IGHV3 11 | ENSG00000211941 | NCBI 28450

Details for: IGHV3 11

Gene ID: 28450

Symbol: IGHV3 11

Ensembl ID: ENSG00000211941

Description: immunoglobulin heavy variable 3-11

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.3316
Cell Significance Index: 5.1300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.1570
Cell Significance Index: 2.2800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0041
Cell Significance Index: -3.0900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0322
Cell Significance Index: -3.2900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0366
Cell Significance Index: -0.9200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0474
Cell Significance Index: -1.2900
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0493
Cell Significance Index: -0.7000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0579
Cell Significance Index: -3.5500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0615
Cell Significance Index: -1.6500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0755
Cell Significance Index: -9.7500
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1039
Cell Significance Index: -1.2900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1070
Cell Significance Index: -1.2200
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.1136
Cell Significance Index: -1.2700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1296
Cell Significance Index: -9.6600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1350
Cell Significance Index: -3.4500
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.1470
Cell Significance Index: -1.6700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1492
Cell Significance Index: -3.7200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1563
Cell Significance Index: -1.9800
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.1628
Cell Significance Index: -1.1700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1670
Cell Significance Index: -4.0500
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1675
Cell Significance Index: -1.9800
Cell Name: stromal cell (CL0000499)
Fold Change: -0.1718
Cell Significance Index: -1.7600
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: -0.1779
Cell Significance Index: -1.6500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1898
Cell Significance Index: -3.7100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1915
Cell Significance Index: -4.8800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1924
Cell Significance Index: -8.9700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1934
Cell Significance Index: -1.5800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1948
Cell Significance Index: -3.6000
Cell Name: monocyte (CL0000576)
Fold Change: -0.1999
Cell Significance Index: -2.3000
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2153
Cell Significance Index: -2.4100
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2231
Cell Significance Index: -2.6300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2237
Cell Significance Index: -1.4900
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.2277
Cell Significance Index: -1.8800
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2282
Cell Significance Index: -3.9000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2315
Cell Significance Index: -3.1800
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.2342
Cell Significance Index: -2.7800
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2358
Cell Significance Index: -4.0100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2363
Cell Significance Index: -3.0900
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2365
Cell Significance Index: -3.0600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2393
Cell Significance Index: -3.8800
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.2470
Cell Significance Index: -1.9900
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.2610
Cell Significance Index: -3.6200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2684
Cell Significance Index: -13.9500
Cell Name: thymocyte (CL0000893)
Fold Change: -0.2699
Cell Significance Index: -3.4100
Cell Name: eosinophil (CL0000771)
Fold Change: -0.2811
Cell Significance Index: -2.4900
Cell Name: plasmablast (CL0000980)
Fold Change: -0.2877
Cell Significance Index: -2.6700
Cell Name: naive B cell (CL0000788)
Fold Change: -0.2906
Cell Significance Index: -3.0600
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.2942
Cell Significance Index: -3.3300
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.2961
Cell Significance Index: -3.2700
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.2990
Cell Significance Index: -2.9300
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3073
Cell Significance Index: -3.1200
Cell Name: myelocyte (CL0002193)
Fold Change: -0.3079
Cell Significance Index: -3.2900
Cell Name: promonocyte (CL0000559)
Fold Change: -0.3080
Cell Significance Index: -3.2900
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3099
Cell Significance Index: -3.3900
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.3106
Cell Significance Index: -3.4100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.3168
Cell Significance Index: -4.3100
Cell Name: granulocyte (CL0000094)
Fold Change: -0.3225
Cell Significance Index: -3.8900
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3262
Cell Significance Index: -3.4700
Cell Name: glial cell (CL0000125)
Fold Change: -0.3277
Cell Significance Index: -3.5900
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3322
Cell Significance Index: -4.3600
Cell Name: muscle cell (CL0000187)
Fold Change: -0.3324
Cell Significance Index: -3.1800
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3365
Cell Significance Index: -3.2300
Cell Name: acinar cell (CL0000622)
Fold Change: -0.3376
Cell Significance Index: -4.2400
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.3378
Cell Significance Index: -2.9100
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.3477
