Details for: FCGR3B

Gene ID: 2215

Symbol: FCGR3B

Ensembl ID: ENSG00000162747

Description: Fc gamma receptor IIIb

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4131
    Cell Significance Index: 11.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1036
    Cell Significance Index: 1.3400
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.0674
    Cell Significance Index: 0.4700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0523
    Cell Significance Index: 0.7500
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.0195
    Cell Significance Index: 0.0500
  • Cell Name: mature neutrophil (CL0000096)
    Fold Change: 0.0122
    Cell Significance Index: 0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0011
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0035
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0052
    Cell Significance Index: -1.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0057
    Cell Significance Index: -2.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0069
    Cell Significance Index: -0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0113
    Cell Significance Index: -2.0400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0124
    Cell Significance Index: -2.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0130
    Cell Significance Index: -2.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0156
    Cell Significance Index: -1.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0173
    Cell Significance Index: -2.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0206
    Cell Significance Index: -2.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0222
    Cell Significance Index: -3.0500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0226
    Cell Significance Index: -0.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0352
    Cell Significance Index: -2.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0364
    Cell Significance Index: -2.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0366
    Cell Significance Index: -1.0200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0388
    Cell Significance Index: -0.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0406
    Cell Significance Index: -0.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0409
    Cell Significance Index: -2.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0440
    Cell Significance Index: -1.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0477
    Cell Significance Index: -0.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0481
    Cell Significance Index: -2.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0502
    Cell Significance Index: -2.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0525
    Cell Significance Index: -2.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0526
    Cell Significance Index: -1.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0558
    Cell Significance Index: -2.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0615
    Cell Significance Index: -1.9600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0635
    Cell Significance Index: -0.7100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0662
    Cell Significance Index: -0.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0665
    Cell Significance Index: -1.2300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0696
    Cell Significance Index: -0.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0702
    Cell Significance Index: -1.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0743
    Cell Significance Index: -1.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0745
    Cell Significance Index: -1.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0762
    Cell Significance Index: -1.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0791
    Cell Significance Index: -2.5900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0809
    Cell Significance Index: -1.3100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0819
    Cell Significance Index: -0.8800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0820
    Cell Significance Index: -2.0900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0825
    Cell Significance Index: -0.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0831
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0834
    Cell Significance Index: -2.2700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0836
    Cell Significance Index: -0.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0846
    Cell Significance Index: -2.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0849
    Cell Significance Index: -2.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0861
    Cell Significance Index: -2.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0865
    Cell Significance Index: -2.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0869
    Cell Significance Index: -1.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0907
    Cell Significance Index: -2.4300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0915
    Cell Significance Index: -0.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0962
    Cell Significance Index: -3.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0964
    Cell Significance Index: -2.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0995
    Cell Significance Index: -2.1500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1053
    Cell Significance Index: -0.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1055
    Cell Significance Index: -2.5300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1056
    Cell Significance Index: -0.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1073
    Cell Significance Index: -2.3500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1079
    Cell Significance Index: -1.3400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1101
    Cell Significance Index: -0.9800
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.1102
    Cell Significance Index: -0.8400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1105
    Cell Significance Index: -1.6100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1113
    Cell Significance Index: -1.2600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1116
    Cell Significance Index: -1.5300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1120
    Cell Significance Index: -1.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1123
    Cell Significance Index: -2.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1131
    Cell Significance Index: -2.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1153
    Cell Significance Index: -1.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1185
    Cell Significance Index: -2.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1204
    Cell Significance Index: -2.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1216
    Cell Significance Index: -2.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1332
    Cell Significance Index: -2.6000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1335
    Cell Significance Index: -1.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1357
    Cell Significance Index: -2.3400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1382
    Cell Significance Index: -1.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1421
    Cell Significance Index: -1.5100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1453
    Cell Significance Index: -1.2800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1453
    Cell Significance Index: -1.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1457
    Cell Significance Index: -2.5200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1460
    Cell Significance Index: -1.3200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1508
    Cell Significance Index: -1.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1508
    Cell Significance Index: -2.5400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1513
    Cell Significance Index: -1.8300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1522
    Cell Significance Index: -1.8400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1553
    Cell Significance Index: -2.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1577
    Cell Significance Index: -1.6100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1578
    Cell Significance Index: -2.0600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1589
    Cell Significance Index: -1.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1595
    Cell Significance Index: -2.6700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1633
    Cell Significance Index: -1.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** FCGR3B is a type III transmembrane receptor, consisting of an extracellular domain (Fc region) and an intracellular domain (ITAM). The Fc region contains three immunoglobulin-like domains (Ig-like domains 1-3), which are responsible for binding to the Fc region of IgG antibodies. 2. **Expression:** FCGR3B is expressed on various cell types, including natural killer (NK) cells, macrophages, neutrophils, and epithelial cells, as well as on stem cells and cancer cells. 3. **Function:** FCGR3B plays a key role in the regulation of immune responses, including ADCC, which involves the binding of IgG antibodies to the Fc region of target cells, followed by the activation of immune cells, such as NK cells and macrophages. 4. **Regulation:** FCGR3B is regulated by various signaling pathways, including the PI3K/Akt pathway, which is involved in the activation of immune cells and the regulation of inflammatory processes. **Pathways and Functions:** 1. **Antibody-dependent cellular cytotoxicity (ADCC):** FCGR3B mediates ADCC by binding to the Fc region of IgG antibodies, which are attached to target cells. This binding activates immune cells, such as NK cells and macrophages, leading to the destruction of target cells. 2. **Innate immunity:** FCGR3B plays a key role in the regulation of innate immunity, including the activation of immune cells and the regulation of inflammatory processes. 3. **Cell surface receptor signaling pathway:** FCGR3B is involved in the regulation of cell surface receptor signaling pathways, including the PI3K/Akt pathway. 4. **Extracellular exosome:** FCGR3B is involved in the regulation of extracellular exosomes, which are small vesicles that contain proteins and lipids released by cells. **Clinical Significance:** 1. **Immunotherapies:** FCGR3B is a target for immunotherapies, such as monoclonal antibodies, which are designed to modulate the immune response and treat diseases, such as cancer and autoimmune disorders. 2. **Autoimmune diseases:** FCGR3B is involved in the regulation of autoimmune diseases, such as rheumatoid arthritis and lupus, where the receptor's ability to bind to IgG antibodies leads to the activation of immune cells and the production of autoantibodies. 3. **Cancer:** FCGR3B is expressed on cancer cells and is involved in the regulation of tumor growth and metastasis. 4. **Infectious diseases:** FCGR3B is involved in the regulation of infectious diseases, such as HIV and tuberculosis, where the receptor's ability to bind to IgG antibodies leads to the activation of immune cells and the regulation of inflammatory processes. In conclusion, FCGR3B is a key player in the immune system's effector functions, and its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and infectious diseases. Further research is needed to fully understand the role of FCGR3B in the immune system and its potential as a therapeutic target.

