Details for: IGHV1 3

Gene ID: 28473

Symbol: IGHV1 3

Ensembl ID: ENSG00000211935

Description: immunoglobulin heavy variable 1-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 10.9034
    Cell Significance Index: 226.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 6.5014
    Cell Significance Index: 228.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.6259
    Cell Significance Index: 148.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.2720
    Cell Significance Index: 106.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.1238
    Cell Significance Index: 118.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.7266
    Cell Significance Index: 80.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 3.0565
    Cell Significance Index: 46.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0066
    Cell Significance Index: 191.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9559
    Cell Significance Index: 43.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7163
    Cell Significance Index: 43.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6724
    Cell Significance Index: 14.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4807
    Cell Significance Index: 52.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3785
    Cell Significance Index: 37.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3309
    Cell Significance Index: 298.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2437
    Cell Significance Index: 39.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2424
    Cell Significance Index: 16.7600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1192
    Cell Significance Index: 1.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0262
    Cell Significance Index: 0.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0020
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0101
    Cell Significance Index: -0.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0129
    Cell Significance Index: -0.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0296
    Cell Significance Index: -3.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0414
    Cell Significance Index: -5.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0710
    Cell Significance Index: -5.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0806
    Cell Significance Index: -1.1500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0829
    Cell Significance Index: -1.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0954
    Cell Significance Index: -4.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1001
    Cell Significance Index: -2.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1105
    Cell Significance Index: -2.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1294
    Cell Significance Index: -4.7500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1304
    Cell Significance Index: -1.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1329
    Cell Significance Index: -3.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1462
    Cell Significance Index: -3.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1579
    Cell Significance Index: -4.6500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1623
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1674
    Cell Significance Index: -1.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1720
    Cell Significance Index: -2.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1778
    Cell Significance Index: -4.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1966
    Cell Significance Index: -9.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2173
    Cell Significance Index: -5.0200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2220
    Cell Significance Index: -4.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2253
    Cell Significance Index: -3.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2256
    Cell Significance Index: -4.1700
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2256
    Cell Significance Index: -2.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2266
    Cell Significance Index: -3.6700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2450
    Cell Significance Index: -3.1700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2470
    Cell Significance Index: -2.9800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2532
    Cell Significance Index: -2.8300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2574
    Cell Significance Index: -4.4000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2652
    Cell Significance Index: -3.8500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2669
    Cell Significance Index: -3.8900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2674
    Cell Significance Index: -3.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2708
    Cell Significance Index: -7.2300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2742
    Cell Significance Index: -3.3100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2775
    Cell Significance Index: -2.8400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2826
    Cell Significance Index: -3.8800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2843
    Cell Significance Index: -3.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2848
    Cell Significance Index: -4.9100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.2854
    Cell Significance Index: -2.9700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2855
    Cell Significance Index: -2.9600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2882
    Cell Significance Index: -3.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2956
    Cell Significance Index: -4.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2985
    Cell Significance Index: -4.8000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2992
    Cell Significance Index: -3.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3033
    Cell Significance Index: -5.3600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3059
    Cell Significance Index: -3.5200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3071
    Cell Significance Index: -3.6300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3189
    Cell Significance Index: -3.9200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3198
    Cell Significance Index: -3.6200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3226
    Cell Significance Index: -4.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3249
    Cell Significance Index: -3.0500
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.3265
    Cell Significance Index: -3.0300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3283
    Cell Significance Index: -4.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3321
    Cell Significance Index: -3.3700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3324
    Cell Significance Index: -3.5300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3330
    Cell Significance Index: -4.3700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3359
    Cell Significance Index: -3.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3365
    Cell Significance Index: -3.4900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3389
    Cell Significance Index: -3.4400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3394
    Cell Significance Index: -4.0700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3401
    Cell Significance Index: -3.4100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3408
    Cell Significance Index: -3.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3419
    Cell Significance Index: -4.0400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3434
    Cell Significance Index: -3.7700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3467
    Cell Significance Index: -3.5200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3473
    Cell Significance Index: -3.7000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3478
    Cell Significance Index: -4.1100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3490
    Cell Significance Index: -4.8300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3496
    Cell Significance Index: -4.1500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.3510
    Cell Significance Index: -3.7500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3511
    Cell Significance Index: -3.8400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3539
    Cell Significance Index: -4.9600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3544
    Cell Significance Index: -3.4600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3568
    Cell Significance Index: -4.3400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.3629
    Cell Significance Index: -3.5500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3676
    Cell Significance Index: -4.3700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3682
    Cell Significance Index: -4.7300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3683
    Cell Significance Index: -3.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV1-3 is a germline-encoded gene, meaning that it does not undergo significant somatic recombination or mutation during B cell development. This characteristic allows for the transmission of functional genes from parent to offspring. The IGHV1-3 gene is primarily expressed in cells of the immune system, including B cells, T cells, and certain subsets of granulocytes and monocytes. Its expression is also observed in non-immune cells, such as enterocytes and goblet cells, suggesting a broader role in immune surveillance and tissue homeostasis. **Pathways and Functions:** IGHV1-3 gene expression is intricately linked to the immune response, particularly in the context of antigen recognition and presentation. The variable region encoded by IGHV1-3 is responsible for binding to specific epitopes on pathogens, triggering a cascade of downstream signaling events that activate immune cells. The signaling pathways involved in IGHV1-3 function include: 1. **Antigen binding**: The IGHV1-3 variable region binds to specific antigens, triggering the activation of immune cells. 2. **Immunoglobulin complex formation**: The IGHV1-3 gene contributes to the formation of the immunoglobulin complex, which is essential for the recognition and elimination of pathogens. 3. **Immunoglobulin-mediated immune response**: IGHV1-3 plays a critical role in the activation of B cells, T cells, and other immune cells, leading to the production of antibodies and immune responses. **Clinical Significance:** The IGHV1-3 gene has significant clinical implications, particularly in the context of immune-mediated disorders. Abnormalities in IGHV1-3 gene expression have been implicated in various conditions, including: 1. **Autoimmune diseases**: Dysregulation of IGHV1-3 gene expression has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: Alterations in IGHV1-3 gene expression have been observed in certain types of cancer, including B cell lymphomas and leukemias. 3. **Infectious diseases**: IGHV1-3 plays a crucial role in the recognition and elimination of pathogens, and its dysregulation may contribute to the development of infectious diseases. In conclusion, the IGHV1-3 gene is a vital component of the immune system, playing a critical role in antigen recognition and immune response activation. Its dysregulation has significant clinical implications, highlighting the importance of understanding the complex interactions between the IGHV1-3 gene and the immune system. Further research is necessary to elucidate the mechanisms underlying IGHV1-3 gene function and its role in immune-mediated disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.