Details for: AMY1C

Gene ID: 278

Symbol: AMY1C

Ensembl ID: ENSG00000187733

Description: amylase alpha 1C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.0768
    Cell Significance Index: 9.4800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2570
    Cell Significance Index: 3.2500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.1101
    Cell Significance Index: 1.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0688
    Cell Significance Index: 0.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0253
    Cell Significance Index: 4.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0030
    Cell Significance Index: 0.1300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0016
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0017
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0043
    Cell Significance Index: -0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0046
    Cell Significance Index: -0.9200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0066
    Cell Significance Index: -0.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0138
    Cell Significance Index: -0.4500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0174
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0180
    Cell Significance Index: -0.6300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0189
    Cell Significance Index: -0.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0275
    Cell Significance Index: -0.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0300
    Cell Significance Index: -0.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0314
    Cell Significance Index: -0.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0328
    Cell Significance Index: -0.6500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0332
    Cell Significance Index: -0.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0384
    Cell Significance Index: -0.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0393
    Cell Significance Index: -0.9800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0394
    Cell Significance Index: -0.4000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0402
    Cell Significance Index: -0.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0407
    Cell Significance Index: -1.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0440
    Cell Significance Index: -0.6300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0445
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0460
    Cell Significance Index: -0.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0462
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0465
    Cell Significance Index: -0.4900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0474
    Cell Significance Index: -0.5600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0485
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0493
    Cell Significance Index: -1.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0497
    Cell Significance Index: -1.0600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0500
    Cell Significance Index: -0.5300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0506
    Cell Significance Index: -0.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0547
    Cell Significance Index: -0.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0549
    Cell Significance Index: -1.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0553
    Cell Significance Index: -1.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0560
    Cell Significance Index: -0.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0588
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0601
    Cell Significance Index: -1.1800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0633
    Cell Significance Index: -0.7700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0633
    Cell Significance Index: -0.5700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0654
    Cell Significance Index: -1.1100
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0655
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0656
    Cell Significance Index: -0.7300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0663
    Cell Significance Index: -0.6000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0728
    Cell Significance Index: -0.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0738
    Cell Significance Index: -1.8800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0745
    Cell Significance Index: -1.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0746
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0754
    Cell Significance Index: -0.9500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0774
    Cell Significance Index: -0.9800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0775
    Cell Significance Index: -1.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0779
    Cell Significance Index: -1.9000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0786
    Cell Significance Index: -0.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0805
    Cell Significance Index: -0.9600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0808
    Cell Significance Index: -0.9100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0811
    Cell Significance Index: -0.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0827
    Cell Significance Index: -1.9100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0847
    Cell Significance Index: -1.0300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0848
    Cell Significance Index: -0.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0867
    Cell Significance Index: -1.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0871
    Cell Significance Index: -1.0700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0888
    Cell Significance Index: -1.0300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0900
    Cell Significance Index: -1.0700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0912
    Cell Significance Index: -1.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0920
    Cell Significance Index: -1.1800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0922
    Cell Significance Index: -1.0300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0926
    Cell Significance Index: -1.1100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0930
    Cell Significance Index: -1.0300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0931
    Cell Significance Index: -1.1000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0938
    Cell Significance Index: -1.0300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0951
    Cell Significance Index: -1.0100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0952
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0964
    Cell Significance Index: -1.0300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0964
    Cell Significance Index: -1.0200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0970
    Cell Significance Index: -0.9200
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0970
    Cell Significance Index: -0.9000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0980
    Cell Significance Index: -1.0000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0985
    Cell Significance Index: -1.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0990
    Cell Significance Index: -1.1700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0995
    Cell Significance Index: -1.1500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1002
    Cell Significance Index: -1.1100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1003
    Cell Significance Index: -0.8300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1004
    Cell Significance Index: -0.9900
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.1034
    Cell Significance Index: -1.0200
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1042
    Cell Significance Index: -1.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1050
    Cell Significance Index: -0.9300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1059
    Cell Significance Index: -1.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1067
    Cell Significance Index: -0.6300
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.1068
    Cell Significance Index: -1.1000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1079
    Cell Significance Index: -1.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Amylase alpha 1C is a member of the amylase family, which is responsible for the degradation of starches and other complex carbohydrates into simpler sugars. The alpha 1C isoform is specifically involved in the breakdown of oligosaccharides, which are short-chain carbohydrates. This enzyme is also known to be involved in calcium ion binding, chloride ion binding, and carbohydrate metabolic processes, highlighting its importance in various cellular functions. **Pathways and Functions:** The AMY1C gene is associated with several key pathways, including: 1. **Alpha-amylase activity**: This is the primary function of AMY1C, where it breaks down starches and oligosaccharides into simpler sugars. 2. **Calcium ion binding**: AMY1C interacts with calcium ions, which are essential for the proper functioning of the enzyme. 3. **Carbohydrate metabolic process**: AMY1C is involved in the breakdown of carbohydrates, which is crucial for energy production and overall metabolic health. 4. **Digestion**: AMY1C plays a role in the digestion of dietary carbohydrates, which is essential for maintaining proper nutrition. 5. **Extracellular space**: AMY1C is expressed in various extracellular spaces, including the extracellular exosome and extracellular space, highlighting its role in maintaining cellular homeostasis. **Clinical Significance:** The AMY1C gene has significant implications for various diseases and disorders, including: 1. **Amylase deficiency**: Mutations in the AMY1C gene can lead to amylase deficiency, a condition characterized by impaired carbohydrate digestion and malabsorption. 2. **Neurological disorders**: The expression of AMY1C in neural cells suggests a potential link between this gene and neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune system dysfunction**: The expression of AMY1C in immune cells highlights its potential role in maintaining immune function and preventing autoimmune diseases. 4. **Cancer**: The expression of AMY1C in cancer cells suggests a potential role in cancer development and progression. In conclusion, the AMY1C gene plays a critical role in carbohydrate metabolism, immune function, and neurological processes. Further research is necessary to fully elucidate the function of this gene and its implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.