Genular Protein ID: 3009150842

Symbol: FCG3B_HUMAN

Name: Low affinity immunoglobulin gamma Fc region receptor III-B

UniProtKB Accession Codes:

O75015

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 12 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2526846

Title: Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.

PubMed ID: 2526846

DOI: 10.1084/jem.170.2.481

PubMed ID: 2967436

Title: The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.

PubMed ID: 2967436

DOI: 10.1038/333568a0

PubMed ID: 2521732

Title: Human Fc-gamma-RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.

PubMed ID: 2521732

DOI: 10.1073/pnas.86.3.1013

PubMed ID: 2525780

Title: A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.

PubMed ID: 2525780

DOI: 10.1073/pnas.86.13.5079

PubMed ID: 15245367

Title: Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles.

PubMed ID: 15245367

DOI: 10.1111/j.1399-0039.2004.00259.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 7836402

Title: The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.

PubMed ID: 7836402

DOI: 10.1074/jbc.270.3.1350

PubMed ID: 1825220

Title: Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

PubMed ID: 1825220

PubMed ID: 10917521

Title: The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.

PubMed ID: 10917521

DOI: 10.1038/35018508

PubMed ID: 11021536

Title: Crystal structure of the extracellular domain of a human Fc gamma RIII.

PubMed ID: 11021536

DOI: 10.1016/s1074-7613(00)00038-8

PubMed ID: 9028335

Title: Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb.

PubMed ID: 9028335

Sequence Information:

  • Length: 233
  • Mass: 26243
  • Checksum: 4EC0CDDE2ACF0CAC
  • Sequence:
    • MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA YSPEDNSTQW 
FHNENLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE 
EDPIHLRCHS WKNTALHKVT YLQNGKDRKY FHHNSDFHIP KATLKDSGSY FCRGLVGSKN 
VSSETVNITI TQGLAVSTIS SFSPPGYQVS FCLVMVLLFA VDTGLYFSVK TNI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.