TRBV7 9 | ENSG00000278030 | NCBI 28589

Details for: TRBV7 9

Gene ID: 28589

Symbol: TRBV7 9

Ensembl ID: ENSG00000278030

Description: T cell receptor beta variable 7-9

Associated with

Adaptive immune system
(R-HSA-1280218)
Costimulation by the cd28 family
(R-HSA-388841)
Downstream tcr signaling
(R-HSA-202424)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Pd-1 signaling
(R-HSA-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Tcr signaling
(R-HSA-202403)
Translocation of zap-70 to immunological synapse
(R-HSA-202430)
Adaptive immune response
(GO:0002250)
Cell surface receptor signaling pathway
(GO:0007166)
Immune response
(GO:0006955)
Mhc protein binding
(GO:0042287)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
T cell receptor complex
(GO:0042101)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.6969
Cell Significance Index: 3.8000
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.0261
Cell Significance Index: 0.2600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0066
Cell Significance Index: -5.0200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0266
Cell Significance Index: -5.3300
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0447
Cell Significance Index: -0.5000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0595
Cell Significance Index: -6.0800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0980
Cell Significance Index: -2.3800
Cell Name: helper T cell (CL0000912)
Fold Change: -0.1049
Cell Significance Index: -1.4900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1215
Cell Significance Index: -5.7100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1219
Cell Significance Index: -6.3300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1608
Cell Significance Index: -4.3000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1930
Cell Significance Index: -4.9300
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1941
Cell Significance Index: -4.8500
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2029
Cell Significance Index: -5.1700
Cell Name: pericyte (CL0000669)
Fold Change: -0.2060
Cell Significance Index: -2.4700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2096
Cell Significance Index: -3.5600
Cell Name: T cell (CL0000084)
Fold Change: -0.2126
Cell Significance Index: -2.5100
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.2346
Cell Significance Index: -2.3700
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2396
Cell Significance Index: -4.1300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2397
Cell Significance Index: -6.4000
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2440
Cell Significance Index: -3.3200
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2454
Cell Significance Index: -2.9000
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2493
Cell Significance Index: -4.2000
Cell Name: peg cell (CL4033014)
Fold Change: -0.2504
Cell Significance Index: -5.7900
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.2687
Cell Significance Index: -4.3200
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.2717
Cell Significance Index: -2.2000
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: -0.2723
Cell Significance Index: -0.8300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2729
Cell Significance Index: -5.3400
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.2838
Cell Significance Index: -2.6600
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.2838
Cell Significance Index: -2.8800
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.2856
Cell Significance Index: -2.4100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.2874
Cell Significance Index: -3.5900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2884
Cell Significance Index: -5.3300
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.2901
Cell Significance Index: -2.7500
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.2931
Cell Significance Index: -4.0300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2952
Cell Significance Index: -4.9400
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.2969
Cell Significance Index: -2.3100
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2969
Cell Significance Index: -4.5100
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.3037
Cell Significance Index: -3.1500
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.3040
Cell Significance Index: -2.5900
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.3082
Cell Significance Index: -2.6500
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: -0.3126
Cell Significance Index: -2.1500
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.3166
Cell Significance Index: -3.1900
Cell Name: memory T cell (CL0000813)
Fold Change: -0.3173
Cell Significance Index: -2.6300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3184
Cell Significance Index: -4.7000
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3346
Cell Significance Index: -5.7200
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.3371
Cell Significance Index: -3.2400
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.3395
Cell Significance Index: -4.2000
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3396
Cell Significance Index: -4.9300
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.3423
Cell Significance Index: -5.8800
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3430
Cell Significance Index: -5.5600
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.3511
Cell Significance Index: -3.0300
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.3514
Cell Significance Index: -5.6700
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.3529
Cell Significance Index: -3.6400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.3540
Cell Significance Index: -5.1600
Cell Name: basal cell (CL0000646)
Fold Change: -0.3597
Cell Significance Index: -4.2800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3605
Cell Significance Index: -5.0000
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.3640
Cell Significance Index: -4.7100
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.3681
Cell Significance Index: -5.1600
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.3707
