Details for: GGT1

Gene ID: 2678

Symbol: GGT1

Ensembl ID: ENSG00000100031

Description: gamma-glutamyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.17
    Marker Score: 6237
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.6
    Marker Score: 3767
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169342
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.4
    Marker Score: 1686
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.99
    Marker Score: 3507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5293
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.88
    Marker Score: 894
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.86
    Marker Score: 1322
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.78
    Marker Score: 2460
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.73
    Marker Score: 4667
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.73
    Marker Score: 2388
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 650.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2862
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.65
    Marker Score: 1073
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.65
    Marker Score: 431
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.63
    Marker Score: 2704
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.62
    Marker Score: 4021
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.6
    Marker Score: 140
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 310.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.57
    Marker Score: 443
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.56
    Marker Score: 2710
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.56
    Marker Score: 252
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.53
    Marker Score: 223
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.51
    Marker Score: 115
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.51
    Marker Score: 548
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.49
    Marker Score: 2916
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.49
    Marker Score: 251
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.48
    Marker Score: 2605
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.46
    Marker Score: 146
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.46
    Marker Score: 266
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.46
    Marker Score: 1122
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 270
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.45
    Marker Score: 2880
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 140
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.43
    Marker Score: 916
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.4
    Marker Score: 649
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 145
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.38
    Marker Score: 668
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.38
    Marker Score: 173
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.35
    Marker Score: 976
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.34
    Marker Score: 128
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.33
    Marker Score: 100
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.32
    Marker Score: 115
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.31
    Marker Score: 387.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.3
    Marker Score: 815
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.3
    Marker Score: 335
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.29
    Marker Score: 304
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.28
    Marker Score: 82
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.28
    Marker Score: 77
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.28
    Marker Score: 245
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.28
    Marker Score: 102
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.27
    Marker Score: 3650
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.27
    Marker Score: 290
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.27
    Marker Score: 181
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.27
    Marker Score: 112
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.26
    Marker Score: 600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.26
    Marker Score: 146
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 301
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.25
    Marker Score: 117
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.25
    Marker Score: 94
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.24
    Marker Score: 170
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.24
    Marker Score: 172
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.24
    Marker Score: 1010
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.24
    Marker Score: 59
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.23
    Marker Score: 64
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.22
    Marker Score: 158
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.22
    Marker Score: 139
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.21
    Marker Score: 11931
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.21
    Marker Score: 337
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.21
    Marker Score: 153
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.21
    Marker Score: 189
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.21
    Marker Score: 46
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.21
    Marker Score: 181
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.21
    Marker Score: 81
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.21
    Marker Score: 2080
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.2
    Marker Score: 102
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2
    Marker Score: 754

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Other Information

**Key characteristics:** * GGT1 is a protein of the cytochrome P450 family. * It is expressed in a variety of cells, including retinal cone cells, kidney proximal straight tubule epithelial cells, mural cells, type I pneumocyte, cerebral cortex GABAergic interneuron, forebrain radial glial cell, epithelial cell of proximal tubule, absorptive cell, tuft cell of colon, and BEST4+ intestinal epithelial cell. * GGT1 is a highly conserved protein, with a sequence similarity of over 90% between humans and rodents. **Pathways and functions:** * GGT1 is involved in several important pathways, including the detoxification of aflatoxins, the metabolism of fatty acids, and the regulation of immune responses. * It catalyzes the transfer of a glutamate group from glutamine to various substrates, including aflatoxins, 2-hydroxyglutarate, and 3-nitrotyrosine. * This activity helps to detoxify aflatoxins and protect cells from their toxic effects. * GGT1 is also involved in the metabolism of fatty acids, including the synthesis of eicosanoids, which are important mediators of inflammation and pain. * It also plays a role in the regulation of immune responses, as it is expressed in cells that are involved in immune surveillance. **Clinical significance:** * Mutations in the GGT1 gene have been linked to an increased risk of liver damage and cancer. * In some cases, GGT1 mutations can also cause aflatoxin-induced liver damage. * As a result, GGT1 is a potential therapeutic target for the prevention and treatment of aflatoxin-induced liver damage. **Additional information:** * The GGT1 gene is located on chromosome 15q21.1. * It is a highly expressed gene, with more than 2,000 copies of GGT1 per cell. * GGT1 is a well-characterized protein that has been extensively studied in both humans and animals.

