Details for: GOT1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.85
Marker Score: 63610 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.33
Marker Score: 2811 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.32
Marker Score: 4709 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.12
Marker Score: 1999.5 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.1
Marker Score: 5629 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.01
Marker Score: 3329 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.89
Marker Score: 2007 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.76
Marker Score: 929 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.73
Marker Score: 725 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.67
Marker Score: 548 - Cell Name: germ cell (CL0000586)
Fold Change: 1.62
Marker Score: 2828 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.54
Marker Score: 5476.5 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.54
Marker Score: 3878 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.51
Marker Score: 55659 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.5
Marker Score: 1202 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167757 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.43
Marker Score: 2210 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.42
Marker Score: 387 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.4
Marker Score: 5788 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.38
Marker Score: 1948 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.35
Marker Score: 13948 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.34
Marker Score: 11545 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.31
Marker Score: 4109 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.3
Marker Score: 11183 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.3
Marker Score: 304 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.26
Marker Score: 5458 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.24
Marker Score: 4420 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.2
Marker Score: 5744 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.19
Marker Score: 72889 - Cell Name: osteoclast (CL0000092)
Fold Change: 1.18
Marker Score: 590 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.18
Marker Score: 374 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.18
Marker Score: 2774 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.17
Marker Score: 7547 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.16
Marker Score: 4483 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.16
Marker Score: 893 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.15
Marker Score: 17991 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.14
Marker Score: 6103 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.1
Marker Score: 10448 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.08
Marker Score: 2472 - Cell Name: stem cell (CL0000034)
Fold Change: 1.07
Marker Score: 2535 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.03
Marker Score: 1024 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.01
Marker Score: 9466 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1
Marker Score: 1019 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71706 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47931 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.99
Marker Score: 663 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.99
Marker Score: 296 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.99
Marker Score: 3229 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30393 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.97
Marker Score: 519 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.97
Marker Score: 507 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.97
Marker Score: 36720 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.96
Marker Score: 14376 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.95
Marker Score: 5724 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.95
Marker Score: 1393 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2403 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.94
Marker Score: 2067 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 484 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 440 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.93
Marker Score: 3649 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.93
Marker Score: 1000 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.92
Marker Score: 996 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5244 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.92
Marker Score: 562 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.91
Marker Score: 18174 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.91
Marker Score: 942 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.9
Marker Score: 1195 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.89
Marker Score: 334.5 - Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.89
Marker Score: 369 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.88
Marker Score: 2517 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.87
Marker Score: 505 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.87
Marker Score: 6443 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308 - Cell Name: neuron (CL0000540)
Fold Change: 0.84
Marker Score: 3437 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.83
Marker Score: 883 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.82
Marker Score: 1259 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.81
Marker Score: 6344.5 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.81
Marker Score: 197 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.81
Marker Score: 3384 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.81
Marker Score: 676 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.8
Marker Score: 1143 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.8
Marker Score: 3328 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.79
Marker Score: 6025 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 312 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.78
Marker Score: 1246 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 590 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.77
Marker Score: 423 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.76
Marker Score: 851 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.76
Marker Score: 514 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.76
Marker Score: 1541 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.76
Marker Score: 1581 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.76
Marker Score: 221 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.75
Marker Score: 515 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.75
Marker Score: 1196 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.74
Marker Score: 464 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.74
Marker Score: 248 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.73
Marker Score: 1799
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Other Information
Genular Protein ID: 3606885451
Symbol: AATC_HUMAN
Name: Cysteine aminotransferase, cytoplasmic
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1974457
Title: Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection.
PubMed ID: 1974457
DOI: 10.1021/bi00474a011
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2241899
Title: The amino acid sequence of cytosolic aspartate aminotransferase from human liver.
PubMed ID: 2241899
DOI: 10.1042/bj2700651
PubMed ID: 16039064
Title: Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients.
PubMed ID: 16039064
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21900944
Title: Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels.
PubMed ID: 21900944
DOI: 10.1038/jhg.2011.105
PubMed ID: 22633534
Title: Relationship between glutamate, GOT and GPT levels in maternal and fetal blood: a potential mechanism for fetal neuroprotection.
PubMed ID: 22633534
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27827456
Title: 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium.
PubMed ID: 27827456
DOI: 10.1038/srep36749
Sequence Information:
- Length: 413
- Mass: 46248
- Checksum: 69FE68BF0C045219
- Sequence:
MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV LPVVKKVEQK IANDNSLNHE YLPILGLAEF RSCASRLALG DDSPALKEKR VGGVQSLGGT GALRIGADFL ARWYNGTNNK NTPVYVSSPT WENHNAVFSA AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN APEFSIVVLH ACAHNPTGID PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA IRYFVSEGFE FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT WNHITDQIGM FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY VATSIHEAVT KIQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.