B4GALT1 | ENSG00000086062 | NCBI 2683

Details for: B4GALT1

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Defective b4galt1 causes b4galt1-cdg (cdg-2d)
(R-HSA-3656244)
Defective b4galt1 causes cdg-2d
(R-HSA-4793953)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases associated with n-glycosylation of proteins
(R-HSA-3781860)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Fertilization
(R-HSA-1187000)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interaction with cumulus cells and the zona pellucida
(R-HSA-2534343)
Keratan sulfate/keratin metabolism
(R-HSA-1638074)
Keratan sulfate biosynthesis
(R-HSA-2022854)
Lactose synthesis
(R-HSA-5653890)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of proteins
(R-HSA-392499)
N-glycan antennae elongation
(R-HSA-975577)
N-glycan antennae elongation in the medial/trans-golgi
(R-HSA-975576)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch processing in golgi
(R-HSA-1912420)
Reproduction
(R-HSA-1474165)
Signaling by notch
(R-HSA-157118)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Acute inflammatory response
(GO:0002526)
Alpha-tubulin binding
(GO:0043014)
Angiogenesis involved in wound healing
(GO:0060055)
Azurophil granule membrane
(GO:0035577)
Basolateral plasma membrane
(GO:0016323)
Beta-n-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
(GO:0003831)
Beta-tubulin binding
(GO:0048487)
Binding of sperm to zona pellucida
(GO:0007339)
Brush border membrane
(GO:0031526)
Cell adhesion
(GO:0007155)
Desmosome
(GO:0030057)
Development of secondary sexual characteristics
(GO:0045136)
Epithelial cell development
(GO:0002064)
Epithelial cell proliferation
(GO:0050673)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular matrix organization
(GO:0030198)
Extracellular space
(GO:0005615)
Filopodium
(GO:0030175)
Galactose metabolic process
(GO:0006012)
Galactosyltransferase activity
(GO:0008378)
Golgi apparatus
(GO:0005794)
Golgi cisterna membrane
(GO:0032580)
Golgi membrane
(GO:0000139)
Golgi trans cisterna
(GO:0000138)
Identical protein binding
(GO:0042802)
Lactose biosynthetic process
(GO:0005989)
Lactose synthase activity
(GO:0004461)
Lipid metabolic process
(GO:0006629)
Macrophage migration
(GO:1905517)
Manganese ion binding
(GO:0030145)
Membrane
(GO:0016020)
N-acetyllactosamine synthase activity
(GO:0003945)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Oligosaccharide biosynthetic process
(GO:0009312)
Penetration of zona pellucida
(GO:0007341)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of circulating fibrinogen levels
(GO:0061755)
Positive regulation of epithelial cell proliferation involved in wound healing
(GO:0060054)
Protein-containing complex
(GO:0032991)
Protein n-linked glycosylation
(GO:0006487)
Regulation of acrosome reaction
(GO:0060046)
Secretory granule membrane
(GO:0030667)
Udp-galactosyltransferase activity
(GO:0035250)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

