Details for: TRAV16

Gene ID: 28667

Symbol: TRAV16

Ensembl ID: ENSG00000211796

Description: T cell receptor alpha variable 16

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,088
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,280
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,846
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,178
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,061
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.44
    Marker Score: 1,361
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.37
    Marker Score: 323
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.31
    Marker Score: 551
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.28
    Marker Score: 249
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.24
    Marker Score: 263
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.23
    Marker Score: 102
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.18
    Marker Score: 312
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.17
    Marker Score: 724
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.16
    Marker Score: 175
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.16
    Marker Score: 8,252
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.15
    Marker Score: 300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.11
    Marker Score: 321
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.11
    Marker Score: 81
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.11
    Marker Score: 156
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.11
    Marker Score: 79
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.1
    Marker Score: 80
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.1
    Marker Score: 221
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.09
    Marker Score: 228
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.09
    Marker Score: 76
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.09
    Marker Score: 864
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.08
    Marker Score: 132
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.08
    Marker Score: 62
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.08
    Marker Score: 913
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 58
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.02
    Marker Score: 56
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 62
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 31

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor alpha variable:** TRAV16 is a member of the TCR alpha variable region, which is responsible for recognizing and binding to specific antigens. 2. **Significant expression in diverse cell types:** TRAV16 is expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, and cerebral cortex GABAergic interneurons. 3. **Adaptive immune response:** TRAV16 is involved in the adaptive immune response, which is a specific and targeted response to pathogens or antigens. 4. **T cell receptor complex:** TRAV16 is part of the TCR complex, which is a complex of proteins that work together to recognize and bind to antigens. **Pathways and Functions:** The TRAV16 gene is involved in several key pathways and functions: 1. **Recognition and binding to antigens:** TRAV16 recognizes and binds to specific antigens, which triggers the activation and proliferation of T cells. 2. **Activation of T cells:** The binding of TRAV16 to antigens activates T cells, leading to their proliferation and differentiation into effector cells. 3. **Cytotoxic T cell activation:** TRAV16 is specifically expressed in alpha-beta cytotoxic T cells, which play a crucial role in eliminating infected cells or tumor cells. 4. **Immune response regulation:** TRAV16 is involved in regulating the immune response, including the activation and suppression of T cells. **Clinical Significance:** The TRAV16 gene has significant clinical implications, particularly in the context of immune-related disorders: 1. **Autoimmune diseases:** Alterations in TRAV16 expression have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer immunotherapy:** TRAV16 is a target for cancer immunotherapy, as it can be used to enhance the activation and proliferation of cytotoxic T cells. 3. **Infectious diseases:** TRAV16 is involved in the recognition and binding to pathogens, which is critical for the immune response to infections. 4. **Neurological disorders:** The expression of TRAV16 in neurons and glial cells has implications for the development and treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the TRAV16 gene is a critical component of the adaptive immune system, playing a pivotal role in recognizing and binding to specific antigens. Its expression in various cell types and involvement in the adaptive immune response make it a valuable target for the development of immunotherapies and treatments for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.