Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mesangial cell (CL0000650)
Fold Change: 15.77
Marker Score: 19035 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 12.3
Marker Score: 10100 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 4.47
Marker Score: 13252 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.05
Marker Score: 71942 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 4.02
Marker Score: 16773 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.58
Marker Score: 30255 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.46
Marker Score: 7592 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.68
Marker Score: 7658.5 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.49
Marker Score: 55632 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.19
Marker Score: 8616 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.18
Marker Score: 6254 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.61
Marker Score: 723 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.52
Marker Score: 20177 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.49
Marker Score: 3504 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168878 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.47
Marker Score: 2777 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.46
Marker Score: 2967 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.43
Marker Score: 18800 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.31
Marker Score: 723 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20110 - Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 1.2
Marker Score: 387 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.19
Marker Score: 714 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.13
Marker Score: 3784 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.1
Marker Score: 529 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.08
Marker Score: 21423 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.04
Marker Score: 581 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.03
Marker Score: 1241 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1
Marker Score: 347 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71802 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48027 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.99
Marker Score: 3821 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.98
Marker Score: 5872 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.94
Marker Score: 786.5 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.94
Marker Score: 9711 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.94
Marker Score: 1442 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5316 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.91
Marker Score: 289 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.9
Marker Score: 724 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.9
Marker Score: 340 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.87
Marker Score: 3094.5 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.85
Marker Score: 241 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.84
Marker Score: 910 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.82
Marker Score: 1924 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.81
Marker Score: 5300 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 611 - Cell Name: germ cell (CL0000586)
Fold Change: 0.78
Marker Score: 1371 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1255 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703 - Cell Name: endocardial cell (CL0002350)
Fold Change: 0.76
Marker Score: 431 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.75
Marker Score: 241 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.69
Marker Score: 222 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177 - Cell Name: interneuron (CL0000099)
Fold Change: 0.68
Marker Score: 312 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.68
Marker Score: 588 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.67
Marker Score: 322 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.66
Marker Score: 218 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.64
Marker Score: 674 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.59
Marker Score: 165 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.58
Marker Score: 1447 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.58
Marker Score: 337 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: promonocyte (CL0000559)
Fold Change: 0.55
Marker Score: 357 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.55
Marker Score: 324 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.55
Marker Score: 256 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.54
Marker Score: 137 - Cell Name: neural crest cell (CL0011012)
Fold Change: 0.54
Marker Score: 573 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.53
Marker Score: 576 - Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.52
Marker Score: 128 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.52
Marker Score: 941 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.51
Marker Score: 184 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.49
Marker Score: 153 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.49
Marker Score: 457 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.48
Marker Score: 201 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.48
Marker Score: 2579 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.47
Marker Score: 981 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.47
Marker Score: 334 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.47
Marker Score: 104 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.46
Marker Score: 789 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.46
Marker Score: 1263 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.46
Marker Score: 252 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.44
Marker Score: 114.5 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.44
Marker Score: 2035 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.43
Marker Score: 175 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.42
Marker Score: 188 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.42
Marker Score: 146 - Cell Name: neural cell (CL0002319)
Fold Change: 0.42
Marker Score: 202 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.42
Marker Score: 145 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.42
Marker Score: 14386 - Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.41
Marker Score: 115 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.41
Marker Score: 585 - Cell Name: glial cell (CL0000125)
Fold Change: 0.39
Marker Score: 429 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.39
Marker Score: 101 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.39
Marker Score: 247 - Cell Name: osteoblast (CL0000062)
Fold Change: 0.39
Marker Score: 207 - Cell Name: chondrocyte (CL0000138)
Fold Change: 0.36
Marker Score: 164
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Other Information
Genular Protein ID: 1535692116
Symbol: FBN2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8120105
Title: Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.
PubMed ID: 8120105
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 1852206
Title: Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.
PubMed ID: 1852206
DOI: 10.1038/352330a0
PubMed ID: 15131124
Title: MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.
PubMed ID: 15131124
PubMed ID: 18339631
Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
PubMed ID: 18339631
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 23010571
Title: A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module.
PubMed ID: 23010571
PubMed ID: 24899048
Title: Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.
PubMed ID: 24899048
DOI: 10.1093/hmg/ddu276
PubMed ID: 26601954
Title: Characterization of microfibrillar-associated protein 4 (MFAP4) as a tropoelastin- and fibrillin-binding protein involved in elastic fiber formation.
PubMed ID: 26601954
PubMed ID: 32329225
Title: Placensin is a glucogenic hormone secreted by human placenta.
PubMed ID: 32329225
PubMed ID: 34411563
Title: POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.