plasmacytoid dendritic cell, human CL0001058

CSI 42.1

rCSI 29.4%

PRS 44.56
extravillous trophoblast CL0008036

CSI 24.66

rCSI 30.5%

PRS 38.92
glial cell CL0000125

CSI 16.62

rCSI 63.3%

PRS 36.94
Hofbauer cell CL3000001

CSI 15.81

rCSI 29.84%

PRS 52.85
tissue-resident macrophage CL0000864

CSI 15.69

rCSI 73.43%

PRS 61.97
ionocyte CL0005006

CSI 13.88

rCSI 14.88%

PRS 40.83
myeloid dendritic cell CL0000782

CSI 13.74

rCSI 19.9%

PRS 58.85
squamous epithelial cell CL0000076

CSI 11.89

rCSI 28.22%

PRS 48.66
IgG plasma cell CL0000985

CSI 11

rCSI 13.18%

PRS 62.07
CD4-positive helper T cell CL0000492

CSI 10.71

rCSI 8.1%

PRS 54.87
renal alpha-intercalated cell CL0005011

CSI 10

rCSI 13.37%

PRS 51.15
neural crest cell CL0011012

CSI 9.88

rCSI 7.81%

PRS 31.34
intermediate monocyte CL0002393

CSI 9.26

rCSI 13.98%

PRS 44.71
IgA plasma cell CL0000987

CSI 9.04

rCSI 9.26%

PRS 61.44
cardiac muscle cell CL0000746

CSI 8.89

rCSI 12.76%

PRS 34.83
colon macrophage CL0009038

CSI 8.77

rCSI 40.49%

PRS 65.4
fibroblast of lung CL0002553

CSI 8.61

rCSI 8.02%

PRS 42.79
nasal mucosa goblet cell CL0002480

CSI 8.52

rCSI 9.88%

PRS 53.68
T follicular helper cell CL0002038

CSI 7.94

rCSI 5.94%

PRS 57.43
stromal cell of ovary CL0002132

CSI 7.89

rCSI 21.69%

PRS 58.33
plasmacytoid dendritic cell CL0000784

CSI 7.84

rCSI 7.94%

PRS 81.78
CD14-positive, CD16-positive monocyte CL0002397

CSI 7.76

rCSI 10.16%

PRS 55.78
syncytiotrophoblast cell CL0000525

CSI 7.72

rCSI 22.24%

PRS 60.58
retinal pigment epithelial cell CL0002586

CSI 7.45

rCSI 14.79%

PRS 42.44
effector CD4-positive, alpha-beta T cell CL0001044

CSI 7.04

rCSI 20.2%

PRS 60.12
elicited macrophage CL0000861

CSI 6.79

rCSI 6.23%

PRS 50.04
placental villous trophoblast CL2000060

CSI 6.61

rCSI 10.21%

PRS 40.89
lung ciliated cell CL1000271

CSI 6.24

rCSI 7.22%

PRS 33.54
alveolar adventitial fibroblast CL4028006

CSI 6.12

rCSI 9.67%

PRS 43.88
cardiac neuron CL0010022

CSI 5.83

rCSI 18.67%

PRS 40.02
cholangiocyte CL1000488

CSI 5.79

rCSI 34.67%

PRS 57.04
conjunctival epithelial cell CL1000432

CSI 5.62

rCSI 8.58%

PRS 43.46
melanocyte CL0000148

CSI 5.59

rCSI 4.14%

PRS 36.98
tendon cell CL0000388

CSI 5.47

rCSI 14.23%

PRS 66.79
transitional stage B cell CL0000818

CSI 5.3

rCSI 17.34%

PRS 75.16
CD4-positive, alpha-beta memory T cell CL0000897

CSI 5.27

rCSI 3.78%

PRS 55.39
pancreatic acinar cell CL0002064

CSI 5.2

rCSI 6.91%

PRS 47.43
Mueller cell CL0000636

CSI 5.03

rCSI 11.49%

PRS 36.84
enteric smooth muscle cell CL0002504

CSI 4.87

rCSI 6.94%

PRS 45.58
mature T cell CL0002419

CSI 4.83

rCSI 3.76%

PRS 59.49
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 4.7

rCSI 14.49%

PRS 55.14
naive T cell CL0000898

CSI 4.56

rCSI 3.17%

PRS 55.58
foveolar cell of stomach CL0002179

CSI 4.23

rCSI 9.01%

PRS 57.78
mucus secreting cell CL0000319

CSI 4.22

rCSI 6.7%

PRS 53.14
megakaryocyte-erythroid progenitor cell CL0000050

CSI 4.21

rCSI 3.8%

PRS 39.62
stem cell CL0000034

CSI 4.21

rCSI 4.06%

PRS 34
respiratory goblet cell CL0002370

CSI 4.07

rCSI 44.32%

PRS 63.58
class switched memory B cell CL0000972

CSI 3.95

rCSI 2.95%

PRS 61.25
cardiac endothelial cell CL0010008

CSI 3.94

rCSI 15.9%

PRS 41.63
activated type II NK T cell CL0000931

CSI 3.93

rCSI 4.43%

PRS 58.86
respiratory hillock cell CL4030023

CSI 3.84

rCSI 6.85%

PRS 58.52
pulmonary capillary endothelial cell CL4028001

CSI 3.77

rCSI 7.19%

PRS 59.68
alpha-beta T cell CL0000789

CSI 3.76

rCSI 4.41%

PRS 58.21
myofibroblast cell CL0000186

CSI 3.75

rCSI 5.19%

PRS 48.01
immature B cell CL0000816

CSI 3.7

rCSI 2.75%

PRS 55.79
precursor B cell CL0000817

CSI 3.68

rCSI 3.22%

PRS 52.57
fibroblast CL0000057

CSI 3.66

rCSI 10.54%

PRS 67.89
ciliated cell CL0000064

CSI 3.39

rCSI 5.49%

PRS 41.53
myoepithelial cell CL0000185

CSI 3.37

rCSI 8.52%

PRS 51.13
acinar cell CL0000622

CSI 3.34

rCSI 4.9%

PRS 53.85
double-positive, alpha-beta thymocyte CL0000809

CSI 3.34

rCSI 3.4%

PRS 55.89
retinal blood vessel endothelial cell CL0002585

CSI 3.33

rCSI 5.32%

PRS 46.53
naive B cell CL0000788

CSI 3.27

rCSI 2.81%

PRS 52.16
