Details for: TRBV11 2

Gene ID: 28581

Symbol: TRBV11 2

Ensembl ID: ENSG00000241657

Description: T cell receptor beta variable 11-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.8124
    Cell Significance Index: 4.4300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.5070
    Cell Significance Index: 4.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2608
    Cell Significance Index: 7.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1688
    Cell Significance Index: 2.4600
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.1031
    Cell Significance Index: 0.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0072
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0134
    Cell Significance Index: -2.6900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0169
    Cell Significance Index: -0.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0188
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0305
    Cell Significance Index: -0.2600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0378
    Cell Significance Index: -0.3400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0381
    Cell Significance Index: -0.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0475
    Cell Significance Index: -1.1500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0692
    Cell Significance Index: -0.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0957
    Cell Significance Index: -1.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0969
    Cell Significance Index: -1.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1080
    Cell Significance Index: -1.1200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1133
    Cell Significance Index: -1.0600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1173
    Cell Significance Index: -1.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1176
    Cell Significance Index: -2.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1279
    Cell Significance Index: -2.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1291
    Cell Significance Index: -3.2900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1371
    Cell Significance Index: -1.3000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1410
    Cell Significance Index: -0.9700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1429
    Cell Significance Index: -1.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1488
    Cell Significance Index: -1.4300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1493
    Cell Significance Index: -1.2600
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1525
    Cell Significance Index: -1.4900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1536
    Cell Significance Index: -1.3300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1594
    Cell Significance Index: -1.6900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1600
    Cell Significance Index: -1.6500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1750
    Cell Significance Index: -2.0300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1759
    Cell Significance Index: -2.1400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1793
    Cell Significance Index: -2.3600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1828
    Cell Significance Index: -1.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1828
    Cell Significance Index: -4.8800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1830
    Cell Significance Index: -1.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1862
    Cell Significance Index: -2.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1868
    Cell Significance Index: -2.3600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1876
    Cell Significance Index: -1.8900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1878
    Cell Significance Index: -2.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1880
    Cell Significance Index: -3.4800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1884
    Cell Significance Index: -2.1400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1892
    Cell Significance Index: -1.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1907
    Cell Significance Index: -2.4500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1926
    Cell Significance Index: -3.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1932
    Cell Significance Index: -2.5000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1949
    Cell Significance Index: -2.1400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1953
    Cell Significance Index: -2.4400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1973
    Cell Significance Index: -2.4000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1992
    Cell Significance Index: -2.3700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2025
    Cell Significance Index: -2.1300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2036
    Cell Significance Index: -2.4200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2076
    Cell Significance Index: -1.7400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2099
    Cell Significance Index: -2.5800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2127
    Cell Significance Index: -2.5500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2128
    Cell Significance Index: -2.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2170
    Cell Significance Index: -3.5200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2189
    Cell Significance Index: -2.6100
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2213
    Cell Significance Index: -2.0100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2250
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2297
    Cell Significance Index: -2.5600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2307
    Cell Significance Index: -3.7100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2308
    Cell Significance Index: -2.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2311
    Cell Significance Index: -3.9500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2327
    Cell Significance Index: -1.8100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2372
    Cell Significance Index: -1.8100
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.2395
    Cell Significance Index: -2.5900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2395
    Cell Significance Index: -2.1100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2399
    Cell Significance Index: -2.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2407
    Cell Significance Index: -3.4200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2416
    Cell Significance Index: -3.6700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2436
    Cell Significance Index: -2.8300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2461
    Cell Significance Index: -2.0400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2465
    Cell Significance Index: -1.9700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2480
    Cell Significance Index: -2.6000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2508
    Cell Significance Index: -2.6000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2540
    Cell Significance Index: -2.7500
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.2544
    Cell Significance Index: -2.3500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2560
    Cell Significance Index: -2.8000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2561
    Cell Significance Index: -2.7200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2572
    Cell Significance Index: -2.0300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2583
    Cell Significance Index: -2.5900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2587
    Cell Significance Index: -2.8900
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.2590
    Cell Significance Index: -2.5600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2598
    Cell Significance Index: -2.8300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2607
    Cell Significance Index: -3.0000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2618
    Cell Significance Index: -2.9500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2624
    Cell Significance Index: -2.6000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2637
    Cell Significance Index: -3.1300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2650
    Cell Significance Index: -2.2400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2654
    Cell Significance Index: -3.7200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2663
    Cell Significance Index: -2.7000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2667
    Cell Significance Index: -2.4500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2669
    Cell Significance Index: -3.1400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2711
    Cell Significance Index: -2.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2713
    Cell Significance Index: -3.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** TRBV11-2 is significantly expressed in a wide range of T cell subsets, including central memory CD4+ T cells, alpha-beta cytotoxic T cells, and T-helper 17 cells. 2. **T Cell Receptor Complexity:** As a variable region of the TCR, TRBV11-2 contributes to the generation of diverse TCR sequences, enabling the recognition of a vast array of antigens. 3. **Cell Surface Receptor Signaling:** TRBV11-2 is involved in cell surface receptor signaling pathways, which are crucial for T cell activation, proliferation, and differentiation. 4. **Plasma Membrane Interactions:** The gene's expression on platelets suggests its involvement in plasma membrane interactions, possibly modulating immune responses. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBV11-2 plays a critical role in the adaptive immune response, enabling T cells to recognize and respond to pathogens. 2. **Cell Surface Receptor Signaling Pathway:** The gene's involvement in cell surface receptor signaling pathways is essential for T cell activation, proliferation, and differentiation. 3. **T Cell Receptor Complex:** TRBV11-2 contributes to the generation of diverse TCR sequences, which interact with major histocompatibility complex (MHC) molecules to recognize antigens. 4. **Immune Evasion:** The expression of TRBV11-2 on exhausted T cells and T follicular helper cells suggests its involvement in immune evasion mechanisms, enabling T cells to evade immune destruction. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in TRBV11-2 could lead to immunodeficiency disorders, such as impaired T cell function and increased susceptibility to infections. 2. **Cancer Immunotherapy:** TRBV11-2's expression on T cells and platelets suggests its potential role in cancer immunotherapy, where T cells can be engineered to recognize and target cancer cells. 3. **Autoimmune Diseases:** The gene's involvement in immune evasion mechanisms may also contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Vaccine Development:** Understanding the role of TRBV11-2 in T cell recognition and response may inform the development of more effective vaccines, which can stimulate a robust and diverse T cell response. In conclusion, TRBV11-2 is a complex gene involved in various aspects of the adaptive immune response. Further research is necessary to fully elucidate its functions and clinical significance, but its involvement in T cell receptor signaling, plasma membrane interactions, and immune evasion mechanisms highlights its importance in maintaining immune homeostasis and preventing disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.