IGHV3 13 | ENSG00000211942 | NCBI 28449

Details for: IGHV3 13

Gene ID: 28449

Symbol: IGHV3 13

Ensembl ID: ENSG00000211942

Description: immunoglobulin heavy variable 3-13

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: stromal cell (CL0000499)
Fold Change: 1.6976
Cell Significance Index: 17.3500
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.7995
Cell Significance Index: 8.9400
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.3548
Cell Significance Index: 4.8700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0957
Cell Significance Index: 1.4800
Cell Name: lymphocyte of B lineage (CL0000945)
Fold Change: -0.0371
Cell Significance Index: -0.2800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0599
Cell Significance Index: -0.8700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0668
Cell Significance Index: -6.8300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0675
Cell Significance Index: -1.6400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0842
Cell Significance Index: -2.1000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1393
Cell Significance Index: -3.7300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1837
Cell Significance Index: -2.0900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2123
Cell Significance Index: -13.3800
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.2454
Cell Significance Index: -1.3700
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.2497
Cell Significance Index: -3.6400
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2664
Cell Significance Index: -3.3000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2670
Cell Significance Index: -6.8200
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2946
Cell Significance Index: -5.7600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2986
Cell Significance Index: -13.9200
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.3021
Cell Significance Index: -4.2400
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3127
Cell Significance Index: -5.0700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.3450
Cell Significance Index: -8.7900
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.3518
Cell Significance Index: -4.2800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3527
Cell Significance Index: -10.1100
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3557
Cell Significance Index: -4.1900
Cell Name: club cell (CL0000158)
Fold Change: -0.3598
Cell Significance Index: -3.9200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3603
Cell Significance Index: -6.6600
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.3625
Cell Significance Index: -3.8000
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3639
Cell Significance Index: -6.2200
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.3672
Cell Significance Index: -2.4500
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3740
Cell Significance Index: -3.5900
Cell Name: monocyte (CL0000576)
Fold Change: -0.3889
Cell Significance Index: -4.4800
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.3894
Cell Significance Index: -3.8100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4129
Cell Significance Index: -4.8800
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.4206
Cell Significance Index: -5.5000
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4258
Cell Significance Index: -5.5100
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.4383
Cell Significance Index: -4.5600
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.4427
Cell Significance Index: -5.6100
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.4468
Cell Significance Index: -4.6000
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.4567
Cell Significance Index: -4.8800
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: -0.4572
Cell Significance Index: -4.8800
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.4586
Cell Significance Index: -5.1000
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.4594
Cell Significance Index: -4.2200
Cell Name: alveolar type 1 fibroblast cell (CL4028004)
Fold Change: -0.4611
Cell Significance Index: -4.8800
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.4639
Cell Significance Index: -6.1700
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.4653
Cell Significance Index: -4.8200
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.4801
Cell Significance Index: -4.2300
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.4817
Cell Significance Index: -4.8900
Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.4839
Cell Significance Index: -4.2300
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4858
Cell Significance Index: -5.8600
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.4863
Cell Significance Index: -5.6500
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.4963
Cell Significance Index: -4.0500
Cell Name: plasma cell (CL0000786)
Fold Change: -0.5039
Cell Significance Index: -5.6300
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.5109
Cell Significance Index: -5.0400
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.5173
Cell Significance Index: -4.2700
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.5180
Cell Significance Index: -6.1500
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5201
Cell Significance Index: -5.5300
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5221
Cell Significance Index: -5.7800
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.5322
Cell Significance Index: -5.2600
Cell Name: thymocyte (CL0000893)
Fold Change: -0.5326
Cell Significance Index: -6.7300
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.5334
Cell Significance Index: -7.0000
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.5361
Cell Significance Index: -6.1700
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.5398
Cell Significance Index: -5.8200
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.5422
Cell Significance Index: -6.1100
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.5576
Cell Significance Index: -6.0900
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.5617
Cell Significance Index: -6.0400
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: -0.5636
