Details for: TRAV35

Gene ID: 28647

Symbol: TRAV35

Ensembl ID: ENSG00000211814

Description: T cell receptor alpha variable 35

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2127
    Cell Significance Index: 1.1600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0214
    Cell Significance Index: 0.2700
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: 0.0086
    Cell Significance Index: 0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0086
    Cell Significance Index: -1.7200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0180
    Cell Significance Index: -0.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0228
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0275
    Cell Significance Index: -0.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0283
    Cell Significance Index: -0.4800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0338
    Cell Significance Index: -0.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0347
    Cell Significance Index: -0.8400
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0394
    Cell Significance Index: -0.2900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0403
    Cell Significance Index: -0.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0475
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0482
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0483
    Cell Significance Index: -0.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0516
    Cell Significance Index: -1.1300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0528
    Cell Significance Index: -0.4500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0593
    Cell Significance Index: -0.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0679
    Cell Significance Index: -1.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0699
    Cell Significance Index: -1.7800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0723
    Cell Significance Index: -0.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0741
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0770
    Cell Significance Index: -0.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0834
    Cell Significance Index: -2.0800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0839
    Cell Significance Index: -0.8000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0902
    Cell Significance Index: -1.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0936
    Cell Significance Index: -1.8300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0953
    Cell Significance Index: -1.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0953
    Cell Significance Index: -1.4100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0965
    Cell Significance Index: -0.8000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1064
    Cell Significance Index: -1.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1066
    Cell Significance Index: -1.9700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1079
    Cell Significance Index: -1.8500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1083
    Cell Significance Index: -0.3300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1098
    Cell Significance Index: -1.4100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1114
    Cell Significance Index: -1.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1118
    Cell Significance Index: -1.0800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1129
    Cell Significance Index: -1.3400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1134
    Cell Significance Index: -1.3800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1159
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1166
    Cell Significance Index: -1.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1172
    Cell Significance Index: -1.4400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1181
    Cell Significance Index: -1.3700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1184
    Cell Significance Index: -1.2100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1211
    Cell Significance Index: -1.4400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1223
    Cell Significance Index: -1.4900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1241
    Cell Significance Index: -1.2500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1244
    Cell Significance Index: -1.4800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1254
    Cell Significance Index: -1.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1264
    Cell Significance Index: -1.9200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1273
    Cell Significance Index: -1.3200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1278
    Cell Significance Index: -1.4400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1289
    Cell Significance Index: -1.3900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1289
    Cell Significance Index: -1.4100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1298
    Cell Significance Index: -1.4100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1327
    Cell Significance Index: -1.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1340
    Cell Significance Index: -1.2700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1371
    Cell Significance Index: -1.7900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1402
    Cell Significance Index: -1.4300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1418
    Cell Significance Index: -1.2400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1420
    Cell Significance Index: -1.1500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1420
    Cell Significance Index: -1.9500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1421
    Cell Significance Index: -1.3900
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.1436
    Cell Significance Index: -1.2700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1438
    Cell Significance Index: -1.3300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1441
    Cell Significance Index: -1.5600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1443
    Cell Significance Index: -1.6600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1450
    Cell Significance Index: -1.4300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1451
    Cell Significance Index: -1.6700
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1456
    Cell Significance Index: -1.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1476
    Cell Significance Index: -1.9300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1493
    Cell Significance Index: -1.4900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1499
    Cell Significance Index: -1.9000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1505
    Cell Significance Index: -1.7100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1509
    Cell Significance Index: -1.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1511
    Cell Significance Index: -2.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1515
    Cell Significance Index: -1.7900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1535
    Cell Significance Index: -2.0400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1538
    Cell Significance Index: -1.8100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1555
    Cell Significance Index: -1.3000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1557
    Cell Significance Index: -1.4300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1559
    Cell Significance Index: -1.8600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1561
    Cell Significance Index: -1.9500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1562
    Cell Significance Index: -1.9000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1570
    Cell Significance Index: -1.0800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1570
    Cell Significance Index: -1.8100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1571
    Cell Significance Index: -1.7400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1574
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1576
    Cell Significance Index: -1.4800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1578
    Cell Significance Index: -1.6000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1582
    Cell Significance Index: -1.9100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1590
    Cell Significance Index: -1.3600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1590
    Cell Significance Index: -1.5500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1602
    Cell Significance Index: -1.4600
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1608
    Cell Significance Index: -1.4300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1618
    Cell Significance Index: -1.9400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1624
    Cell Significance Index: -1.4200
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.1626
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV35 is a member of the TRAV (T cell receptor alpha variable) gene family, which encodes the variable regions of the T cell receptor alpha (TCRα) chain. The TCRα chain is a critical component of the T cell receptor complex, responsible for recognizing and binding to specific antigens. TRAV35 is specifically expressed in various immune cells, including central memory CD4-positive T cells, effector CD8-positive T cells, and naive thymus-derived T cells. **Pathways and Functions:** TRAV35 plays a pivotal role in the adaptive immune response by participating in the recognition and binding of antigens to T cells. The TCRα chain, including TRAV35, is composed of a constant region (TRC) and variable regions (TRV). The variable regions are responsible for antigen recognition, and TRAV35 is one of the numerous TRV genes that contribute to this process. The adaptive immune response involves multiple pathways, including the activation of T cells, proliferation, and differentiation into effector cells. TRAV35 is involved in the recognition of antigens presented by MHC class II molecules on antigen-presenting cells (APCs). The interaction between the TCRα chain and MHC class II molecules triggers the activation of T cells, leading to the initiation of the adaptive immune response. TRAV35 also plays a role in the regulation of T cell activation, proliferation, and differentiation. The gene is expressed in various stages of T cell development, from thymocyte to mature T cell. The expression of TRAV35 is tightly regulated by transcription factors and cytokines, ensuring proper T cell development and function. **Clinical Significance:** TRAV35 has significant implications for our understanding of immune-related diseases and disorders. The gene is involved in the pathogenesis of various autoimmune and infectious diseases, including rheumatoid arthritis, multiple sclerosis, and tuberculosis. In autoimmune diseases, TRAV35 can contribute to the dysregulation of T cell responses, leading to excessive or inappropriate activation of T cells. In infectious diseases, TRAV35 can influence the recognition and binding of antigens to T cells, affecting the efficacy of the adaptive immune response. Furthermore, TRAV35 has been implicated in the development of cancer. The gene is expressed in various types of cancer cells, including T cells and tumor-infiltrating lymphocytes. The expression of TRAV35 can influence the immune microenvironment, affecting the efficacy of cancer immunotherapy. In conclusion, TRAV35 is a critical component of the adaptive immune response, and its dysregulation can contribute to various immune-related diseases and disorders. Further research is necessary to fully understand the significance of TRAV35 in immune cell development, function, and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.