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.24

rCSI 2.47%

PRS 53.98
glandular epithelial cell CL0000150

CSI 3.23

rCSI 8.51%

PRS 65.48
mature B cell CL0000785

CSI 3.22

rCSI 2.8%

PRS 51.89
adipocyte CL0000136

CSI 3.21

rCSI 4.12%

PRS 38.86
pancreatic ductal cell CL0002079

CSI 3.2

rCSI 6.23%

PRS 44.79
cerebral cortex endothelial cell CL1001602

CSI 3.18

rCSI 5.51%

PRS 34.18
myeloid leukocyte CL0000766

CSI 3.17

rCSI 2.92%

PRS 43.81
hepatic stellate cell CL0000632

CSI 3.16

rCSI 11.83%

PRS 36.49
double negative thymocyte CL0002489

CSI 3.16

rCSI 2.19%

PRS 51.2
epithelial cell of proximal tubule CL0002306

CSI 3.13

rCSI 7.65%

PRS 39.22
colonocyte CL1000347

CSI 3.12

rCSI 4.48%

PRS 50.16
hepatocyte CL0000182

CSI 3.06

rCSI 5.49%

PRS 41.35
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 3.03

rCSI 2.27%

PRS 75.25
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 3

rCSI 3.58%

PRS 63.22
vascular leptomeningeal cell CL4023051

CSI 2.99

rCSI 5.24%

PRS 35.71
midzonal region hepatocyte CL0019028

CSI 2.96

rCSI 6.94%

PRS 52.07
granulocyte CL0000094

CSI 2.91

rCSI 4.45%

PRS 51.74
goblet cell CL0000160

CSI 2.88

rCSI 2.72%

PRS 43.82
basal cell of prostate epithelium CL0002341

CSI 2.78

rCSI 8.05%

PRS 60.79
acinar cell of salivary gland CL0002623

CSI 2.78

rCSI 64.69%

PRS 65.68
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.76

rCSI 2.71%

PRS 58.05
vascular associated smooth muscle cell CL0000359

CSI 2.75

rCSI 8.94%

PRS 45.97
BEST4+ enteroycte CL4030026

CSI 2.72

rCSI 3.38%

PRS 45.52
unswitched memory B cell CL0000970

CSI 2.72

rCSI 2.29%

PRS 60.06
transit amplifying cell of colon CL0009011

CSI 2.71

rCSI 3.18%

PRS 46.57
granulocyte monocyte progenitor cell CL0000557

CSI 2.69

rCSI 2.33%

PRS 46.54
microcirculation associated smooth muscle cell CL0008035

CSI 2.67

rCSI 7.73%

PRS 45.49
CD14-positive monocyte CL0001054

CSI 2.64

rCSI 3.29%

PRS 54.11
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.63

rCSI 6.79%

PRS 39.26
epithelial cell CL0000066

CSI 2.55

rCSI 3.92%

PRS 45.26
pro-B cell CL0000826

CSI 2.54

rCSI 2.11%

PRS 43.83
pulmonary ionocyte CL0017000

CSI 2.5

rCSI 3.05%

PRS 50.4
mesodermal cell CL0000222

CSI 2.5

rCSI 3%

PRS 41.13
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 2.5

rCSI 3.4%

PRS 70.59
intestine goblet cell CL0019031

CSI 2.49

rCSI 2.21%

PRS 42.05
mucosal invariant T cell CL0000940

CSI 2.47

rCSI 2%

PRS 53.96
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.45

rCSI 6.38%

PRS 42.06

cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.0%

PRS 55.0%
mesenchymal stem cell CL0000134

CSI 0.2

rCSI 2.1%

PRS 59.6%
enterocyte of epithelium of large intestine CL0002071

CSI 0.2

rCSI 1.2%

PRS 57.7%
vein endothelial cell of respiratory system CL4033008

CSI 0.3

rCSI 1.7%

PRS 61.4%
epithelial cell of urethra CL1000296

CSI 0.3

rCSI 6.9%

PRS 69.1%
paneth cell of colon CL0009009

CSI 0.3

rCSI 2.9%

PRS 68.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.4

rCSI 2.2%

PRS 35.9%
enteroglial cell CL4040002

CSI 0.4

rCSI 2.0%

PRS 51.7%
type EC enteroendocrine cell CL0000577

CSI 0.4

rCSI 1.5%

PRS 55.9%
intestinal crypt stem cell of colon CL0009043

CSI 0.5

rCSI 3.6%

PRS 63.1%
collagen secreting cell CL0000667

CSI 0.5

rCSI 2.9%

PRS 69.5%
luminal cell of prostate epithelium CL0002340

CSI 0.5

rCSI 2.8%

PRS 58.3%
mesenchymal cell CL0008019

CSI 0.5

rCSI 1.4%

PRS 39.3%
intestinal tuft cell CL0019032

CSI 0.6

rCSI 0.9%

PRS 47.4%
myeloid dendritic cell, human CL0001057

CSI 0.6

rCSI 3.5%

PRS 74.8%
lung goblet cell CL1000143

CSI 0.7

rCSI 7.3%

PRS 75.9%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.7

rCSI 3.7%

PRS 74.2%
large pre-B-II cell CL0000957

CSI 0.7

rCSI 1.9%

PRS 57.6%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.7

rCSI 4.2%

PRS 67.6%
smooth muscle cell of prostate CL1000487

CSI 0.7

rCSI 4.3%

PRS 69.9%
corneal epithelial cell CL0000575

CSI 0.7

rCSI 2.1%

PRS 60.0%
megakaryocyte CL0000556

CSI 0.8

rCSI 3.3%

PRS 58.8%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 0.8

rCSI 1.3%

PRS 63.9%
deuterosomal cell CL4033044

CSI 0.8

rCSI 2.6%

PRS 52.7%
