Details for: TRAV8 3

Gene ID: 28683

Symbol: TRAV8 3

Ensembl ID: ENSG00000211787

Description: T cell receptor alpha variable 8-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.1168
    Cell Significance Index: 6.0900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4536
    Cell Significance Index: 5.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.3578
    Cell Significance Index: -1.1000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1295
    Cell Significance Index: 1.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0918
    Cell Significance Index: 1.1600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.0878
    Cell Significance Index: 0.2700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0069
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -1.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0049
    Cell Significance Index: -0.6000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0139
    Cell Significance Index: -0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0190
    Cell Significance Index: -3.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0317
    Cell Significance Index: -1.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0433
    Cell Significance Index: -1.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0522
    Cell Significance Index: -0.8800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0534
    Cell Significance Index: -0.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0618
    Cell Significance Index: -0.8000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0624
    Cell Significance Index: -1.0600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0658
    Cell Significance Index: -0.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0667
    Cell Significance Index: -1.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0677
    Cell Significance Index: -1.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0705
    Cell Significance Index: -1.0400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0711
    Cell Significance Index: -0.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0730
    Cell Significance Index: -3.4300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0732
    Cell Significance Index: -1.0400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0764
    Cell Significance Index: -1.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0775
    Cell Significance Index: -1.9800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0785
    Cell Significance Index: -0.8100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0787
    Cell Significance Index: -1.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0814
    Cell Significance Index: -2.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0842
    Cell Significance Index: -2.2900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0849
    Cell Significance Index: -0.9000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0859
    Cell Significance Index: -0.9300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0942
    Cell Significance Index: -0.8100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0945
    Cell Significance Index: -1.1800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0956
    Cell Significance Index: -0.9700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0964
    Cell Significance Index: -1.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0988
    Cell Significance Index: -1.6000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1020
    Cell Significance Index: -1.0300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1022
    Cell Significance Index: -1.0600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1031
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1032
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1080
    Cell Significance Index: -1.0100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1082
    Cell Significance Index: -0.9900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1082
    Cell Significance Index: -1.1600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1092
    Cell Significance Index: -0.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1092
    Cell Significance Index: -1.0500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1109
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1160
    Cell Significance Index: -2.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1183
    Cell Significance Index: -1.9800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1187
    Cell Significance Index: -0.9400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1189
    Cell Significance Index: -1.6300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1199
    Cell Significance Index: -1.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1211
    Cell Significance Index: -1.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1228
    Cell Significance Index: -2.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1246
    Cell Significance Index: -1.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1294
    Cell Significance Index: -2.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1318
    Cell Significance Index: -1.2500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1325
    Cell Significance Index: -2.1300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1362
    Cell Significance Index: -1.5800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1364
    Cell Significance Index: -1.7800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1387
    Cell Significance Index: -1.8700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1388
    Cell Significance Index: -1.7800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1392
    Cell Significance Index: -2.3800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1398
    Cell Significance Index: -1.8400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1399
    Cell Significance Index: -1.5100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1409
    Cell Significance Index: -1.7000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1415
    Cell Significance Index: -1.6700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1472
    Cell Significance Index: -1.7900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1477
    Cell Significance Index: -1.4400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1478
    Cell Significance Index: -1.3300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1480
    Cell Significance Index: -1.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1491
    Cell Significance Index: -1.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1493
    Cell Significance Index: -1.7800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1503
    Cell Significance Index: -1.2700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1520
    Cell Significance Index: -2.1300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1522
    Cell Significance Index: -1.8500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1533
    Cell Significance Index: -1.8500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1536
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1546
    Cell Significance Index: -1.9000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1555
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1558
    Cell Significance Index: -2.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1564
    Cell Significance Index: -2.4200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1565
    Cell Significance Index: -2.0100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1588
    Cell Significance Index: -1.6000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1593
    Cell Significance Index: -1.8100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1600
    Cell Significance Index: -1.4800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1602
    Cell Significance Index: -1.8100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.1605
    Cell Significance Index: -0.9200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1608
    Cell Significance Index: -1.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1608
    Cell Significance Index: -2.1100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1621
    Cell Significance Index: -1.1200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1626
    Cell Significance Index: -2.3700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1630
    Cell Significance Index: -1.3200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1636
    Cell Significance Index: -1.7900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1651
    Cell Significance Index: -1.7800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1651
    Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV8-3 is a single-copy gene located on chromosome 7q32, encoding a 95-amino acid protein that is part of the TCR alpha chain. The gene exhibits high polymorphism, with multiple alleles and variants that contribute to the diversity of the TCR repertoire. TRAV8-3 is specifically expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, goblet cells, granulocyte monocyte progenitor cells, neoplastic cells, and abnormal cells. This widespread expression suggests a critical role in maintaining immune homeostasis and tolerance. **Pathways and Functions:** TRAV8-3 is integral to the adaptive immune response, particularly in the recognition and targeting of antigens by T cells. The gene's product is involved in the assembly and assembly of the TCR complex, which is essential for the activation and proliferation of T cells. TRAV8-3 also plays a role in the regulation of T cell activation and proliferation, influencing the balance between effector and regulatory T cell responses. Furthermore, the gene has been implicated in the modulation of immune responses in various disease contexts, including cancer, autoimmune diseases, and transplantation. **Clinical Significance:** TRAV8-3 has significant clinical implications in several areas: 1. **Cancer Immunotherapy:** The gene's product has been shown to influence the TCR repertoire and the activation of T cells in response to cancer antigens. This has led to the development of cancer immunotherapies that target specific TRAV8-3-expressing T cells. 2. **Autoimmune Diseases:** TRAV8-3 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. The gene's product may contribute to the dysregulation of T cell responses and the development of autoimmunity. 3. **Transplantation:** TRAV8-3 expression has been linked to the rejection of transplanted organs, particularly in the context of T cell-mediated rejection. The gene's product may influence the activation and proliferation of T cells in response to allogenic antigens. 4. **Immunodeficiency:** Variants of TRAV8-3 have been associated with impaired T cell function and immunodeficiency, highlighting the gene's importance in maintaining immune homeostasis. In conclusion, TRAV8-3 is a complex gene with significant immunological implications. Further research into the gene's mechanisms and functions will provide valuable insights into its role in the adaptive immune system and its potential applications in the treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.