Details for: TRAV36DV7

Gene ID: 28646

Symbol: TRAV36DV7

Ensembl ID: ENSG00000211815

Description: T cell receptor alpha variable 36/delta variable 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.0460
    Cell Significance Index: -3.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0147
    Cell Significance Index: -0.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0307
    Cell Significance Index: -0.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0312
    Cell Significance Index: -1.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0339
    Cell Significance Index: -0.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0695
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0704
    Cell Significance Index: -1.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0708
    Cell Significance Index: -4.5700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0737
    Cell Significance Index: -0.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0801
    Cell Significance Index: -8.3400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0802
    Cell Significance Index: -1.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0873
    Cell Significance Index: -1.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1003
    Cell Significance Index: -1.4800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1060
    Cell Significance Index: -1.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1106
    Cell Significance Index: -2.6800
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1144
    Cell Significance Index: -1.1200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1157
    Cell Significance Index: -1.1600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1383
    Cell Significance Index: -1.5000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1391
    Cell Significance Index: -1.6400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1424
    Cell Significance Index: -1.5400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1436
    Cell Significance Index: -1.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1449
    Cell Significance Index: -0.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1525
    Cell Significance Index: -3.8900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1530
    Cell Significance Index: -2.0400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1617
    Cell Significance Index: -1.4800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1663
    Cell Significance Index: -1.7200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1710
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1780
    Cell Significance Index: -1.9800
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.1782
    Cell Significance Index: -1.6500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1862
    Cell Significance Index: -1.4700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1979
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2097
    Cell Significance Index: -2.8800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2135
    Cell Significance Index: -2.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2206
    Cell Significance Index: -5.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2263
    Cell Significance Index: -5.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2316
    Cell Significance Index: -4.2800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2323
    Cell Significance Index: -2.5500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2340
    Cell Significance Index: -3.4100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2351
    Cell Significance Index: -3.7800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2426
    Cell Significance Index: -1.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2478
    Cell Significance Index: -2.5700
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.2487
    Cell Significance Index: -2.3300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2590
    Cell Significance Index: -3.0600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2598
    Cell Significance Index: -1.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2642
    Cell Significance Index: -5.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2766
    Cell Significance Index: -4.4800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.2774
    Cell Significance Index: -3.0300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2818
    Cell Significance Index: -3.6200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2831
    Cell Significance Index: -4.3000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2882
    Cell Significance Index: -1.7100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2984
    Cell Significance Index: -3.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2993
    Cell Significance Index: -4.2000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2995
    Cell Significance Index: -3.9800
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.3012
    Cell Significance Index: -2.2300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3042
    Cell Significance Index: -2.9200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3121
    Cell Significance Index: -3.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3122
    Cell Significance Index: -1.9400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3210
    Cell Significance Index: -2.3100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3268
    Cell Significance Index: -4.5800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3286
    Cell Significance Index: -3.8800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3405
    Cell Significance Index: -3.4400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3424
    Cell Significance Index: -3.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3498
    Cell Significance Index: -4.5900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3542
    Cell Significance Index: -6.0200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3559
    Cell Significance Index: -4.8800
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.3598
    Cell Significance Index: -3.8400
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3605
    Cell Significance Index: -3.8500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3669
    Cell Significance Index: -4.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3670
    Cell Significance Index: -8.4800
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.3673
    Cell Significance Index: -3.6500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3681
    Cell Significance Index: -4.2700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3683
    Cell Significance Index: -3.7600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3685
    Cell Significance Index: -4.8500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3709
    Cell Significance Index: -4.8500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3737
    Cell Significance Index: -3.7300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3739
    Cell Significance Index: -3.5100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3782
    Cell Significance Index: -4.1200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3806
    Cell Significance Index: -3.7100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3817
    Cell Significance Index: -3.6400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3844
    Cell Significance Index: -3.4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3849
    Cell Significance Index: -4.5800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.3868
    Cell Significance Index: -3.5800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3872
    Cell Significance Index: -4.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3883
    Cell Significance Index: -3.9400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3884
    Cell Significance Index: -6.6400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3896
    Cell Significance Index: -4.7400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.3903
    Cell Significance Index: -1.4700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3910
    Cell Significance Index: -4.0500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.3947
    Cell Significance Index: -4.2000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3959
    Cell Significance Index: -4.7000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3973
    Cell Significance Index: -4.4000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3976
    Cell Significance Index: -3.7700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3997
    Cell Significance Index: -4.6000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.4010
    Cell Significance Index: -3.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4026
    Cell Significance Index: -5.2100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4049
    Cell Significance Index: -4.0800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4065
    Cell Significance Index: -4.5000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4067
    Cell Significance Index: -3.6700
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4078
    Cell Significance Index: -4.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TRAV36DV7 gene is a member of the T cell receptor alpha (TRAV) family, which is responsible for encoding the variable region of the T cell receptor alpha chain. This gene is characterized by its expression in a wide range of cell types, including those involved in the central nervous system (CNS), such as glutamatergic neurons, oligodendrocyte precursor cells, and cerebral cortex GABAergic interneurons. The expression of TRAV36DV7 in non-immune cells, such as goblet cells and endothelial cells, highlights its potential role in non-immunological functions. **Pathways and Functions** The TRAV36DV7 gene is involved in several key pathways, including the adaptive immune response and the response to bacterial infections. The adaptive immune response is a complex process that involves the activation and coordination of multiple immune cells, including T cells, B cells, and dendritic cells. The TRAV36DV7 gene plays a critical role in this process by encoding a functional T cell receptor that recognizes and binds to specific antigens. The response to bacterial infections is another critical function of the TRAV36DV7 gene. Bacterial infections can trigger a robust immune response, which involves the activation of T cells and the production of cytokines and chemokines. The TRAV36DV7 gene is involved in this process by encoding a T cell receptor that recognizes and binds to bacterial antigens. **Clinical Significance** The TRAV36DV7 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. In autoimmune diseases, such as multiple sclerosis, the TRAV36DV7 gene may play a role in the activation and expansion of autoreactive T cells, which contribute to disease pathology. In cancer, the TRAV36DV7 gene may be involved in the regulation of immune responses to tumor antigens. T cells expressing TRAV36DV7 may recognize and target tumor cells, leading to the elimination of cancer cells. However, the expression of TRAV36DV7 in non-immunological cells, such as goblet cells and endothelial cells, raises the possibility of off-target effects, where T cells expressing TRAV36DV7 may recognize and target normal cells, leading to tissue damage. In summary, the TRAV36DV7 gene is a critical component of the adaptive immune system, involved in the response to bacterial infections and the regulation of immune responses to tumor antigens. Its expression in non-immunological cells highlights the complexity of its functions and the need for further research to fully understand its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.