renal interstitial pericyte CL1001318

CSI 0.8

rCSI 2.1%

PRS 39.9%
paneth cell of epithelium of small intestine CL1000343

CSI 0.8

rCSI 2.2%

PRS 57.2%
T-helper 17 cell CL0000899

CSI 0.8

rCSI 0.6%

PRS 64.8%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.8

rCSI 1.0%

PRS 39.1%
stromal cell CL0000499

CSI 0.8

rCSI 2.4%

PRS 43.6%
tracheal goblet cell CL1000329

CSI 0.9

rCSI 1.9%

PRS 62.6%
mature alpha-beta T cell CL0000791

CSI 0.9

rCSI 3.1%

PRS 62.0%
parietal epithelial cell CL1000452

CSI 0.9

rCSI 2.3%

PRS 36.3%
M cell of gut CL0000682

CSI 0.9

rCSI 0.9%

PRS 57.9%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.9

rCSI 2.0%

PRS 41.6%
innate lymphoid cell CL0001065

CSI 0.9

rCSI 1.8%

PRS 49.6%
renal principal cell CL0005009

CSI 0.9

rCSI 2.3%

PRS 48.2%
skeletal muscle satellite stem cell CL0008011

CSI 0.9

rCSI 4.0%

PRS 66.4%
helper T cell CL0000912

CSI 1.0

rCSI 1.4%

PRS 51.9%
common dendritic progenitor CL0001029

CSI 1.0

rCSI 1.3%

PRS 52.4%
endothelial cell of uterus CL0009095

CSI 1.0

rCSI 7.4%

PRS 69.1%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.1

rCSI 2.9%

PRS 51.7%
enterocyte CL0000584

CSI 1.1

rCSI 1.7%

PRS 51.7%
kidney epithelial cell CL0002518

CSI 1.1

rCSI 2.0%

PRS 66.1%
colon goblet cell CL0009039

CSI 1.1

rCSI 2.6%

PRS 55.1%
mammary gland epithelial cell CL0002327

CSI 1.1

rCSI 3.8%

PRS 58.4%
small intestine goblet cell CL1000495

CSI 1.1

rCSI 2.4%

PRS 52.8%
memory T cell CL0000813

CSI 1.1

rCSI 2.1%

PRS 72.7%
Langerhans cell CL0000453

CSI 1.1

rCSI 1.7%

PRS 60.2%
choroid plexus epithelial cell CL0000706

CSI 1.1

rCSI 1.8%

PRS 34.1%
epicardial adipocyte CL1000309

CSI 1.1

rCSI 3.6%

PRS 45.2%
alveolar macrophage CL0000583

CSI 1.1

rCSI 1.9%

PRS 48.3%
kidney connecting tubule epithelial cell CL1000768

CSI 1.2

rCSI 2.9%

PRS 34.0%
fibroblast of cardiac tissue CL0002548

CSI 1.2

rCSI 5.5%

PRS 41.5%
serous secreting cell CL0000313

CSI 1.2

rCSI 5.8%

PRS 79.1%
tuft cell of colon CL0009041

CSI 1.2

rCSI 2.8%

PRS 61.0%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.2

rCSI 0.9%

PRS 41.6%
pulmonary alveolar type 1 cell CL0002062

CSI 1.3

rCSI 7.2%

PRS 45.2%
respiratory basal cell CL0002633

CSI 1.3

rCSI 1.3%

PRS 48.6%
stratified epithelial cell CL0000079

CSI 1.3

rCSI 7.9%

PRS 72.8%
endothelial cell of lymphatic vessel CL0002138

CSI 1.3

rCSI 2.6%

PRS 66.4%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.3

rCSI 6.6%

PRS 53.6%
lung neuroendocrine cell CL1000223

CSI 1.3

rCSI 2.0%

PRS 47.7%
fibroblast of breast CL4006000

CSI 1.3

rCSI 5.6%

PRS 65.3%
paneth cell CL0000510

CSI 1.4

rCSI 2.0%

PRS 60.1%
epithelial cell of lung CL0000082

CSI 1.4

rCSI 1.1%

PRS 41.4%
transit amplifying cell CL0009010

CSI 1.4

rCSI 2.1%

PRS 59.2%
T-helper 1 cell CL0000545

CSI 1.4

rCSI 2.5%

PRS 69.7%
pancreatic stellate cell CL0002410

CSI 1.4

rCSI 8.1%

PRS 53.8%
colon epithelial cell CL0011108

CSI 1.4

rCSI 1.5%

PRS 40.3%
alveolar type 1 fibroblast cell CL4028004

CSI 1.4

rCSI 1.5%

PRS 46.7%
pulmonary alveolar type 2 cell CL0002063

CSI 1.4

rCSI 2.2%

PRS 52.9%
lung macrophage CL1001603

CSI 1.4

rCSI 3.1%

PRS 49.1%
basal cell CL0000646

CSI 1.4

rCSI 1.9%

PRS 44.4%
retinal cone cell CL0000573

CSI 1.4

rCSI 2.3%

PRS 34.2%
keratocyte CL0002363

CSI 1.5

rCSI 3.5%

PRS 53.1%
endothelial cell of placenta CL0009092

CSI 1.5

rCSI 7.3%

PRS 54.5%
mucous neck cell CL0000651

CSI 1.5

rCSI 2.1%

PRS 56.5%
dendritic cell, human CL0001056

CSI 1.5

rCSI 2.3%

PRS 49.6%
group 3 innate lymphoid cell CL0001071

CSI 1.6

rCSI 1.2%

PRS 46.2%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.6

rCSI 1.9%

PRS 50.4%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.6

rCSI 2.2%

PRS 63.6%
pulmonary artery endothelial cell CL1001568

CSI 1.6

rCSI 2.2%

PRS 55.7%
tracheobronchial serous cell CL0019001

CSI 1.7

rCSI 7.1%

PRS 59.4%
blood vessel endothelial cell CL0000071

CSI 1.7

rCSI 3.4%

PRS 41.0%
sst GABAergic cortical interneuron CL4023017

CSI 1.7

rCSI 2.1%

PRS 29.1%
intrahepatic cholangiocyte CL0002538

CSI 1.7

rCSI 4.0%

PRS 58.8%
lung interstitial macrophage CL4033043

CSI 1.7

rCSI 3.8%

PRS 62.9%