PubMed ID: 34411563
PubMed ID: 7493032
Title: Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder, congenital contractural arachnodactyly.
PubMed ID: 7493032
DOI: 10.1038/ng1295-456
PubMed ID: 9714438
Title: Clustering of FBN2 mutations in patients with congenital contractural arachnodactyly indicates an important role of the domains encoded by exons 24 through 34 during human development.
PubMed ID: 9714438
DOI: 10.1002/(sici)1096-8628(19980724)78:4<350::aid-ajmg9>3.3.co;2-#
PubMed ID: 9737771
Title: A single mutation that results in an Asp-to-His substitution and partial exon skipping in a family with congenital contractural arachnodactyly.
PubMed ID: 9737771
PubMed ID: 10797416
Title: Two novel fibrillin-2 mutations in congenital contractural arachnodactyly.
PubMed ID: 10797416
DOI: 10.1002/(sici)1096-8628(20000501)92:1<7::aid-ajmg2>3.3.co;2-#
PubMed ID: 11754102
Title: Ten novel FBN2 mutations in congenital contractural arachnodactyly: delineation of the molecular pathogenesis and clinical phenotype.
PubMed ID: 11754102
DOI: 10.1002/humu.10017
PubMed ID: 19006240
Title: Comprehensive clinical and molecular assessment of 32 probands with congenital contractural arachnodactyly: report of 14 novel mutations and review of the literature.
PubMed ID: 19006240
DOI: 10.1002/humu.20854
PubMed ID: 20799338
Title: Evidence for a recurrent microdeletion at chromosome 16p11.2 associated with congenital anomalies of the kidney and urinary tract (CAKUT) and Hirschsprung disease.
PubMed ID: 20799338
DOI: 10.1002/ajmg.a.33628
PubMed ID: 21248752
Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
PubMed ID: 21248752
DOI: 10.1038/nature09639
PubMed ID: 25834781
Title: A novel FBN2 mutation in a Chinese family with congenital contractural arachnodactyly.
PubMed ID: 25834781
PubMed ID: 27196565
Title: Identification of a Novel Missense FBN2 Mutation in a Chinese Family with Congenital Contractural Arachnodactyly Using Exome Sequencing.
PubMed ID: 27196565
Sequence Information:
- Length: 2912
- Mass: 314775
- Checksum: 0F0D78319E9911E6
- Sequence:
MGRRRRLCLQ LYFLWLGCVV LWAQGTAGQP QPPPPKPPRP QPPPQQVRSA TAGSEGGFLA PEYREEGAAV ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG WKTLPGGNQC IVPICRNSCG DGFCSRPNMC TCSSGQISST CGSKSIQQCS VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC ENGCQNGGRC IGPNRCACVY GFTGPQCERD YRTGPCFTQV NNQMCQGQLT GIVCTKTLCC ATIGRAWGHP CEMCPAQPQP CRRGFIPNIR TGACQDVDEC QAIPGICQGG NCINTVGSFE CRCPAGHKQS ETTQKCEDID ECSIIPGICE TGECSNTVGS YFCVCPRGYV TSTDGSRCID QRTGMCFSGL VNGRCAQELP GRMTKMQCCC EPGRCWGIGT IPEACPVRGS EEYRRLCMDG LPMGGIPGSA GSRPGGTGGN GFAPSGNGNG YGPGGTGFIP IPGGNGFSPG VGGAGVGAGG QGPIITGLTI LNQTIDICKH HANLCLNGRC IPTVSSYRCE