Details for: POTEH

Gene ID: 23784

Symbol: POTEH

Ensembl ID: ENSG00000198062

Description: POTE ankyrin domain family member H

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.9883
    Cell Significance Index: 14.4100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.7536
    Cell Significance Index: 9.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1973
    Cell Significance Index: 4.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1622
    Cell Significance Index: 2.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0869
    Cell Significance Index: 0.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0741
    Cell Significance Index: 1.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0609
    Cell Significance Index: 1.5200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0569
    Cell Significance Index: 0.6000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0514
    Cell Significance Index: 0.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0288
    Cell Significance Index: 0.6300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0244
    Cell Significance Index: 0.2200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0118
    Cell Significance Index: 0.2400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0097
    Cell Significance Index: 0.1100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0011
    Cell Significance Index: 0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0010
    Cell Significance Index: 0.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0008
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0016
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0020
    Cell Significance Index: -0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0023
    Cell Significance Index: -0.3100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0026
    Cell Significance Index: -0.5400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0031
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0037
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0038
    Cell Significance Index: -0.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0043
    Cell Significance Index: -0.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0048
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0051
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0055
    Cell Significance Index: -0.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0058
    Cell Significance Index: -0.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0066
    Cell Significance Index: -0.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0072
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0073
    Cell Significance Index: -0.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0074
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0078
    Cell Significance Index: -0.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0083
    Cell Significance Index: -0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0085
    Cell Significance Index: -0.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0089
    Cell Significance Index: -0.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0090
    Cell Significance Index: -0.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0104
    Cell Significance Index: -0.3000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0108
    Cell Significance Index: -0.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0109
    Cell Significance Index: -0.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0111
    Cell Significance Index: -0.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0112
    Cell Significance Index: -0.2200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0120
    Cell Significance Index: -0.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0123
    Cell Significance Index: -0.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0123
    Cell Significance Index: -0.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0134
    Cell Significance Index: -0.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0135
    Cell Significance Index: -0.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0139
    Cell Significance Index: -0.2400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0151
    Cell Significance Index: -0.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0153
    Cell Significance Index: -0.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0154
    Cell Significance Index: -0.3700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0155
    Cell Significance Index: -0.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0159
    Cell Significance Index: -0.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0160
    Cell Significance Index: -0.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0165
    Cell Significance Index: -0.4400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0171
    Cell Significance Index: -0.2000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0171
    Cell Significance Index: -0.2900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0171
    Cell Significance Index: -0.2200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0177
    Cell Significance Index: -0.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0190
    Cell Significance Index: -0.2800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0190
    Cell Significance Index: -0.2300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0194
    Cell Significance Index: -0.2800
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0197
    Cell Significance Index: -0.2100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0198
    Cell Significance Index: -0.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0201
    Cell Significance Index: -0.2200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0202
    Cell Significance Index: -0.2400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0205
    Cell Significance Index: -0.3300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0207
    Cell Significance Index: -0.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0209
    Cell Significance Index: -0.3500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0221
    Cell Significance Index: -0.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0227
    Cell Significance Index: -0.3100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0228
    Cell Significance Index: -0.3100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0228
    Cell Significance Index: -0.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0230
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ankyrin Domain**: The POTEH gene contains an ankyrin domain, a conserved structural motif found in various proteins, including signaling molecules and transcription factors. This domain is thought to play a crucial role in protein-protein interactions, influencing the gene's overall function. 2. **Expression Patterns**: The POTEH gene exhibits a broad expression profile, with significant expression in progenitor cells, endothelial cells, plasma cells, goblet cells, and other cell types. This suggests a diverse range of cellular processes, including cell signaling, differentiation, and survival. 3. **Cell Type-Specific Expression**: The gene's expression is highly cell-type specific, with some cell types exhibiting high expression levels, while others show minimal or no expression. This cell-type specificity may influence the gene's function and regulatory mechanisms. **Pathways and Functions** 1. **Cell Signaling**: The POTEH gene is likely involved in cell signaling pathways, influencing cellular processes such as proliferation, differentiation, and survival. The ankyrin domain may facilitate protein-protein interactions, modulating signaling cascades. 2. **Transcriptional Regulation**: The gene may also play a role in transcriptional regulation, influencing the expression of target genes involved in various cellular processes. The ankyrin domain may interact with transcription factors or chromatin-modifying enzymes, modulating gene expression. 3. **Cellular Differentiation**: POTEH may be involved in cellular differentiation, guiding the development and maturation of various cell types. The gene's expression patterns and ankyrin domain suggest a role in regulating cellular differentiation pathways. **Clinical Significance** 1. **Immunological Disorders**: The POTEH gene's expression in plasma cells and other immune cells suggests a potential role in immunological disorders, such as autoimmune diseases or immunodeficiency syndromes. Further study is needed to determine the gene's involvement in these conditions. 2. **Cancer Research**: The gene's expression in various epithelial cells and stem cells implies a potential role in cancer development and progression. POTEH may be involved in regulating cellular proliferation, differentiation, and survival in cancer cells. 3. **Neurological Disorders**: The gene's expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells suggests a potential role in neurological disorders, such as neurodevelopmental disorders or neurodegenerative diseases. Further study is needed to determine the gene's involvement in these conditions. In conclusion, the POTEH gene is a complex and multifaceted gene with a broad expression profile and potential roles in cell signaling, transcriptional regulation, and cellular differentiation. Further research is needed to fully elucidate the gene's functions and clinical significance in the realm of immunology.

Genular Protein ID: 182351894

Symbol: POTEH_HUMAN

Name: POTE ankyrin domain family member H

UniProtKB Accession Codes:

Q6S545 A2CEK4 A6NCI1 A9Z1W0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15276201

Title: Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

PubMed ID: 15276201

DOI: 10.1016/j.gene.2004.05.009

Sequence Information:

  • Length: 545
  • Mass: 60965
  • Checksum: 35F2B1C6D670B181
  • Sequence:
    • MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFAWCRGSGK SNVGTSGDHD DSAMKTLRSK 
MGKWCCHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGTS 
GDHDDSAMKT LRSKMGKWCC HCFPCCRGSG KNKVGPWGDY DDSAFMEPRY HVRREDLDKL 
HRAAWWGKVP RKDLIVMLKD TDMNKKDKQK RTALHLASAN GNSEVVKLLL DRRCQLNILD 
NKKRTALTKA VQCQEDECAL MLLEHGTDPN IPDEYGNTAL HYAIYNEDKL MAKALLLYGA 
DIESKNKHGL TPLLLGVHEQ KQQVVKFLIK KKANLNALDR YGRTALILAV CCGSASIVSL 
LLEQNIDVSS QDLSGQTARE YAVSSRHNVI CQLLSDYKEK QILKVSSENS NPEQDLKLTS 
EEESQRLKGS ENSQPEEMSQ EPEINKGGDR KVEEEMKKHG STHMGFPENL TNGATADNGD 
DGLIPPRKSR TPESQQFPDT ENEQYHSDEQ NDTQKQLSEE QNTGILQDEI LIHEEKQIEV 
AENEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.