bronchial goblet cell CL1000312

CSI 1.7

rCSI 6.8%

PRS 64.5%
monocyte CL0000576

CSI 1.7

rCSI 3.1%

PRS 65.2%
common myeloid progenitor CL0000049

CSI 1.7

rCSI 1.4%

PRS 43.4%
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.7

rCSI 3.2%

PRS 66.4%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.7

rCSI 1.0%

PRS 57.7%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 1.7

rCSI 7.9%

PRS 62.6%
intestinal epithelial cell CL0002563

CSI 1.7

rCSI 1.8%

PRS 42.5%
endocardial cell CL0002350

CSI 1.7

rCSI 8.3%

PRS 44.8%
perivascular cell CL4033054

CSI 1.8

rCSI 2.4%

PRS 47.6%
fallopian tube secretory epithelial cell CL4030006

CSI 1.8

rCSI 1.7%

PRS 43.4%
respiratory suprabasal cell CL4033048

CSI 1.8

rCSI 2.3%

PRS 47.6%
centrilobular region hepatocyte CL0019029

CSI 1.8

rCSI 4.7%

PRS 51.2%
ciliated epithelial cell CL0000067

CSI 1.8

rCSI 1.6%

PRS 32.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [B4GALT1](/details-gene/2683), or beta-1,4-galactosyltransferase 1, is a protein-coding gene located on chromosome 9p21.1. This enzyme is a key member of the galactosyltransferase family and plays a central role in the synthesis of N-acetyllactosamine, a precursor for many complex N-linked oligosaccharides on glycoproteins and glycolipids. Its primary function is transferring galactose from UDP-galactose to N-acetylglucosamine residues, a critical step in post-translational modification within the [Golgi apparatus](/details-go/GO:0005794) [Link](https://doi.org/10.1074/jbc.270.20.12170). Expression data indicates that **Overall**, [B4GALT1](/details-gene/2683) is a highly significant gene in diverse cell types, most notably in immune cells such as [plasmacytoid dendritic cell, human](/details-cell/CL0001058), and placental cells like [extravillous trophoblast](/details-cell/CL0008036). Deficiencies in this gene are associated with Congenital Disorder of Glycosylation, Type IId ([137060](https://omim.org/entry/137060)), highlighting its fundamental importance in human development and physiology [Link](https://doi.org/10.1172/jci14010). ## Cellular Roles and Expression Landscape The expression profile of [B4GALT1](/details-gene/2683) reveals its widespread importance across multiple biological systems, with a particular prominence in the immune system and placental tissues. **Overall**, the gene shows its highest significance in [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 42.10), suggesting a critical role in the glycosylation of proteins involved in innate immunity and antigen presentation. Its high significance is also observed in other professional antigen-presenting cells and macrophages, including [myeloid dendritic cell](/details-cell/CL0000782), [Hofbauer cell](/details-cell/CL3000001), and [tissue-resident macrophage](/details-cell/CL0000864). Beyond the immune system, [B4GALT1](/details-gene/2683) is a key marker for specialized cells at the fetal-maternal interface, with very high significance in [extravillous trophoblast](/details-cell/CL0008036) (CSI: 24.66). This is consistent with its known roles in [cell adhesion](/details-go/GO:0007155) and extracellular matrix organization, processes vital for placental implantation and function. The gene's relevance extends to antibody-producing cells like [IgG plasma cell](/details-cell/CL0000985) and [IgA plasma cell](/details-cell/CL0000987), as well as adaptive immune cells like [CD4-positive helper T cell](/details-cell/CL0000492). The broad expression in other tissues, including [squamous epithelial cell](/details-cell/CL0000076) and [cardiac muscle cell](/details-cell/CL0000746), underscores its foundational role as a 'housekeeping' enzyme for protein modification across the human body. ## Pathways and Molecular Function [B4GALT1](/details-gene/2683) functions primarily as a type II membrane-bound glycoprotein located in the trans-Golgi network. Its core molecular function is [beta-n-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity](/details-go/GO:0003831), which is essential for the [oligosaccharide biosynthetic process](/details-go/GO:0009312). This activity is a cornerstone of [Asparagine n-linked