDRT15 may play a role in maintaining tissue homeostasis and regulating cellular processes in various organs. **Pathways and Functions:** 1. **Cellular Signaling:** CDRT15 may be involved in regulating cellular signaling pathways, such as the PI3K/AKT pathway, which is critical for cell survival, proliferation, and differentiation. 2. **Cellular Homeostasis:** CDRT15 may play a role in maintaining tissue homeostasis by regulating cellular processes, such as cell proliferation, differentiation, and survival. 3. **Neurotransmission:** CDRT15 is expressed in glutamatergic neurons, which are involved in neurotransmission. CDRT15 may play a role in regulating neurotransmission by modulating the activity of glutamatergic neurons. 4. **Angiogenesis:** CDRT15 is expressed in endothelial cells, which are involved in angiogenesis. CDRT15 may play a role in regulating angiogenesis by modulating the activity of endothelial cells. **Clinical Significance:** 1. **Charcot-Marie-Tooth Disease:** CDRT15 is associated with Charcot-Marie-Tooth disease, a neurodegenerative disorder characterized by peripheral neuropathy and muscle weakness. 2. **Neurological Disorders:** CDRT15 may play a role in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cardiovascular Disease:** CDRT15 is expressed in cardiac endothelial cells, which are involved in cardiovascular disease. CDRT15 may play a role in regulating cardiovascular function and preventing cardiovascular disease. 4. **Cancer:** CDRT15 may play a role in cancer development and progression, particularly in tumors that arise from cells in the central nervous system. In conclusion, CDRT15 is a gene of intricate complexity that is expressed in a wide range of cells and tissues. Further research is necessary to unravel its mysteries and understand its functional significance in regulating cellular processes and maintaining tissue homeostasis. The clinical significance of CDRT15 is still poorly understood, and further studies are required to determine its role in various neurological and cardiovascular disorders.

Genular Protein ID: 338460776

Symbol: CDRTF_HUMAN

Name: CMT1A duplicated region transcript 15 protein

UniProtKB Accession Codes:

Q96T59 B2RUU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11381029

Title: The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes.

PubMed ID: 11381029

DOI: 10.1101/gr.180401

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 188
  • Mass: 20651
  • Checksum: D3654E4F9A5D61BC
  • Sequence:
    • MFSCCFPTSR GCCFRNGGSE SLFRRCRRRL IPHPRRLSPV VIRRIQVPQD SLGQALAGQA 
TPEIPLGLQL HTVLVQEIQE LIEAQTLAPG PCAEVRALPA PAAEPEPAWE EAPPERALEL 
EGAPAKDQTN EELPEITEVP ESIKRRLGRR VPAATPAPRG NLLLQAWMRV HSWASRLFAP 
NVLPGTGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.