Details for: DNMT3L

Gene ID: 29947

Symbol: DNMT3L

Ensembl ID: ENSG00000142182

Description: DNA methyltransferase 3 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 6.8155
    Cell Significance Index: 200.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.5238
    Cell Significance Index: 49.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.2507
    Cell Significance Index: 21.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2146
    Cell Significance Index: 29.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4021
    Cell Significance Index: 5.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1044
    Cell Significance Index: 1.5000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0898
    Cell Significance Index: 1.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0868
    Cell Significance Index: 1.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0743
    Cell Significance Index: 1.8500
  • Cell Name: epithelial cell of proximal tubule segment 1 (CL4030009)
    Fold Change: 0.0739
    Cell Significance Index: 0.3000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0562
    Cell Significance Index: 0.7900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0545
    Cell Significance Index: 0.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0406
    Cell Significance Index: 0.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0321
    Cell Significance Index: 0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0296
    Cell Significance Index: 5.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0248
    Cell Significance Index: 0.6700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0234
    Cell Significance Index: 0.3400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0137
    Cell Significance Index: 0.1100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0113
    Cell Significance Index: 0.0900
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.0108
    Cell Significance Index: 0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0054
    Cell Significance Index: 1.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0051
    Cell Significance Index: 0.1600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0044
    Cell Significance Index: 0.0600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0025
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0022
    Cell Significance Index: 0.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0018
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0007
    Cell Significance Index: 1.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0004
    Cell Significance Index: -0.0600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0008
    Cell Significance Index: -0.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0033
    Cell Significance Index: -0.2700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0038
    Cell Significance Index: -0.4400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0039
    Cell Significance Index: -0.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0045
    Cell Significance Index: -0.3100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.0047
    Cell Significance Index: -0.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0050
    Cell Significance Index: -0.6200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0054
    Cell Significance Index: -0.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0059
    Cell Significance Index: -0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0068
    Cell Significance Index: -0.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0069
    Cell Significance Index: -0.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0070
    Cell Significance Index: -0.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0070
    Cell Significance Index: -0.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0070
    Cell Significance Index: -0.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0090
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0095
    Cell Significance Index: -0.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0096
    Cell Significance Index: -0.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0102
    Cell Significance Index: -0.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0115
    Cell Significance Index: -0.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0125
    Cell Significance Index: -0.3500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0127
    Cell Significance Index: -0.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0129
    Cell Significance Index: -0.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0132
    Cell Significance Index: -0.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0137
    Cell Significance Index: -0.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0146
    Cell Significance Index: -0.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0148
    Cell Significance Index: -0.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0149
    Cell Significance Index: -0.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0150
    Cell Significance Index: -0.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0151
    Cell Significance Index: -0.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0162
    Cell Significance Index: -0.2300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0163
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0187
    Cell Significance Index: -0.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0205
    Cell Significance Index: -0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0207
    Cell Significance Index: -0.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0208
    Cell Significance Index: -0.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0210
    Cell Significance Index: -0.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0213
    Cell Significance Index: -0.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0218
    Cell Significance Index: -1.1000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0224
    Cell Significance Index: -0.5600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0226
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0231
    Cell Significance Index: -0.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0234
    Cell Significance Index: -0.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0236
    Cell Significance Index: -0.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0245
    Cell Significance Index: -0.4100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNMT3L shares structural and functional similarities with DNA methyltransferase 3 (DNMT3), but its enzymatic activity is distinct. Unlike DNMT3, which can methylate both DNA and RNA, DNMT3L is primarily involved in DNA methylation. Its ability to bind to the DNMT3 complex and facilitate the transfer of methyl groups to cytosine residues positions it as a crucial regulator of epigenetic programs. Notably, DNMT3L's role in maintaining genomic imprinting, a process essential for normal development and function, has been well-documented. **Pathways and Functions:** DNMT3L is involved in several key pathways, including: 1. **Autosome Genomic Imprinting:** DNMT3L plays a critical role in maintaining genomic imprinting, a process by which certain genes are silenced or expressed based on their parental origin. 2. **C-5 Methylation of Cytosine:** DNMT3L is responsible for the transfer of methyl groups to cytosine residues, resulting in DNA methylation. 3. **Epigenetic Programming of the Female Pronucleus:** DNMT3L is involved in the epigenetic programming of the female pronucleus, a process essential for proper embryonic development. 4. **Retrotransposon Silencing:** DNMT3L helps to silence retrotransposons, mobile genetic elements that can disrupt gene function and contribute to disease. 5. **Heterochromatin Formation:** DNMT3L contributes to the formation of heterochromatin, a compact, transcriptionally inactive chromatin structure. **Clinical Significance:** Dysregulation of DNMT3L has been implicated in various diseases, including: 1. **Cancer:** DNMT3L's role in maintaining genomic imprinting and silencing retrotransposons makes it a potential target for cancer therapy. 2. **Neurodevelopmental Disorders:** Abnormal DNMT3L expression has been linked to neurodevelopmental disorders, such as autism and schizophrenia. 3. **Reproductive Disorders:** DNMT3L's involvement in genomic imprinting and epigenetic programming of the female pronucleus makes it a potential target for infertility treatments. In conclusion, DNMT3L is a critical component of the DNA methyltransferase complex, playing a pivotal role in regulating gene expression through DNA methylation. Its widespread expression across various cell types highlights its importance in diverse physiological processes, and its dysregulation has been implicated in various diseases. Further research is necessary to fully elucidate the mechanisms by which DNMT3L regulates epigenetic programs and to explore its therapeutic potential.

Genular Protein ID: 3674972796

Symbol: DNM3L_HUMAN

Name: DNA (cytosine-5)-methyltransferase 3-like

UniProtKB Accession Codes:

Q9UJW3 E9PB42 Q9BUJ4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 2 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 REBASE 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10857753

Title: Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.

PubMed ID: 10857753

DOI: 10.1006/geno.2000.6168

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17687327

Title: DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.

PubMed ID: 17687327

DOI: 10.1038/nature05987

PubMed ID: 17713477

Title: Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.

PubMed ID: 17713477

DOI: 10.1038/nature06146

Sequence Information:

  • Length: 386
  • Mass: 43583
  • Checksum: 65EC2AB7492D53B3
  • Sequence:
    • MAAIPALDPE AEPSMDVILV GSSELSSSVS PGTGRDLIAY EVKANQRNIE DICICCGSLQ 
VHTQHPLFEG GICAPCKDKF LDALFLYDDD GYQSYCSICC SGETLLICGN PDCTRCYCFE 
CVDSLVGPGT SGKVHAMSNW VCYLCLPSSR SGLLQRRRKW RSQLKAFYDR ESENPLEMFE 
TVPVWRRQPV RVLSLFEDIK KELTSLGFLE SGSDPGQLKH VVDVTDTVRK DVEEWGPFDL 
VYGATPPLGH TCDRPPSWYL FQFHRLLQYA RPKPGSPRPF FWMFVDNLVL NKEDLDVASR 
FLEMEPVTIP DVHGGSLQNA VRVWSNIPAI RSRHWALVSE EELSLLAQNK QSSKLAAKWP 
TKLVKNCFLP LREYFKYFST ELTSSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.