Details for: IGHV3 15

Gene ID: 28448

Symbol: IGHV3 15

Ensembl ID: ENSG00000211943

Description: immunoglobulin heavy variable 3-15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.6701
    Cell Significance Index: 18.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5526
    Cell Significance Index: 8.5500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4680
    Cell Significance Index: 6.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4126
    Cell Significance Index: 10.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0082
    Cell Significance Index: -1.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0183
    Cell Significance Index: -3.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0235
    Cell Significance Index: -2.4000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0255
    Cell Significance Index: -0.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0297
    Cell Significance Index: -0.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0524
    Cell Significance Index: -3.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0566
    Cell Significance Index: -1.3700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0581
    Cell Significance Index: -0.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0610
    Cell Significance Index: -1.6600
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0641
    Cell Significance Index: -0.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0643
    Cell Significance Index: -4.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0667
    Cell Significance Index: -3.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0759
    Cell Significance Index: -9.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0839
    Cell Significance Index: -0.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0841
    Cell Significance Index: -2.1000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1069
    Cell Significance Index: -0.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1297
    Cell Significance Index: -3.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1302
    Cell Significance Index: -6.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1319
    Cell Significance Index: -9.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1336
    Cell Significance Index: -4.2800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1345
    Cell Significance Index: -1.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1362
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1364
    Cell Significance Index: -23.2900
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.1501
    Cell Significance Index: -1.4900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1688
    Cell Significance Index: -1.6200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1731
    Cell Significance Index: -2.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1751
    Cell Significance Index: -2.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1757
    Cell Significance Index: -6.4500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1778
    Cell Significance Index: -1.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1868
    Cell Significance Index: -4.7600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1878
    Cell Significance Index: -2.2200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1907
    Cell Significance Index: -2.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1920
    Cell Significance Index: -3.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1944
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2026
    Cell Significance Index: -23.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2045
    Cell Significance Index: -3.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2057
    Cell Significance Index: -2.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2073
    Cell Significance Index: -2.8200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2085
    Cell Significance Index: -2.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2159
    Cell Significance Index: -2.9600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2205
    Cell Significance Index: -1.8500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2237
    Cell Significance Index: -1.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2272
    Cell Significance Index: -2.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2343
    Cell Significance Index: -3.0000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2372
    Cell Significance Index: -4.0600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2386
    Cell Significance Index: -3.1200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2501
    Cell Significance Index: -3.0400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2545
    Cell Significance Index: -2.6800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2599
    Cell Significance Index: -2.2200
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.2681
    Cell Significance Index: -2.6500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2692
    Cell Significance Index: -3.2500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2711
    Cell Significance Index: -3.1200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2730
    Cell Significance Index: -3.4500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2786
    Cell Significance Index: -2.3000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2792
    Cell Significance Index: -2.8900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2872
    Cell Significance Index: -2.6700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2884
    Cell Significance Index: -3.1600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2906
    Cell Significance Index: -2.0900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2977
    Cell Significance Index: -3.3700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2985
    Cell Significance Index: -4.1400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3055
    Cell Significance Index: -3.6100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3114
    Cell Significance Index: -4.0000
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.3140
    Cell Significance Index: -3.3900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3156
    Cell Significance Index: -3.8100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3200
    Cell Significance Index: -4.6800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3214
    Cell Significance Index: -3.0600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3222
    Cell Significance Index: -3.3900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3234
    Cell Significance Index: -4.0400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3252
    Cell Significance Index: -3.3200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.3258
    Cell Significance Index: -3.3700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.3268
    Cell Significance Index: -3.2000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3285
    Cell Significance Index: -3.4900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3300
    Cell Significance Index: -4.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3300
    Cell Significance Index: -9.4600
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.3339
    Cell Significance Index: -2.3500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3339
    Cell Significance Index: -3.3900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3346
    Cell Significance Index: -3.6600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.3385
    Cell Significance Index: -3.8400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3397
    Cell Significance Index: -3.9500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3409
    Cell Significance Index: -4.1500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.3435
    Cell Significance Index: -3.2500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3502
    Cell Significance Index: -3.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3541
    Cell Significance Index: -8.1800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3571
    Cell Significance Index: -4.2200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3571
    Cell Significance Index: -3.8500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3577
    Cell Significance Index: -3.9600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3587
    Cell Significance Index: -4.7200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3591
    Cell Significance Index: -4.0800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3624
    Cell Significance Index: -4.1700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3644
    Cell Significance Index: -3.2500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3647
    Cell Significance Index: -3.8800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.3705
    Cell Significance Index: -3.6600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3709
    Cell Significance Index: -4.0900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3730
    Cell Significance Index: -3.6800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.3736
    Cell Significance Index: -3.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** IGHV3-15 is located on chromosome 14q32.11, which is a region known for containing the genes encoding the heavy chains of immunoglobulins. The gene consists of a single coding exon that encodes the variable region of the heavy chain. 2. **Expression Pattern:** IGHV3-15 is highly expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, early T lineage precursor cells, and natural killer cells. This widespread expression suggests a critical role in the development and function of the immune system. 3. **Function:** IGHV3-15 encodes the variable region of the heavy chain of immunoglobulins, which is essential for recognizing and binding to specific antigens. This binding event triggers a cascade of signaling pathways that lead to the activation of immune cells and the initiation of an immune response. **Pathways and Functions:** 1. **Antigen Binding:** IGHV3-15 plays a crucial role in the binding of immunoglobulins to specific antigens. The variable region of the heavy chain, encoded by IGHV3-15, recognizes and binds to antigens, triggering a signaling cascade that leads to the activation of immune cells. 2. **Immunoglobulin Complex Formation:** IGHV3-15 is a key component of the immunoglobulin complex, which is formed by the combination of heavy and light chains. The immunoglobulin complex is essential for the recognition and binding of antigens. 3. **Immunoglobulin Mediated Immune Response:** IGHV3-15 is involved in the immunoglobulin-mediated immune response, which is a critical component of the adaptive immune system. The binding of immunoglobulins to antigens triggers a signaling cascade that leads to the activation of immune cells and the initiation of an immune response. 4. **Plasma Membrane:** IGHV3-15 is expressed on the surface of plasma membrane, where it plays a critical role in the recognition and binding of antigens. **Clinical Significance:** IGHV3-15 has significant clinical implications in the context of immune-mediated diseases, such as autoimmune disorders and cancer. Abnormal expression or mutations in IGHV3-15 can lead to the development of autoimmune disorders, such as rheumatoid arthritis and lupus. Additionally, IGHV3-15 has been implicated in the development of certain types of cancer, such as chronic lymphocytic leukemia (CLL) and multiple myeloma. In conclusion, IGHV3-15 is a critical gene that plays a central role in the development and function of the immune system. Its widespread expression and involvement in various immune-related pathways highlight its importance in the context of immune-mediated diseases. Further research is needed to fully understand the mechanisms by which IGHV3-15 contributes to immune function and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.