Details for: TRBV19

Gene ID: 28568

Symbol: TRBV19

Ensembl ID: ENSG00000211746

Description: T cell receptor beta variable 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.8422
    Cell Significance Index: 4.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0141
    Cell Significance Index: 0.2000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0072
    Cell Significance Index: -0.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0301
    Cell Significance Index: -1.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0307
    Cell Significance Index: -6.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0398
    Cell Significance Index: -5.4600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1074
    Cell Significance Index: -1.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1079
    Cell Significance Index: -5.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1119
    Cell Significance Index: -5.8300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1334
    Cell Significance Index: -1.0800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1337
    Cell Significance Index: -2.2700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1404
    Cell Significance Index: -1.9100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1525
    Cell Significance Index: -1.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1598
    Cell Significance Index: -7.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1604
    Cell Significance Index: -5.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1797
    Cell Significance Index: -4.8900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1861
    Cell Significance Index: -1.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1868
    Cell Significance Index: -5.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1991
    Cell Significance Index: -5.3300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2428
    Cell Significance Index: -0.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2642
    Cell Significance Index: -6.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2766
    Cell Significance Index: -6.7000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2806
    Cell Significance Index: -2.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2902
    Cell Significance Index: -6.1600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3040
    Cell Significance Index: -2.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3103
    Cell Significance Index: -5.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3108
    Cell Significance Index: -6.1500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3143
    Cell Significance Index: -2.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3197
    Cell Significance Index: -6.2500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3241
    Cell Significance Index: -5.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3349
    Cell Significance Index: -6.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3473
    Cell Significance Index: -5.0800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3494
    Cell Significance Index: -3.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3533
    Cell Significance Index: -3.5900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3596
    Cell Significance Index: -4.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3603
    Cell Significance Index: -6.0700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3708
    Cell Significance Index: -3.2000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3728
    Cell Significance Index: -4.0500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.3778
    Cell Significance Index: -3.7000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3839
    Cell Significance Index: -5.8300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3844
    Cell Significance Index: -4.6100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3850
    Cell Significance Index: -3.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3883
    Cell Significance Index: -5.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3911
    Cell Significance Index: -4.9400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3937
    Cell Significance Index: -6.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3964
    Cell Significance Index: -3.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3998
    Cell Significance Index: -3.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4112
    Cell Significance Index: -6.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4127
    Cell Significance Index: -5.0200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4155
    Cell Significance Index: -4.8200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.4158
    Cell Significance Index: -2.8600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4180
    Cell Significance Index: -5.1700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4267
    Cell Significance Index: -5.8600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4294
    Cell Significance Index: -7.3400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4318
    Cell Significance Index: -4.3300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4345
    Cell Significance Index: -6.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4440
    Cell Significance Index: -5.6100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4504
    Cell Significance Index: -4.3900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4521
    Cell Significance Index: -6.2700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4521
    Cell Significance Index: -5.3800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4528
    Cell Significance Index: -6.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4701
    Cell Significance Index: -5.4100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4747
    Cell Significance Index: -5.6100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4749
    Cell Significance Index: -6.2500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.4757
    Cell Significance Index: -4.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4801
    Cell Significance Index: -6.3000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4829
    Cell Significance Index: -5.1200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4835
    Cell Significance Index: -6.0400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.4852
    Cell Significance Index: -3.6100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.4861
    Cell Significance Index: -4.1800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4882
    Cell Significance Index: -4.1200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4887
    Cell Significance Index: -5.9400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5065
    Cell Significance Index: -6.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5086
    Cell Significance Index: -6.0100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5101
    Cell Significance Index: -6.6000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5105
    Cell Significance Index: -6.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.5119
    Cell Significance Index: -5.6700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5180
    Cell Significance Index: -6.0900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5230
    Cell Significance Index: -5.7300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.5269
    Cell Significance Index: -4.7400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.5278
    Cell Significance Index: -5.6900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.5307
    Cell Significance Index: -6.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5327
    Cell Significance Index: -6.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5331
    Cell Significance Index: -6.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5383
    Cell Significance Index: -5.8700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5411
    Cell Significance Index: -5.0800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5431
    Cell Significance Index: -7.0900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.5478
    Cell Significance Index: -5.6800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5509
    Cell Significance Index: -7.3200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5528
    Cell Significance Index: -6.2300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5539
    Cell Significance Index: -6.0400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5542
    Cell Significance Index: -6.5200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.5552
    Cell Significance Index: -4.6400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5554
    Cell Significance Index: -6.7000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5599
    Cell Significance Index: -6.2600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.5602
    Cell Significance Index: -6.2200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.5608
    Cell Significance Index: -6.0800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5613
    Cell Significance Index: -6.1400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5623
    Cell Significance Index: -6.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The TRBV19 gene is located on chromosome 14q32.33, a region known for its high density of immune-related genes. The gene consists of a variable (V) region, which is responsible for antigen recognition, and a constant (C) region, which determines the TCR's specificity. 2. **Expression Patterns:** TRBV19 is expressed in a wide range of cell types, including CD8-positive alpha-beta cytotoxic T cells, goblet cells, and granulocyte-monocyte progenitor cells. Its expression in neoplastic and abnormal cells suggests a potential role in cancer and immune dysregulation. 3. **Function:** The TRBV19 gene contributes to the adaptive immune response by encoding a TCR that recognizes and binds to specific antigens. This interaction triggers a signaling cascade that activates T cells, leading to an immune response. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBV19 gene is involved in the adaptive immune response, which is a specific and targeted response to antigens. The TCR encoded by TRBV19 recognizes and binds to antigens, triggering a signaling cascade that activates T cells. 2. **Alpha-Beta T Cell Receptor Complex:** The TRBV19 gene is part of the alpha-beta TCR complex, which is a heterodimeric receptor composed of an alpha chain and a beta chain. The alpha-beta TCR complex is responsible for recognizing and binding to antigens. 3. **Cell Surface Receptor Signaling Pathway:** The TRBV19 gene is involved in cell surface receptor signaling, which is a critical process for T cell activation and proliferation. 4. **Plasma Membrane:** The TRBV19 gene is embedded in the plasma membrane, which is the outermost layer of the cell membrane. **Clinical Significance:** 1. **Cancer:** The expression of TRBV19 in neoplastic and abnormal cells suggests a potential role in cancer. Further research is needed to understand how TRBV19 contributes to cancer development and progression. 2. **Immune Dysregulation:** The expression of TRBV19 in abnormal cells highlights its potential role in immune dysregulation. Abnormal TCR expression has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Vaccine Development:** The TRBV19 gene may be a target for vaccine development, as it encodes a TCR that can recognize and bind to specific antigens. Understanding the function and expression patterns of TRBV19 may lead to the development of novel vaccines. 4. **Immunotherapy:** The TRBV19 gene may be a target for immunotherapy, as it encodes a TCR that can recognize and bind to specific antigens. Understanding the function and expression patterns of TRBV19 may lead to the development of novel immunotherapies. In conclusion, the TRBV19 gene is a crucial component of the adaptive immune response, and its expression in various cell types highlights its potential role in cancer and immune dysregulation. Further research is needed to understand the function and expression patterns of TRBV19, which may lead to the development of novel vaccines and immunotherapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.