Details for: IGKV3D 15

Gene ID: 28875

Symbol: IGKV3D 15

Ensembl ID: ENSG00000224041

Description: immunoglobulin kappa variable 3D-15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0052
    Cell Significance Index: -0.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0573
    Cell Significance Index: -5.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0741
    Cell Significance Index: -3.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1891
    Cell Significance Index: -5.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2171
    Cell Significance Index: -5.5300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2271
    Cell Significance Index: -5.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2310
    Cell Significance Index: -5.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2312
    Cell Significance Index: -5.6000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2329
    Cell Significance Index: -2.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2721
    Cell Significance Index: -5.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3154
    Cell Significance Index: -5.8300
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.3557
    Cell Significance Index: -2.7300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3559
    Cell Significance Index: -4.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3826
    Cell Significance Index: -4.3500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.3840
    Cell Significance Index: -3.1700
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.4056
    Cell Significance Index: -3.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4378
    Cell Significance Index: -7.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4811
    Cell Significance Index: -5.6800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4846
    Cell Significance Index: -5.7600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4934
    Cell Significance Index: -5.5600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4990
    Cell Significance Index: -5.3800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.5046
    Cell Significance Index: -3.3600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5057
    Cell Significance Index: -5.5400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5171
    Cell Significance Index: -5.9500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5227
    Cell Significance Index: -5.7000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5231
    Cell Significance Index: -6.3100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.5274
    Cell Significance Index: -5.7600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.5332
    Cell Significance Index: -5.5300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5392
    Cell Significance Index: -6.2100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.5404
    Cell Significance Index: -5.5600
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.5411
    Cell Significance Index: -5.7800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5467
    Cell Significance Index: -6.8300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5519
    Cell Significance Index: -6.1100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5520
    Cell Significance Index: -5.6300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.5547
    Cell Significance Index: -5.8700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.5553
    Cell Significance Index: -5.6100
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5610
    Cell Significance Index: -6.1900
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.5710
    Cell Significance Index: -5.3200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5714
    Cell Significance Index: -5.5700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.5767
    Cell Significance Index: -5.8100
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.5821
    Cell Significance Index: -6.2200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.5845
    Cell Significance Index: -5.4000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.5878
    Cell Significance Index: -5.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5920
    Cell Significance Index: -10.1200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5949
    Cell Significance Index: -7.9100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5959
    Cell Significance Index: -5.7200
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.5985
    Cell Significance Index: -5.6300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.6021
    Cell Significance Index: -8.3500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.6047
    Cell Significance Index: -5.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6074
    Cell Significance Index: -7.8600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6093
    Cell Significance Index: -5.7200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.6118
    Cell Significance Index: -6.9500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.6233
    Cell Significance Index: -5.5600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6265
    Cell Significance Index: -5.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.6283
    Cell Significance Index: -7.0200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.6293
    Cell Significance Index: -5.8400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6310
    Cell Significance Index: -6.2300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.6347
    Cell Significance Index: -6.7400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.6352
    Cell Significance Index: -6.3400
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.6352
    Cell Significance Index: -5.6300
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.6374
    Cell Significance Index: -5.6000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.6444
    Cell Significance Index: -6.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.6451
    Cell Significance Index: -6.2000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.6498
    Cell Significance Index: -5.8100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.6535
    Cell Significance Index: -5.5200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.6581
    Cell Significance Index: -8.0000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.6584
    Cell Significance Index: -6.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.6660
    Cell Significance Index: -7.8700
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.6703
    Cell Significance Index: -6.2200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.6730
    Cell Significance Index: -7.1600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.6852
    Cell Significance Index: -6.1000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.6862
    Cell Significance Index: -7.4400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.6903
    Cell Significance Index: -6.3400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.6903
    Cell Significance Index: -7.1500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.7022
    Cell Significance Index: -7.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.7051
    Cell Significance Index: -7.1600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.7066
    Cell Significance Index: -4.8600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.7101
    Cell Significance Index: -5.7500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.7173
    Cell Significance Index: -5.5800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.7242
    Cell Significance Index: -7.9500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.7253
    Cell Significance Index: -9.3400
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.7345
    Cell Significance Index: -5.6400
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.7472
    Cell Significance Index: -8.3000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.7514
    Cell Significance Index: -7.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7527
    Cell Significance Index: -7.9400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.7594
    Cell Significance Index: -7.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.7643
    Cell Significance Index: -7.1500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.7673
    Cell Significance Index: -6.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7692
    Cell Significance Index: -10.9300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.7738
    Cell Significance Index: -8.3200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.7752
    Cell Significance Index: -7.1700
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.7804
    Cell Significance Index: -6.3600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.7815
    Cell Significance Index: -9.0700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.7857
    Cell Significance Index: -6.7800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.7858
    Cell Significance Index: -5.5300
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.7860
    Cell Significance Index: -5.5400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.7885
    Cell Significance Index: -8.3100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.7892
    Cell Significance Index: -12.6900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.7895
    Cell Significance Index: -9.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.7978
    Cell Significance Index: -10.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV3D15 shares several key characteristics with other immunoglobulin genes, including: 1. **Variable region**: IGKV3D15 encodes a variable region that is responsible for binding to specific antigens, allowing the immune system to recognize and respond to pathogens. 2. **Constant region**: The constant region of IGKV3D15 is involved in the assembly and secretion of immunoglobulins, which are critical for the immune response. 3. **Diversity**: IGKV3D15 exhibits high diversity, with multiple alleles and variants that enable the immune system to respond to a wide range of pathogens. 4. **Expression**: IGKV3D15 is expressed in various cell types, including T cells, lymphocytes, and epithelial cells, indicating its broad involvement in immune regulation and function. **Pathways and Functions:** IGKV3D15 is involved in several key pathways and functions, including: 1. **Adaptive immune response**: IGKV3D15 plays a crucial role in the adaptive immune response, which is characterized by the activation of specific immune cells, such as T cells and B cells. 2. **Immunoglobulin production**: IGKV3D15 is involved in the assembly and secretion of immunoglobulins, which are critical for the immune response. 3. **Plasma membrane regulation**: IGKV3D15 is expressed on the plasma membrane of certain cells, where it regulates the assembly and secretion of immunoglobulins. 4. **Cell signaling**: IGKV3D15 is involved in cell signaling pathways that regulate immune cell activation and proliferation. **Clinical Significance:** IGKV3D15 has significant clinical implications, particularly in the context of immune-related disorders. Some potential applications of IGKV3D15 include: 1. **Immunodeficiency disorders**: IGKV3D15 mutations or deletions may contribute to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune diseases**: IGKV3D15 may play a role in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system is dysregulated. 3. **Cancer**: IGKV3D15 may be involved in the development and progression of certain cancers, such as lymphoma and leukemia, where the immune system is disrupted. 4. **Vaccine development**: IGKV3D15 may be targeted in the development of vaccines, where it can be used as a target antigen to induce immune responses. In conclusion, IGKV3D15 is a complex gene that plays a critical role in the immune system. Its involvement in various pathways and functions makes it a valuable target for understanding immune-related disorders and developing novel therapeutic strategies. Further research is needed to fully elucidate the role of IGKV3D15 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.