Gene AMY1C - ENSG00000187733 | NCBI Gene ID: 278

Details for: AMY1C

Gene ID: 278

Symbol: AMY1C

Ensembl ID: ENSG00000187733

Description: amylase alpha 1C

Associated with

Digestion
(R-HSA-8935690)
Digestion and absorption
(R-HSA-8963743)
Digestion of dietary carbohydrate
(R-HSA-189085)
Alpha-amylase activity
(GO:0004556)
Calcium ion binding
(GO:0005509)
Carbohydrate metabolic process
(GO:0005975)
Chloride ion binding
(GO:0031404)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Oligosaccharide metabolic process
(GO:0009311)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.98
Marker Score: 162032.5
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.68
Marker Score: 8263
Cell Name: progenitor cell (CL0011026)
Fold Change: 4.72
Marker Score: 30402
Cell Name: microglial cell (CL0000129)
Fold Change: 3.75
Marker Score: 6829
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.15
Marker Score: 3168
Cell Name: plasma cell (CL0000786)
Fold Change: 1.99
Marker Score: 2223
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.46
Marker Score: 694
Cell Name: B cell (CL0000236)
Fold Change: 1.28
Marker Score: 1217
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.16
Marker Score: 3995
Cell Name: goblet cell (CL0000160)
Fold Change: 1.05
Marker Score: 6949
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71790
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48018
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: T cell (CL0000084)
Fold Change: 0.96
Marker Score: 1662
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5351
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.88
Marker Score: 1433
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.85
Marker Score: 1931
Cell Name: mast cell (CL0000097)
Fold Change: 0.84
Marker Score: 489
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 714
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.78
Marker Score: 405
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1201.5
Cell Name: fibroblast (CL0000057)
Fold Change: 0.73
Marker Score: 701
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.68
Marker Score: 544
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.48
Marker Score: 247
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.48
Marker Score: 285
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.42
Marker Score: 379
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.27
Marker Score: 60
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.23
Marker Score: 58
Cell Name: macrophage (CL0000235)
Fold Change: 0.22
Marker Score: 243
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.19
Marker Score: 53
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.15
Marker Score: 58
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.13
Marker Score: 59
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.12
Marker Score: 58
Cell Name: naive T cell (CL0000898)
Fold Change: 0.12
Marker Score: 77
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.12
Marker Score: 53.5
Cell Name: Unknown (CL0000003)
Fold Change: 0.11
Marker Score: 330
Cell Name: pericyte (CL0000669)
Fold Change: 0.1
Marker Score: 60
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.1
Marker Score: 60
Cell Name: neutrophil (CL0000775)
Fold Change: 0.09
Marker Score: 52.5
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.09
Marker Score: 59
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.08
Marker Score: 57
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.07
Marker Score: 60
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.07
Marker Score: 115
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.07
Marker Score: 60
Cell Name: club cell (CL0000158)
Fold Change: 0.07
Marker Score: 81
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.07
Marker Score: 110
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.07
Marker Score: 573
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.07
Marker Score: 139
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.06
Marker Score: 43
Cell Name: monocyte (CL0000576)
Fold Change: 0.06
Marker Score: 74
Cell Name: stromal cell (CL0000499)
Fold Change: 0.05
Marker Score: 63.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.05
Marker Score: 57
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.05
Marker Score: 53
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.05
Marker Score: 58
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.05
Marker Score: 59
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.05
Marker Score: 68.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.05
Marker Score: 77
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.05
Marker Score: 59.5
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.04
Marker Score: 57
Cell Name: supporting cell (CL0000630)
Fold Change: 0.04
Marker Score: 76
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.04
Marker Score: 253
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.04
Marker Score: 81
Cell Name: basal cell (CL0000646)
Fold Change: 0.04
Marker Score: 50
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.04
Marker Score: 54
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.03
Marker Score: 60
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.03
Marker Score: 97
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.03
Marker Score: 60
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.03
Marker Score: 54
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.03
Marker Score: 53
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.02
Marker Score: 40
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.02
Marker Score: 60
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.02
Marker Score: 55
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.02
Marker Score: 53
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.02
Marker Score: 58
Cell Name: secretory cell (CL0000151)
Fold Change: 0.02
Marker Score: 39
Cell Name: lactocyte (CL0002325)
Fold Change: 0.02
Marker Score: 257
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.01
Marker Score: 55
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.01
Marker Score: 60
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.01
Marker Score: 38
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0
Marker Score: 43
Cell Name: cell in vitro (CL0001034)
Fold Change: 0
Marker Score: 118
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0
Marker Score: 60
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0
Marker Score: 60
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0
Marker Score: 60
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0
Marker Score: 56

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Other Information

Description

**Key characteristics:** * AMY1C is a glycoprotein with a molecular weight of approximately 120 kDa. * It is found in the cytoplasm of cells. * It is a transmembrane protein with two extracellular domains and two intracellular domains. * The extracellular domain is responsible for binding to amylose substrates. * The intracellular domain is responsible for the catalytic activity of the enzyme. **Pathways and functions:** * AMY1C is involved in a variety of cellular processes, including digestion, absorption, and metabolism. * It is involved in the hydrolysis of dietary carbohydrates into simpler sugars, which can be absorbed into the bloodstream. * It is also involved in the regulation of calcium ion concentrations in the cell. * It is a key enzyme in the exocytosis of proteins and glycoproteins from cells. **Clinical significance:** * Mutations in the AMY1C gene have been linked to amyloidosis, a rare genetic disorder characterized by the accumulation of amyloids in various tissues. * In amyloidosis, AMY1C is expressed in excess in certain cells, leading to the formation of amyloids. * Amyloidosis can cause damage to organs such as the kidneys, heart, and brain. * Development of new therapies for amyloidosis is an active area of research.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.