Genular Protein ID: 2199861024

Symbol: GGT1_HUMAN

Name: Glutathione hydrolase 1 proenzyme

UniProtKB Accession Codes:

P19440 Q08247 Q14404 Q8TBS1 Q9UMK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 4 EMBL 14 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 7 PIR 5 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 Rhea 13 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2904146

Title: Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

PubMed ID: 2904146

DOI: 10.1073/pnas.85.23.8840

PubMed ID: 2907498

Title: The primary structure of human gamma-glutamyl transpeptidase.

PubMed ID: 2907498

DOI: 10.1016/0378-1119(88)90307-1

PubMed ID: 2563599

Title: Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.

PubMed ID: 2563599

DOI: 10.1016/0041-008x(89)90052-5

PubMed ID: 2568315

Title: Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat.

PubMed ID: 2568315

DOI: 10.1016/0378-1119(89)90002-4

PubMed ID: 1968061

Title: An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues.

PubMed ID: 1968061

DOI: 10.1016/s0021-9258(19)39761-3

PubMed ID: 1378736

Title: Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues.

PubMed ID: 1378736

DOI: 10.1016/0006-2952(92)90140-e

PubMed ID: 7689219

Title: Human lung expresses unique gamma-glutamyl transpeptidase transcripts.

PubMed ID: 7689219

DOI: 10.1073/pnas.90.16.7461

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2896486

Title: Renal gamma-glutamyl transpeptidases: structural and immunological studies.

PubMed ID: 2896486

DOI: 10.1016/0003-9861(88)90390-6

PubMed ID: 10392451

Title: Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

PubMed ID: 10392451

DOI: 10.1016/s0305-0491(99)00013-9

PubMed ID: 19463

Title: Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit.

PubMed ID: 19463

DOI: 10.1016/s0021-9258(17)40026-3

PubMed ID: 2900635

Title: In vitro translation and processing of human hepatoma cell (Hep G2) gamma-glutamyl transpeptidase.

PubMed ID: 2900635

DOI: 10.1016/0006-291x(88)90263-x

PubMed ID: 8095045

Title: Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis.

PubMed ID: 8095045

DOI: 10.1016/s0021-9258(18)53567-5

PubMed ID: 7759490

Title: Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit.

PubMed ID: 7759490

DOI: 10.1074/jbc.270.21.12471

PubMed ID: 7673200

Title: Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase.

PubMed ID: 7673200

DOI: 10.1074/jbc.270.38.22223

PubMed ID: 8827453

Title: Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase.

PubMed ID: 8827453

DOI: 10.1093/oxfordjournals.jbchem.a021363

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 17924658

Title: Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase.

PubMed ID: 17924658

DOI: 10.1021/bi700956c

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20622017

Title: Analysis of site-specific glycosylation of renal and hepatic gamma-glutamyl transpeptidase from normal human tissue.

PubMed ID: 20622017

DOI: 10.1074/jbc.m110.145938

PubMed ID: 21447318

Title: Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.

PubMed ID: 21447318

DOI: 10.1016/j.ab.2011.03.026

PubMed ID: 23682772

Title: Human GGT2 does not autocleave into a functional enzyme: a cautionary tale for interpretation of microarray data on redox signaling.

PubMed ID: 23682772

DOI: 10.1089/ars.2012.4997

PubMed ID: 24047895

Title: Novel insights into eukaryotic gamma-glutamyl transpeptidase 1 from the crystal structure of the glutamate-bound human enzyme.

PubMed ID: 24047895

DOI: 10.1074/jbc.m113.498139

PubMed ID: 26013825

Title: Human gamma-Glutamyl Transpeptidase 1: Structures of the free enzyme, inhibitor-bound tetrahedral transition states, and glutamate-bound enzyme reveal novel movement within the active site during catalysis.

PubMed ID: 26013825

DOI: 10.1074/jbc.m115.659680

PubMed ID: 27791009

Title: Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.

PubMed ID: 27791009

DOI: 10.1073/pnas.1607003113

PubMed ID: 29483667

Title: Gamma-glutamyl transpeptidase deficiency caused by a large homozygous intragenic deletion in GGT1.

PubMed ID: 29483667

DOI: 10.1038/s41431-018-0122-6

Sequence Information:

  • Length: 569
  • Mass: 61410
  • Checksum: 71AE12485239A69F
  • Sequence:
    • MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD 
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN 
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN 
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD 
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR 
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD 
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE 
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA 
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF 
IAVVQAIVRT AGGWAAASDS RKGGEPAGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.