Details for: IGHV4 4

Gene ID: 28401

Symbol: IGHV4 4

Ensembl ID: ENSG00000276775

Description: immunoglobulin heavy variable 4-4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,822
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.61
    Marker Score: 1,890
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.26
    Marker Score: 343
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.25
    Marker Score: 197
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.17
    Marker Score: 435
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.12
    Marker Score: 293
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.1
    Marker Score: 166
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.09
    Marker Score: 1,023
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.08
    Marker Score: 66
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.08
    Marker Score: 176
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.07
    Marker Score: 59
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.06
    Marker Score: 129
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.03
    Marker Score: 58
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.03
    Marker Score: 6
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 37
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.02
    Marker Score: 48
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 37
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 494
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 404
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.01
    Marker Score: 11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure:** The IGHV4-4 gene is a member of the immunoglobulin heavy chain (IGH) gene family, which consists of four variable (V) regions (VH, VL, VH2, and VH3). The IGHV4-4 gene is characterized by its unique VH region, which is distinct from other IGHV genes. 2. **Expression patterns:** The IGHV4-4 gene is significantly expressed in various cell types, including plasmablasts, natural killer cells, megakaryocytes, and certain types of immune cells, such as CD16-positive and CD56-dim natural killer cells. 3. **Antibody production:** The IGHV4-4 gene is involved in the production of antibodies, which are critical for recognizing and eliminating pathogens. **Pathways and Functions:** 1. **Antigen binding:** The IGHV4-4 gene plays a crucial role in antigen binding, which is essential for the recognition of pathogens by the immune system. 2. **Immunoglobulin complex formation:** The IGHV4-4 gene is involved in the formation of immunoglobulin complexes, which are essential for the activation of the complement system and the elimination of pathogens. 3. **Immunoglobulin-mediated immune response:** The IGHV4-4 gene is involved in the immunoglobulin-mediated immune response, which is critical for the recognition and elimination of pathogens. 4. **Cell signaling:** The IGHV4-4 gene is involved in cell signaling, which is essential for the activation of immune cells and the regulation of immune responses. **Clinical Significance:** 1. **Immunodeficiency disorders:** Mutations in the IGHV4-4 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune diseases:** The IGHV4-4 gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 3. **Cancer:** The IGHV4-4 gene has been associated with certain types of cancer, such as multiple myeloma, where the immune system is compromised. 4. **Vaccine development:** The IGHV4-4 gene has been used as a target for vaccine development, as it is involved in the production of antibodies against specific pathogens. In conclusion, the IGHV4-4 gene is a critical component of the human immune system, and its dysregulation has been associated with various immunodeficiency disorders, autoimmune diseases, and cancers. Further research is needed to fully understand the mechanisms underlying the IGHV4-4 gene and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.