Details for: TRAV35

Gene ID: 28647

Symbol: TRAV35

Ensembl ID: ENSG00000211814

Description: T cell receptor alpha variable 35

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.16
    Marker Score: 1,251
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.68
    Marker Score: 572
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.32
    Marker Score: 550
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.24
    Marker Score: 198
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.23
    Marker Score: 404
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.18
    Marker Score: 83
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.18
    Marker Score: 159
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.17
    Marker Score: 151
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.15
    Marker Score: 165
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.14
    Marker Score: 274
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 413
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.12
    Marker Score: 507
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.09
    Marker Score: 4,680
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.07
    Marker Score: 181
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.07
    Marker Score: 97
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.06
    Marker Score: 91
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.06
    Marker Score: 692
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.06
    Marker Score: 155
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 85
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.03
    Marker Score: 340
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 98
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 85
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV35 is a member of the TRAV (T cell receptor alpha variable) gene family, which encodes the variable regions of the T cell receptor alpha (TCRα) chain. The TCRα chain is a critical component of the T cell receptor complex, responsible for recognizing and binding to specific antigens. TRAV35 is specifically expressed in various immune cells, including central memory CD4-positive T cells, effector CD8-positive T cells, and naive thymus-derived T cells. **Pathways and Functions:** TRAV35 plays a pivotal role in the adaptive immune response by participating in the recognition and binding of antigens to T cells. The TCRα chain, including TRAV35, is composed of a constant region (TRC) and variable regions (TRV). The variable regions are responsible for antigen recognition, and TRAV35 is one of the numerous TRV genes that contribute to this process. The adaptive immune response involves multiple pathways, including the activation of T cells, proliferation, and differentiation into effector cells. TRAV35 is involved in the recognition of antigens presented by MHC class II molecules on antigen-presenting cells (APCs). The interaction between the TCRα chain and MHC class II molecules triggers the activation of T cells, leading to the initiation of the adaptive immune response. TRAV35 also plays a role in the regulation of T cell activation, proliferation, and differentiation. The gene is expressed in various stages of T cell development, from thymocyte to mature T cell. The expression of TRAV35 is tightly regulated by transcription factors and cytokines, ensuring proper T cell development and function. **Clinical Significance:** TRAV35 has significant implications for our understanding of immune-related diseases and disorders. The gene is involved in the pathogenesis of various autoimmune and infectious diseases, including rheumatoid arthritis, multiple sclerosis, and tuberculosis. In autoimmune diseases, TRAV35 can contribute to the dysregulation of T cell responses, leading to excessive or inappropriate activation of T cells. In infectious diseases, TRAV35 can influence the recognition and binding of antigens to T cells, affecting the efficacy of the adaptive immune response. Furthermore, TRAV35 has been implicated in the development of cancer. The gene is expressed in various types of cancer cells, including T cells and tumor-infiltrating lymphocytes. The expression of TRAV35 can influence the immune microenvironment, affecting the efficacy of cancer immunotherapy. In conclusion, TRAV35 is a critical component of the adaptive immune response, and its dysregulation can contribute to various immune-related diseases and disorders. Further research is necessary to fully understand the significance of TRAV35 in immune cell development, function, and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.