Details for: TRAV12 1

Gene ID: 28674

Symbol: TRAV12 1

Ensembl ID: ENSG00000211785

Description: T cell receptor alpha variable 12-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7959
    Cell Significance Index: 4.3400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.6262
    Cell Significance Index: 5.1900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1678
    Cell Significance Index: 1.8800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0456
    Cell Significance Index: 0.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0186
    Cell Significance Index: 0.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0328
    Cell Significance Index: -4.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0360
    Cell Significance Index: -3.6800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0519
    Cell Significance Index: -0.5200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0567
    Cell Significance Index: -0.6800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0842
    Cell Significance Index: -1.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0860
    Cell Significance Index: -2.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0871
    Cell Significance Index: -2.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1111
    Cell Significance Index: -5.2200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1320
    Cell Significance Index: -1.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1368
    Cell Significance Index: -3.4900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1376
    Cell Significance Index: -1.3900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1444
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1454
    Cell Significance Index: -1.4800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1459
    Cell Significance Index: -1.3700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1465
    Cell Significance Index: -1.7300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1546
    Cell Significance Index: -2.1200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1608
    Cell Significance Index: -1.3700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1657
    Cell Significance Index: -1.1400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1688
    Cell Significance Index: -1.6000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1751
    Cell Significance Index: -2.6600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1779
    Cell Significance Index: -2.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1799
    Cell Significance Index: -3.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1809
    Cell Significance Index: -2.9300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1828
    Cell Significance Index: -1.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1828
    Cell Significance Index: -3.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1867
    Cell Significance Index: -3.4500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1919
    Cell Significance Index: -1.6500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1927
    Cell Significance Index: -1.5600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1959
    Cell Significance Index: -1.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1972
    Cell Significance Index: -3.4000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2014
    Cell Significance Index: -2.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2019
    Cell Significance Index: -2.9800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2024
    Cell Significance Index: -2.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2050
    Cell Significance Index: -1.9700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2115
    Cell Significance Index: -3.4000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2141
    Cell Significance Index: -1.9800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2145
    Cell Significance Index: -2.7800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2208
    Cell Significance Index: -2.2900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2213
    Cell Significance Index: -2.2300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2266
    Cell Significance Index: -3.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2270
    Cell Significance Index: -3.8800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2371
    Cell Significance Index: -2.7500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2385
    Cell Significance Index: -2.9800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2386
    Cell Significance Index: -2.5300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2393
    Cell Significance Index: -2.8200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.2420
    Cell Significance Index: -2.8100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2440
    Cell Significance Index: -3.4200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2448
    Cell Significance Index: -2.9100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2490
    Cell Significance Index: -2.2400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2495
    Cell Significance Index: -2.6900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2506
    Cell Significance Index: -3.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2524
    Cell Significance Index: -3.0700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2524
    Cell Significance Index: -3.2500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2530
    Cell Significance Index: -3.2500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2530
    Cell Significance Index: -3.3300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2544
    Cell Significance Index: -2.4800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2556
    Cell Significance Index: -2.6500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2560
    Cell Significance Index: -2.8000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2573
    Cell Significance Index: -3.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2579
    Cell Significance Index: -2.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2588
    Cell Significance Index: -2.8200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2620
    Cell Significance Index: -4.4500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2637
    Cell Significance Index: -3.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2650
    Cell Significance Index: -3.6700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2676
    Cell Significance Index: -3.0400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2687
    Cell Significance Index: -2.0900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2692
    Cell Significance Index: -2.9900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2696
    Cell Significance Index: -3.9300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.2728
    Cell Significance Index: -2.9800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2729
    Cell Significance Index: -2.9900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2743
    Cell Significance Index: -2.9800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2750
    Cell Significance Index: -2.8100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2758
    Cell Significance Index: -2.8000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2758
    Cell Significance Index: -2.9900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2764
    Cell Significance Index: -3.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2776
    Cell Significance Index: -3.2800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2794
    Cell Significance Index: -3.2200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2798
    Cell Significance Index: -3.3300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2803
    Cell Significance Index: -2.2400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2805
    Cell Significance Index: -3.3300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2813
    Cell Significance Index: -3.3100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.2824
    Cell Significance Index: -3.3000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.2825
    Cell Significance Index: -2.9900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.2845
    Cell Significance Index: -2.7800
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.2846
    Cell Significance Index: -2.9300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2858
    Cell Significance Index: -2.5000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2882
    Cell Significance Index: -3.0400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2892
    Cell Significance Index: -2.9500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2899
    Cell Significance Index: -2.9900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2945
    Cell Significance Index: -2.9900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2955
    Cell Significance Index: -3.4000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2961
    Cell Significance Index: -2.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2965
    Cell Significance Index: -3.8700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2965
    Cell Significance Index: -3.9400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.2987
    Cell Significance Index: -2.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable Region Encoding**: TRAV12.1 encodes a variable region of the alpha chain of the TCR, which is essential for recognizing and binding to specific peptide antigens. 2. **High Expression in Immune Cells**: This gene is significantly expressed in hematopoietic cells, goblet cells, CD8-positive T cells, and granulocyte-monocyte progenitor cells, highlighting its role in the adaptive immune response. 3. **Association with Neoplastic and Abnormal Cells**: TRAV12.1 is also expressed in neoplastic and abnormal cells, suggesting its involvement in the development and progression of various cancers. 4. **Involvement in Intestinal Immunity**: The expression of TRAV12.1 in intestinal crypt stem cells of the colon indicates its role in maintaining intestinal immunity and preventing pathogens from colonizing the gut. **Pathways and Functions:** 1. **Adaptive Immune Response**: TRAV12.1 plays a critical role in the adaptive immune response by encoding a variable region of the TCR, which recognizes and binds to specific peptide antigens. 2. **Peptide Antigen Binding**: The TCR complex, including TRAV12.1, binds to peptide antigens presented by major histocompatibility complex (MHC) molecules, triggering an immune response. 3. **T Cell Receptor Complex**: TRAV12.1 is part of the TCR complex, which is essential for recognizing and binding to specific peptide antigens. 4. **Cytokine Signaling**: The TCR complex, including TRAV12.1, can also modulate cytokine signaling, influencing the activation and proliferation of T cells. **Clinical Significance:** The TRAV12.1 gene has significant clinical implications, particularly in the context of cancer and autoimmune diseases. Aberrant expression of TRAV12.1 has been linked to various cancers, including leukemia and lymphoma. Additionally, dysregulation of TRAV12.1 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, TRAV12.1 is a critical gene that plays a vital role in the adaptive immune response. Its expression in various cell types and its involvement in cancer and autoimmune diseases underscore its importance in human health and disease. Further research is necessary to fully elucidate the mechanisms by which TRAV12.1 regulates the immune response and to explore its therapeutic potential.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.