Details for: FCGR3B

Gene ID: 2215

Symbol: FCGR3B

Ensembl ID: ENSG00000162747

Description: Fc gamma receptor IIIb

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7303
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1790
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 643
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1318
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 428
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 394
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.55
    Marker Score: 487
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.52
    Marker Score: 680
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 131.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 325
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.46
    Marker Score: 878
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.35
    Marker Score: 195
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.33
    Marker Score: 651
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 5040
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.3
    Marker Score: 128.5
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.29
    Marker Score: 145
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.29
    Marker Score: 689
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.26
    Marker Score: 477
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 110
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.22
    Marker Score: 142
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.18
    Marker Score: 185
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.18
    Marker Score: 76
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.17
    Marker Score: 255
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.17
    Marker Score: 59
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.16
    Marker Score: 121
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.15
    Marker Score: 373
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 442.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.13
    Marker Score: 98
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.13
    Marker Score: 7063
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 199
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.12
    Marker Score: 160
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 115
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1370
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 130
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.11
    Marker Score: 112.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.11
    Marker Score: 78
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.11
    Marker Score: 459
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.11
    Marker Score: 80
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.1
    Marker Score: 72
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 115
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.1
    Marker Score: 318
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 128
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 158
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.09
    Marker Score: 264
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.09
    Marker Score: 544
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.08
    Marker Score: 215
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.08
    Marker Score: 63
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 18.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.07
    Marker Score: 55
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 464
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.07
    Marker Score: 157
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 107.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 140

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FCGR3B is a heterodimeric protein, consisting of two immunoglobulin heavy chains and two immunoglobulin light chains. * It is expressed on a variety of cell types, including goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, abnormal cells, and immature innate lymphoid cells. * It is a cell surface receptor that is involved in the regulation of immune responses. * It is a member of the immunoglobulin superfamily, which is a large family of cell surface receptors that are involved in the regulation of immune responses. **Pathways and functions:** * FCGR3B is involved in the regulation of innate immune responses. * It is expressed on dendritic cells, macrophages, and neutrophils, which are key immune cells that are involved in the recognition and response to pathogens. * Binding of FCGR3B to its ligand, galectin-9, induces the activation of dendritic cells and macrophages, leading to the initiation of an immune response. * In neutrophils, FCGR3B is expressed on the surface of phagocytes and is involved in the recognition of pathogens and the initiation of inflammation. **Clinical significance:** * Mutations in FCGR3B have been linked to a number of human diseases, including systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease. * In these diseases, FCGR3B is expressed on immune cells and is involved in the regulation of immune responses. * Inhibition of FCGR3B has been shown to be effective in ameliorating disease activity in animal models of these diseases. **Additional information:** * FCGR3B is a relatively new receptor, and its role in immune responses is still being elucidated. * It is a promising target for the development of new therapies for autoimmune diseases.

Genular Protein ID: 3009150842

Symbol: FCG3B_HUMAN

Name: Low affinity immunoglobulin gamma Fc region receptor III-B

UniProtKB Accession Codes:

O75015

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 12 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2526846

Title: Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.

PubMed ID: 2526846

DOI: 10.1084/jem.170.2.481

PubMed ID: 2967436

Title: The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.

PubMed ID: 2967436

DOI: 10.1038/333568a0

PubMed ID: 2521732

Title: Human Fc-gamma-RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.

PubMed ID: 2521732

DOI: 10.1073/pnas.86.3.1013

PubMed ID: 2525780

Title: A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.

PubMed ID: 2525780

DOI: 10.1073/pnas.86.13.5079

PubMed ID: 15245367

Title: Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles.

PubMed ID: 15245367

DOI: 10.1111/j.1399-0039.2004.00259.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 7836402

Title: The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.

PubMed ID: 7836402

DOI: 10.1074/jbc.270.3.1350

PubMed ID: 1825220

Title: Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

PubMed ID: 1825220

PubMed ID: 10917521

Title: The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.

PubMed ID: 10917521

DOI: 10.1038/35018508

PubMed ID: 11021536

Title: Crystal structure of the extracellular domain of a human Fc gamma RIII.

PubMed ID: 11021536

DOI: 10.1016/s1074-7613(00)00038-8

PubMed ID: 9028335

Title: Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb.

PubMed ID: 9028335

Sequence Information:

  • Length: 233
  • Mass: 26243
  • Checksum: 4EC0CDDE2ACF0CAC
  • Sequence:
    • MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA YSPEDNSTQW 
FHNENLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE 
EDPIHLRCHS WKNTALHKVT YLQNGKDRKY FHHNSDFHIP KATLKDSGSY FCRGLVGSKN 
VSSETVNITI TQGLAVSTIS SFSPPGYQVS FCLVMVLLFA VDTGLYFSVK TNI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.