Details for: GGT1

Gene ID: 2678

Symbol: GGT1

Ensembl ID: ENSG00000100031

Description: gamma-glutamyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.6447
    Cell Significance Index: -4.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.3221
    Cell Significance Index: -4.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.4121
    Cell Significance Index: -4.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 8.9674
    Cell Significance Index: 224.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.2903
    Cell Significance Index: 88.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.6452
    Cell Significance Index: -4.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4876
    Cell Significance Index: -4.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1969
    Cell Significance Index: 33.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1946
    Cell Significance Index: 417.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.9136
    Cell Significance Index: 19.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5977
    Cell Significance Index: 158.0500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5781
    Cell Significance Index: 12.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.4185
    Cell Significance Index: -3.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8638
    Cell Significance Index: 25.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8524
    Cell Significance Index: 24.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8382
    Cell Significance Index: 136.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8093
    Cell Significance Index: 88.0300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.7514
    Cell Significance Index: 2.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5054
    Cell Significance Index: 30.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4676
    Cell Significance Index: 32.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4547
    Cell Significance Index: 410.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2700
    Cell Significance Index: 53.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1747
    Cell Significance Index: 4.4900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1531
    Cell Significance Index: 1.1700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.1470
    Cell Significance Index: 1.9600
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1123
    Cell Significance Index: 0.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1028
    Cell Significance Index: 56.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0978
    Cell Significance Index: 2.8800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0853
    Cell Significance Index: 0.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0814
    Cell Significance Index: 23.4300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0781
    Cell Significance Index: 1.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0752
    Cell Significance Index: 3.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0689
    Cell Significance Index: 1.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0680
    Cell Significance Index: 1.4900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0560
    Cell Significance Index: 0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0558
    Cell Significance Index: 7.2100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0514
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0433
    Cell Significance Index: 1.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0419
    Cell Significance Index: 4.8800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0380
    Cell Significance Index: 0.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0379
    Cell Significance Index: 0.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0357
    Cell Significance Index: 0.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0318
    Cell Significance Index: 2.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0258
    Cell Significance Index: 0.5600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0242
    Cell Significance Index: 0.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0132
    Cell Significance Index: 10.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0129
    Cell Significance Index: 2.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0107
    Cell Significance Index: 1.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0099
    Cell Significance Index: 1.1700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0065
    Cell Significance Index: 0.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0019
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0023
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0029
    Cell Significance Index: -0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0048
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0066
    Cell Significance Index: -2.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0106
    Cell Significance Index: -4.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0142
    Cell Significance Index: -0.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0182
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0232
    Cell Significance Index: -4.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0249
    Cell Significance Index: -3.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0306
    Cell Significance Index: -2.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0325
    Cell Significance Index: -4.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0361
    Cell Significance Index: -2.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0366
    Cell Significance Index: -2.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0433
    Cell Significance Index: -0.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0449
    Cell Significance Index: -3.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0452
    Cell Significance Index: -2.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0479
    Cell Significance Index: -1.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0512
    Cell Significance Index: -1.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0524
    Cell Significance Index: -1.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0524
    Cell Significance Index: -0.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0534
    Cell Significance Index: -2.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0567
    Cell Significance Index: -2.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0568
    Cell Significance Index: -1.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0608
    Cell Significance Index: -3.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0616
    Cell Significance Index: -1.6500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0619
    Cell Significance Index: -0.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0626
    Cell Significance Index: -2.0000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0658
    Cell Significance Index: -0.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0669
    Cell Significance Index: -1.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0712
    Cell Significance Index: -1.7800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0715
    Cell Significance Index: -0.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0727
    Cell Significance Index: -4.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0736
    Cell Significance Index: -1.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0742
    Cell Significance Index: -1.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0754
    Cell Significance Index: -3.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0802
    Cell Significance Index: -4.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0805
    Cell Significance Index: -4.1800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0813
    Cell Significance Index: -1.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0889
    Cell Significance Index: -1.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0927
    Cell Significance Index: -2.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0964
    Cell Significance Index: -1.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0985
    Cell Significance Index: -2.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GGT1 exhibits the following key characteristics: 1. **Enzyme specificity**: GGT1 is a gamma-glutamyltransferase that catalyzes the transfer of gamma-glutamyl groups to amino acids, peptides, or other molecules. 2. **Substrate specificity**: GGT1 has a broad substrate specificity, including glutathione, amino acids, peptides, and other molecules. 3. **Catalytic activity**: GGT1 catalyzes the transfer of gamma-glutamyl groups to its substrates, facilitating the synthesis, conjugation, and recycling of glutathione. 4. **Expression pattern**: GGT1 is highly expressed in various tissues, including the retina, kidney, and brain. 5. **Regulatory mechanisms**: GGT1 is subject to various regulatory mechanisms, including post-translational modifications, protein-protein interactions, and transcriptional control. **Pathways and Functions** GGT1 is involved in several physiological and pathological pathways, including: 1. **Glutathione metabolism**: GGT1 plays a critical role in the synthesis, conjugation, and recycling of glutathione, a key antioxidant molecule. 2. **Inflammatory response**: GGT1 is involved in the regulation of inflammatory responses, including the production of leukotrienes and the activation of immune cells. 3. **Parasitic infections**: GGT1 has been implicated in the growth and survival of Leishmania parasites, a protozoan that causes leishmaniasis. 4. **Metabolic disorders**: GGT1 is involved in the regulation of metabolic disorders, including those related to biological oxidation enzymes and lipid metabolism. 5. **Antioxidant defense**: GGT1 contributes to the antioxidant defense system by facilitating the synthesis and recycling of glutathione. **Clinical Significance** GGT1 has significant clinical implications, including: 1. **Detoxification of aflatoxins**: GGT1 is involved in the detoxification of aflatoxins, a group of mycotoxins produced by Aspergillus species. 2. **Leishmaniasis**: GGT1 has been identified as a potential target for the treatment of leishmaniasis, a parasitic disease that affects millions of people worldwide. 3. **Metabolic disorders**: GGT1 is implicated in the pathogenesis of metabolic disorders, including those related to biological oxidation enzymes and lipid metabolism. 4. **Inflammatory diseases**: GGT1 contributes to the regulation of inflammatory responses, including those involved in diseases such as arthritis and asthma. 5. **Cancer**: GGT1 has been identified as a potential biomarker for cancer, including colorectal and breast cancers. In conclusion, GGT1 is an enzyme with a wide range of cellular and physiological functions, including the regulation of glutathione metabolism, inflammatory responses, and parasitic infections. Its clinical significance is underscored by its involvement in the detoxification of aflatoxins, leishmaniasis, metabolic disorders, and inflammatory diseases, making it a promising target for the development of novel therapeutic strategies.