Cell Significance Index: -4.3000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.3734
Cell Significance Index: -3.6400
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.3745
Cell Significance Index: -4.0600
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.3750
Cell Significance Index: -2.7900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.3783
Cell Significance Index: -4.7800
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.3840
Cell Significance Index: -3.8500
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3887
Cell Significance Index: -5.3300
Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.3917
Cell Significance Index: -4.8900
Cell Name: mast cell (CL0000097)
Fold Change: -0.3921
Cell Significance Index: -5.1600
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: -0.3925
Cell Significance Index: -3.2800
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4032
Cell Significance Index: -5.1800
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.4041
Cell Significance Index: -5.9100
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.4070
Cell Significance Index: -4.8100
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.4078
Cell Significance Index: -4.9600
Cell Name: microglial cell (CL0000129)
Fold Change: -0.4082
Cell Significance Index: -4.8000
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.4107
Cell Significance Index: -4.3600
Cell Name: fibroblast (CL0000057)
Fold Change: -0.4143
Cell Significance Index: -3.8900
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -0.4195
Cell Significance Index: -3.8800
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.4206
Cell Significance Index: -5.0000
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4260
Cell Significance Index: -5.5900
Cell Name: blood cell (CL0000081)
Fold Change: -0.4323
Cell Significance Index: -3.6900
Cell Name: monocyte (CL0000576)
Fold Change: -0.4337
Cell Significance Index: -4.9900
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.4349
Cell Significance Index: -4.9400
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.4396
Cell Significance Index: -3.8500
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.4397
Cell Significance Index: -4.8900
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.4437
Cell Significance Index: -4.6000
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.4450
Cell Significance Index: -4.8900
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.4461
Cell Significance Index: -4.8800
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.4472
Cell Significance Index: -5.4400
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.4476
Cell Significance Index: -4.8400
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4480
Cell Significance Index: -4.8300
Cell Name: naive T cell (CL0000898)
Fold Change: -0.4480
Cell Significance Index: -4.0700
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.4501
Cell Significance Index: -5.1800
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.4507
Cell Significance Index: -5.5400
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4553
Cell Significance Index: -5.0200
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4560
Cell Significance Index: -5.5000
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4566
Cell Significance Index: -5.9600
Cell Name: B cell (CL0000236)
Fold Change: -0.4570
Cell Significance Index: -5.4000
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.4579
Cell Significance Index: -4.1200
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.4588
Cell Significance Index: -4.8400
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4605
Cell Significance Index: -5.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The TRBV7-9 gene is a member of the T cell receptor beta (TRBV) family, which consists of over 40 variable regions. These variable regions are responsible for recognizing and binding to specific peptide antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. The TRBV7-9 gene is characterized by its ability to generate a diverse repertoire of T cell receptors, allowing for a tailored immune response against a wide range of pathogens. **Pathways and Functions** The TRBV7-9 gene is involved in various signaling pathways that regulate T cell activation, proliferation, and differentiation. The primary pathways associated with TRBV7-9 include: 1. **T cell receptor signaling**: The TRBV7-9 gene encodes for a variable region that recognizes and binds to specific peptide antigens presented by MHC molecules. Upon antigen binding, the T cell receptor complex undergoes a conformational change, triggering a signaling cascade that activates downstream pathways. 2. **Costimulation by the CD28 family**: The TRBV7-9 gene is involved in the costimulatory signaling pathway, which is essential for T cell activation. CD28 is a co-stimulatory molecule that provides a second signal to T cells, ensuring their activation and proliferation. 3. **Downstream TCR signaling**: The TRBV7-9 gene is involved in the downstream signaling pathways that regulate T cell activation, proliferation, and differentiation. These pathways include the activation of Zap-70, a protein kinase that phosphorylates and activates downstream signaling molecules. **Clinical Significance** The TRBV7-9 gene has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Dysregulation of the TRBV7-9 gene has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where the immune system mistakenly attacks healthy tissues. 2. **Cancer**: The TRBV7-9 gene has been identified as a potential target for cancer immunotherapy. Its dysregulation has been linked to the development of various types of cancer, including leukemia and lymphoma. 3. **Infectious diseases**: The TRBV7-9 gene plays a crucial role in recognizing and responding to specific pathogens, and its dysregulation has been linked to infectious diseases, such as HIV and tuberculosis. In conclusion, the TRBV7-9 gene is a critical component of the adaptive immune system, and its dysregulation has significant implications for our understanding of immune-related disorders. Further research is needed to fully elucidate the role of the TRBV7-9 gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.