Details for: TRBV5 1

Gene ID: 28614

Symbol: TRBV5 1

Ensembl ID: ENSG00000211734

Description: T cell receptor beta variable 5-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.4781
    Cell Significance Index: 8.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3101
    Cell Significance Index: 20.2700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.9864
    Cell Significance Index: 7.9900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.5939
    Cell Significance Index: 1.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0288
    Cell Significance Index: -0.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0383
    Cell Significance Index: -7.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0423
    Cell Significance Index: -4.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0671
    Cell Significance Index: -1.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0682
    Cell Significance Index: -1.8300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0725
    Cell Significance Index: -1.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0755
    Cell Significance Index: -1.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0817
    Cell Significance Index: -0.9300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0961
    Cell Significance Index: -1.4100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1022
    Cell Significance Index: -1.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1067
    Cell Significance Index: -1.2600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1087
    Cell Significance Index: -0.8800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1255
    Cell Significance Index: -1.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1268
    Cell Significance Index: -3.2400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1298
    Cell Significance Index: -1.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1364
    Cell Significance Index: -6.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1421
    Cell Significance Index: -4.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1452
    Cell Significance Index: -3.7000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1483
    Cell Significance Index: -1.0200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1485
    Cell Significance Index: -1.6600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1561
    Cell Significance Index: -1.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1584
    Cell Significance Index: -3.6600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1595
    Cell Significance Index: -2.7500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1609
    Cell Significance Index: -1.5100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1622
    Cell Significance Index: -1.4000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1666
    Cell Significance Index: -1.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1696
    Cell Significance Index: -1.6300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1802
    Cell Significance Index: -2.1300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1831
    Cell Significance Index: -1.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1833
    Cell Significance Index: -1.8600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1842
    Cell Significance Index: -1.9100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1875
    Cell Significance Index: -3.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1910
    Cell Significance Index: -3.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1943
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1950
    Cell Significance Index: -4.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1953
    Cell Significance Index: -3.2900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2052
    Cell Significance Index: -2.0000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2059
    Cell Significance Index: -3.3100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2075
    Cell Significance Index: -2.2000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2083
    Cell Significance Index: -3.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2087
    Cell Significance Index: -3.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2115
    Cell Significance Index: -3.0700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2147
    Cell Significance Index: -2.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2156
    Cell Significance Index: -2.7900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2183
    Cell Significance Index: -2.0700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2204
    Cell Significance Index: -2.3700
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.2213
    Cell Significance Index: -2.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2230
    Cell Significance Index: -3.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2265
    Cell Significance Index: -3.4400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2303
    Cell Significance Index: -2.7100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2334
    Cell Significance Index: -3.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2337
    Cell Significance Index: -3.4500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2368
    Cell Significance Index: -3.0900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2384
    Cell Significance Index: -2.0500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2394
    Cell Significance Index: -3.4900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2437
    Cell Significance Index: -2.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2457
    Cell Significance Index: -3.1000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2467
    Cell Significance Index: -2.6800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2481
    Cell Significance Index: -1.9300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2493
    Cell Significance Index: -3.0300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2538
    Cell Significance Index: -3.0900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2546
    Cell Significance Index: -2.6400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2564
    Cell Significance Index: -3.0800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2566
    Cell Significance Index: -2.5900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2567
    Cell Significance Index: -2.1500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2600
    Cell Significance Index: -3.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2611
    Cell Significance Index: -4.3700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2618
    Cell Significance Index: -3.6700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2629
    Cell Significance Index: -3.4600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2651
    Cell Significance Index: -2.9100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2704
    Cell Significance Index: -3.3800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2708
    Cell Significance Index: -3.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2715
    Cell Significance Index: -2.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2742
    Cell Significance Index: -3.2400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2752
    Cell Significance Index: -3.0100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2764
    Cell Significance Index: -2.9800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2774
    Cell Significance Index: -3.8100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2778
    Cell Significance Index: -3.3800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2780
    Cell Significance Index: -3.3000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.2781
    Cell Significance Index: -2.9700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2784
    Cell Significance Index: -2.5800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2802
    Cell Significance Index: -2.8900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2807
    Cell Significance Index: -2.5500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2818
    Cell Significance Index: -3.0700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2826
    Cell Significance Index: -3.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2836
    Cell Significance Index: -3.0900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2839
    Cell Significance Index: -3.1100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2842
    Cell Significance Index: -3.7300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2852
    Cell Significance Index: -3.2400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2859
    Cell Significance Index: -3.0600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2864
    Cell Significance Index: -3.5200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2881
    Cell Significance Index: -3.2000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2890
    Cell Significance Index: -2.9300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2892
    Cell Significance Index: -3.0900
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2901
    Cell Significance Index: -2.6100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2910
    Cell Significance Index: -3.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene location and expression:** The TRBV5-1 gene is located on the X chromosome (Ensembl ID: ENSG00000211734) and is significantly expressed in various immune cells, including granulocyte monocyte progenitor cells, early T lineage precursors, and CD8-positive alpha-beta cytotoxic T cells. 2. **T cell receptor structure:** TRBV5-1 is a variable region of the TCR beta chain, which forms a complex with the TCR alpha chain to recognize antigens. 3. **Molecular weight and structure:** The molecular weight of TRBV5-1 is approximately 40 kDa, and its structure consists of a variable region, a complementarity-determining region (CDR), and a framework region. **Pathways and Functions:** 1. **Adaptive immune response:** TRBV5-1 plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens, which triggers the activation of immune cells and the production of cytokines. 2. **Cell surface receptor signaling:** TRBV5-1 is a cell surface receptor that interacts with its ligands, leading to the activation of downstream signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. 3. **Plasma membrane signaling:** TRBV5-1 also interacts with the plasma membrane, leading to the activation of various signaling pathways, including the NF-κB and JNK pathways. **Clinical Significance:** 1. **Immune-mediated diseases:** Alterations in TRBV5-1 expression have been implicated in various immune-mediated diseases, including autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** TRBV5-1 has been identified as a potential therapeutic target for cancer treatment, as it is overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Vaccine development:** TRBV5-1 has been explored as a potential antigen for vaccine development, as it is involved in the recognition of antigens and the activation of immune cells. In conclusion, the TRBV5-1 gene is a critical component of the adaptive immune response, and its dysregulation has been implicated in various immune-mediated diseases and cancer. Further research is needed to fully understand the role of TRBV5-1 in immune function and its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.