Details for: TRAV36DV7

Gene ID: 28646

Symbol: TRAV36DV7

Ensembl ID: ENSG00000211815

Description: T cell receptor alpha variable 36/delta variable 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,086
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.33
    Marker Score: 5,357
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,177
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.44
    Marker Score: 4,447
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,809
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,574
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,652
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,727
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,059
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,337
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 734
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.6
    Marker Score: 400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.53
    Marker Score: 324
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.16
    Marker Score: 137
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.15
    Marker Score: 81
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.14
    Marker Score: 233
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 407
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.13
    Marker Score: 232
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.12
    Marker Score: 134
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.12
    Marker Score: 169
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.1
    Marker Score: 108
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.09
    Marker Score: 395
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.09
    Marker Score: 77
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.09
    Marker Score: 170
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.08
    Marker Score: 4,367
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.07
    Marker Score: 168
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.07
    Marker Score: 726
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.07
    Marker Score: 55
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 576
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.04
    Marker Score: 100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.04
    Marker Score: 115
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 49
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TRAV36DV7 gene is a member of the T cell receptor alpha (TRAV) family, which is responsible for encoding the variable region of the T cell receptor alpha chain. This gene is characterized by its expression in a wide range of cell types, including those involved in the central nervous system (CNS), such as glutamatergic neurons, oligodendrocyte precursor cells, and cerebral cortex GABAergic interneurons. The expression of TRAV36DV7 in non-immune cells, such as goblet cells and endothelial cells, highlights its potential role in non-immunological functions. **Pathways and Functions** The TRAV36DV7 gene is involved in several key pathways, including the adaptive immune response and the response to bacterial infections. The adaptive immune response is a complex process that involves the activation and coordination of multiple immune cells, including T cells, B cells, and dendritic cells. The TRAV36DV7 gene plays a critical role in this process by encoding a functional T cell receptor that recognizes and binds to specific antigens. The response to bacterial infections is another critical function of the TRAV36DV7 gene. Bacterial infections can trigger a robust immune response, which involves the activation of T cells and the production of cytokines and chemokines. The TRAV36DV7 gene is involved in this process by encoding a T cell receptor that recognizes and binds to bacterial antigens. **Clinical Significance** The TRAV36DV7 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. In autoimmune diseases, such as multiple sclerosis, the TRAV36DV7 gene may play a role in the activation and expansion of autoreactive T cells, which contribute to disease pathology. In cancer, the TRAV36DV7 gene may be involved in the regulation of immune responses to tumor antigens. T cells expressing TRAV36DV7 may recognize and target tumor cells, leading to the elimination of cancer cells. However, the expression of TRAV36DV7 in non-immunological cells, such as goblet cells and endothelial cells, raises the possibility of off-target effects, where T cells expressing TRAV36DV7 may recognize and target normal cells, leading to tissue damage. In summary, the TRAV36DV7 gene is a critical component of the adaptive immune system, involved in the response to bacterial infections and the regulation of immune responses to tumor antigens. Its expression in non-immunological cells highlights the complexity of its functions and the need for further research to fully understand its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.