Details for: EIF4E1B

Gene ID: 253314

Symbol: EIF4E1B

Ensembl ID: ENSG00000175766

Description: eukaryotic translation initiation factor 4E family member 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9120
    Cell Significance Index: 22.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8823
    Cell Significance Index: 55.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6639
    Cell Significance Index: 8.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5989
    Cell Significance Index: 120.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2399
    Cell Significance Index: 69.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2240
    Cell Significance Index: 2.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1833
    Cell Significance Index: 65.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0509
    Cell Significance Index: 2.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0080
    Cell Significance Index: 0.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0065
    Cell Significance Index: 0.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0097
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0102
    Cell Significance Index: -4.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0132
    Cell Significance Index: -7.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0146
    Cell Significance Index: -0.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0172
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0350
    Cell Significance Index: -7.3800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0363
    Cell Significance Index: -0.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0396
    Cell Significance Index: -7.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0420
    Cell Significance Index: -7.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0426
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0430
    Cell Significance Index: -7.3400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0467
    Cell Significance Index: -0.5900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0468
    Cell Significance Index: -0.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0528
    Cell Significance Index: -1.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0531
    Cell Significance Index: -7.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0563
    Cell Significance Index: -7.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0570
    Cell Significance Index: -6.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0629
    Cell Significance Index: -7.7300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0662
    Cell Significance Index: -0.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0663
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0672
    Cell Significance Index: -7.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0684
    Cell Significance Index: -2.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0716
    Cell Significance Index: -4.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0757
    Cell Significance Index: -7.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0868
    Cell Significance Index: -3.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0972
    Cell Significance Index: -2.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0977
    Cell Significance Index: -5.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0999
    Cell Significance Index: -7.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1032
    Cell Significance Index: -2.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1043
    Cell Significance Index: -3.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1195
    Cell Significance Index: -2.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1212
    Cell Significance Index: -2.5300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1255
    Cell Significance Index: -0.8700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1303
    Cell Significance Index: -1.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1325
    Cell Significance Index: -5.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1363
    Cell Significance Index: -3.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1394
    Cell Significance Index: -7.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1403
    Cell Significance Index: -6.3600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1417
    Cell Significance Index: -1.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1577
    Cell Significance Index: -5.9700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1613
    Cell Significance Index: -2.0400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1628
    Cell Significance Index: -2.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1674
    Cell Significance Index: -4.1800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1723
    Cell Significance Index: -2.0600
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1952
    Cell Significance Index: -2.2800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2003
    Cell Significance Index: -2.5000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2012
    Cell Significance Index: -2.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2114
    Cell Significance Index: -10.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2187
    Cell Significance Index: -5.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2208
    Cell Significance Index: -6.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2236
    Cell Significance Index: -6.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2347
    Cell Significance Index: -5.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2422
    Cell Significance Index: -6.4900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2439
    Cell Significance Index: -4.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2451
    Cell Significance Index: -7.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2506
    Cell Significance Index: -6.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2535
    Cell Significance Index: -5.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2566
    Cell Significance Index: -6.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2588
    Cell Significance Index: -6.9100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2644
    Cell Significance Index: -5.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2645
    Cell Significance Index: -6.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2697
    Cell Significance Index: -6.9300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.2896
    Cell Significance Index: -3.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2917
    Cell Significance Index: -6.7400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3140
    Cell Significance Index: -4.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3208
    Cell Significance Index: -8.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3208
    Cell Significance Index: -13.1500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3215
    Cell Significance Index: -4.1700
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.3232
    Cell Significance Index: -3.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3253
    Cell Significance Index: -6.8100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3328
    Cell Significance Index: -3.7600
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.3539
    Cell Significance Index: -3.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3540
    Cell Significance Index: -6.1200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.3641
    Cell Significance Index: -4.5600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3682
    Cell Significance Index: -4.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3684
    Cell Significance Index: -5.5200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3850
    Cell Significance Index: -4.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3877
    Cell Significance Index: -7.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3920
    Cell Significance Index: -7.6500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3930
    Cell Significance Index: -5.8800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4035
    Cell Significance Index: -6.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** EIF4E1B is a member of the eukaryotic translation initiation factor 4E (eIF4E) family, which is responsible for binding to the 7-methylguanosine (m7G) cap of mRNA and facilitating the recruitment of the ribosome. 2. **Cellular Localization:** EIF4E1B is predominantly localized to the cytoplasm, where it interacts with eIF4E and other translation initiation factors to regulate mRNA translation. 3. **Regulation of Translation:** EIF4E1B plays a crucial role in regulating translation initiation by modulating the activity of eIF4E and other translation initiation factors. 4. **Interactions with Other Proteins:** EIF4E1B interacts with various proteins, including eIF4E, eIF3, and eIF2, to regulate translation initiation. **Pathways and Functions:** 1. **Eukaryotic Translation Initiation Complex:** EIF4E1B is a key component of the eukaryotic translation initiation complex, which is responsible for recruiting the ribosome to the mRNA. 2. **Regulation of Translation Initiation:** EIF4E1B regulates translation initiation by modulating the activity of eIF4E and other translation initiation factors. 3. **mRNA Stability and Decay:** EIF4E1B also plays a role in regulating mRNA stability and decay by interacting with mRNA-binding proteins. 4. **Cellular Homeostasis:** EIF4E1B is essential for maintaining cellular homeostasis by regulating protein synthesis and preventing excessive protein production. **Clinical Significance:** Dysregulation of EIF4E1B has been implicated in various diseases, including: 1. **Cancer:** EIF4E1B overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** EIF4E1B has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Inflammatory Diseases:** EIF4E1B has been shown to play a role in inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 4. **Metabolic Disorders:** EIF4E1B has been implicated in metabolic disorders, including type 2 diabetes and obesity. In conclusion, EIF4E1B is a critical component of the eukaryotic translation initiation complex, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the role of EIF4E1B in human disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 4223819930

Symbol: I4E1B_HUMAN

Name: Eukaryotic translation initiation factor 4E type 1B

UniProtKB Accession Codes:

A6NMX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 DNASU 1 EMBL 1 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 16191198

Title: Phylogenetic analysis of eIF4E-family members.

PubMed ID: 16191198

DOI: 10.1186/1471-2148-5-48

Sequence Information:

  • Length: 242
  • Mass: 27596
  • Checksum: C441D5F0A082339D
  • Sequence:
    • MLAVEVSEAE GGIREWEEEE KEEEAAERTP TGEKSPNSPR TLLSLRGKAR TGGPMEVKLE 
LHPLQNRWAL WFFKNDRSRA WQDNLHLVTK VDTVEDFWAL YSHIQLASKL SSGCDYALFK 
DGIQPMWEDS RNKRGGRWLV SLAKQQRHIE LDRLWLETLL CLIGESFEEH SREVCGAVVN 
IRTKGDKIAV WTREAENQAG VLHVGRVYKE RLGLSPKTII GYQAHADTAT KSNSLAKNKF 
VV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.