Details for: FOXE1

Gene ID: 2304

Symbol: FOXE1

Ensembl ID: ENSG00000178919

Description: forkhead box E1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 4.27
    Marker Score: 6138
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3177
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.37
    Marker Score: 4319
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.24
    Marker Score: 1609
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7387
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.08
    Marker Score: 2043
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.93
    Marker Score: 708
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.91
    Marker Score: 1021.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1821
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11607
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 473
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.69
    Marker Score: 666
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1104
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 408
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.67
    Marker Score: 391
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 512
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.63
    Marker Score: 3777
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.61
    Marker Score: 508
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.54
    Marker Score: 421
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 222
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 480
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.46
    Marker Score: 219
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.43
    Marker Score: 239
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 377
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 231
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 234
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.39
    Marker Score: 5293
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.34
    Marker Score: 438
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.32
    Marker Score: 401
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 130
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.28
    Marker Score: 193
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.27
    Marker Score: 283
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.25
    Marker Score: 706
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 224
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.22
    Marker Score: 1642
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.22
    Marker Score: 145
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.21
    Marker Score: 218
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 152
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.14
    Marker Score: 1059
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.14
    Marker Score: 222
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 273
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.12
    Marker Score: 1034
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.12
    Marker Score: 207
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 182
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.1
    Marker Score: 20
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.1
    Marker Score: 141
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 63.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.08
    Marker Score: 154
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 90
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 218.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 25

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Other Information

**Key characteristics:** - FOXE1 is a forkhead box protein, a family of transcription factors that play a crucial role in regulating gene expression. - It is a key regulator of cell differentiation and migration, and its expression is often associated with the development of complex tissues. - FOXE1 directly binds to DNA sequences known as Rna polymerase ii-specific DNA binding elements (RnaPII-SREs) in the promoters of target genes. - It acts as a repressor, inhibiting the expression of its target genes by blocking the binding of transcription factors that promote their transcription. **Pathways and functions:** - FOXE1 is involved in various cellular processes, including embryonic development, tissue differentiation, and immune responses. - In the early stages of development, FOXE1 is expressed in the neural tube and is essential for the survival and differentiation of neural tube cells. - In epithelial cells, FOXE1 is required for the proper differentiation of respiratory, vascular, and cardiac epithelium. - In immune cells, FOXE1 promotes the development and survival of dendritic cells, which are critical for immune surveillance. - FOXE1 also plays a role in the development and maintenance of the thyroid gland. **Clinical significance:** - Mutations in the FOXE1 gene have been linked to several human diseases, including lung cancer, heart disease, and autoimmune disorders. - Studies of FOXE1 have also shown that it is a potential therapeutic target for cancer and other diseases. - Inhibition of FOXE1 signaling has been shown to suppress tumor growth and promote the development of anti-tumor immune responses. **Conclusion:** The FOXE1 gene is a key regulator of cell differentiation, migration, and immune responses. Its expression and activity are tightly controlled by various factors, including growth factors, cytokines, and other transcription factors. Understanding the role of FOXE1 in disease and development has important implications for the development of novel therapeutic strategies for various human diseases.

Genular Protein ID: 1239993768

Symbol: FOXE1_HUMAN

Name: Forkhead box protein E1

UniProtKB Accession Codes:

O00358 O75765 Q5T109 Q99526

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9052737

Title: The novel human HNF-3/fork head-like 5 gene: chromosomal localization and expression pattern.

PubMed ID: 9052737

DOI: 10.1089/dna.1997.16.165

PubMed ID: 9169137

Title: FKHL15, a new human member of the forkhead gene family located on chromosome 9q22.

PubMed ID: 9169137

DOI: 10.1006/geno.1997.4692

PubMed ID: 10403172

Title: Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2).

PubMed ID: 10403172

DOI: 10.1016/s0300-9084(99)80092-3

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 9697705

Title: Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia.

PubMed ID: 9697705

DOI: 10.1038/1294

PubMed ID: 21177256

Title: MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1.

PubMed ID: 21177256

DOI: 10.1093/hmg/ddq547

PubMed ID: 25381600

Title: Identification of a novel germline FOXE1 variant in patients with familial non-medullary thyroid carcinoma (FNMTC).

PubMed ID: 25381600

DOI: 10.1007/s12020-014-0470-0

PubMed ID: 12165566

Title: A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate.

PubMed ID: 12165566

DOI: 10.1093/hmg/11.17.2051

PubMed ID: 16882747

Title: A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis.

PubMed ID: 16882747

DOI: 10.1210/jc.2006-0405

PubMed ID: 20094846

Title: Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis.

PubMed ID: 20094846

DOI: 10.1007/s10528-009-9306-7

PubMed ID: 20484477

Title: Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism.

PubMed ID: 20484477

DOI: 10.1210/jc.2010-0275

PubMed ID: 24219130

Title: A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression.

PubMed ID: 24219130

DOI: 10.1089/thy.2013.0417

Sequence Information:

  • Length: 373
  • Mass: 38076
  • Checksum: D201EAF05572FCF0
  • Sequence:
    • MTAESGPPPP QPEVLATVKE ERGETAAGAG VPGEATGRGA GGRRRKRPLQ RGKPPYSYIA 
LIAMAIAHAP ERRLTLGGIY KFITERFPFY RDNPKKWQNS IRHNLTLNDC FLKIPREAGR 
PGKGNYWALD PNAEDMFESG SFLRRRKRFK RSDLSTYPAY MHDAAAAAAA AAAAAAAAAI 
FPGAVPAARP PYPGAVYAGY APPSLAAPPP VYYPAASPGP CRVFGLVPER PLSPELGPAP 
SGPGGSCAFA SAGAPATTTG YQPAGCTGAR PANPSAYAAA YAGPDGAYPQ GAGSAIFAAA 
GRLAGPASPP AGGSSGGVET TVDFYGRTSP GQFGALGACY NPGGQLGGAS AGAYHARHAA 
AYPGGIDRFV SAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.