Details for: TRAV5

Gene ID: 28688

Symbol: TRAV5

Ensembl ID: ENSG00000211779

Description: T cell receptor alpha variable 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.5691
    Cell Significance Index: 62.2300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5098
    Cell Significance Index: 2.7800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1727
    Cell Significance Index: 1.9300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1067
    Cell Significance Index: 1.0700
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0826
    Cell Significance Index: 0.6000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0224
    Cell Significance Index: 0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0052
    Cell Significance Index: -1.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0064
    Cell Significance Index: -1.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0140
    Cell Significance Index: -0.2400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0220
    Cell Significance Index: -1.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0257
    Cell Significance Index: -1.2100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0260
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0289
    Cell Significance Index: -0.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0344
    Cell Significance Index: -0.9200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0386
    Cell Significance Index: -0.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0408
    Cell Significance Index: -1.9000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0467
    Cell Significance Index: -0.5900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0477
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0493
    Cell Significance Index: -0.8500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0507
    Cell Significance Index: -0.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0559
    Cell Significance Index: -1.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0583
    Cell Significance Index: -0.8600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0585
    Cell Significance Index: -0.8500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0587
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0614
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0638
    Cell Significance Index: -0.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0642
    Cell Significance Index: -1.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0659
    Cell Significance Index: -1.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0681
    Cell Significance Index: -1.3400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0695
    Cell Significance Index: -0.8600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0732
    Cell Significance Index: -0.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0737
    Cell Significance Index: -1.4800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0739
    Cell Significance Index: -0.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0744
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0759
    Cell Significance Index: -0.7100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0784
    Cell Significance Index: -1.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0854
    Cell Significance Index: -1.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0854
    Cell Significance Index: -1.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0873
    Cell Significance Index: -1.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0907
    Cell Significance Index: -2.4700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0912
    Cell Significance Index: -0.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0920
    Cell Significance Index: -1.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0926
    Cell Significance Index: -1.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0951
    Cell Significance Index: -0.7400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0951
    Cell Significance Index: -0.8700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0956
    Cell Significance Index: -0.9700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0966
    Cell Significance Index: -1.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0968
    Cell Significance Index: -1.7900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0972
    Cell Significance Index: -0.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0983
    Cell Significance Index: -0.9500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0986
    Cell Significance Index: -1.1600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0988
    Cell Significance Index: -0.8000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1009
    Cell Significance Index: -1.0700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1064
    Cell Significance Index: -0.8400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1082
    Cell Significance Index: -1.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1084
    Cell Significance Index: -1.5400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1103
    Cell Significance Index: -1.4700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1117
    Cell Significance Index: -1.4700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1118
    Cell Significance Index: -1.0900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1122
    Cell Significance Index: -1.1300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1125
    Cell Significance Index: -1.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1125
    Cell Significance Index: -1.7400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1126
    Cell Significance Index: -1.4700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1138
    Cell Significance Index: -1.5600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1147
    Cell Significance Index: -1.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1148
    Cell Significance Index: -1.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1177
    Cell Significance Index: -1.7200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1189
    Cell Significance Index: -1.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1189
    Cell Significance Index: -2.3200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1193
    Cell Significance Index: -1.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1197
    Cell Significance Index: -1.5100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1207
    Cell Significance Index: -1.9400
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.1221
    Cell Significance Index: -0.9200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1222
    Cell Significance Index: -1.1300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1248
    Cell Significance Index: -1.4700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1250
    Cell Significance Index: -1.5200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1250
    Cell Significance Index: -1.4700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1250
    Cell Significance Index: -1.4400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1251
    Cell Significance Index: -1.0000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1258
    Cell Significance Index: -1.5600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1265
    Cell Significance Index: -1.4700
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1266
    Cell Significance Index: -1.2400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1269
    Cell Significance Index: -1.4300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1275
    Cell Significance Index: -1.1000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1286
    Cell Significance Index: -1.4800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1310
    Cell Significance Index: -1.6100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1312
    Cell Significance Index: -1.5600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1331
    Cell Significance Index: -1.5800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1338
    Cell Significance Index: -1.5400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1341
    Cell Significance Index: -1.7500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1345
    Cell Significance Index: -1.4500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1357
    Cell Significance Index: -1.7400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1358
    Cell Significance Index: -1.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV5 is a member of the TRAV family, which consists of approximately 60 variable region genes that encode the variable regions of the T cell receptor alpha chain. These genes are highly polymorphic, resulting in a diverse repertoire of T cell receptors. The TRAV5 gene is characterized by its ability to encode a unique variable region that is recognized by the T cell receptor alpha chain. This region is crucial for the specificity and affinity of T cell receptor interactions with antigens. **Pathways and Functions:** TRAV5 is involved in the adaptive immune response, specifically in the recognition and targeting of pathogens by T cells. The T cell receptor alpha chain, which includes the TRAV5 gene, recognizes antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. The interaction between the T cell receptor and antigen is mediated by the variable region encoded by TRAV5. This region is responsible for the specificity and affinity of the interaction, allowing T cells to recognize and respond to specific pathogens. The TRAV5 gene is also involved in the regulation of T cell activation and proliferation. Upon recognition of antigens, T cells undergo activation, proliferation, and differentiation, which is mediated by the TRAV5 gene. The expression of TRAV5 is essential for the proper functioning of the immune system, as it contributes to the recognition and targeting of pathogens by T cells. **Clinical Significance:** Dysregulation of the TRAV5 gene has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, alterations in the TRAV5 gene have been associated with autoimmune diseases such as multiple sclerosis and type 1 diabetes. Additionally, the TRAV5 gene has been implicated in the development of certain types of cancer, including leukemia and lymphoma. Furthermore, the TRAV5 gene has been used as a marker for T cell activation and proliferation. The expression of TRAV5 has been detected in the blood of patients with autoimmune diseases and cancer, suggesting its potential as a diagnostic marker. In conclusion, the TRAV5 gene plays a crucial role in the adaptive immune response, and its dysregulation has been implicated in various immune-related disorders. Further research is needed to fully understand the mechanisms by which TRAV5 contributes to the immune system, as well as its potential as a diagnostic marker. **Significantly expressed cells:** - Granulocyte-monocyte progenitor cell - Early T lineage precursor - Neutrophil progenitor cell - Neutrophil - Common myeloid progenitor - Pro-B cell - Precursor B cell - Megakaryocyte-erythroid progenitor cell - Fraction A pre-pro B cell - T follicular helper cell **Pathways/Ontology:** - Adaptive immune response - Response to bacterium - T cell receptor complex **References:** [Insert references to relevant studies and articles] Note: The references provided should be based on the actual research and studies related to the TRAV5 gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.