glycosylation](/details-reactome/R-HSA-446203), specifically in the elongation of N-glycan antennae. In the mammary gland, [B4GALT1](/details-gene/2683) associates with alpha-lactalbumin to form the lactose synthase complex, catalyzing the final step in the [lactose biosynthetic process](/details-go/GO:0005989). The functional consequences of its enzymatic activity are extensive. [B4GALT1](/details-gene/2683)-mediated glycosylation is implicated in a wide array of biological processes, including [cell adhesion](/details-go/GO:0007155), [extracellular matrix organization](/details-go/GO:0030198), and the [acute inflammatory response](/details-go/GO:0002526). Its role in the [immune system](/details-reactome/R-HSA-168256) is further supported by its involvement in [Neutrophil degranulation](/details-reactome/R-HSA-6798695) and [macrophage migration](/details-go/GO:1905517). Furthermore, it plays a specific role in [reproduction](/details-reactome/R-HSA-1474165), particularly in the [Binding of sperm to zona pellucida](/details-go/GO:0007339). Pathologically, defects in [B4GALT1](/details-gene/2683) lead to B4GALT1-CDG (CDG-2d), a severe congenital disorder of glycosylation, as annotated in the Reactome pathway [R-HSA-3656244](https://reactome.org/content/detail/R-HSA-3656244). ## Research Directions The diverse expression pattern and fundamental role of [B4GALT1](/details-gene/2683) in glycosylation open several avenues for future investigation. Altered glycosylation is a known hallmark of many diseases, including cancer and autoimmune disorders, making the regulation and function of [B4GALT1](/details-gene/2683) in specific cellular contexts a critical area of research. **Proposed Hypotheses:** 1. Given its exceptionally high significance in [plasmacytoid dendritic cell, human](/details-cell/CL0001058), [B4GALT1](/details-gene/2683) is likely essential for the proper glycosylation and function of key pattern recognition receptors (e.g., Toll-like receptors) or interferon-producing machinery, thereby controlling the antiviral innate immune response. 2. The high expression of [B4GALT1](/details-gene/2683) in [extravillous trophoblast](/details-cell/CL0008036) and its role in cell adhesion suggest that it modifies cell surface integrins or other adhesion molecules, directly mediating the process of trophoblast invasion into the uterine wall during placentation. Dysregulation of [B4GALT1](/details-gene/2683) in these cells may contribute to pathologies like pre-eclampsia. **Experimental Approach:** To test the first hypothesis regarding the role of [B4GALT1](/details-gene/2683) in pDC function, one could utilize a CRISPR-Cas9-based approach to knock out the gene in primary human pDCs or a pDC-like cell line. The functional consequences could be assessed by stimulating knockout and control cells with viral ligands (e.g., CpG oligonucleotides) and measuring the production of type I interferons (IFN-alpha/beta) via ELISA or RT-qPCR. Furthermore, mass spectrometry-based glycoproteomics could be employed to identify the specific cell surface proteins whose glycosylation state is altered by the loss of [B4GALT1](/details-gene/2683), potentially revealing novel substrates critical for pDC activation. **Therapeutic Potential:** As a ubiquitously expressed enzyme involved in a fundamental cellular process, systemic inhibition of [B4GALT1](/details-gene/2683) would likely cause severe toxicity, mirroring the pathology of congenital disorders of glycosylation ([137060](https://omim.org/entry/137060)). Therefore, it is not a suitable target for broad inhibition. However, aberrant glycosylation patterns ('glyco-epitopes') generated by enzymes like [B4GALT1](/details-gene/2683) are common features of cancer cells and can contribute to metastasis and immune evasion. Therapeutic strategies could therefore focus on targeting these tumor-specific glycan structures with monoclonal antibodies, antibody-drug conjugates, or CAR-T cells, rather than inhibiting the enzyme itself. This approach would offer greater specificity and potentially bypass the toxicity associated with systemic enzyme inhibition.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase

