Details for: FOXE1

Gene ID: 2304

Symbol: FOXE1

Ensembl ID: ENSG00000178919

Description: forkhead box E1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 3.4271
    Cell Significance Index: 69.7400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.0232
    Cell Significance Index: 45.2300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.8753
    Cell Significance Index: 30.5500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4155
    Cell Significance Index: 3.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3226
    Cell Significance Index: 8.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2019
    Cell Significance Index: 24.8300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1199
    Cell Significance Index: 2.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1107
    Cell Significance Index: 1.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1047
    Cell Significance Index: 1.5000
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0821
    Cell Significance Index: 0.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0430
    Cell Significance Index: 19.0100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0212
    Cell Significance Index: 0.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0154
    Cell Significance Index: 8.4100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0136
    Cell Significance Index: 0.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0077
    Cell Significance Index: 0.2100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0030
    Cell Significance Index: 0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0058
    Cell Significance Index: -2.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0077
    Cell Significance Index: -1.5500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0080
    Cell Significance Index: -0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0088
    Cell Significance Index: -1.5900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0096
    Cell Significance Index: -2.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0098
    Cell Significance Index: -1.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0117
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0121
    Cell Significance Index: -2.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0132
    Cell Significance Index: -1.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0150
    Cell Significance Index: -2.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0151
    Cell Significance Index: -2.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0163
    Cell Significance Index: -1.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0203
    Cell Significance Index: -2.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0224
    Cell Significance Index: -2.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0224
    Cell Significance Index: -2.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0246
    Cell Significance Index: -1.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0252
    Cell Significance Index: -0.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0276
    Cell Significance Index: -0.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0277
    Cell Significance Index: -1.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0302
    Cell Significance Index: -0.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0327
    Cell Significance Index: -1.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0342
    Cell Significance Index: -2.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0391
    Cell Significance Index: -1.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0394
    Cell Significance Index: -0.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0399
    Cell Significance Index: -1.2700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0408
    Cell Significance Index: -0.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0417
    Cell Significance Index: -2.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0426
    Cell Significance Index: -0.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0427
    Cell Significance Index: -1.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0445
    Cell Significance Index: -0.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0501
    Cell Significance Index: -0.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0511
    Cell Significance Index: -2.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0513
    Cell Significance Index: -1.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0523
    Cell Significance Index: -1.0300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0559
    Cell Significance Index: -0.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0560
    Cell Significance Index: -1.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0562
    Cell Significance Index: -0.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0604
    Cell Significance Index: -0.8600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0617
    Cell Significance Index: -0.5100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0627
    Cell Significance Index: -0.8000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0639
    Cell Significance Index: -0.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0644
    Cell Significance Index: -2.8000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0657
    Cell Significance Index: -0.8300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0679
    Cell Significance Index: -0.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0680
    Cell Significance Index: -1.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0683
    Cell Significance Index: -1.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0708
    Cell Significance Index: -2.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0736
    Cell Significance Index: -2.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0746
    Cell Significance Index: -2.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0757
    Cell Significance Index: -1.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0770
    Cell Significance Index: -1.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0784
    Cell Significance Index: -1.8800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0791
    Cell Significance Index: -0.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0804
    Cell Significance Index: -1.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0806
    Cell Significance Index: -2.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0810
    Cell Significance Index: -1.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0839
    Cell Significance Index: -1.4500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0847
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0859
    Cell Significance Index: -1.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0861
    Cell Significance Index: -2.2000
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0880
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0891
    Cell Significance Index: -1.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0898
    Cell Significance Index: -1.8800
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0942
    Cell Significance Index: -0.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0945
    Cell Significance Index: -1.5000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1001
    Cell Significance Index: -1.3500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1006
    Cell Significance Index: -0.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1014
    Cell Significance Index: -2.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1024
    Cell Significance Index: -2.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1024
    Cell Significance Index: -1.4700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1027
    Cell Significance Index: -1.2300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1040
    Cell Significance Index: -1.5100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1045
    Cell Significance Index: -1.3400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1050
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXE1 is a member of the forkhead box (FOX) family of transcription factors, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is a large protein containing six forkhead domains, which interact with chromatin and other transcription factors to modulate gene transcription. FOXE1 is highly expressed in various cell types, including immune cells, epithelial cells, and endothelial cells. **Pathways and Functions:** FOXE1 is involved in multiple signaling pathways, including: 1. **Wnt/β-catenin signaling pathway**: FOXE1 regulates the expression of Wnt/β-catenin target genes, which are involved in cell differentiation, proliferation, and survival. 2. **Notch signaling pathway**: FOXE1 modulates the expression of Notch target genes, which are involved in cell fate determination and differentiation. 3. **RNA polymerase II-mediated transcription**: FOXE1 regulates the expression of genes involved in transcriptional regulation, including those involved in immune responses. FOXE1 functions as a transcriptional regulator, influencing the expression of genes involved in: 1. **Immune cell differentiation**: FOXE1 regulates the expression of genes involved in the differentiation of immune cells, such as T cells and B cells. 2. **Cell migration and adhesion**: FOXE1 influences the expression of genes involved in cell migration and adhesion, which are critical for immune cell trafficking and tissue homing. 3. **Epithelial development and maintenance**: FOXE1 regulates the expression of genes involved in epithelial development and maintenance, including those involved in the development of the thymus and thyroid gland. **Clinical Significance:** Dysregulation of FOXE1 has been implicated in various human diseases, including: 1. **Autoimmune disorders**: FOXE1 has been shown to regulate the expression of genes involved in immune tolerance, and its dysregulation may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: FOXE1 has been implicated in cancer development and progression, particularly in epithelial-derived cancers, such as breast and lung cancer. 3. **Immunodeficiency disorders**: FOXE1 mutations have been associated with immunodeficiency disorders, such as thymic hypoplasia and thyroid dysgenesis. In conclusion, FOXE1 is a critical transcription factor involved in various cellular processes, including immune cell differentiation, migration, and development. Its dysregulation has been implicated in various human diseases, highlighting the importance of FOXE1 in immunological contexts. Further research is needed to fully elucidate the mechanisms by which FOXE1 regulates immune cell function and to explore its therapeutic potential in diseases characterized by immune dysfunction.

