Details for: GPR3

Gene ID: 2827

Symbol: GPR3

Ensembl ID: ENSG00000181773

Description: G protein-coupled receptor 3

Associated with

  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Cytoplasm
    (GO:0005737)
  • G protein-coupled receptor activity
    (GO:0004930)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of camp-mediated signaling
    (GO:0043950)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Protein binding
    (GO:0005515)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of meiotic nuclear division
    (GO:0040020)
  • Regulation of metabolic process
    (GO:0019222)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.23
    Marker Score: 2338
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.09
    Marker Score: 795
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.04
    Marker Score: 2144
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14571
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9
    Marker Score: 611
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1783
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2977
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.6
    Marker Score: 191
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.6
    Marker Score: 188
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 335.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.52
    Marker Score: 742
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 236
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.43
    Marker Score: 247
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.41
    Marker Score: 165
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.39
    Marker Score: 233
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.36
    Marker Score: 349
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.34
    Marker Score: 2233
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 104
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.32
    Marker Score: 116
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 136
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.29
    Marker Score: 208
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.29
    Marker Score: 293
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 117
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.27
    Marker Score: 150
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.27
    Marker Score: 140
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.26
    Marker Score: 92
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 64
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.23
    Marker Score: 317
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 508
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.21
    Marker Score: 87
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.21
    Marker Score: 137
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.19
    Marker Score: 179
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.17
    Marker Score: 212
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.17
    Marker Score: 172
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.16
    Marker Score: 168
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 106
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.15
    Marker Score: 608
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 229
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.15
    Marker Score: 179
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.13
    Marker Score: 213
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.13
    Marker Score: 4698
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.12
    Marker Score: 106
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.12
    Marker Score: 458
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.12
    Marker Score: 244
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.12
    Marker Score: 122
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1187.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.1
    Marker Score: 194.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.1
    Marker Score: 142
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 133
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 80
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.09
    Marker Score: 212
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.08
    Marker Score: 56.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.08
    Marker Score: 82.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.08
    Marker Score: 51.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.08
    Marker Score: 133
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.08
    Marker Score: 319
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.07
    Marker Score: 91
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.07
    Marker Score: 19

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Other Information

**Key characteristics:** * GPR3 is a transmembrane protein with a single extracellular domain and seven transmembrane domains. * It is a member of the GPCR superfamily, which are characterized by their ability to bind to G proteins. * GPR3 is a ligand-gated channel, meaning that it opens or closes when a specific ligand binds to it. * It is expressed in high levels in immune cells, such as macrophages and dendritic cells. * It is also expressed in various cell types, including endothelial cells, hepatocytes, and cancer cells. **Pathways and functions:** * GPR3 is a key regulator of the cyclic AMP (cAMP) pathway, a signaling pathway that is involved in a variety of cellular processes, including inflammation, metabolism, and cell proliferation. * Activation of GPR3 by its ligand, 12-lipoxygenase A (12-LOX), leads to the activation of the cAMP pathway. * The cAMP pathway is a major regulator of inflammation, as it can induce the production of pro-inflammatory cytokines and chemokines. * GPR3 also plays a role in the regulation of cold-induced thermogenesis, positive regulation of camp-mediated signaling, and positive regulation of cold-induced thermogenesis. **Clinical significance:** * Mutations in GPR3 have been linked to a number of human diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. * Targeting GPR3 has been explored as a therapeutic strategy for these diseases. * A number of drugs that block the activity of GPR3 have been developed and tested in clinical trials for the treatment of inflammatory diseases, but none have been found to be effective. **Conclusion:** GPR3 is a key regulator of inflammation, metabolism, and cell proliferation. Its expression and activity are regulated by a variety of factors, including the cAMP pathway and other signaling pathways. Mutations in GPR3 have been linked to a number of human diseases, and targeting GPR3 has been explored as a therapeutic strategy for these diseases.

Genular Protein ID: 1830285704

Symbol: GPR3_HUMAN

Name: G-protein coupled receptor 3

UniProtKB Accession Codes:

P46089 A8K570

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8530049

Title: Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.

PubMed ID: 8530049

DOI: 10.1006/geno.1995.1154

PubMed ID: 7698767

Title: Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system.

PubMed ID: 7698767

DOI: 10.1006/geno.1994.1635

PubMed ID: 7639700

Title: Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.

PubMed ID: 7639700

DOI: 10.1042/bj3090837

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851889

Title: Cloning of human genes encoding novel G protein-coupled receptors.

PubMed ID: 7851889

DOI: 10.1006/geno.1994.1549

PubMed ID: 12220620

Title: Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.

PubMed ID: 12220620

DOI: 10.1016/s0898-6568(02)00041-4

PubMed ID: 19286662

Title: Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.

PubMed ID: 19286662

DOI: 10.1074/jbc.m806516200

PubMed ID: 19213921

Title: The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.

PubMed ID: 19213921

DOI: 10.1126/science.1160649

PubMed ID: 34048700

Title: Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.

PubMed ID: 34048700

DOI: 10.1016/j.cell.2021.04.037

Sequence Information:

  • Length: 330
  • Mass: 35010
  • Checksum: 0F82E89200968D1E
  • Sequence:
    • MMWGAGSPLA WLSAGSGNVN VSSVGPAEGP TGPAAPLPSP KAWDVVLCIS GTLVSCENAL 
VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAV FCIGSAEMSL VLVGVLAMAF 
TASIGSLLAI TVDRYLSLYN ALTYYSETTV TRTYVMLALV WGGALGLGLL PVLAWNCLDG 
LTTCGVVYPL SKNHLVVLAI AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV 
ATRKGIATLA VVLGAFAACW LPFTVYCLLG DAHSPPLYTY LTLLPATYNS MINPIIYAFR 
NQDVQKVLWA VCCCCSSSKI PFRSRSPSDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.