Details for: FSHB

Gene ID: 2488

Symbol: FSHB

Ensembl ID: ENSG00000131808

Description: follicle stimulating hormone subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.7973
    Cell Significance Index: 29.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.5855
    Cell Significance Index: 40.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9664
    Cell Significance Index: 16.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6523
    Cell Significance Index: 8.4400
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.6512
    Cell Significance Index: 8.5700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1939
    Cell Significance Index: 2.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0419
    Cell Significance Index: 0.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0356
    Cell Significance Index: 0.5100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0343
    Cell Significance Index: 0.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0324
    Cell Significance Index: 0.4700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0280
    Cell Significance Index: 0.2900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0020
    Cell Significance Index: 0.0800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0003
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0013
    Cell Significance Index: -0.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0015
    Cell Significance Index: -0.5500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0038
    Cell Significance Index: -0.1200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0080
    Cell Significance Index: -0.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0101
    Cell Significance Index: -0.6800
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0118
    Cell Significance Index: -0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0119
    Cell Significance Index: -0.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0133
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0134
    Cell Significance Index: -0.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0136
    Cell Significance Index: -0.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0149
    Cell Significance Index: -0.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0161
    Cell Significance Index: -0.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0163
    Cell Significance Index: -0.5700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0167
    Cell Significance Index: -0.2000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0168
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0177
    Cell Significance Index: -0.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0181
    Cell Significance Index: -0.2200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0193
    Cell Significance Index: -0.2000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0194
    Cell Significance Index: -0.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0195
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0231
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0233
    Cell Significance Index: -0.2800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0242
    Cell Significance Index: -0.2400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0248
    Cell Significance Index: -0.2700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0249
    Cell Significance Index: -0.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0251
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0255
    Cell Significance Index: -0.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0261
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0264
    Cell Significance Index: -0.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0267
    Cell Significance Index: -0.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0269
    Cell Significance Index: -0.5300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0269
    Cell Significance Index: -0.6700
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0278
    Cell Significance Index: -0.2800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0282
    Cell Significance Index: -0.5600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0295
    Cell Significance Index: -0.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0296
    Cell Significance Index: -0.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0297
    Cell Significance Index: -0.6300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0297
    Cell Significance Index: -0.4000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0312
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0329
    Cell Significance Index: -0.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0332
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0332
    Cell Significance Index: -0.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0339
    Cell Significance Index: -0.6700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0347
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0349
    Cell Significance Index: -0.3000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0350
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0363
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0374
    Cell Significance Index: -0.3700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0375
    Cell Significance Index: -0.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0384
    Cell Significance Index: -0.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0396
    Cell Significance Index: -0.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0396
    Cell Significance Index: -0.4700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0405
    Cell Significance Index: -0.4500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0405
    Cell Significance Index: -0.5400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0411
    Cell Significance Index: -0.5000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0416
    Cell Significance Index: -0.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0421
    Cell Significance Index: -0.5400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0455
    Cell Significance Index: -0.6300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0485
    Cell Significance Index: -0.5700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0485
    Cell Significance Index: -0.6100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0493
    Cell Significance Index: -0.5900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0495
    Cell Significance Index: -0.6600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0499
    Cell Significance Index: -0.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0505
    Cell Significance Index: -0.5500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0505
    Cell Significance Index: -0.5500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0506
    Cell Significance Index: -0.6600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0508
    Cell Significance Index: -0.6500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0522
    Cell Significance Index: -0.3400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0535
    Cell Significance Index: -0.6700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0542
    Cell Significance Index: -0.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0548
    Cell Significance Index: -0.6800
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.0549
    Cell Significance Index: -0.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** FSHB is a beta subunit of the FSH hormone, consisting of 144 amino acids. 2. **Expression:** FSHB is expressed in various cell types, including erythrocytes, pericytes, goblet cells, megakaryocytes, cardiac endothelial cells, absorptive cells, intestinal crypt stem cells of colon, cardiac muscle myoblasts, and transit amplifying cells. 3. **Function:** FSHB interacts with the FSH receptor to activate signaling pathways that regulate FSH-dependent processes, such as female gamete generation, female pregnancy, and spermatogenesis. **Pathways and Functions:** 1. **G Protein-Coupled Receptor Signaling Pathway:** FSHB binds to the FSH receptor, triggering a G protein-coupled receptor signaling cascade that activates downstream signaling pathways. 2. **Positive Regulation of Gene Expression:** FSHB stimulates the expression of various genes involved in FSH-dependent processes, including those involved in spermatogenesis and female gamete generation. 3. **Regulation of Osteoclast Differentiation:** FSHB has been shown to regulate the differentiation of osteoclasts, which play a crucial role in bone resorption. 4. **Sertoli Cell Proliferation:** FSHB stimulates the proliferation of Sertoli cells, which are essential for spermatogenesis. **Clinical Significance:** 1. **Reproductive Disorders:** Mutations in the FSHB gene have been associated with reproductive disorders, including infertility and premature ovarian failure. 2. **Osteoporosis:** Alterations in FSHB expression have been linked to osteoporosis, a condition characterized by decreased bone density and increased risk of fractures. 3. **Cancer:** FSHB has been implicated in the development and progression of various cancers, including ovarian, breast, and prostate cancers. 4. **Therapeutic Applications:** FSHB has been used as a therapeutic target for the treatment of reproductive disorders and osteoporosis. In conclusion, the FSHB gene plays a critical role in regulating various biological processes, including reproductive and endocrine functions. Further research on the FSHB gene is necessary to fully understand its mechanisms of action and to explore its therapeutic potential in the treatment of various diseases.

