Details for: OR10J1

Gene ID: 26476

Symbol: OR10J1

Ensembl ID: ENSG00000196184

Description: olfactory receptor family 10 subfamily J member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.1890
    Cell Significance Index: 62.3500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.3763
    Cell Significance Index: 5.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3142
    Cell Significance Index: 8.0100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2231
    Cell Significance Index: 4.5400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1375
    Cell Significance Index: 1.5500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0487
    Cell Significance Index: 0.6300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0252
    Cell Significance Index: 0.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0218
    Cell Significance Index: 0.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0033
    Cell Significance Index: 0.1400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0017
    Cell Significance Index: 0.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.4800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0021
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0056
    Cell Significance Index: -1.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0082
    Cell Significance Index: -1.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0082
    Cell Significance Index: -0.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0109
    Cell Significance Index: -0.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0148
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0160
    Cell Significance Index: -0.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0163
    Cell Significance Index: -0.5200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0187
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0199
    Cell Significance Index: -0.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0213
    Cell Significance Index: -0.4600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0230
    Cell Significance Index: -0.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0240
    Cell Significance Index: -1.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0247
    Cell Significance Index: -0.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0248
    Cell Significance Index: -0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0264
    Cell Significance Index: -1.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0286
    Cell Significance Index: -0.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0301
    Cell Significance Index: -0.7500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0309
    Cell Significance Index: -0.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0314
    Cell Significance Index: -0.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0335
    Cell Significance Index: -0.7000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0335
    Cell Significance Index: -0.3400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0345
    Cell Significance Index: -0.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0349
    Cell Significance Index: -0.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0359
    Cell Significance Index: -0.7200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0363
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0388
    Cell Significance Index: -0.5900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0389
    Cell Significance Index: -0.5400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0398
    Cell Significance Index: -0.6800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0399
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0410
    Cell Significance Index: -0.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0411
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0414
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0422
    Cell Significance Index: -1.2100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0437
    Cell Significance Index: -0.3400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0440
    Cell Significance Index: -0.7500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0448
    Cell Significance Index: -0.4900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0472
    Cell Significance Index: -0.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0480
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0495
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0498
    Cell Significance Index: -0.9200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0508
    Cell Significance Index: -0.6000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0532
    Cell Significance Index: -0.7000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0542
    Cell Significance Index: -0.6500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0568
    Cell Significance Index: -0.7800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0576
    Cell Significance Index: -0.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0576
    Cell Significance Index: -0.8300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0585
    Cell Significance Index: -0.8200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0588
    Cell Significance Index: -0.7000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0590
    Cell Significance Index: -1.4300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0592
    Cell Significance Index: -0.7400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0602
    Cell Significance Index: -0.8000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0605
    Cell Significance Index: -0.6300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0607
    Cell Significance Index: -0.7800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0607
    Cell Significance Index: -0.7000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0610
    Cell Significance Index: -0.8000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0614
    Cell Significance Index: -0.6800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0617
    Cell Significance Index: -0.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0618
    Cell Significance Index: -0.6400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0621
    Cell Significance Index: -0.7200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0634
    Cell Significance Index: -0.6800
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0634
    Cell Significance Index: -0.6700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0638
    Cell Significance Index: -0.5700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0641
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0650
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0655
    Cell Significance Index: -0.6300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0683
    Cell Significance Index: -0.9100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0687
    Cell Significance Index: -1.1100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0697
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0697
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0699
    Cell Significance Index: -0.8500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0708
    Cell Significance Index: -0.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0733
    Cell Significance Index: -0.8300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0737
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0737
    Cell Significance Index: -0.6100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0740
    Cell Significance Index: -0.8700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0751
    Cell Significance Index: -0.6900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0754
    Cell Significance Index: -0.7700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0765
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR10J1 is a member of the G protein-coupled receptor (GPCR) family, which is the largest family of receptors in the human genome. GPCRs are known for their role in transducing signals from extracellular ligands to intracellular effectors. OR10J1 is specifically expressed in various cell types, including goblet cells, pericytes, and absorptive cells, which are primarily involved in the epithelial lining of the respiratory and gastrointestinal tracts. Notably, OR10J1 is also expressed in cardiac endothelial cells, suggesting a potential role in cardiovascular health. **Pathways and Functions:** OR10J1 plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. The gene is part of the olfactory signaling pathway, which is responsible for processing odorant molecules and transmitting signals to the brain. Upon binding to its ligand, OR10J1 triggers a G protein-coupled receptor signaling pathway, leading to the activation of downstream effectors and the initiation of a signaling cascade. This cascade ultimately results in the perception of a specific odorant. In addition to its role in sensory perception, OR10J1 has been implicated in other biological processes, including the regulation of cell proliferation and differentiation. For instance, OR10J1 has been shown to influence the expression of genes involved in the development and maintenance of epithelial tissues. **Clinical Significance:** OR10J1 has been identified as a potential biomarker for various diseases, including respiratory and gastrointestinal disorders. For example, studies have shown that OR10J1 is differentially expressed in patients with asthma and chronic obstructive pulmonary disease (COPD). Similarly, OR10J1 has been implicated in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD). Furthermore, OR10J1 has been explored as a potential therapeutic target for the treatment of neurological disorders, including Alzheimer's disease. Research has shown that OR10J1 is differentially expressed in the brains of patients with Alzheimer's disease, suggesting a potential role in the disease's pathogenesis. In conclusion, OR10J1 is a fascinating gene that plays a critical role in sensory perception and other biological processes. Its unique characteristics, pathways, and functions make it an attractive target for research and potential therapeutic applications. As our understanding of OR10J1 continues to evolve, we may uncover new insights into the complex relationships between olfactory receptors and human health.

Genular Protein ID: 2845604105

Symbol: O10J1_HUMAN

Name: Olfactory receptor 10J1

UniProtKB Accession Codes:

P30954 Q2M1M8 Q5VSV1 Q6IET5 Q96R56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1370859

Title: Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

PubMed ID: 1370859

DOI: 10.1038/355453a0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 320
  • Mass: 35925
  • Checksum: 1AA1B612519EFD25
  • Sequence:
    • MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL AGNIIIVTII 
RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS QPISLAGCAT QMFFFVTFGI 
TNCFLLTAMG YDRYVAICNP LRYMVIMNKR LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC 
ARKVPHFFCD IRPVMKLSCI DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS 
VEGRKKAFAT CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY 
TLRNKEVKDA LCRAVGGKFS

Genular Protein ID: 3702291751

Symbol: A0A126GWQ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A126GWQ9

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 5 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 3 RuleBase 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 309
  • Mass: 34628
  • Checksum: 4B12A16B13EDB4E4
  • Sequence:
    • MKRENFTLIT DFVFQGFSSF HEQQITLFGV FLALYILTLA GNIIIVTIIR MDLHLHTPMY 
FFLSMLSTSE TVYTLVILPR MLSSLVGMSQ PISLAGCATQ MFFFVTFGIT NCFLLTAMGY 
DRYVAICNPL RYMVIMNKRL RIQLVLGACS IGLIVAITQV TSVFRLPFCA RKVPHFFCDI 
RPVMKLSCID TTVNEILTLI ISVLVLVVPM GLVFISYVLI ISTILKIASV EGRKKAFATC 
ASHLTVVIVH YSCASIAYLK PKSENTREHD QLISVTYTVI TPLLNPVVYT LRNKEVKDAL 
CRAVGGKFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.