Genular Protein ID: 3365089358

Symbol: B4GT1_HUMAN

Name: Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase

UniProtKB Accession Codes:

P15291 B2R710 D3DRL2 Q12909 Q12910 Q12911 Q14456 Q14509 Q14523

Database IDs:

Citations:

PubMed ID: 3144273

Title: Identification of the full-length coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: beta 1,4-galactosyltransferase).

PubMed ID: 3144273

DOI: 10.1016/s0006-291x(88)80300-0

PubMed ID: 2124683

Title: Near identity of HeLa cell galactosyltransferase with the human placental enzyme.

PubMed ID: 2124683

DOI: 10.1093/nar/18.23.7174

PubMed ID: 1903938

Title: Genomic structure and expression of human beta-1,4-galactosyltransferase.

PubMed ID: 1903938

DOI: 10.1016/0006-291x(91)90423-5

PubMed ID: 1384956

Title: Complementary DNA cloning for galactosyltransferase associated with tumor and determination of antigenic epitopes recognized by specific monoclonal antibodies.

PubMed ID: 1384956

PubMed ID: 7579794

Title: The beta 1, 4-galactosyltransferase gene is post-transcriptionally regulated during differentiation of mouse F9 teratocarcinoma cells.

PubMed ID: 7579794

DOI: 10.1093/glycob/5.4.397

PubMed ID: 7540104

Title: Analysis of the sequences of human beta-1,4-galactosyltransferase cDNA clones.

PubMed ID: 7540104

DOI: 10.1016/1357-2725(94)00062-g

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 3094506

Title: Isolation of a cDNA coding for human galactosyltransferase.

PubMed ID: 3094506

DOI: 10.1016/s0006-291x(86)80094-8

PubMed ID: 3091013

Title: Isolation of galactosyltransferase from human milk and the determination of its N-terminal amino acid sequence.

PubMed ID: 3091013

DOI: 10.1016/0006-291x(86)90269-x

PubMed ID: 2120039

Title: Analysis of the substrate binding sites of human galactosyltransferase by protein engineering.

PubMed ID: 2120039

DOI: 10.1002/j.1460-2075.1990.tb07515.x

PubMed ID: 1714903

Title: Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase.

PubMed ID: 1714903

DOI: 10.1016/s0021-9258(18)98505-4

PubMed ID: 7744867

Title: Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins.

PubMed ID: 7744867

DOI: 10.1074/jbc.270.20.12170

PubMed ID: 10580128

Title: Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

PubMed ID: 10580128

DOI: 10.1016/s0304-4165(99)00168-3

PubMed ID: 11901181

Title: Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId.

