Details for: POTEH

Gene ID: 23784

Symbol: POTEH

Ensembl ID: ENSG00000198062

Description: POTE ankyrin domain family member H

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53,064
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,179
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2,213
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7,315
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,448
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,194
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 532
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.56
    Marker Score: 326
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 225
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 203
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 185
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.2
    Marker Score: 220
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.17
    Marker Score: 299
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.15
    Marker Score: 281
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.13
    Marker Score: 267
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 186
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.07
    Marker Score: 1,067
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 119
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.04
    Marker Score: 253
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 81
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 53
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.02
    Marker Score: 81
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 36
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 464
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.01
    Marker Score: 90
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 56
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.01
    Marker Score: 117
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.01
    Marker Score: 212
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.01
    Marker Score: 52
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.01
    Marker Score: 74
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.01
    Marker Score: 202

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ankyrin Domain**: The POTEH gene contains an ankyrin domain, a conserved structural motif found in various proteins, including signaling molecules and transcription factors. This domain is thought to play a crucial role in protein-protein interactions, influencing the gene's overall function. 2. **Expression Patterns**: The POTEH gene exhibits a broad expression profile, with significant expression in progenitor cells, endothelial cells, plasma cells, goblet cells, and other cell types. This suggests a diverse range of cellular processes, including cell signaling, differentiation, and survival. 3. **Cell Type-Specific Expression**: The gene's expression is highly cell-type specific, with some cell types exhibiting high expression levels, while others show minimal or no expression. This cell-type specificity may influence the gene's function and regulatory mechanisms. **Pathways and Functions** 1. **Cell Signaling**: The POTEH gene is likely involved in cell signaling pathways, influencing cellular processes such as proliferation, differentiation, and survival. The ankyrin domain may facilitate protein-protein interactions, modulating signaling cascades. 2. **Transcriptional Regulation**: The gene may also play a role in transcriptional regulation, influencing the expression of target genes involved in various cellular processes. The ankyrin domain may interact with transcription factors or chromatin-modifying enzymes, modulating gene expression. 3. **Cellular Differentiation**: POTEH may be involved in cellular differentiation, guiding the development and maturation of various cell types. The gene's expression patterns and ankyrin domain suggest a role in regulating cellular differentiation pathways. **Clinical Significance** 1. **Immunological Disorders**: The POTEH gene's expression in plasma cells and other immune cells suggests a potential role in immunological disorders, such as autoimmune diseases or immunodeficiency syndromes. Further study is needed to determine the gene's involvement in these conditions. 2. **Cancer Research**: The gene's expression in various epithelial cells and stem cells implies a potential role in cancer development and progression. POTEH may be involved in regulating cellular proliferation, differentiation, and survival in cancer cells. 3. **Neurological Disorders**: The gene's expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells suggests a potential role in neurological disorders, such as neurodevelopmental disorders or neurodegenerative diseases. Further study is needed to determine the gene's involvement in these conditions. In conclusion, the POTEH gene is a complex and multifaceted gene with a broad expression profile and potential roles in cell signaling, transcriptional regulation, and cellular differentiation. Further research is needed to fully elucidate the gene's functions and clinical significance in the realm of immunology.

Genular Protein ID: 182351894

Symbol: POTEH_HUMAN

Name: POTE ankyrin domain family member H

UniProtKB Accession Codes:

Q6S545 A2CEK4 A6NCI1 A9Z1W0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15276201

Title: Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

PubMed ID: 15276201

DOI: 10.1016/j.gene.2004.05.009

Sequence Information:

  • Length: 545
  • Mass: 60965
  • Checksum: 35F2B1C6D670B181
  • Sequence:
    • MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFAWCRGSGK SNVGTSGDHD DSAMKTLRSK 
MGKWCCHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGTS 
GDHDDSAMKT LRSKMGKWCC HCFPCCRGSG KNKVGPWGDY DDSAFMEPRY HVRREDLDKL 
HRAAWWGKVP RKDLIVMLKD TDMNKKDKQK RTALHLASAN GNSEVVKLLL DRRCQLNILD 
NKKRTALTKA VQCQEDECAL MLLEHGTDPN IPDEYGNTAL HYAIYNEDKL MAKALLLYGA 
DIESKNKHGL TPLLLGVHEQ KQQVVKFLIK KKANLNALDR YGRTALILAV CCGSASIVSL 
LLEQNIDVSS QDLSGQTARE YAVSSRHNVI CQLLSDYKEK QILKVSSENS NPEQDLKLTS 
EEESQRLKGS ENSQPEEMSQ EPEINKGGDR KVEEEMKKHG STHMGFPENL TNGATADNGD 
DGLIPPRKSR TPESQQFPDT ENEQYHSDEQ NDTQKQLSEE QNTGILQDEI LIHEEKQIEV 
AENEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.