Details for: TRAV16

Gene ID: 28667

Symbol: TRAV16

Ensembl ID: ENSG00000211796

Description: T cell receptor alpha variable 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2655
    Cell Significance Index: 19.5800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.2296
    Cell Significance Index: 9.9600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4988
    Cell Significance Index: 2.7200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.4004
    Cell Significance Index: 4.3500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1596
    Cell Significance Index: 1.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0222
    Cell Significance Index: -2.7300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0406
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0561
    Cell Significance Index: -0.6400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0562
    Cell Significance Index: -0.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0563
    Cell Significance Index: -2.9300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0577
    Cell Significance Index: -0.7900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0609
    Cell Significance Index: -0.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0706
    Cell Significance Index: -3.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0728
    Cell Significance Index: -0.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0900
    Cell Significance Index: -2.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0975
    Cell Significance Index: -1.6800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0998
    Cell Significance Index: -0.8500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1050
    Cell Significance Index: -1.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1201
    Cell Significance Index: -3.0600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1254
    Cell Significance Index: -1.3000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1259
    Cell Significance Index: -2.1200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1260
    Cell Significance Index: -1.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1266
    Cell Significance Index: -2.0500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1512
    Cell Significance Index: -1.3000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1623
    Cell Significance Index: -1.6400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1675
    Cell Significance Index: -2.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1680
    Cell Significance Index: -3.2900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1732
    Cell Significance Index: -1.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1764
    Cell Significance Index: -3.2600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1813
    Cell Significance Index: -1.8800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1876
    Cell Significance Index: -2.5300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1892
    Cell Significance Index: -1.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1901
    Cell Significance Index: -3.2500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2034
    Cell Significance Index: -2.8900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2047
    Cell Significance Index: -2.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2050
    Cell Significance Index: -1.9700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2062
    Cell Significance Index: -2.0100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2083
    Cell Significance Index: -2.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2110
    Cell Significance Index: -2.2900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2147
    Cell Significance Index: -2.6100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2152
    Cell Significance Index: -2.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2154
    Cell Significance Index: -3.1800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2160
    Cell Significance Index: -2.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2172
    Cell Significance Index: -2.5200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2231
    Cell Significance Index: -2.1900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2249
    Cell Significance Index: -2.3900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2268
    Cell Significance Index: -1.8800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2300
    Cell Significance Index: -2.3500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2319
    Cell Significance Index: -2.1500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2329
    Cell Significance Index: -3.0700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2348
    Cell Significance Index: -3.0700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2350
    Cell Significance Index: -2.5700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2362
    Cell Significance Index: -2.5100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2368
    Cell Significance Index: -2.8400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2374
    Cell Significance Index: -2.5700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2399
    Cell Significance Index: -2.0700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2410
    Cell Significance Index: -3.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2431
    Cell Significance Index: -3.2300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2437
    Cell Significance Index: -2.4600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2441
    Cell Significance Index: -2.0400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2465
    Cell Significance Index: -2.9300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2465
    Cell Significance Index: -2.0800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2467
    Cell Significance Index: -2.6600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2477
    Cell Significance Index: -2.8500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2494
    Cell Significance Index: -2.8100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2504
    Cell Significance Index: -2.2900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2505
    Cell Significance Index: -2.6400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2509
    Cell Significance Index: -2.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2511
    Cell Significance Index: -3.3000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2513
    Cell Significance Index: -2.3000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2515
    Cell Significance Index: -1.7300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2557
    Cell Significance Index: -2.3000
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.2576
    Cell Significance Index: -2.5200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2635
    Cell Significance Index: -2.9300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2638
    Cell Significance Index: -2.9300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2642
    Cell Significance Index: -3.0400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2670
    Cell Significance Index: -3.1600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2678
    Cell Significance Index: -3.1700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2687
    Cell Significance Index: -3.1900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2701
    Cell Significance Index: -2.5000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2710
    Cell Significance Index: -3.4900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2755
    Cell Significance Index: -2.4100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2770
    Cell Significance Index: -2.1600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2779
    Cell Significance Index: -2.2500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2782
    Cell Significance Index: -3.6000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2795
    Cell Significance Index: -2.7900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2804
    Cell Significance Index: -2.8600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2811
    Cell Significance Index: -3.1400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2814
    Cell Significance Index: -3.6800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2827
    Cell Significance Index: -3.0800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2828
    Cell Significance Index: -3.7700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2834
    Cell Significance Index: -2.7200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2835
    Cell Significance Index: -3.1400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2851
    Cell Significance Index: -3.1300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2853
    Cell Significance Index: -3.0100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2865
    Cell Significance Index: -3.6300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2865
    Cell Significance Index: -2.2600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2894
    Cell Significance Index: -2.8000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2895
    Cell Significance Index: -3.0800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2899
    Cell Significance Index: -2.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor alpha variable:** TRAV16 is a member of the TCR alpha variable region, which is responsible for recognizing and binding to specific antigens. 2. **Significant expression in diverse cell types:** TRAV16 is expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, and cerebral cortex GABAergic interneurons. 3. **Adaptive immune response:** TRAV16 is involved in the adaptive immune response, which is a specific and targeted response to pathogens or antigens. 4. **T cell receptor complex:** TRAV16 is part of the TCR complex, which is a complex of proteins that work together to recognize and bind to antigens. **Pathways and Functions:** The TRAV16 gene is involved in several key pathways and functions: 1. **Recognition and binding to antigens:** TRAV16 recognizes and binds to specific antigens, which triggers the activation and proliferation of T cells. 2. **Activation of T cells:** The binding of TRAV16 to antigens activates T cells, leading to their proliferation and differentiation into effector cells. 3. **Cytotoxic T cell activation:** TRAV16 is specifically expressed in alpha-beta cytotoxic T cells, which play a crucial role in eliminating infected cells or tumor cells. 4. **Immune response regulation:** TRAV16 is involved in regulating the immune response, including the activation and suppression of T cells. **Clinical Significance:** The TRAV16 gene has significant clinical implications, particularly in the context of immune-related disorders: 1. **Autoimmune diseases:** Alterations in TRAV16 expression have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer immunotherapy:** TRAV16 is a target for cancer immunotherapy, as it can be used to enhance the activation and proliferation of cytotoxic T cells. 3. **Infectious diseases:** TRAV16 is involved in the recognition and binding to pathogens, which is critical for the immune response to infections. 4. **Neurological disorders:** The expression of TRAV16 in neurons and glial cells has implications for the development and treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the TRAV16 gene is a critical component of the adaptive immune system, playing a pivotal role in recognizing and binding to specific antigens. Its expression in various cell types and involvement in the adaptive immune response make it a valuable target for the development of immunotherapies and treatments for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.