Cell Significance Index: -4.2700
Cell Name: glial cell (CL0000125)
Fold Change: -0.5659
Cell Significance Index: -6.2000
Cell Name: mucus secreting cell (CL0000319)
Fold Change: -0.5688
Cell Significance Index: -5.8100
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.5723
Cell Significance Index: -5.8100
Cell Name: platelet (CL0000233)
Fold Change: -0.5725
Cell Significance Index: -5.8900
Cell Name: promonocyte (CL0000559)
Fold Change: -0.5758
Cell Significance Index: -6.1500
Cell Name: myelocyte (CL0002193)
Fold Change: -0.5784
Cell Significance Index: -6.1800
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.5912
Cell Significance Index: -4.8900
Cell Name: T cell (CL0000084)
Fold Change: -0.5933
Cell Significance Index: -7.0100
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.6040
Cell Significance Index: -6.6600
Cell Name: osteoclast (CL0000092)
Fold Change: -0.6044
Cell Significance Index: -6.1700
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.6104
Cell Significance Index: -5.6400
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.6128
Cell Significance Index: -5.8900
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.6197
Cell Significance Index: -7.0400
Cell Name: naive B cell (CL0000788)
Fold Change: -0.6202
Cell Significance Index: -6.5300
Cell Name: blood cell (CL0000081)
Fold Change: -0.6207
Cell Significance Index: -5.2900
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.6262
Cell Significance Index: -5.8300
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.6279
Cell Significance Index: -7.4200
Cell Name: mast cell (CL0000097)
Fold Change: -0.6330
Cell Significance Index: -8.3300
Cell Name: immature B cell (CL0000816)
Fold Change: -0.6389
Cell Significance Index: -6.0500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.6432
Cell Significance Index: -10.9300
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.6437
Cell Significance Index: -6.2800
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.6460
Cell Significance Index: -7.1600
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.6516
Cell Significance Index: -6.9200
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.6530
Cell Significance Index: -7.0800
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.6570
Cell Significance Index: -5.8600
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.6570
Cell Significance Index: -5.2800
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.6598
Cell Significance Index: -6.9600
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.6641
Cell Significance Index: -8.6700
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.6666
Cell Significance Index: -6.2100
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.6677
Cell Significance Index: -5.8400
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: -0.6753
Cell Significance Index: -5.8600
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.6772
Cell Significance Index: -6.0500
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.6783
Cell Significance Index: -5.3200
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.6825
Cell Significance Index: -6.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Immunoglobulin structure**: The IGHV3-13 gene encodes for the heavy chain variable region of the Ig molecule, which is composed of three domains (VH, VL, and CH). This region is responsible for antigen recognition and binding. 2. **Antigen binding**: The IGHV3-13 gene is involved in the binding of antigens to the B cell receptor (BCR), leading to the activation of B cells and the initiation of the immune response. 3. **Cellular expression**: The IGHV3-13 gene is significantly expressed in various cell types, including endothelial cells, granulocytes, and hematopoietic cells. 4. **Pathway involvement**: The IGHV3-13 gene is involved in multiple signaling pathways, including the activation of the BCR, the complement cascade, and the regulation of actin dynamics for phagocytic cup formation. **Pathways and Functions** 1. **Adaptive immune system**: The IGHV3-13 gene plays a crucial role in the adaptive immune system by encoding for the heavy chain variable region of the Ig molecule, which is responsible for antigen recognition and binding. 2. **Anti-inflammatory response**: The IGHV3-13 gene is involved in the anti-inflammatory response by regulating the activation of B cells and the production of anti-inflammatory cytokines. 3. **Antigen activation**: The IGHV3-13 gene is involved in the activation of B cells by antigen binding, leading to the production of antibodies and the initiation of the immune response. 4. **Complement cascade**: The IGHV3-13 gene is involved in the regulation of the complement cascade, which is a crucial component of the innate immune system. 5. **Phagocytosis**: The IGHV3-13 gene is involved in the regulation of actin dynamics for phagocytic cup formation, which is essential for the clearance of pathogens and foreign particles. **Clinical Significance** 1. **Leishmania infection**: The IGHV3-13 gene is significantly involved in the pathogenesis of Leishmania infections, where it plays a crucial role in the recognition and binding of antigens to B cells. 2. **Parasitic infections**: The IGHV3-13 gene is involved in the pathogenesis of various parasitic infections, including Leishmania, where it regulates the activation of B cells and the production of anti-parasitic antibodies. 3. **Immunodeficiency diseases**: The IGHV3-13 gene is involved in the pathogenesis of immunodeficiency diseases, where it regulates the activation of B cells and the production of antibodies. 4. **Cancer**: The IGHV3-13 gene is involved in the pathogenesis of various cancers, including B-cell lymphomas, where it regulates the activation of B cells and the production of anti-tumor antibodies. In conclusion, the IGHV3-13 gene plays a crucial role in the adaptive immune system, regulating the recognition and binding of antigens to B cells and the initiation of the immune response. Its significance extends to various diseases, including Leishmania infections, parasitic infections, immunodeficiency diseases, and cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.