Genular Protein ID: 1239993768

Symbol: FOXE1_HUMAN

Name: Forkhead box protein E1

UniProtKB Accession Codes:

O00358 O75765 Q5T109 Q99526

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9052737

Title: The novel human HNF-3/fork head-like 5 gene: chromosomal localization and expression pattern.

PubMed ID: 9052737

DOI: 10.1089/dna.1997.16.165

PubMed ID: 9169137

Title: FKHL15, a new human member of the forkhead gene family located on chromosome 9q22.

PubMed ID: 9169137

DOI: 10.1006/geno.1997.4692

PubMed ID: 10403172

Title: Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2).

PubMed ID: 10403172

DOI: 10.1016/s0300-9084(99)80092-3

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 9697705

Title: Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia.

PubMed ID: 9697705

DOI: 10.1038/1294

PubMed ID: 21177256

Title: MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1.

PubMed ID: 21177256

DOI: 10.1093/hmg/ddq547

PubMed ID: 25381600

Title: Identification of a novel germline FOXE1 variant in patients with familial non-medullary thyroid carcinoma (FNMTC).

PubMed ID: 25381600

DOI: 10.1007/s12020-014-0470-0

PubMed ID: 12165566

Title: A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate.

PubMed ID: 12165566

DOI: 10.1093/hmg/11.17.2051

PubMed ID: 16882747

Title: A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis.

PubMed ID: 16882747

DOI: 10.1210/jc.2006-0405

PubMed ID: 20094846

Title: Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis.

PubMed ID: 20094846

DOI: 10.1007/s10528-009-9306-7

PubMed ID: 20484477

Title: Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism.

PubMed ID: 20484477

DOI: 10.1210/jc.2010-0275

PubMed ID: 24219130

Title: A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression.

PubMed ID: 24219130

DOI: 10.1089/thy.2013.0417

Sequence Information:

  • Length: 373
  • Mass: 38076
  • Checksum: D201EAF05572FCF0
  • Sequence:
    • MTAESGPPPP QPEVLATVKE ERGETAAGAG VPGEATGRGA GGRRRKRPLQ RGKPPYSYIA 
LIAMAIAHAP ERRLTLGGIY KFITERFPFY RDNPKKWQNS IRHNLTLNDC FLKIPREAGR 
PGKGNYWALD PNAEDMFESG SFLRRRKRFK RSDLSTYPAY MHDAAAAAAA AAAAAAAAAI 
FPGAVPAARP PYPGAVYAGY APPSLAAPPP VYYPAASPGP CRVFGLVPER PLSPELGPAP 
SGPGGSCAFA SAGAPATTTG YQPAGCTGAR PANPSAYAAA YAGPDGAYPQ GAGSAIFAAA 
GRLAGPASPP AGGSSGGVET TVDFYGRTSP GQFGALGACY NPGGQLGGAS AGAYHARHAA 
AYPGGIDRFV SAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.