Cell Significance Index: -3.3100
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.3495
Cell Significance Index: -4.4900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3502
Cell Significance Index: -10.0400
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.3527
Cell Significance Index: -3.5800
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.3571
Cell Significance Index: -3.8500
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.3585
Cell Significance Index: -4.6800
Cell Name: paneth cell (CL0000510)
Fold Change: -0.3596
Cell Significance Index: -3.7200
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.3600
Cell Significance Index: -4.3800
Cell Name: peg cell (CL4033014)
Fold Change: -0.3606
Cell Significance Index: -8.3300
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.3609
Cell Significance Index: -3.5600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3628
Cell Significance Index: -17.0500
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3636
Cell Significance Index: -3.9100
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.3640
Cell Significance Index: -4.0300
Cell Name: B cell (CL0000236)
Fold Change: -0.3647
Cell Significance Index: -4.3100
Cell Name: blood cell (CL0000081)
Fold Change: -0.3661
Cell Significance Index: -3.1200
Cell Name: mast cell (CL0000097)
Fold Change: -0.3663
Cell Significance Index: -4.8200
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.3664
Cell Significance Index: -4.3300
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3670
Cell Significance Index: -4.5900
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.3699
Cell Significance Index: -4.6800
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.3731
Cell Significance Index: -3.9700
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.3750
Cell Significance Index: -4.3500
Cell Name: M cell of gut (CL0000682)
Fold Change: -0.3781
Cell Significance Index: -3.1500
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.3835
Cell Significance Index: -4.2700
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.3854
Cell Significance Index: -4.2100
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.3875
Cell Significance Index: -4.5000
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.3895
Cell Significance Index: -3.9400
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.3895
Cell Significance Index: -4.0400
Cell Name: platelet (CL0000233)
Fold Change: -0.3917
Cell Significance Index: -4.0300
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.3927
Cell Significance Index: -3.2000
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.3936
Cell Significance Index: -4.5300
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.3955
Cell Significance Index: -4.3800
Cell Name: club cell (CL0000158)
Fold Change: -0.3956
Cell Significance Index: -4.3100
Cell Name: immature B cell (CL0000816)
Fold Change: -0.3974
Cell Significance Index: -3.7600
Cell Name: T cell (CL0000084)
Fold Change: -0.3977
Cell Significance Index: -4.7000
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.3993
Cell Significance Index: -5.8400
Cell Name: mucus secreting cell (CL0000319)
Fold Change: -0.4014
Cell Significance Index: -4.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Immunoglobulin Heavy Chain Variable Region**: The IGHV3-11 gene encodes for a distinct immunoglobulin heavy chain variable region, which is responsible for recognizing and binding to specific antigens. 2. **Adaptive Immune Response**: The IGHV3-11 gene is involved in the adaptive immune response, which is a specific and highly effective defense mechanism against pathogens. 3. **Cell Surface Interactions**: The IGHV3-11 gene plays a crucial role in cell surface interactions, including antigen binding, cell adhesion, and signaling. 4. **Regulation of Immune Response**: The IGHV3-11 gene is involved in regulating the immune response, including the activation of B cells, the production of antibodies, and the modulation of immune cell functions. **Pathways and Functions:** 1. **Antigen Binding**: The IGHV3-11 gene encodes for an immunoglobulin heavy chain variable region that recognizes and binds to specific antigens. 2. **Cell Surface Interactions**: The IGHV3-11 gene plays a crucial role in cell surface interactions, including antigen binding, cell adhesion, and signaling. 3. **Immune Response Regulation**: The IGHV3-11 gene is involved in regulating the immune response, including the activation of B cells, the production of antibodies, and the modulation of immune cell functions. 4. **Complement Cascade**: The IGHV3-11 gene is involved in the complement cascade, a series of reactions that help eliminate pathogens from the body. 5. **Innate Immune Response**: The IGHV3-11 gene plays a role in the innate immune response, which provides immediate defense against pathogens. **Clinical Significance:** 1. **Leishmania Infection**: The IGHV3-11 gene has been implicated in the immune response to Leishmania parasites, highlighting its potential as a therapeutic target for treating this disease. 2. **Parasitic Infections**: The IGHV3-11 gene is involved in the immune response to parasitic infections, including those caused by Leishmania and other pathogens. 3. **Autoimmune Diseases**: The IGHV3-11 gene may play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, due to its involvement in immune response regulation. 4. **Cancer Immunotherapy**: The IGHV3-11 gene may be used as a target for cancer immunotherapy, as it is involved in the regulation of immune cell functions and the production of antibodies. In conclusion, the IGHV3-11 gene is a critical component of the human immune system, and its involvement in multiple cellular processes highlights its importance in maintaining immune homeostasis. Further research is needed to fully understand the role of this gene in the immune system and to explore its potential as a therapeutic target for treating various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.