Details for: TRBV5 4

Gene ID: 28611

Symbol: TRBV5 4

Ensembl ID: ENSG00000230099

Description: T cell receptor beta variable 5-4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.1864
    Cell Significance Index: 9.6100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4897
    Cell Significance Index: 2.6700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.2559
    Cell Significance Index: 2.7800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0765
    Cell Significance Index: 0.8600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0076
    Cell Significance Index: -0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0126
    Cell Significance Index: -2.5300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0197
    Cell Significance Index: -0.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0265
    Cell Significance Index: -0.4100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0356
    Cell Significance Index: -0.5200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0379
    Cell Significance Index: -0.5200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0412
    Cell Significance Index: -0.7000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0440
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0475
    Cell Significance Index: -0.4800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0501
    Cell Significance Index: -0.7300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0507
    Cell Significance Index: -0.6400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0519
    Cell Significance Index: -0.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0527
    Cell Significance Index: -1.4100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0657
    Cell Significance Index: -0.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0770
    Cell Significance Index: -3.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0772
    Cell Significance Index: -1.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0775
    Cell Significance Index: -1.9800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0837
    Cell Significance Index: -1.0100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0845
    Cell Significance Index: -0.7000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0908
    Cell Significance Index: -1.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0911
    Cell Significance Index: -2.3200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0916
    Cell Significance Index: -0.6300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0927
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0930
    Cell Significance Index: -0.8700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1013
    Cell Significance Index: -0.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1015
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1025
    Cell Significance Index: -0.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1082
    Cell Significance Index: -2.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1082
    Cell Significance Index: -1.6000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1095
    Cell Significance Index: -1.3600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1127
    Cell Significance Index: -1.2000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1147
    Cell Significance Index: -1.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1170
    Cell Significance Index: -2.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1191
    Cell Significance Index: -1.2400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1199
    Cell Significance Index: -1.3000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1202
    Cell Significance Index: -1.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1212
    Cell Significance Index: -2.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1238
    Cell Significance Index: -1.1900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1253
    Cell Significance Index: -1.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1271
    Cell Significance Index: -2.4900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1275
    Cell Significance Index: -1.5000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1280
    Cell Significance Index: -1.2900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1307
    Cell Significance Index: -1.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1309
    Cell Significance Index: -2.4200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1310
    Cell Significance Index: -1.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1352
    Cell Significance Index: -1.7500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1397
    Cell Significance Index: -1.6200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1407
    Cell Significance Index: -1.7300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1412
    Cell Significance Index: -1.6600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1414
    Cell Significance Index: -2.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1441
    Cell Significance Index: -1.5700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.1443
    Cell Significance Index: -1.5600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1485
    Cell Significance Index: -1.5400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1487
    Cell Significance Index: -1.8100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1500
    Cell Significance Index: -1.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1533
    Cell Significance Index: -2.1300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1562
    Cell Significance Index: -1.6800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1573
    Cell Significance Index: -1.8700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1575
    Cell Significance Index: -2.1600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1590
    Cell Significance Index: -1.5500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1623
    Cell Significance Index: -1.5900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1654
    Cell Significance Index: -1.5300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1667
    Cell Significance Index: -1.7000
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1675
    Cell Significance Index: -1.8600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1695
    Cell Significance Index: -1.9500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1700
    Cell Significance Index: -1.8600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1715
    Cell Significance Index: -1.5000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1723
    Cell Significance Index: -1.7000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1725
    Cell Significance Index: -1.9600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1741
    Cell Significance Index: -1.8600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1743
    Cell Significance Index: -2.0300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1747
    Cell Significance Index: -1.4600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1758
    Cell Significance Index: -1.9200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1759
    Cell Significance Index: -1.8300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1770
    Cell Significance Index: -1.8800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1776
    Cell Significance Index: -1.9500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1779
    Cell Significance Index: -2.8600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1783
    Cell Significance Index: -2.2900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1786
    Cell Significance Index: -2.1200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1802
    Cell Significance Index: -2.3700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1823
    Cell Significance Index: -2.3800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1881
    Cell Significance Index: -1.8400
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1891
    Cell Significance Index: -1.9200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1898
    Cell Significance Index: -2.1200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1901
    Cell Significance Index: -1.6200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1937
    Cell Significance Index: -1.5300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1958
    Cell Significance Index: -2.1200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1966
    Cell Significance Index: -2.1200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1967
    Cell Significance Index: -1.6600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1988
    Cell Significance Index: -2.2400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1990
    Cell Significance Index: -2.2900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2003
    Cell Significance Index: -1.4900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.2006
    Cell Significance Index: -1.9600
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.2007
    Cell Significance Index: -1.9800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2032
    Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location**: The TRBV5-4 gene is located on chromosome 7q34 and is part of the TCR beta (TCRB) gene cluster. 2. **Expression**: TRBV5-4 is significantly expressed in a range of immune cells, including granulocyte-monocyte progenitor cells, early T lineage precursors, precursor B cells, neutrophils, and CD8+ T cells. 3. **Function**: TRBV5-4 contributes to the diversity of the TCR repertoire, enabling the recognition of a wide range of antigens. 4. **Cellular localization**: TRBV5-4 is expressed on the surface of T cells, where it interacts with the TCR complex to recognize antigens. **Pathways and Functions:** 1. **Adaptive Immune Response**: TRBV5-4 plays a critical role in the adaptive immune response, allowing T cells to recognize and respond to pathogens. 2. **Cell Surface Receptor Signaling Pathway**: The TCR complex, including TRBV5-4, interacts with antigen-presenting cells to initiate signaling pathways that activate T cells. 3. **Plasma Membrane**: TRBV5-4 is embedded in the plasma membrane, where it interacts with other components of the TCR complex to recognize antigens. 4. **T Cell Receptor Complex**: TRBV5-4 is part of the TCR complex, which consists of alpha, beta, gamma, and delta chains. The TCR complex recognizes antigens presented by major histocompatibility complex (MHC) molecules. **Clinical Significance:** 1. **Autoimmune Diseases**: Alterations in TRBV5-4 expression or function may contribute to autoimmune diseases, such as multiple sclerosis or type 1 diabetes. 2. **Cancer Immunotherapy**: The TCR complex, including TRBV5-4, plays a crucial role in cancer immunotherapy, where T cells are engineered to recognize and attack cancer cells. 3. **Vaccine Development**: Understanding the role of TRBV5-4 in the adaptive immune response may inform the development of new vaccines that target specific T cell responses. 4. **Immunodeficiency Disorders**: Mutations or deletions in the TRBV5-4 gene may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, TRBV5-4 is a critical component of the adaptive immune response, contributing to the diversity of the TCR repertoire and enabling the recognition of a wide range of antigens. Further research into the functions and clinical significance of TRBV5-4 may provide insights into the development of new immunotherapies and vaccines.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.