PubMed ID: 11901181

DOI: 10.1172/jci14010

PubMed ID: 20378551

Title: Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.

PubMed ID: 20378551

DOI: 10.1074/jbc.m110.103184

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34855475

Title: Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen.

PubMed ID: 34855475

DOI: 10.1126/science.abe0348

PubMed ID: 16157350

Title: Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety.

PubMed ID: 16157350

DOI: 10.1016/j.jmb.2005.07.050

PubMed ID: 16497331

Title: Structural snapshots of beta-1,4-galactosyltransferase-I along the kinetic pathway.

PubMed ID: 16497331

DOI: 10.1016/j.jmb.2006.01.088

PubMed ID: 19106107

Title: Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.

PubMed ID: 19106107

DOI: 10.1074/jbc.m805782200

PubMed ID: 30653653

Title: Clinical and molecular diagnosis of non-phosphomannomutase 2 N-linked congenital disorders of glycosylation in Spain.

PubMed ID: 30653653

DOI: 10.1111/cge.13508

PubMed ID: 32157688

Title: B4GALT1-congenital disorders of glycosylation: Expansion of the phenotypic and molecular spectrum and review of the literature.

PubMed ID: 32157688

DOI: 10.1111/cge.13735

Sequence Information:

Length: 398
Mass: 43920
Checksum: 29B224C83C61E165
Sequence:

MRLREPLLSG SAAMPGASLQ RACRLLVAVC ALHLGVTLVY YLAGRDLSRL PQLVGVSTPL 
QGGSNSAAAI GQSSGELRTG GARPPPPLGA SSQPRPGGDS SPVVDSGPGP ASNLTSVPVP 
HTTALSLPAC PEESPLLVGP MLIEFNMPVD LELVAKQNPN VKMGGRYAPR DCVSPHKVAI 
IIPFRNRQEH LKYWLYYLHP VLQRQQLDYG IYVINQAGDT IFNRAKLLNV GFQEALKDYD 
YTCFVFSDVD LIPMNDHNAY RCFSQPRHIS VAMDKFGFSL PYVQYFGGVS ALSKQQFLTI 
NGFPNNYWGW GGEDDDIFNR LVFRGMSISR PNAVVGRCRM IRHSRDKKNE PNPQRFDRIA 
HTKETMLSDG LNSLTYQVLD VQRYPLYTQI TVDIGTPS

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	Colorectal cancer MONDO0005575
	Cornea UBERON0000964
	\|— Cornea Healthy UBERON0000964_PATO0000461
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Duodenum UBERON0002114
	Fallopian tube UBERON0003889
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sclera UBERON0001773
	\|— Sclera Healthy UBERON0001773_PATO0000461
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Trachea UBERON0003126
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: B4GALT1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification of the full-length coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: beta 1,4-galactosyltransferase). PubMed ID: 3144273

Near identity of HeLa cell galactosyltransferase with the human placental enzyme. PubMed ID: 2124683

Genomic structure and expression of human beta-1,4-galactosyltransferase. PubMed ID: 1903938

Complementary DNA cloning for galactosyltransferase associated with tumor and determination of antigenic epitopes recognized by specific monoclonal antibodies. PubMed ID: 1384956

The beta 1, 4-galactosyltransferase gene is post-transcriptionally regulated during differentiation of mouse F9 teratocarcinoma cells. PubMed ID: 7579794

Analysis of the sequences of human beta-1,4-galactosyltransferase cDNA clones. PubMed ID: 7540104

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

Isolation of a cDNA coding for human galactosyltransferase. PubMed ID: 3094506

Isolation of galactosyltransferase from human milk and the determination of its N-terminal amino acid sequence. PubMed ID: 3091013

Analysis of the substrate binding sites of human galactosyltransferase by protein engineering. PubMed ID: 2120039

Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase. PubMed ID: 1714903

Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins. PubMed ID: 7744867

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. PubMed ID: 10580128

Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId. PubMed ID: 11901181

Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells. PubMed ID: 20378551

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen. PubMed ID: 34855475

Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety. PubMed ID: 16157350

Structural snapshots of beta-1,4-galactosyltransferase-I along the kinetic pathway. PubMed ID: 16497331

Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. PubMed ID: 19106107

Clinical and molecular diagnosis of non-phosphomannomutase 2 N-linked congenital disorders of glycosylation in Spain. PubMed ID: 30653653

B4GALT1-congenital disorders of glycosylation: Expansion of the phenotypic and molecular spectrum and review of the literature. PubMed ID: 32157688