Details for: GPR31

Gene ID: 2853

Symbol: GPR31

Ensembl ID: ENSG00000120436

Description: G protein-coupled receptor 31

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8286
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3184
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 878
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 804
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71842
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48067
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.81
    Marker Score: 1051.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.8
    Marker Score: 470
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.78
    Marker Score: 781
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 401.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 506
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1414.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 391.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1180
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 480
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6530
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 216
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 210
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 679
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.31
    Marker Score: 1872
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.06
    Marker Score: 190
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 121
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.04
    Marker Score: 50.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 52
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 91
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 8.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 36
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 7

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Other Information

**Key characteristics:** * GPR31 is a member of the GPCR class a/1 (rhodopsin-like receptors). * It is a transmembrane protein with seven transmembrane domains. * It is expressed in high levels in oligodendrocyte precursor cells, blood vessel endothelial cells, granulocyte monocyte progenitor cells, early T lineage precursor cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and natural killer cells. * It is a negative regulator of inflammatory response and a positive regulator of immune response. * It is involved in the regulation of plasma membrane function, cell migration, and apoptosis. **Pathways and functions:** * GPR31 is a receptor for arachidonic acid, a lipid molecule that is involved in inflammation and immune responses. * It is also a receptor for bioactive lipids, which are molecules that activate GPCRs. * Activation of GPR31 by arachidonic acid and bioactive lipids leads to the activation of the G protein Galpha(i), which in turn activates downstream signaling pathways. * These pathways include the activation of protein kinase C, the inhibition of phosphatases, and the activation of transcription factors. * Activation of these downstream pathways leads to the expression of inflammatory cytokines and chemokines, which can promote inflammation. **Clinical significance:** * Mutations in GPR31 have been linked to several autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. * GPCR31 is a potential therapeutic target for these disorders, as it is a key regulator of inflammation and immune responses. * Inhibition of GPR31 has been shown to reduce inflammation and improve disease activity in animal models of autoimmune disorders.

Genular Protein ID: 2221267051

Symbol: GPR31_HUMAN

Name: 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

UniProtKB Accession Codes:

O00270 B0M0K2 Q4VBL3 Q9NQ20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205127

Title: Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor.

PubMed ID: 9205127

DOI: 10.1006/geno.1997.4754

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21712392

Title: Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid.

PubMed ID: 21712392

DOI: 10.1074/jbc.m110.216564

PubMed ID: 26965684

Title: 12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression.

PubMed ID: 26965684

DOI: 10.1096/fj.201500076

PubMed ID: 28619714

Title: The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

PubMed ID: 28619714

DOI: 10.1083/jcb.201609096

PubMed ID: 29227475

Title: An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury.

PubMed ID: 29227475

DOI: 10.1038/nm.4451

PubMed ID: 31119277

Title: GPR31 and GPR151 are activated under acidic conditions.

PubMed ID: 31119277

DOI: 10.1093/jb/mvz042

Sequence Information:

  • Length: 319
  • Mass: 35075
  • Checksum: 2ACD0350AD7FB53A
  • Sequence:
    • MPFPNCSAPS TVVATAVGVL LGLECGLGLL GNAVALWTFL FRVRVWKPYA VYLLNLALAD 
LLLAACLPFL AAFYLSLQAW HLGRVGCWAL HFLLDLSRSV GMAFLAAVAL DRYLRVVHPR 
LKVNLLSPQA ALGVSGLVWL LMVALTCPGL LISEAAQNST RCHSFYSRAD GSFSIIWQEA 
LSCLQFVLPF GLIVFCNAGI IRALQKRLRE PEKQPKLQRA QALVTLVVVL FALCFLPCFL 
ARVLMHIFQN LGSCRALCAV AHTSDVTGSL TYLHSVLNPV VYCFSSPTFR SSYRRVFHTL 
RGKGQAAEPP DFNPRDSYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.