Genular Protein ID: 2199861024

Symbol: GGT1_HUMAN

Name: Glutathione hydrolase 1 proenzyme

UniProtKB Accession Codes:

P19440 Q08247 Q14404 Q8TBS1 Q9UMK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 4 EMBL 14 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 5 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 Rhea 13 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2904146

Title: Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

PubMed ID: 2904146

DOI: 10.1073/pnas.85.23.8840

PubMed ID: 2907498

Title: The primary structure of human gamma-glutamyl transpeptidase.

PubMed ID: 2907498

DOI: 10.1016/0378-1119(88)90307-1

PubMed ID: 2563599

Title: Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.

PubMed ID: 2563599

DOI: 10.1016/0041-008x(89)90052-5

PubMed ID: 2568315

Title: Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat.

PubMed ID: 2568315

DOI: 10.1016/0378-1119(89)90002-4

PubMed ID: 1968061

Title: An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues.

PubMed ID: 1968061

DOI: 10.1016/s0021-9258(19)39761-3

PubMed ID: 1378736

Title: Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues.

PubMed ID: 1378736

DOI: 10.1016/0006-2952(92)90140-e

PubMed ID: 7689219

Title: Human lung expresses unique gamma-glutamyl transpeptidase transcripts.

PubMed ID: 7689219

DOI: 10.1073/pnas.90.16.7461

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2896486

Title: Renal gamma-glutamyl transpeptidases: structural and immunological studies.

PubMed ID: 2896486

DOI: 10.1016/0003-9861(88)90390-6

PubMed ID: 10392451

Title: Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

PubMed ID: 10392451

DOI: 10.1016/s0305-0491(99)00013-9

PubMed ID: 19463

Title: Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit.

PubMed ID: 19463

DOI: 10.1016/s0021-9258(17)40026-3

PubMed ID: 2900635

Title: In vitro translation and processing of human hepatoma cell (Hep G2) gamma-glutamyl transpeptidase.

PubMed ID: 2900635

DOI: 10.1016/0006-291x(88)90263-x

PubMed ID: 8095045

Title: Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis.

PubMed ID: 8095045

DOI: 10.1016/s0021-9258(18)53567-5

PubMed ID: 7759490

Title: Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit.

PubMed ID: 7759490

DOI: 10.1074/jbc.270.21.12471

PubMed ID: 7673200

Title: Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase.

PubMed ID: 7673200

DOI: 10.1074/jbc.270.38.22223

PubMed ID: 8827453

Title: Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase.

PubMed ID: 8827453

DOI: 10.1093/oxfordjournals.jbchem.a021363

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 17924658

Title: Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase.

PubMed ID: 17924658

DOI: 10.1021/bi700956c

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20622017

Title: Analysis of site-specific glycosylation of renal and hepatic gamma-glutamyl transpeptidase from normal human tissue.

PubMed ID: 20622017

DOI: 10.1074/jbc.m110.145938

PubMed ID: 21447318

Title: Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.

PubMed ID: 21447318

DOI: 10.1016/j.ab.2011.03.026

PubMed ID: 23682772

Title: Human GGT2 does not autocleave into a functional enzyme: a cautionary tale for interpretation of microarray data on redox signaling.

PubMed ID: 23682772

DOI: 10.1089/ars.2012.4997

PubMed ID: 24047895

Title: Novel insights into eukaryotic gamma-glutamyl transpeptidase 1 from the crystal structure of the glutamate-bound human enzyme.

PubMed ID: 24047895

DOI: 10.1074/jbc.m113.498139

PubMed ID: 26013825

Title: Human gamma-Glutamyl Transpeptidase 1: Structures of the free enzyme, inhibitor-bound tetrahedral transition states, and glutamate-bound enzyme reveal novel movement within the active site during catalysis.

PubMed ID: 26013825

DOI: 10.1074/jbc.m115.659680

PubMed ID: 27791009

Title: Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.

PubMed ID: 27791009

DOI: 10.1073/pnas.1607003113

PubMed ID: 29483667

Title: Gamma-glutamyl transpeptidase deficiency caused by a large homozygous intragenic deletion in GGT1.

PubMed ID: 29483667

DOI: 10.1038/s41431-018-0122-6

Sequence Information:

  • Length: 569
  • Mass: 61410
  • Checksum: 71AE12485239A69F
  • Sequence:
    • MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD 
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN 
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN 
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD 
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR 
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD 
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE 
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA 
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF 
IAVVQAIVRT AGGWAAASDS RKGGEPAGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.