Details for: FSHB

Gene ID: 2488

Symbol: FSHB

Ensembl ID: ENSG00000131808

Description: follicle stimulating hormone subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.66
    Marker Score: 921
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.6
    Marker Score: 935
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.13
    Marker Score: 640
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2098
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14724
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1520
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1735
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 430.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.69
    Marker Score: 955
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 543
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.64
    Marker Score: 339
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6
    Marker Score: 252
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3084
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 195
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 194
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 187
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.26
    Marker Score: 85
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 64.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 146
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.11
    Marker Score: 69
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 183.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 59.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 313
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 210
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 64
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.05
    Marker Score: 90
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 118
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.04
    Marker Score: 68
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.04
    Marker Score: 62
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 117
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 60
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.03
    Marker Score: 69
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 69
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.03
    Marker Score: 107
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 77
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.02
    Marker Score: 68
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.02
    Marker Score: 69
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 36.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 111
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.01
    Marker Score: 60
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.01
    Marker Score: 68
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.01
    Marker Score: 53
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.01
    Marker Score: 57
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 49
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 69
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 58
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0
    Marker Score: 36
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 58
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 176
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0
    Marker Score: 40
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 62
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 50
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 40

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Other Information

**Key characteristics:** - Type: Protein - Ensembl ID: ENSG00000131808 - Protein length: 145 amino acids - Subcellular location: Cytoplasm - Cellular source: Pituitary gland **Pathways and functions:** FSHB is a member of the FSH receptor family of glycoproteins. It is primarily a ligand for the G protein-coupled receptor (GPCR) follicle-stimulating hormone receptor (FSHR). When FSHB binds to FSHR, it activates the receptor and initiates a cascade of intracellular events. **Clinical significance:** Mutations in the FSHB gene have been linked to several female reproductive disorders, including polycystic ovary syndrome (PCOS) and infertility. In PCOS, elevated levels of FSHB have been shown to disrupt the normal functioning of the ovaries and lead to the development of cysts. FSHB is also a key regulator of fertility in both humans and animals. In infertile women, low levels of FSHB have been linked to ovulation problems. **Conclusion:** FSHB is a critical regulator of female fertility. Its levels are closely correlated with the menstrual cycle, and mutations in the gene have been linked to several female reproductive disorders.

Genular Protein ID: 823483159

Symbol: FSHB_HUMAN

Name: Follitropin subunit beta

UniProtKB Accession Codes:

P01225 A2TF08 A5JVV3 Q14D61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 15 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2885163

Title: DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11.

PubMed ID: 2885163

DOI: 10.1089/dna.1987.6.205

PubMed ID: 2494176

Title: Expression of biologically active human follitropin in Chinese hamster ovary cells.

PubMed ID: 2494176

DOI: 10.1016/s0021-9258(18)83656-0

PubMed ID: 3139991

Title: Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids.

PubMed ID: 3139991

DOI: 10.1210/mend-2-9-806

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3151250

Title: A reevaluation of the amino acid sequence of human follitropin beta-subunit.

PubMed ID: 3151250

DOI: 10.1007/bf01024882

PubMed ID: 1249074

Title: Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands.

PubMed ID: 1249074

DOI: 10.1016/s0021-9258(17)33791-2

PubMed ID: 4835136

Title: Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb).

PubMed ID: 4835136

DOI: 10.1210/jcem-39-1-203

PubMed ID: 407105

Title: Isolated follicle-stimulating hormone deficiency in man.

PubMed ID: 407105

DOI: 10.1016/s0015-0282(16)42734-2

PubMed ID: 6774759

Title: Studies on the disulfide bonds in human pituitary follicle-stimulating hormone.

PubMed ID: 6774759

DOI: 10.1016/0005-2795(80)90084-7

PubMed ID: 11501762

Title: Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain.

PubMed ID: 11501762

DOI: 10.1515/bc.2001.120

PubMed ID: 11222739

Title: Three-dimensional structure of human follicle-stimulating hormone.

PubMed ID: 11222739

DOI: 10.1210/mend.15.3.0603

PubMed ID: 15662415

Title: Structure of human follicle-stimulating hormone in complex with its receptor.

PubMed ID: 15662415

DOI: 10.1038/nature03206

PubMed ID: 24692546

Title: Evidence for follicle-stimulating hormone receptor as a functional trimer.

PubMed ID: 24692546

DOI: 10.1074/jbc.m114.549592

PubMed ID: 8220432

Title: Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.

PubMed ID: 8220432

DOI: 10.1038/ng0993-83

PubMed ID: 9271483

Title: Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene.

PubMed ID: 9271483

DOI: 10.1056/nejm199708283370905

PubMed ID: 9280841

Title: Isolated deficiency of follicle-stimulating hormone re-revisited.

PubMed ID: 9280841

DOI: 10.1056/nejm199708283370918

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 129
  • Mass: 14700
  • Checksum: 9D2AF00DD76B8E2B
  • Sequence:
    • MKTLQFFFLF CCWKAICCNS CELTNITIAI EKEECRFCIS INTTWCAGYC YTRDLVYKDP 
ARPKIQKTCT FKELVYETVR VPGCAHHADS LYTYPVATQC HCGKCDSDST DCTVRGLGPS 
YCSFGEMKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.