CNMGYKQDAN GDCIDVDECT SNPCTNGDCV NTPGSYYCKC HAGFQRTPTK QACIDIDECI QNGVLCKNGR CVNTDGSFQC ICNAGFELTT DGKNCVDHDE CTTTNMCLNG MCINEDGSFK CICKPGFVLA PNGRYCTDVD ECQTPGICMN GHCINSEGSF RCDCPPGLAV GMDGRVCVDT HMRSTCYGGI KKGVCVRPFP GAVTKSECCC ANPDYGFGEP CQPCPAKNSA EFHGLCSSGV GITVDGRDIN ECALDPDICA NGICENLRGS YRCNCNSGYE PDASGRNCID IDECLVNRLL CDNGLCRNTP GSYSCTCPPG YVFRTETETC EDINECESNP CVNGACRNNL GSFNCECSPG SKLSSTGLIC IDSLKGTCWL NIQDSRCEVN INGATLKSEC CATLGAAWGS PCERCELDTA CPRGLARIKG VTCEDVNECE VFPGVCPNGR CVNSKGSFHC ECPEGLTLDG TGRVCLDIRM EQCYLKWDED ECIHPVPGKF RMDACCCAVG AAWGTECEEC PKPGTKEYET LCPRGAGFAN RGDVLTGRPF YKDINECKAF PGMCTYGKCR NTIGSFKCRC NSGFALDMEE RNCTDIDECR ISPDLCGSGI CVNTPGSFEC ECFEGYESGF MMMKNCMDID ECERNPLLCR GGTCVNTEGS FQCDCPLGHE LSPSREDCVD INECSLSDNL CRNGKCVNMI GTYQCSCNPG YQATPDRQGC TDIDECMIMN GGCDTQCTNS EGSYECSCSE GYALMPDGRS CADIDECENN PDICDGGQCT NIPGEYRCLC YDGFMASMDM KTCIDVNECD LNSNICMFGE CENTKGSFIC HCQLGYSVKK GTTGCTDVDE CEIGAHNCDM HASCLNIPGS FKCSCREGWI GNGIKCIDLD ECSNGTHQCS INAQCVNTPG SYRCACSEGF TGDGFTCSDV DECAENINLC ENGQCLNVPG AYRCECEMGF TPASDSRSCQ DIDECSFQNI CVFGTCNNLP GMFHCICDDG YELDRTGGNC TDIDECADPI NCVNGLCVNT PGRYECNCPP DFQLNPTGVG CVDNRVGNCY LKFGPRGDGS LSCNTEIGVG VSRSSCCCSL GKAWGNPCET CPPVNSTEYY TLCPGGEGFR PNPITIILED IDECQELPGL CQGGNCINTF GSFQCECPQG YYLSEDTRIC EDIDECFAHP GVCGPGTCYN TLGNYTCICP PEYMQVNGGH NCMDMRKSFC YRSYNGTTCE NELPFNVTKR MCCCTYNVGK AWNKPCEPCP TPGTADFKTI CGNIPGFTFD IHTGKAVDID ECKEIPGICA NGVCINQIGS FRCECPTGFS YNDLLLVCED IDECSNGDNL CQRNADCINS PGSYRCECAA GFKLSPNGAC VDRNECLEIP NVCSHGLCVD LQGSYQCICH NGFKASQDQT MCMDVDECER HPCGNGTCKN TVGSYNCLCY PGFELTHNND CLDIDECSSF FGQVCRNGRC FNEIGSFKCL CNEGYELTPD GKNCIDTNEC VALPGSCSPG TCQNLEGSFR CICPPGYEVK SENCIDINEC DEDPNICLFG SCTNTPGGFQ CLCPPGFVLS DNGRRCFDTR QSFCFTNFEN GKCSVPKAFN TTKAKCCCSK MPGEGWGDPC ELCPKDDEVA FQDLCPYGHG TVPSLHDTRE DVNECLESPG ICSNGQCINT DGSFRCECPM GYNLDYTGVR CVDTDECSIG NPCGNGTCTN VIGSFECNCN EGFEPGPMMN CEDINECAQN PLLCAFRCMN TFGSYECTCP IGYALREDQK MCKDLDECAE GLHDCESRGM MCKNLIGTFM CICPPGMARR PDGEGCVDEN ECRTKPGICE NGRCVNIIGS YRCECNEGFQ SSSSGTECLD NRQGLCFAEV LQTICQMASS SRNLVTKSEC CCDGGRGWGH QCELCPLPGT AQYKKICPHG PGYTTDGRDI DECKVMPNLC TNGQCINTMG SFRCFCKVGY TTDISGTSCI DLDECSQSPK PCNYICKNTE GSYQCSCPRG YVLQEDGKTC KDLDECQTKQ HNCQFLCVNT LGGFTCKCPP GFTQHHTACI DNNECGSQPS LCGAKGICQN TPGSFSCECQ RGFSLDATGL NCEDVDECDG NHRCQHGCQN ILGGYRCGCP QGYIQHYQWN QCVDENECSN PNACGSASCY NTLGSYKCAC PSGFSFDQFS SACHDVNECS SSKNPCNYGC SNTEGGYLCG CPPGYYRVGQ GHCVSGMGFN KGQYLSLDTE VDEENALSPE ACYECKINGY SKKDSRQKRS IHEPDPTAVE QISLESVDMD SPVNMKFNLS HLGSKEHILE LRPAIQPLNN HIRYVISQGN DDSVFRIHQR NGLSYLHTAK KKLMPGTYTL EITSIPLYKK KELKKLEESN EDDYLLGELG EALRMRLQIQ LY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.