Details for: TRBV7 2

Gene ID: 28596

Symbol: TRBV7 2

Ensembl ID: ENSG00000282939

Description: T cell receptor beta variable 7-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.4269
    Cell Significance Index: 16.9400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.8793
    Cell Significance Index: 2.6800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.8564
    Cell Significance Index: 4.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0146
    Cell Significance Index: -2.9300
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0158
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0364
    Cell Significance Index: -2.2300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0470
    Cell Significance Index: -0.6600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0485
    Cell Significance Index: -0.6600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0571
    Cell Significance Index: -0.9700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0584
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0588
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0642
    Cell Significance Index: -0.5200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0677
    Cell Significance Index: -0.9900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0715
    Cell Significance Index: -0.8900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0728
    Cell Significance Index: -0.7100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0869
    Cell Significance Index: -0.7400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0872
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0884
    Cell Significance Index: -0.8500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0887
    Cell Significance Index: -0.7700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0930
    Cell Significance Index: -0.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0964
    Cell Significance Index: -2.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0990
    Cell Significance Index: -2.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1032
    Cell Significance Index: -2.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1102
    Cell Significance Index: -5.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1195
    Cell Significance Index: -2.0600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1208
    Cell Significance Index: -1.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1235
    Cell Significance Index: -2.0800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1277
    Cell Significance Index: -1.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1321
    Cell Significance Index: -3.2000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1321
    Cell Significance Index: -2.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1330
    Cell Significance Index: -1.3500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1335
    Cell Significance Index: -2.6100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1361
    Cell Significance Index: -1.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1385
    Cell Significance Index: -2.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1398
    Cell Significance Index: -2.3400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1413
    Cell Significance Index: -1.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1426
    Cell Significance Index: -2.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1437
    Cell Significance Index: -1.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1584
    Cell Significance Index: -2.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1605
    Cell Significance Index: -4.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1607
    Cell Significance Index: -2.0300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1647
    Cell Significance Index: -1.9100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1650
    Cell Significance Index: -2.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1667
    Cell Significance Index: -2.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1694
    Cell Significance Index: -2.4600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1701
    Cell Significance Index: -1.4100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1710
    Cell Significance Index: -2.0800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1739
    Cell Significance Index: -1.5800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1754
    Cell Significance Index: -1.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1754
    Cell Significance Index: -2.5900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1765
    Cell Significance Index: -1.8300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1817
    Cell Significance Index: -2.5200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1825
    Cell Significance Index: -1.4200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1841
    Cell Significance Index: -1.9800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1847
    Cell Significance Index: -2.3400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1860
    Cell Significance Index: -2.5500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1860
    Cell Significance Index: -1.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1870
    Cell Significance Index: -2.3200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1903
    Cell Significance Index: -3.0600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1904
    Cell Significance Index: -2.4900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1906
    Cell Significance Index: -1.9200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1912
    Cell Significance Index: -2.2500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1921
    Cell Significance Index: -2.7300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1933
    Cell Significance Index: -2.3500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1949
    Cell Significance Index: -2.5700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1969
    Cell Significance Index: -2.4600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1974
    Cell Significance Index: -1.6500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1978
    Cell Significance Index: -1.8300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2009
    Cell Significance Index: -2.0400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2012
    Cell Significance Index: -2.5800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2016
    Cell Significance Index: -2.0800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2054
    Cell Significance Index: -2.4800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2056
    Cell Significance Index: -1.5300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2102
    Cell Significance Index: -2.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2103
    Cell Significance Index: -2.7600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2104
    Cell Significance Index: -2.3200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2110
    Cell Significance Index: -2.2800
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2112
    Cell Significance Index: -1.9000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2116
    Cell Significance Index: -2.4400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2129
    Cell Significance Index: -2.3200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.2136
    Cell Significance Index: -2.4500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2147
    Cell Significance Index: -2.5900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2148
    Cell Significance Index: -2.3500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2162
    Cell Significance Index: -3.0300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2166
    Cell Significance Index: -3.2900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2174
    Cell Significance Index: -2.4700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.2186
    Cell Significance Index: -2.0200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2191
    Cell Significance Index: -2.8600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2201
    Cell Significance Index: -2.4800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2218
    Cell Significance Index: -2.6600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2218
    Cell Significance Index: -1.9400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2242
    Cell Significance Index: -2.5800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2245
    Cell Significance Index: -2.7600
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2256
    Cell Significance Index: -2.4100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2265
    Cell Significance Index: -2.3100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2273
    Cell Significance Index: -2.4900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2287
    Cell Significance Index: -2.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV7-2 gene is a member of the T cell receptor beta (TRBC) family, which is responsible for encoding the variable region of the T cell receptor beta chain. This gene exhibits high polymorphism, resulting in a diverse repertoire of T cell receptors. The TRBV7-2 gene is characterized by its unique combination of nucleotide and amino acid sequences, which confer specificity and diversity to the T cell receptor. Notably, the TRBV7-2 gene is also associated with the development of certain T cell subsets, such as alpha-beta T cells and type I NK T cells. **Pathways and Functions:** The TRBV7-2 gene is integrated into several key pathways, including the adaptive immune response, cell surface receptor signaling pathway, and plasma membrane. The adaptive immune response is a complex process that involves the activation of immune cells, such as T cells and B cells, to recognize and eliminate pathogens. The TRBV7-2 gene plays a critical role in this process by encoding the T cell receptor, which recognizes and binds to specific antigens. The cell surface receptor signaling pathway involves the activation of downstream signaling molecules, which regulate various cellular processes, including proliferation, differentiation, and survival. The TRBV7-2 gene is also involved in the regulation of immune cell development and function. For example, the gene is expressed in double-negative thymocytes, which are precursor cells to T cells. The TRBV7-2 gene helps to guide the development of these cells into mature T cells, which are essential for the adaptive immune response. Furthermore, the gene is also expressed in T follicular helper cells, which play a crucial role in the regulation of B cell responses. **Clinical Significance:** The TRBV7-2 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. For example, alterations in the TRBV7-2 gene have been associated with autoimmune disorders, such as multiple sclerosis and type 1 diabetes. Additionally, the gene has been implicated in the development of certain types of cancer, including leukemia and lymphoma. Furthermore, the TRBV7-2 gene has potential applications in immunotherapy and vaccine development. For instance, the gene can be used to engineer T cells with specific T cell receptor properties, which can recognize and eliminate cancer cells. Additionally, the gene can be used to develop vaccines that stimulate specific T cell responses, providing protection against infectious diseases. In conclusion, the TRBV7-2 gene is a critical component of the adaptive immune system, and its unique characteristics and functions have significant implications for our understanding of immune responses and disease. Further research is needed to fully elucidate the role of the TRBV7-2 gene in human health and disease, but the current evidence suggests that it holds great promise for the development of novel immunotherapeutic strategies and vaccine approaches.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.