Genular Protein ID: 823483159

Symbol: FSHB_HUMAN

Name: Follitropin subunit beta

UniProtKB Accession Codes:

P01225 A2TF08 A5JVV3 Q14D61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 15 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2885163

Title: DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11.

PubMed ID: 2885163

DOI: 10.1089/dna.1987.6.205

PubMed ID: 2494176

Title: Expression of biologically active human follitropin in Chinese hamster ovary cells.

PubMed ID: 2494176

DOI: 10.1016/s0021-9258(18)83656-0

PubMed ID: 3139991

Title: Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids.

PubMed ID: 3139991

DOI: 10.1210/mend-2-9-806

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3151250

Title: A reevaluation of the amino acid sequence of human follitropin beta-subunit.

PubMed ID: 3151250

DOI: 10.1007/bf01024882

PubMed ID: 1249074

Title: Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands.

PubMed ID: 1249074

DOI: 10.1016/s0021-9258(17)33791-2

PubMed ID: 4835136

Title: Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb).

PubMed ID: 4835136

DOI: 10.1210/jcem-39-1-203

PubMed ID: 407105

Title: Isolated follicle-stimulating hormone deficiency in man.

PubMed ID: 407105

DOI: 10.1016/s0015-0282(16)42734-2

PubMed ID: 6774759

Title: Studies on the disulfide bonds in human pituitary follicle-stimulating hormone.

PubMed ID: 6774759

DOI: 10.1016/0005-2795(80)90084-7

PubMed ID: 11501762

Title: Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain.

PubMed ID: 11501762

DOI: 10.1515/bc.2001.120

PubMed ID: 11222739

Title: Three-dimensional structure of human follicle-stimulating hormone.

PubMed ID: 11222739

DOI: 10.1210/mend.15.3.0603

PubMed ID: 15662415

Title: Structure of human follicle-stimulating hormone in complex with its receptor.

PubMed ID: 15662415

DOI: 10.1038/nature03206

PubMed ID: 24692546

Title: Evidence for follicle-stimulating hormone receptor as a functional trimer.

PubMed ID: 24692546

DOI: 10.1074/jbc.m114.549592

PubMed ID: 8220432

Title: Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.

PubMed ID: 8220432

DOI: 10.1038/ng0993-83

PubMed ID: 9271483

Title: Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene.

PubMed ID: 9271483

DOI: 10.1056/nejm199708283370905

PubMed ID: 9280841

Title: Isolated deficiency of follicle-stimulating hormone re-revisited.

PubMed ID: 9280841

DOI: 10.1056/nejm199708283370918

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 129
  • Mass: 14700
  • Checksum: 9D2AF00DD76B8E2B
  • Sequence:
    • MKTLQFFFLF CCWKAICCNS CELTNITIAI EKEECRFCIS INTTWCAGYC YTRDLVYKDP 
ARPKIQKTCT FKELVYETVR VPGCAHHADS LYTYPVATQC HCGKCDSDST DCTVRGLGPS 
YCSFGEMKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.