Details for: OR10H3

Gene ID: 26532

Symbol: OR10H3

Ensembl ID: ENSG00000171936

Description: olfactory receptor family 10 subfamily H member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1327
    Cell Significance Index: 1.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0076
    Cell Significance Index: 0.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0023
    Cell Significance Index: 0.4200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0002
    Cell Significance Index: -0.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0006
    Cell Significance Index: -0.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0008
    Cell Significance Index: -0.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0012
    Cell Significance Index: -0.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0015
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0021
    Cell Significance Index: -0.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0025
    Cell Significance Index: -0.0500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0037
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0052
    Cell Significance Index: -0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0052
    Cell Significance Index: -0.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0054
    Cell Significance Index: -0.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0054
    Cell Significance Index: -0.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0056
    Cell Significance Index: -0.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0057
    Cell Significance Index: -0.1200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0074
    Cell Significance Index: -0.1000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0076
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0081
    Cell Significance Index: -0.1600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0081
    Cell Significance Index: -0.1700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0086
    Cell Significance Index: -0.1000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0091
    Cell Significance Index: -0.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0093
    Cell Significance Index: -0.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0097
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0098
    Cell Significance Index: -0.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0100
    Cell Significance Index: -0.1700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0102
    Cell Significance Index: -0.1000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0104
    Cell Significance Index: -0.0800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0108
    Cell Significance Index: -0.1300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0111
    Cell Significance Index: -0.1400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0113
    Cell Significance Index: -0.1500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0113
    Cell Significance Index: -0.1600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0114
    Cell Significance Index: -0.1300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0117
    Cell Significance Index: -0.1100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0117
    Cell Significance Index: -0.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0120
    Cell Significance Index: -0.1500
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0120
    Cell Significance Index: -0.1400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0121
    Cell Significance Index: -0.1400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0123
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0124
    Cell Significance Index: -0.1000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0127
    Cell Significance Index: -0.1400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0128
    Cell Significance Index: -0.1700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0129
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0131
    Cell Significance Index: -0.1400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0131
    Cell Significance Index: -0.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0133
    Cell Significance Index: -0.1500
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0137
    Cell Significance Index: -0.1500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0141
    Cell Significance Index: -0.1600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0141
    Cell Significance Index: -0.1500
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0143
    Cell Significance Index: -0.1600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0145
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0145
    Cell Significance Index: -0.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0147
    Cell Significance Index: -0.1500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0148
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Family 10 Subfamily H Member 3**: OR10H3 is a member of the olfactory receptor family 10, which is responsible for detecting chemical stimuli involved in sensory perception of smell. 2. **Significant Expression in Various Cell Types**: OR10H3 is expressed in a wide range of cell types, including pericytes, cardiac endothelial cells, immature innate lymphoid cells, and macrophages, among others. 3. **Unique Expression Patterns**: OR10H3 exhibits distinct expression patterns in different tissues, including the heart, kidney, and immune cells. 4. **G-Protein Coupled Receptor Activity**: OR10H3 is a G-protein coupled receptor, which enables it to transmit signals in response to chemical stimuli. **Pathways and Functions:** 1. **Detection of Chemical Stimulus Involved in Sensory Perception of Smell**: OR10H3 plays a crucial role in detecting chemical stimuli involved in sensory perception of smell, allowing us to perceive and differentiate between various odors. 2. **Expression and Translocation of Olfactory Receptors**: OR10H3 is involved in the expression and translocation of olfactory receptors, which is essential for the proper functioning of the olfactory system. 3. **G-Protein Coupled Receptor Signaling Pathway**: OR10H3 utilizes the G-protein coupled receptor signaling pathway to transmit signals in response to chemical stimuli. 4. **Olfactory Signaling Pathway**: OR10H3 is integral to the olfactory signaling pathway, which enables us to perceive and differentiate between various odors. **Clinical Significance:** 1. **Implications for Olfactory Disorders**: OR10H3 has been implicated in various olfactory disorders, including anosmia and hyposmia. Understanding the role of OR10H3 in olfaction may lead to the development of novel therapeutic strategies for these disorders. 2. **Relationship to Other Physiological Processes**: OR10H3's involvement in sensory perception of smell and olfactory signaling pathways has far-reaching implications for our understanding of other physiological processes, including cardiovascular function and immune responses. 3. **Potential Applications in Diagnostic and Therapeutic Medicine**: OR10H3's expression in various cell types and its involvement in sensory perception of smell make it a potential target for diagnostic and therapeutic applications in medicine. In conclusion, OR10H3 is a fascinating gene that has shed light on the complexities of olfaction and its relationship to other physiological processes. Further research is needed to fully elucidate the functions and clinical significance of OR10H3, but its unique expression patterns and functional properties make it an exciting area of study in the field of immunology.

Genular Protein ID: 2376113795

Symbol: O10H3_HUMAN

Name: Olfactory receptor 10H3

UniProtKB Accession Codes:

O60404 Q2HIZ3 Q6IFQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 316
  • Mass: 35721
  • Checksum: D055291FB9B49BC3
  • Sequence:
    • MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV WIERRLHTPM 
YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI QMFFSFMFGF THSFLLMVMG 
YDHYVTICHP LHYNMLMSPR GCAHLVAWTW AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC 
HVLSLLKLAC GSKTSSVIMG VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF 
STCVSHLTVV VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK 
NAINKNFCRR FCPLSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.